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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1975 1
1976 1
1978 4
1979 3
1980 1
1983 4
1985 2
1986 2
1987 1
1988 5
1989 5
1990 6
1991 3
1992 8
1993 3
1994 12
1995 11
1996 11
1997 17
1998 14
1999 11
2000 5
2001 11
2002 9
2003 21
2004 11
2005 13
2006 18
2007 11
2008 13
2009 23
2010 21
2011 29
2012 42
2013 39
2014 50
2015 38
2016 55
2017 68
2018 50
2019 53
2020 66
2021 61
2022 64
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833 results
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Page 1
Antibiotic resistance.
Frieri M, Kumar K, Boutin A. Frieri M, et al. J Infect Public Health. 2017 Jul-Aug;10(4):369-378. doi: 10.1016/j.jiph.2016.08.007. Epub 2016 Sep 6. J Infect Public Health. 2017. PMID: 27616769 Free article. Review.
Multidrug resistance patterns in Gram-positive and -negative bacteria are difficult to treat and may even be untreatable with conventional antibiotics. There is currently a shortage of effective therapies, lack of successful prevention measures, and only a few new antibiot …
Multidrug resistance patterns in Gram-positive and -negative bacteria are difficult to treat and may even be untreatable with convent …
Mycoplasma genitalium: A Review.
Gnanadurai R, Fifer H. Gnanadurai R, et al. Microbiology (Reading). 2020 Jan;166(1):21-29. doi: 10.1099/mic.0.000830. Microbiology (Reading). 2020. PMID: 31329090 Review.
First isolated in 1981, much is still unknown regarding its natural history in untreated infection. It is recognized as a sexually transmitted pathogen causing acute and chronic non-gonococcal urethritis (NGU) in men, with a growing body of evidence to suggest it also caus …
First isolated in 1981, much is still unknown regarding its natural history in untreated infection. It is recognized as a sexually tr …
Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS.
Smith SP, Wu G, Fooks AR, Ma J, Banyard AC. Smith SP, et al. J Gen Virol. 2019 Aug;100(8):1171-1186. doi: 10.1099/jgv.0.001269. Epub 2019 Jun 25. J Gen Virol. 2019. PMID: 31237530 Review.
Despite the availability of safe and effective vaccines, the clinical stages of rabies encephalitis remain untreatable, with few survivors being documented. A principal obstacle to the treatment of rabies is the neurotropic nature of the virus, with the blood-brain barrier …
Despite the availability of safe and effective vaccines, the clinical stages of rabies encephalitis remain untreatable, with few surv …
New guidelines for hospital-acquired pneumonia/ventilator-associated pneumonia: USA vs. Europe.
Martin-Loeches I, Rodriguez AH, Torres A. Martin-Loeches I, et al. Curr Opin Crit Care. 2018 Oct;24(5):347-352. doi: 10.1097/MCC.0000000000000535. Curr Opin Crit Care. 2018. PMID: 30063491 Review.
There is an implicit risk, when appropriate means broad spectrum, that liberal use of antimicrobial combinations will encourage the emergence of multidrug resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant bacteria (PDR) and generate untreatable inf …
There is an implicit risk, when appropriate means broad spectrum, that liberal use of antimicrobial combinations will encourage the emergenc …
International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).
Tsuji BT, Pogue JM, Zavascki AP, Paul M, Daikos GL, Forrest A, Giacobbe DR, Viscoli C, Giamarellou H, Karaiskos I, Kaye D, Mouton JW, Tam VH, Thamlikitkul V, Wunderink RG, Li J, Nation RL, Kaye KS. Tsuji BT, et al. Pharmacotherapy. 2019 Jan;39(1):10-39. doi: 10.1002/phar.2209. Pharmacotherapy. 2019. PMID: 30710469 Free PMC article.
Their clinical use has recently resurged, assuming an important role as salvage therapy for otherwise untreatable gram-negative infections. Since their reintroduction into the clinic, significant confusion remains due to the existence of several different convention …
Their clinical use has recently resurged, assuming an important role as salvage therapy for otherwise untreatable gram-negative in …
Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.
Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. Ernst CM, et al. Nat Med. 2020 May;26(5):705-711. doi: 10.1038/s41591-020-0825-4. Epub 2020 Apr 13. Nat Med. 2020. PMID: 32284589 Free PMC article.
We demonstrate that K. pneumoniae can enhance its pathogenicity by adopting two opposing infection programs through easily acquired gain- and loss-of-function mutations. ...In the latter case, drug-tolerant K. pneumoniae can persist to yield potentially untreatab …
We demonstrate that K. pneumoniae can enhance its pathogenicity by adopting two opposing infection programs through easily acq …
Defeating Antibiotic-Resistant Bacteria: Exploring Alternative Therapies for a Post-Antibiotic Era.
Wang CH, Hsieh YH, Powers ZM, Kao CY. Wang CH, et al. Int J Mol Sci. 2020 Feb 5;21(3):1061. doi: 10.3390/ijms21031061. Int J Mol Sci. 2020. PMID: 32033477 Free PMC article. Review.
We therefore are heading for a post-antibiotic era in which common infections become untreatable and once again deadly. There is thus an emergent need for both novel classes of antibiotics and novel approaches to treatment, including the repurposing of existing drug …
We therefore are heading for a post-antibiotic era in which common infections become untreatable and once again deadly. There …
Reaching the End of the Line: Urinary Tract Infections.
Tamadonfar KO, Omattage NS, Spaulding CN, Hultgren SJ. Tamadonfar KO, et al. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0014-2019. Microbiol Spectr. 2019. PMID: 31172909 Free article. Review.
Additionally, catheter-associated UTIs (CAUTI), caused by Enterococcus and Staphylococcus as well as UPEC, represent a major health care concern. The host's response of depositing fibrinogen at the site of infection has been found to be critical to establishing CAUT …
Additionally, catheter-associated UTIs (CAUTI), caused by Enterococcus and Staphylococcus as well as UPEC, represent a major health care con …
Multidrug efflux pumps: structure, function and regulation.
Du D, Wang-Kan X, Neuberger A, van Veen HW, Pos KM, Piddock LJV, Luisi BF. Du D, et al. Nat Rev Microbiol. 2018 Sep;16(9):523-539. doi: 10.1038/s41579-018-0048-6. Nat Rev Microbiol. 2018. PMID: 30002505 Review.
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. ...Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in viru …
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become …
833 results