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7,152 results

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Page 1
The Recovery Experience Questionnaire: development and validation of a measure for assessing recuperation and unwinding from work.
Sonnentag S, Fritz C. Sonnentag S, et al. J Occup Health Psychol. 2007 Jul;12(3):204-21. doi: 10.1037/1076-8998.12.3.204. J Occup Health Psychol. 2007. PMID: 17638488
Drawing on the mood regulation and job-stress recovery literature, four self-report measures for assessing how individuals unwind and recuperate from work during leisure time were developed (Study 1). Confirmatory factor analyses with a calibration and a cross-validation s …
Drawing on the mood regulation and job-stress recovery literature, four self-report measures for assessing how individuals unwind and …
Mechanism of DNA unwinding by MCM8-9 in complex with HROB.
Acharya A, Bret H, Huang JW, Mütze M, Göse M, Kissling VM, Seidel R, Ciccia A, Guérois R, Cejka P. Acharya A, et al. Nat Commun. 2024 Apr 27;15(1):3584. doi: 10.1038/s41467-024-47936-8. Nat Commun. 2024. PMID: 38678026 Free PMC article.
MCM8-9-HROB prefer branched DNA structures, and display low DNA unwinding processivity. MCM8-9 unwinds DNA as a hexamer that assembles from dimers on DNA in the presence of ATP. ...The ATPase site formed at the labile interface contributes disproportionally more to …
MCM8-9-HROB prefer branched DNA structures, and display low DNA unwinding processivity. MCM8-9 unwinds DNA as a hexamer that a …
The MCM2-7 Complex: Roles beyond DNA Unwinding.
Rankin BD, Rankin S. Rankin BD, et al. Biology (Basel). 2024 Apr 13;13(4):258. doi: 10.3390/biology13040258. Biology (Basel). 2024. PMID: 38666870 Free PMC article. Review.
The MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replication, thereby providing the single-stranded replication template. ...
The MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replicati …
Structural dynamics of DNA unwinding by a replicative helicase.
Shahid T, Danazumi AU, Tehseen M, Alhudhali L, Clark AR, Savva CG, Hamdan SM, De Biasio A. Shahid T, et al. Nature. 2025 May;641(8061):240-249. doi: 10.1038/s41586-025-08766-w. Epub 2025 Mar 19. Nature. 2025. PMID: 40108462 Free PMC article.
Hexameric helicases are nucleotide-driven molecular machines that unwind DNA to initiate replication across all domains of life. Despite decades of intensive study, several critical aspects of their function remain unresolved(1): the site and mechanism of DNA strand separa …
Hexameric helicases are nucleotide-driven molecular machines that unwind DNA to initiate replication across all domains of life. Desp …
Mechanisms of helicase-catalyzed DNA unwinding.
Lohman TM, Bjornson KP. Lohman TM, et al. Annu Rev Biochem. 1996;65:169-214. doi: 10.1146/annurev.bi.65.070196.001125. Annu Rev Biochem. 1996. PMID: 8811178 Review.
These enzymes unwind duplex DNA and translocate along DNA in reactions that are coupled to the binding and hydrolysis of 5'-nucleoside triphosphates (NTP). ...Recent studies of DNA and NTP binding and DNA unwinding by the Escherichia coli (E. coli) Rep helicase sugg …
These enzymes unwind duplex DNA and translocate along DNA in reactions that are coupled to the binding and hydrolysis of 5'-nucleosid …
Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously.
Thompson MD, Malone EG, Byrd AK. Thompson MD, et al. Methods Enzymol. 2022;672:1-27. doi: 10.1016/bs.mie.2022.02.018. Epub 2022 Mar 25. Methods Enzymol. 2022. PMID: 35934470 Free PMC article.
Helicases catalyze the unwinding of duplex nucleic acids to aid a variety of cellular processes. Although helicases unwind duplex DNA in the same direction that they translocate on single-stranded DNA, forked duplexes provide opportunities to monitor unwinding …
Helicases catalyze the unwinding of duplex nucleic acids to aid a variety of cellular processes. Although helicases unwind dup …
G-Quadruplex Unwinding Molecular Mechanisms by Helicases and Their Applications.
Sun J, Wang Y, Huang Y, Chen Z. Sun J, et al. Int J Mol Sci. 2026 Feb 7;27(4):1629. doi: 10.3390/ijms27041629. Int J Mol Sci. 2026. PMID: 41751764 Free PMC article. Review.
Due to their unusual thermodynamic stability, G4s serve as physical barriers to DNA/RNA unwinding, thereby impeding replication, transcription, and translation and compromising genome integrity. ...In this review, we summarize recent structural advances-primarily derived f …
Due to their unusual thermodynamic stability, G4s serve as physical barriers to DNA/RNA unwinding, thereby impeding replication, tran …
Translocation and unwinding mechanisms of RNA and DNA helicases.
Pyle AM. Pyle AM. Annu Rev Biophys. 2008;37:317-36. doi: 10.1146/annurev.biophys.37.032807.125908. Annu Rev Biophys. 2008. PMID: 18573084 Review.
There are two mechanisms by which RNA helicase enzymes unwind RNA: The nonprocessive DEAD group catalyzes local unwinding of short duplexes adjacent to their binding sites. Members of the processive DExH group often translocate along single-stranded RNA and displace …
There are two mechanisms by which RNA helicase enzymes unwind RNA: The nonprocessive DEAD group catalyzes local unwinding of s …
Unwinding the structure and function of the archaeal MCM helicase.
Sakakibara N, Kelman LM, Kelman Z. Sakakibara N, et al. Mol Microbiol. 2009 Apr;72(2):286-96. doi: 10.1111/j.1365-2958.2009.06663.x. Mol Microbiol. 2009. PMID: 19415794 Free article. Review.
During chromosomal DNA replication, the replicative helicase unwinds the duplex DNA to provide the single-stranded DNA substrate for the polymerase. ...The enzyme utilizes the energy of ATP hydrolysis to translocate along one strand of the duplex and unwind the comp …
During chromosomal DNA replication, the replicative helicase unwinds the duplex DNA to provide the single-stranded DNA substrate for …
Nucleosomal DNA unwinding pathway through canonical and non-canonical histone disassembly.
Nozawa H, Nagae F, Ogihara S, Hirano R, Yamazaki H, Iizuka R, Akatsu M, Kujirai T, Takada S, Kurumizaka H, Uemura S. Nozawa H, et al. Commun Biol. 2024 Sep 14;7(1):1144. doi: 10.1038/s42003-024-06856-5. Commun Biol. 2024. PMID: 39277674 Free PMC article.
This study utilized solid-state nanopores to investigate DNA unwinding dynamics, applying local force between DNA and histones. Comparative analysis of canonical H2A and H2A.B nucleosomes demonstrated that the H2A.B variant required a lower voltage for complete DNA unwi …
This study utilized solid-state nanopores to investigate DNA unwinding dynamics, applying local force between DNA and histones. Compa …
7,152 results