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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1911 1
1915 1
1916 1
1917 1
1919 1
1921 1
1924 1
1926 2
1928 1
1933 1
1939 1
1945 1
1946 1
1947 1
1949 1
1950 1
1952 3
1953 3
1956 3
1957 2
1959 4
1960 3
1961 2
1962 1
1963 5
1964 5
1965 2
1966 3
1967 5
1968 6
1969 6
1970 10
1971 5
1972 2
1973 8
1974 10
1975 110
1976 104
1977 115
1978 89
1979 102
1980 119
1981 119
1982 133
1983 178
1984 173
1985 158
1986 177
1987 180
1988 193
1989 216
1990 226
1991 261
1992 242
1993 224
1994 241
1995 220
1996 249
1997 234
1998 301
1999 263
2000 277
2001 278
2002 271
2003 340
2004 340
2005 348
2006 420
2007 371
2008 371
2009 387
2010 442
2011 494
2012 478
2013 533
2014 493
2015 525
2016 538
2017 541
2018 586
2019 550
2020 629
2021 516
2022 398
2023 400
2024 608
2025 678
2026 417

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15,565 results

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Page 1
Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial.
Webster R, Salam A, de Silva HA, Selak V, Stepien S, Rajapakse S, Amarasekara S, Amarasena N, Billot L, de Silva AP, Fernando M, Guggilla R, Jan S, Jayawardena J, Maulik PK, Mendis S, Mendis S, Munasinghe J, Naik N, Prabhakaran D, Ranasinghe G, Thom S, Tisserra N, Senaratne V, Wijekoon S, Wijeyasingam S, Rodgers A, Patel A; TRIUMPH Study Group. Webster R, et al. JAMA. 2018 Aug 14;320(6):566-579. doi: 10.1001/jama.2018.10359. JAMA. 2018. PMID: 30120478 Free PMC article. Clinical Trial.
IMPORTANCE: Poorly controlled hypertension is a leading global public health problem requiring new treatment strategies. OBJECTIVE: To assess whether a low-dose triple combination antihypertensive medication would achieve better blood pressure (BP) control vs usual …
IMPORTANCE: Poorly controlled hypertension is a leading global public health problem requiring new treatment strategies. OBJECTIVE: To asses …
Ketorolac.
[No authors listed] [No authors listed] 2025 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000057 Free Books & Documents. Review.
Milk levels of ketorolac are low with the usual oral dosage, but milk levels have not been measured after higher injectable dosages or with the nasal spray. Ketorolac injection is used for a short time (typically 24 hours) after cesarean section in some hospi …
Milk levels of ketorolac are low with the usual oral dosage, but milk levels have not been measured after higher injectable …
Tapentadol.
[No authors listed] [No authors listed] 2025 Dec 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Dec 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30835408 Free Books & Documents. Review.
Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics.[1] Little information is available on the use of tapentadol during breastfeeding. ...If tapentadol is required by the mother of a newborn, it is not a reason to d …
Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics.[1] Little information …
Methadone.
[No authors listed] [No authors listed] 2026 May 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2026 May 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000292 Free Books & Documents. Review.
Most infants receive an estimated dose of methadone ranging from 1 to 3% of the mother's weight-adjusted methadone dosage with a few receiving 5 to 6%, which is less than the dosage used for treating neonatal abstinence. ...If the baby shows signs of increase …
Most infants receive an estimated dose of methadone ranging from 1 to 3% of the mother's weight-adjusted methadone dosage with …
Tramadol.
[No authors listed] [No authors listed] 2026 Apr 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2026 Apr 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000319 Free Books & Documents. Review.
The excretion of tramadol into milk is low and even lower amounts of the active metabolite, O-desmethyltramadol, are excreted. With usual maternal dosage, the amount excreted into breastmilk is much less than the dose that has been given to newborn infants fo …
The excretion of tramadol into milk is low and even lower amounts of the active metabolite, O-desmethyltramadol, are excreted. With usual …
Meperidine.
[No authors listed] [No authors listed] 2026 Mar 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2026 Mar 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000291 Free Books & Documents. Review.
Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics. If the mother of a newborn requires meperidine, it is not a reason to discontinue breastfeeding; however, once the mother's milk comes in, it is best to provide p …
Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics. If the mother of a new …
Morphine.
[No authors listed] [No authors listed] 2026 May 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2026 May 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000296 Free Books & Documents. Review.
Maternal use of oral opioids during breastfeeding can cause infant drowsiness, which may progress to rare but severe central nervous system depression, although low-dose morphine might be preferred over other opiates.[1,2] Newborn infants seem to be particularly sensitive …
Maternal use of oral opioids during breastfeeding can cause infant drowsiness, which may progress to rare but severe central nervous system …
Lamotrigine clinical pharmacokinetics.
Rambeck B, Wolf P. Rambeck B, et al. Clin Pharmacokinet. 1993 Dec;25(6):433-43. doi: 10.2165/00003088-199325060-00003. Clin Pharmacokinet. 1993. PMID: 8119045 Review.
The area under the plasma concentration-time curve indicates dose-linear pharmacokinetics. The degree of plasma protein binding is 56%. Saliva concentrations are 46% of the plasma concentration. ...Other observations indicate that the interaction of carbamazepine and lamot …
The area under the plasma concentration-time curve indicates dose-linear pharmacokinetics. The degree of plasma protein binding is 56 …
Vigabatrin. Clinical pharmacokinetics.
Rey E, Pons G, Olive G. Rey E, et al. Clin Pharmacokinet. 1992 Oct;23(4):267-78. doi: 10.2165/00003088-199223040-00003. Clin Pharmacokinet. 1992. PMID: 1395360 Review.
There were no other interactions with most concurrently administered anticonvulsants. The usual dosage of vigabatrin as add-on treatment in adults is 2 to 4g daily. Higher dosages up to 80 mg/kg daily were required in children. A dosage adjustment was …
There were no other interactions with most concurrently administered anticonvulsants. The usual dosage of vigabatrin as add-on …
Aripiprazole Therapy and CYP2D6 Genotype.
Dean L, Kane M. Dean L, et al. 2016 Sep 22 [updated 2025 Apr 21]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. MINI Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2016 Sep 22 [updated 2025 Apr 21]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. MINI Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 28520375 Free Books & Documents. Review.
Approximately 8% of Caucasians, 3-8% of Black/African Americans and up to 2% of Asians cannot metabolize CYP2D6 substrates and are classified as "poor metabolizers." (2) The FDA-approved drug label for aripiprazole states that in CYP2D6 poor metabolizers, half of the usual …
Approximately 8% of Caucasians, 3-8% of Black/African Americans and up to 2% of Asians cannot metabolize CYP2D6 substrates and are classifie …
15,565 results
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