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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1911 1
1915 1
1916 1
1917 1
1919 1
1921 1
1926 2
1933 1
1947 1
1952 2
1953 2
1956 2
1957 2
1959 3
1960 2
1961 1
1962 1
1963 5
1964 2
1965 1
1966 1
1967 4
1968 4
1969 3
1970 4
1971 5
1972 1
1973 3
1974 2
1975 62
1976 62
1977 63
1978 55
1979 57
1980 71
1981 74
1982 94
1983 112
1984 103
1985 99
1986 96
1987 107
1988 96
1989 120
1990 139
1991 154
1992 140
1993 132
1994 144
1995 131
1996 147
1997 128
1998 171
1999 166
2000 166
2001 142
2002 142
2003 176
2004 174
2005 177
2006 212
2007 188
2008 189
2009 183
2010 210
2011 233
2012 252
2013 254
2014 237
2015 255
2016 267
2017 256
2018 269
2019 274
2020 371
2021 343
2022 344
2023 328
2024 319
2025 300
2026 201

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8,513 results

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Page 1
Efficacy and Safety of Low-Dose Triple and Quadruple Combination Pills vs Monotherapy, Usual Care, or Placebo for the Initial Management of Hypertension: A Systematic Review and Meta-analysis.
Wang N, Rueter P, Atkins E, Webster R, Huffman M, de Silva A, Chow C, Patel A, Rodgers A. Wang N, et al. JAMA Cardiol. 2023 Jun 1;8(6):606-611. doi: 10.1001/jamacardio.2023.0720. JAMA Cardiol. 2023. PMID: 37099314 Free PMC article.
IMPORTANCE: Low-dose combination (LDC) antihypertensives consisting of 3 or 4 blood pressure (BP)-lowering drugs have emerged as a potentially important therapy for the initial management of hypertension. ...At 4 to 12 weeks follow-up, LDC was associated with a greater mea …
IMPORTANCE: Low-dose combination (LDC) antihypertensives consisting of 3 or 4 blood pressure (BP)-lowering drugs have emerged as a po …
Dose, Content, and Context of Usual Care in Stroke Upper Limb Motor Interventions: A Systematic Review.
Newton SP, Dalton EJ, Ang JY, Klaic M, Thijs V, Hayward KS. Newton SP, et al. Clin Rehabil. 2023 Nov;37(11):1437-1450. doi: 10.1177/02692155231172295. Epub 2023 May 7. Clin Rehabil. 2023. PMID: 37151039 Free PMC article.
OBJECTIVE: The objectives of this systematic review were to describe the current dose and content of usual care upper limb motor intervention for inpatients following stroke and examine if context factors alter dose and content. ...Consistent reporting of the …
OBJECTIVE: The objectives of this systematic review were to describe the current dose and content of usual care upper limb mot …
Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial.
Webster R, Salam A, de Silva HA, Selak V, Stepien S, Rajapakse S, Amarasekara S, Amarasena N, Billot L, de Silva AP, Fernando M, Guggilla R, Jan S, Jayawardena J, Maulik PK, Mendis S, Mendis S, Munasinghe J, Naik N, Prabhakaran D, Ranasinghe G, Thom S, Tisserra N, Senaratne V, Wijekoon S, Wijeyasingam S, Rodgers A, Patel A; TRIUMPH Study Group. Webster R, et al. JAMA. 2018 Aug 14;320(6):566-579. doi: 10.1001/jama.2018.10359. JAMA. 2018. PMID: 30120478 Free PMC article. Clinical Trial.
IMPORTANCE: Poorly controlled hypertension is a leading global public health problem requiring new treatment strategies. OBJECTIVE: To assess whether a low-dose triple combination antihypertensive medication would achieve better blood pressure (BP) control vs usual …
IMPORTANCE: Poorly controlled hypertension is a leading global public health problem requiring new treatment strategies. OBJECTIVE: To asses …
The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial.
Heyland DK, Patel J, Compher C, Rice TW, Bear DE, Lee ZY, González VC, O'Reilly K, Regala R, Wedemire C, Ibarra-Estrada M, Stoppe C, Ortiz-Reyes L, Jiang X, Day AG; EFFORT Protein Trial team. Heyland DK, et al. Lancet. 2023 Feb 18;401(10376):568-576. doi: 10.1016/S0140-6736(22)02469-2. Epub 2023 Jan 25. Lancet. 2023. PMID: 36708732 Clinical Trial.
FINDINGS: Between Jan 17, 2018, and Dec 3, 2021, 1329 patients were randomised and 1301 (97.9%) were included in the analysis (645 in the high-dose protein group and 656 in usual dose group). By 60 days after randomisation, the cumulative incidence of alive h …
FINDINGS: Between Jan 17, 2018, and Dec 3, 2021, 1329 patients were randomised and 1301 (97.9%) were included in the analysis (645 in the hi …
High-Dose, High-Intensity Stroke Rehabilitation: Why Aren't We Giving It?
Lin DJ, Cramer SC, Boyne P, Khatri P, Krakauer JW. Lin DJ, et al. Stroke. 2025 May;56(5):1351-1364. doi: 10.1161/STROKEAHA.124.043650. Epub 2025 Apr 28. Stroke. 2025. PMID: 40294175 Free PMC article.
There is convergent evidence indicating that high dose, high intensity rehabilitation is effective for improving outcomes after stroke with large effect sizes compared to usual care. ...We contend that reasons for lack of implementation of high dose, high int …
There is convergent evidence indicating that high dose, high intensity rehabilitation is effective for improving outcomes after strok …
Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial.
AVERT Trial Collaboration group. AVERT Trial Collaboration group. Lancet. 2015 Jul 4;386(9988):46-55. doi: 10.1016/S0140-6736(15)60690-0. Epub 2015 Apr 16. Lancet. 2015. PMID: 25892679 Free article. Clinical Trial.
We aimed to compare the effectiveness of frequent, higher dose, very early mobilisation with usual care after stroke. METHODS: We did this parallel-group, single-blind, randomised controlled trial at 56 acute stroke units in five countries. ...FINDINGS: Between July …
We aimed to compare the effectiveness of frequent, higher dose, very early mobilisation with usual care after stroke. METHODS: …
Early mobilisation post-stroke: a systematic review and meta-analysis of individual participant data.
Rethnam V, Langhorne P, Churilov L, Hayward KS, Herisson F, Poletto SR, Tong Y, Bernhardt J. Rethnam V, et al. Disabil Rehabil. 2022 Apr;44(8):1156-1163. doi: 10.1080/09638288.2020.1789229. Epub 2020 Jul 16. Disabil Rehabil. 2022. PMID: 32673130
PURPOSE: To investigate the safety and efficacy of early mobilisation (EM) compared to usual care by meta-analysing individual participant data (IPD). MATERIALS AND METHODS: IPD were sought from randomised controlled trials comparing out-of-bed mobilisation starting within …
PURPOSE: To investigate the safety and efficacy of early mobilisation (EM) compared to usual care by meta-analysing individual partic …
Comparison of double-dose vs. usual dose of nicorandil for the prevention of contrast-induced nephropathy after cardiac catheterization.
Zeng Z, Fu X, Zhang X, Fu N. Zeng Z, et al. Int Urol Nephrol. 2019 Nov;51(11):1999-2004. doi: 10.1007/s11255-019-02244-9. Epub 2019 Aug 5. Int Urol Nephrol. 2019. PMID: 31385178 Clinical Trial.
METHODS: We recorded outcomes from 330 patients who were randomly divided to either a double-dose (30 mg/day) nicorandil group or to a usual-dose (15 mg/day) nicorandil group or a control group (hydration only). ...There was a significant difference in the oc …
METHODS: We recorded outcomes from 330 patients who were randomly divided to either a double-dose (30 mg/day) nicorandil group or to …
To Screen or not to Screen: Low Dose Computed Tomography in Comparison to Chest Radiography or Usual Care in Reducing Morbidity and Mortality from Lung Cancer.
Dajac J, Kamdar J, Moats A, Nguyen B. Dajac J, et al. Cureus. 2016 Apr 27;8(4):e589. doi: 10.7759/cureus.589. Cureus. 2016. PMID: 27375974 Free PMC article. Review.
This paper seeks to address the question: Can the mortality of lung cancer be decreased by screening with low-dose computerized tomography (LDCT) in higher risk patients compared to chest X-rays (CXR) or regular patient care? ...The ITALUNG and NELSON trials demonstrated t …
This paper seeks to address the question: Can the mortality of lung cancer be decreased by screening with low-dose computerized tomog …
Biological responses during high-dose protein nutrition in the critically ill: a randomized controlled trial.
Kristof AS, Hong M, Boufaied N, Tousson-Abouelazm N, Dandamudi S, Joung KB, Hatzakorzian R, Port M, Campisi G, Piccirillo CA, Fonseca GJ, Ding J, Heyland DK, Labbé DP, Wykes L, Schricker T. Kristof AS, et al. Am J Clin Nutr. 2025 Aug;122(2):612-623. doi: 10.1016/j.ajcnut.2025.05.025. Epub 2025 Jun 26. Am J Clin Nutr. 2025. PMID: 40617772 Free article. Clinical Trial.
RESULTS: Thirty-three patients were randomly assigned, and 25 completed the study. The increase in WBPB for the high-dose group was 10.0 3.7, and that for the moderate and usual-dose groups were 6.7 2.9 and 6.6 3.6, mumol/kg/h (mean SEM) respectively. After a …
RESULTS: Thirty-three patients were randomly assigned, and 25 completed the study. The increase in WBPB for the high-dose group was 1 …
8,513 results