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Response predictors of a topical corticosteroid-based regimen for dry eyes: A real-life study.
Utheim TP, Chen X, Fineide F, Steinkjer T, Heegaard S, Kolko M, Dartt DA, Khan AZ. Utheim TP, et al. Acta Ophthalmol. 2024 Sep 30. doi: 10.1111/aos.16758. Online ahead of print. Acta Ophthalmol. 2024. PMID: 39344883
PURPOSE: To examine the effectiveness and identify clinical response predictors of a short corticosteroid-based regimen consisting of topical preservative-free 0.1% dexamethasone (Monopex, Thea Laboratories) in conjunction with artificial tears (AT) for dry eyes in a real- …
PURPOSE: To examine the effectiveness and identify clinical response predictors of a short corticosteroid-based regimen consisting of topica …
Whole genome sequencing and characterization of Corynebacterium isolated from the healthy and dry eye ocular surface.
Naqvi M, Utheim TP, Charnock C. Naqvi M, et al. Among authors: utheim tp. BMC Microbiol. 2024 Sep 28;24(1):368. doi: 10.1186/s12866-024-03517-9. BMC Microbiol. 2024. PMID: 39342108 Free PMC article.
BACKGROUND: The purpose of this study was to characterize Corynebacterium isolated from the ocular surface of dry eye disease patients and healthy controls. We aimed to investigate the pathogenic potential of these isolates in relation to ocular surface health. ...
BACKGROUND: The purpose of this study was to characterize Corynebacterium isolated from the ocular surface of dry eye disease patient …
Review of Hydroxypropyl Methylcellulose in Artificial Tears for the Treatment of Dry Eye Disease.
Mysen OMB, Hynnekleiv L, Magnø MS, Vehof J, Utheim TP. Mysen OMB, et al. Among authors: utheim tp. Acta Ophthalmol. 2024 Sep 1. doi: 10.1111/aos.16753. Online ahead of print. Acta Ophthalmol. 2024. PMID: 39219040 Review.
Dry eye disease (DED) is a highly prevalent condition, resulting in reduced quality of life, lower participation in social life and impaired work efficiency. ...
Dry eye disease (DED) is a highly prevalent condition, resulting in reduced quality of life, lower participation in social life and i …
Topical glaucoma medications - Possible implications on the meibomian glands.
Fineide F, Magnø M, Dahlø K, Kolko M, Heegaard S, Vehof J, Utheim TP. Fineide F, et al. Among authors: utheim tp. Acta Ophthalmol. 2024 Nov;102(7):735-748. doi: 10.1111/aos.16728. Epub 2024 Jun 1. Acta Ophthalmol. 2024. PMID: 38822682 Review.
Well-functioning meibomian glands are paramount for maintaining a stable tear film, and their dysfunction is the most common cause of dry eye disease. There is a growing concern that both topical glaucoma medications themselves and their added preservatives damage the meib …
Well-functioning meibomian glands are paramount for maintaining a stable tear film, and their dysfunction is the most common cause of dry …
Tear cytokine levels are reduced in patients treated with intravitreal injections.
Malmin A, Thomseth VM, Førland PT, Aass HCD, Reppe S, Olsen MVT, Lindtjørn B, Chen X, Haugen IBK, Utheim TP, Forsaa VA. Malmin A, et al. Among authors: utheim tp. Ocul Surf. 2024 Apr;32:222-226. doi: 10.1016/j.jtos.2024.03.004. Epub 2024 Mar 13. Ocul Surf. 2024. PMID: 38490478 Free article.
A Preservative-Free Approach - Effects on Dry Eye Signs and Symptoms After Cataract Surgery.
Jensen P, Nilsen C, Gundersen M, Gundersen KG, Potvin R, Gazerani P, Chen X, Utheim TP, Utheim ØA. Jensen P, et al. Among authors: utheim tp. Clin Ophthalmol. 2024 Feb 26;18:591-604. doi: 10.2147/OPTH.S446804. eCollection 2024. Clin Ophthalmol. 2024. PMID: 38435373 Free PMC article.
PURPOSE: To compare the effect of treatment with preservative-free dexamethasone, NSAIDs and trehalose/hyaluronic acid eye drops with the preservative benzalkonium chloride containing dexamethasone and NSAIDs after cataract surgery in dry versus non-dry eyes. PATIEN …
PURPOSE: To compare the effect of treatment with preservative-free dexamethasone, NSAIDs and trehalose/hyaluronic acid eye drops with the pr …
Heritability of tear fluid cytokines in healthy twins.
Bjerager J, Magnø M, Chen X, Belmouhand M, Aass HCD, Reppe S, Heegaard S, Larsen M, Utheim TP. Bjerager J, et al. Among authors: utheim tp. Ocul Surf. 2024 Apr;32:145-153. doi: 10.1016/j.jtos.2024.02.005. Epub 2024 Feb 20. Ocul Surf. 2024. PMID: 38387783
This suggests that a higher success in ocular surface disease drug discovery may be anticipated for drugs that have targets in specific populations, and points to the importance of emphasizing known preventive measures of ocular surface disease and examinations of close relatives …
This suggests that a higher success in ocular surface disease drug discovery may be anticipated for drugs that have targets in specific popu …
Culture- and non-culture-based approaches reveal unique features of the ocular microbiome in dry eye patients.
Naqvi M, Fineide F, Utheim TP, Charnock C. Naqvi M, et al. Among authors: utheim tp. Ocul Surf. 2024 Apr;32:123-129. doi: 10.1016/j.jtos.2024.02.002. Epub 2024 Feb 12. Ocul Surf. 2024. PMID: 38354907 Free article.
PURPOSE: The purpose of this study was to investigate the ocular microbiome in individuals with dry eye disease and to identify features of their ocular microbiome of possible health and diagnostic significance. METHODS: Conjunctival samples were collected from both eyes i …
PURPOSE: The purpose of this study was to investigate the ocular microbiome in individuals with dry eye disease and to identify featu …
Using machine learning model explanations to identify proteins related to severity of meibomian gland dysfunction.
Storås AM, Fineide F, Magnø M, Thiede B, Chen X, Strümke I, Halvorsen P, Galtung H, Jensen JL, Utheim TP, Riegler MA. Storås AM, et al. Among authors: utheim tp. Sci Rep. 2023 Dec 22;13(1):22946. doi: 10.1038/s41598-023-50342-7. Sci Rep. 2023. PMID: 38135766 Free PMC article.
Meibomian gland dysfunction is the most common cause of dry eye disease and leads to significantly reduced quality of life and social burdens. ...
Meibomian gland dysfunction is the most common cause of dry eye disease and leads to significantly reduced quality of life and social …
Allogeneic mesenchymal stem cell therapy for dry eye disease in patients with Sjogren's syndrome: A randomized clinical trial.
Møller-Hansen M, Larsen AC, Wiencke AK, Terslev L, Siersma V, Andersen TT, Hansen AE, Bruunsgaard H, Haack-Sørensen M, Ekblond A, Kastrup J, Utheim TP, Heegaard S. Møller-Hansen M, et al. Among authors: utheim tp. Ocul Surf. 2024 Jan;31:1-8. doi: 10.1016/j.jtos.2023.11.007. Epub 2023 Dec 2. Ocul Surf. 2024. PMID: 38049032 Clinical Trial.
PURPOSE: This double-blinded randomized clinical trial aimed to evaluate the efficacy of injecting allogeneic adipose-derived mesenchymal stem cells (ASCs) into the lacrimal gland (LG) for the treatment of dry eye disease (DED) secondary to Sjogren's syndrome (SS). METHODS …
PURPOSE: This double-blinded randomized clinical trial aimed to evaluate the efficacy of injecting allogeneic adipose-derived mesenchymal st …
Tear and Saliva Metabolomics in Evaporative Dry Eye Disease in Females.
Fineide FA, Tashbayev B, Elgstøen KBP, Sandås EM, Rootwelt H, Hynne H, Chen X, Ræder S, Vehof J, Dartt D, Jensen JL, Utheim TP. Fineide FA, et al. Among authors: utheim tp. Metabolites. 2023 Nov 2;13(11):1125. doi: 10.3390/metabo13111125. Metabolites. 2023. PMID: 37999221 Free PMC article.
Accurate diagnosis of dry eye disease (DED) is challenging, and even today there is no gold standard biomarker of DED. ...These metabolites and biomarkers could be important for diagnosing and monitoring disease as well as for new therapeutic targets and strategies. As DED …
Accurate diagnosis of dry eye disease (DED) is challenging, and even today there is no gold standard biomarker of DED. ...These metab …
Chalazion Treatment: A Concise Review of Clinical Trials.
Tashbayev B, Chen X, Utheim TP. Tashbayev B, et al. Among authors: utheim tp. Curr Eye Res. 2024 Feb;49(2):109-118. doi: 10.1080/02713683.2023.2279014. Epub 2024 Jan 18. Curr Eye Res. 2024. PMID: 37937798 Review.
RNA Profiles of Tear Fluid Extracellular Vesicles in Patients with Dry Eye-Related Symptoms.
Cross T, Øvstebø R, Brusletto BS, Trøseid AS, Olstad OK, Aspelin T, Jackson CJ, Chen X, Utheim TP, Haug KBF. Cross T, et al. Among authors: utheim tp. Int J Mol Sci. 2023 Oct 20;24(20):15390. doi: 10.3390/ijms242015390. Int J Mol Sci. 2023. PMID: 37895069 Free PMC article.
Currently, diagnosing and stratifying dry eye disease (DED) require multiple tests, motivating interest in a single definitive test. ...Schirmer strips were used to collect tears from 10 patients presenting with dry eye-related symptoms at the Norwegian Dry E …
Currently, diagnosing and stratifying dry eye disease (DED) require multiple tests, motivating interest in a single definitive test. …
Meibomian Gland Dysfunction Is Associated with Low Levels of Immunoglobulin Chains and Cystatin-SN.
Muttuvelu DV, Cehofski LJ, Holtz J, Utheim TP, Chen X, Vorum H, Heegaard S, Rasmussen MLR, Khan AM, Abduljabar AB, Honoré B. Muttuvelu DV, et al. Among authors: utheim tp. Int J Mol Sci. 2023 Oct 12;24(20):15115. doi: 10.3390/ijms242015115. Int J Mol Sci. 2023. PMID: 37894795 Free PMC article.
Meibomian gland dysfunction (MGD) is a highly prevalent condition and the most common cause of evaporative dry eye disease. Studying the proteome of MGD can result in important advances in the management of the condition. ...
Meibomian gland dysfunction (MGD) is a highly prevalent condition and the most common cause of evaporative dry eye disease. Studying …
Tear film proteome changes following Tobradex® therapy in anterior blepharitis.
Muttuvelu DV, Cehofski LJ, Utheim TP, Chen X, Vorum H, Rasmussen MLR, Heegaard S, Khan AM, Abduljabar AB, Honoré B. Muttuvelu DV, et al. Among authors: utheim tp. Acta Ophthalmol. 2024 Jun;102(4):e565-e576. doi: 10.1111/aos.15792. Epub 2023 Oct 14. Acta Ophthalmol. 2024. PMID: 37837306
Greater adherence to a mediterranean diet is associated with lower C-reactive protein (CRP) levels, but not to lower odds of having dry eye disease.
Magno MS, Moschowits E, Morthen MK, Beining MW, Jansonius NM, Hammond CJ, Utheim TP, Vehof J. Magno MS, et al. Among authors: utheim tp. Ocul Surf. 2023 Oct;30:196-203. doi: 10.1016/j.jtos.2023.09.013. Epub 2023 Oct 1. Ocul Surf. 2023. PMID: 37783428 Free article.
PURPOSE: To investigate the hypothesis that a Mediterranean diet is associated with a lower risk of having dry eye disease (DED) in the general population. METHODS: DED was assessed using the Women's Health Study (WHS) dry eye questionnaire in 58,993 participants fr …
PURPOSE: To investigate the hypothesis that a Mediterranean diet is associated with a lower risk of having dry eye disease (DED) in t …
Cross-sectional Study Exploring Vision-related Quality of Life in Dry Eye Disease in a Norwegian Optometric Practice.
Erøy ÅA, Utheim TP, Sundling V. Erøy ÅA, et al. Among authors: utheim tp. Optom Vis Sci. 2023 Oct 1;100(10):679-687. doi: 10.1097/OPX.0000000000002058. Epub 2023 Sep 27. Optom Vis Sci. 2023. PMID: 37751404 Free PMC article.
PURPOSE: This study aimed to explore the vision-related quality of life of patients with dry eye disease and the potential benefits of screening for dry eye disease in Norwegian optometric practice. ...RESULTS: Forty-nine patients participated in the study; 29 (59%) …
PURPOSE: This study aimed to explore the vision-related quality of life of patients with dry eye disease and the potential benefits o …
Intense pulsed light treatment in meibomian gland dysfunction: Past, present, and future.
Fineide F, Magnø MS, Khan AZ, Chen X, Vehof J, Utheim TP. Fineide F, et al. Among authors: utheim tp. Acta Ophthalmol. 2024 Jun;102(4):e414-e442. doi: 10.1111/aos.15759. Epub 2023 Sep 13. Acta Ophthalmol. 2024. PMID: 37702308 Review.
Dry eye disease is a highly prevalent condition, which can substantially impair quality of life, work productivity, and vision. ...
Dry eye disease is a highly prevalent condition, which can substantially impair quality of life, work productivity, and vision. ...
Non-Coding RNA in Salivary Extracellular Vesicles: A New Frontier in Sjögren's Syndrome Diagnostics?
Cross T, Haug KBF, Brusletto BS, Ommundsen SK, Trøseid AS, Aspelin T, Olstad OK, Aass HCD, Galtung HK, Utheim TP, Jensen JL, Øvstebø R. Cross T, et al. Among authors: utheim tp. Int J Mol Sci. 2023 Aug 29;24(17):13409. doi: 10.3390/ijms241713409. Int J Mol Sci. 2023. PMID: 37686214 Free PMC article.
Sjogren's syndrome is an autoimmune rheumatic disease characterized by inflammation of the salivary and lacrimal glands, often manifesting as dry mouth and dry eyes. To simplify diagnostics of primary Sjogren's syndrome (pSS), a non-invasive marker is needed. ...
Sjogren's syndrome is an autoimmune rheumatic disease characterized by inflammation of the salivary and lacrimal glands, often manifesting a …
Surgical Procedures in the Treatment of Dry Eye Disease.
Møller-Hansen M, Utheim TP, Heegaard S. Møller-Hansen M, et al. Among authors: utheim tp. J Ocul Pharmacol Ther. 2023 Dec;39(10):692-698. doi: 10.1089/jop.2023.0063. Epub 2023 Aug 11. J Ocul Pharmacol Ther. 2023. PMID: 37566528 Review.
Dry eye disease (DED) is a multifactorial disease affecting 5% to 50% in different populations. ...Further development of these treatment modalities might prove pivotal in treating dry eye patients in the future....
Dry eye disease (DED) is a multifactorial disease affecting 5% to 50% in different populations. ...Further development of these treat …
Prevalence of Dry Eye Disease Among Individuals Scheduled for Cataract Surgery in a Norwegian Cataract Clinic.
Graae Jensen P, Gundersen M, Nilsen C, Gundersen KG, Potvin R, Gazerani P, Chen X, Utheim TP, Utheim ØA. Graae Jensen P, et al. Among authors: utheim tp. Clin Ophthalmol. 2023 Apr 27;17:1233-1243. doi: 10.2147/OPTH.S407805. eCollection 2023. Clin Ophthalmol. 2023. PMID: 37138823 Free PMC article.
PURPOSE: To determine the prevalence of dry eye disease (DED) in patients scheduled for cataract surgery in a Norwegian eye clinic. ...Additional tests were the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, tear meniscus height (TMH), Schirmer 1, tear f …
PURPOSE: To determine the prevalence of dry eye disease (DED) in patients scheduled for cataract surgery in a Norwegian eye clinic. . …
TFOS Lifestyle: Impact of the digital environment on the ocular surface.
Wolffsohn JS, Lingham G, Downie LE, Huntjens B, Inomata T, Jivraj S, Kobia-Acquah E, Muntz A, Mohamed-Noriega K, Plainis S, Read M, Sayegh RR, Singh S, Utheim TP, Craig JP. Wolffsohn JS, et al. Among authors: utheim tp. Ocul Surf. 2023 Apr;28:213-252. doi: 10.1016/j.jtos.2023.04.004. Epub 2023 Apr 14. Ocul Surf. 2023. PMID: 37062428 Free article.
A comparison between hyaluronic acid and other single ingredient eye drops for dry eye, a review.
Hynnekleiv L, Magno M, Moschowits E, Tønseth KA, Vehof J, Utheim TP. Hynnekleiv L, et al. Among authors: utheim tp. Acta Ophthalmol. 2024 Feb;102(1):25-37. doi: 10.1111/aos.15675. Epub 2023 Apr 12. Acta Ophthalmol. 2024. PMID: 37042308 Review.
Dry eye disease (DED) is a highly prevalent and debilitating condition. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a long history as a safe and effective DED treatment. ...
Dry eye disease (DED) is a highly prevalent and debilitating condition. Hyaluronic acid (HA) is a naturally occurring glycosaminoglyc …
Risk associated with treatments for meibomian gland dysfunction.
Magno MS, Olafsson J, Beining M, Moschowits E, Lagali N, Wolffsohn JS, Craig JP, Vehof J, Dartt DA, Utheim TP. Magno MS, et al. Among authors: utheim tp. Cont Lens Anterior Eye. 2023 Apr;46(2):101818. doi: 10.1016/j.clae.2023.101818. Epub 2023 Feb 7. Cont Lens Anterior Eye. 2023. PMID: 36754735 No abstract available.
Hot towels: The bedrock of Meibomian gland dysfunction treatment - A review.
Schjerven Magno M, Olafsson J, Beining M, Moschowits E, Lagali N, Wolffsohn JS, Craig JP, Vehof J, Dartt DA, Utheim TP. Schjerven Magno M, et al. Among authors: utheim tp. Cont Lens Anterior Eye. 2023 Apr;46(2):101775. doi: 10.1016/j.clae.2022.101775. Epub 2022 Oct 28. Cont Lens Anterior Eye. 2023. PMID: 36715292 Free article. Review.
METHODS: Studies were identified through PubMed on the May 28, 2021, with the search terms: (warm* OR heat* OR thermal* OR towel OR wet towel) AND (meibomian OR MGD OR eyelid OR "dry eye" OR DED). All relevant original articles with English full-text were included. ...
METHODS: Studies were identified through PubMed on the May 28, 2021, with the search terms: (warm* OR heat* OR thermal* OR towel OR wet towe …
Associations between Serial Intravitreal Injections and Dry Eye.
Malmin A, Thomseth VM, Førland PT, Khan AZ, Hetland HB, Chen X, Haugen IK, Utheim TP, Forsaa VA. Malmin A, et al. Among authors: utheim tp. Ophthalmology. 2023 May;130(5):509-515. doi: 10.1016/j.ophtha.2023.01.009. Epub 2023 Jan 21. Ophthalmology. 2023. PMID: 36693594 Free article.
The work-related burden of dry eye.
Morthen MK, Magno MS, Utheim TP, Hammond CJ, Vehof J. Morthen MK, et al. Among authors: utheim tp. Ocul Surf. 2023 Apr;28:30-36. doi: 10.1016/j.jtos.2023.01.006. Epub 2023 Jan 21. Ocul Surf. 2023. PMID: 36690155 Free article.
PURPOSE: To investigate the relationship between dry eye disease (DED) and work functioning, unemployment, absenteeism, and worry about job loss. ...For participants with highly symptomatic dry eye impaired work functioning was even higher (59.1%) and similar to tha …
PURPOSE: To investigate the relationship between dry eye disease (DED) and work functioning, unemployment, absenteeism, and worry abo …
The relationship between sedentary behavior and dry eye disease.
Nguyen L, Magno MS, Utheim TP, Hammond CJ, Vehof J. Nguyen L, et al. Among authors: utheim tp. Ocul Surf. 2023 Apr;28:11-17. doi: 10.1016/j.jtos.2023.01.002. Epub 2023 Jan 5. Ocul Surf. 2023. PMID: 36621639 Free article.
PURPOSE: Sedentary behavior (SB) has been linked with low-grade systemic inflammation, which could play a role in the development of dry eye disease (DED). This cross-sectional study aims to investigate the association between SB and DED. ...
PURPOSE: Sedentary behavior (SB) has been linked with low-grade systemic inflammation, which could play a role in the development of dry …
Role of stem cells in regenerative treatment of dry eye disease caused by lacrimal gland dysfunction.
Jackson CJ, Naqvi M, Gundersen KG, Utheim TP. Jackson CJ, et al. Among authors: utheim tp. Acta Ophthalmol. 2023 Jun;101(4):360-375. doi: 10.1111/aos.15629. Epub 2022 Dec 23. Acta Ophthalmol. 2023. PMID: 36564971 Free article. Review.
An ageing population and increased screen use in younger people have contributed to a rise in incidence of dry eye disease (DED). Quality of life can be significantly affected by DED, with patients experiencing eye dryness, burning, pain and sensitivity to light. ...
An ageing population and increased screen use in younger people have contributed to a rise in incidence of dry eye disease (DED). Qua …
Early ocular surface and tear film status in congenital aniridia indicates a supportive treatment window.
Fries FN, Moslemani K, Utheim TP, Seitz B, Käsmann-Kellner B, Lagali NS. Fries FN, et al. Among authors: utheim tp. Br J Ophthalmol. 2023 Dec 18;108(1):30-36. doi: 10.1136/bjo-2021-320774. Br J Ophthalmol. 2023. PMID: 36517210 Free PMC article.
OSDI, blink rate, Schirmer, OSS, TFBUT and OPI were not associated with type of PAX6 mutation, but OSDI, OSS and blink rate associated with grade of aniridia-associated keratopathy. CONCLUSIONS: Ocular surface damage and dry eye signs appear in congenital aniridia regardle …
OSDI, blink rate, Schirmer, OSS, TFBUT and OPI were not associated with type of PAX6 mutation, but OSDI, OSS and blink rate associated with …
Predicting an unstable tear film through artificial intelligence.
Fineide F, Storås AM, Chen X, Magnø MS, Yazidi A, Riegler MA, Utheim TP. Fineide F, et al. Among authors: utheim tp. Sci Rep. 2022 Dec 10;12(1):21416. doi: 10.1038/s41598-022-25821-y. Sci Rep. 2022. PMID: 36496510 Free PMC article.
Dry eye disease is one of the most common ophthalmological complaints and is defined by a loss of tear film homeostasis. ...In this pilot study, we retrospectively included clinical data from 431 patients with dry eye disease examined in the Norwegian Dry Eye …
Dry eye disease is one of the most common ophthalmological complaints and is defined by a loss of tear film homeostasis. ...In this p …
Seasonal variations in presenting symptoms and signs of dry eye disease in Norway.
Eidet JR, Chen X, Ræder S, Badian RA, Utheim TP. Eidet JR, et al. Among authors: utheim tp. Sci Rep. 2022 Dec 6;12(1):21046. doi: 10.1038/s41598-022-25557-9. Sci Rep. 2022. PMID: 36473933 Free PMC article.
The study investigated the seasonal variations of presenting symptoms and signs of dry eye disease (DED) in Norway. 652 consecutive DED patients examined between August 2012 and May 2015 in Oslo, Norway, were included. ...Signs and symptoms of DED generally did not correla …
The study investigated the seasonal variations of presenting symptoms and signs of dry eye disease (DED) in Norway. 652 consecutive D …
Time and Temperature Stability of TGF-β1, EGF and IGF-1 in 20% and 100% Human Serum.
Jirsova K, Levova K, Kalousova M, Fales I, Frankova V, Vesela V, Zima T, Utheim TP, Bednar J. Jirsova K, et al. Among authors: utheim tp. Folia Biol (Praha). 2022;68(2):45-49. Folia Biol (Praha). 2022. PMID: 36384261 Free article.
Autologous serum eye drops (ASEDs) are used as a treatment for severe dry eye disease. The concentration and stability of various growth factors in ASEDs is determinative for their efficiency. ...
Autologous serum eye drops (ASEDs) are used as a treatment for severe dry eye disease. The concentration and stability of various gro …
Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A review.
Vernhardsdottir RR, Magno MS, Hynnekleiv L, Lagali N, Dartt DA, Vehof J, Jackson CJ, Utheim TP. Vernhardsdottir RR, et al. Among authors: utheim tp. Ocul Surf. 2022 Oct;26:211-221. doi: 10.1016/j.jtos.2022.08.010. Epub 2022 Sep 20. Ocul Surf. 2022. PMID: 36210626 Review.
BACKGROUND: Dry eye disease (DED) is among the most prevalent ophthalmic conditions but is often underdiagnosed and mistreated. ...The search terms were: (antibiotics OR azithromycin OR doxycycline OR minocycline) AND (dry eye disease OR meibomian gland OR blepharit …
BACKGROUND: Dry eye disease (DED) is among the most prevalent ophthalmic conditions but is often underdiagnosed and mistreated. ...Th …
Change in Ocular Surface Staining during Eyelid Warming Is Related to Tear Cytokine Levels.
Landsend ECS, Olafsson J, Lai X, Aass HCD, Utheim TP. Landsend ECS, et al. Among authors: utheim tp. J Ophthalmol. 2022 Aug 3;2022:5103231. doi: 10.1155/2022/5103231. eCollection 2022. J Ophthalmol. 2022. PMID: 35967518 Free PMC article.
PURPOSE: To investigate the changes in the tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated with eyelid warming and to correlate these changes with clinical parameters for dry eye disease (DED). METHODS: Seventy patients with MGD were includ …
PURPOSE: To investigate the changes in the tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated with eyelid warm …
The relationship between habitual water intake and dry eye disease.
Nguyen L, Magno MS, Utheim TP, Jansonius NM, Hammond CJ, Vehof J. Nguyen L, et al. Among authors: utheim tp. Acta Ophthalmol. 2023 Feb;101(1):65-73. doi: 10.1111/aos.15227. Epub 2022 Aug 8. Acta Ophthalmol. 2023. PMID: 35941821 Free PMC article.
DED was assessed using the Women's Health Study (WHS) dry eye questionnaire. Water intake was calculated from food frequency questionnaires. ...The main outcome measure was WHS-defined DED. Highly symptomatic dry eye and clinical diagnosis of DED were secondary outc …
DED was assessed using the Women's Health Study (WHS) dry eye questionnaire. Water intake was calculated from food frequency question …
Topical glaucoma medications - Clinical implications for the ocular surface.
Fineide F, Lagali N, Adil MY, Arita R, Kolko M, Vehof J, Utheim TP. Fineide F, et al. Among authors: utheim tp. Ocul Surf. 2022 Oct;26:19-49. doi: 10.1016/j.jtos.2022.07.007. Epub 2022 Jul 31. Ocul Surf. 2022. PMID: 35921942 Free article. Review.
A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise …
A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pha …
The relationship between ocular and oral dryness in a cohort from the 65-year-old population in Norway.
Hynne H, Tashbayev B, Diep MT, Sødal ATT, Badian RA, Chen X, Lai X, Utheim TP, Hove LH, Jensen JL. Hynne H, et al. Among authors: utheim tp. Sci Rep. 2022 Jun 13;12(1):9805. doi: 10.1038/s41598-022-13985-6. Sci Rep. 2022. PMID: 35697848 Free PMC article.
In the present study, the relationship between dry eyes and dry mouth was explored in 150 65-year-old subjects randomly selected from the general population in Oslo, Norway. ...When the participants were categorized based on their ocular symptoms, poorer values were …
In the present study, the relationship between dry eyes and dry mouth was explored in 150 65-year-old subjects randomly select …
Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1.
Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Olsen MV, et al. Among authors: utheim tp. Int J Mol Sci. 2022 Jun 2;23(11):6233. doi: 10.3390/ijms23116233. Int J Mol Sci. 2022. PMID: 35682912 Free PMC article.
As MaR2 and MaR1 modulate conjunctival goblet cell function, they each may have potential as novel, but differing, options for the treatment of ocular surface inflammatory diseases including allergic conjunctivitis and dry eye disease. We conclude that in conjunctival GC M …
As MaR2 and MaR1 modulate conjunctival goblet cell function, they each may have potential as novel, but differing, options for the treatment …
Hyaluronic acid in the treatment of dry eye disease.
Hynnekleiv L, Magno M, Vernhardsdottir RR, Moschowits E, Tønseth KA, Dartt DA, Vehof J, Utheim TP. Hynnekleiv L, et al. Among authors: utheim tp. Acta Ophthalmol. 2022 Dec;100(8):844-860. doi: 10.1111/aos.15159. Epub 2022 May 5. Acta Ophthalmol. 2022. PMID: 35514082 Free PMC article. Review.
Dry eye disease (DED) is a highly prevalent and debilitating condition affecting several hundred million people worldwide. ...Literature searches were conducted in PubMed, including MEDLINE, and in Embase via Ovid with the search term: "(hyaluronic acid OR hyaluronan OR hy …
Dry eye disease (DED) is a highly prevalent and debilitating condition affecting several hundred million people worldwide. ...Literat …
Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease.
Fjaervoll K, Fjaervoll H, Magno M, Nøland ST, Dartt DA, Vehof J, Utheim TP. Fjaervoll K, et al. Among authors: utheim tp. Acta Ophthalmol. 2022 Dec;100(8):861-877. doi: 10.1111/aos.15150. Epub 2022 Apr 19. Acta Ophthalmol. 2022. PMID: 35441459 Free PMC article. Review.
BACKGROUND: Visual display terminal (VDT) use is a key risk factor for dry eye disease (DED). Visual display terminal (VDT) use reduces the blink rate and increases the number of incomplete blinks. ...METHODS: A PubMed search of the literature investigating the relationshi …
BACKGROUND: Visual display terminal (VDT) use is a key risk factor for dry eye disease (DED). Visual display terminal (VDT) use reduc …
Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren's Syndrome Patients.
Hynne H, Aqrawi LA, Jensen JL, Thiede B, Palm Ø, Amdal CD, Westgaard KL, Herlofson BB, Utheim TP, Galtung HK. Hynne H, et al. Among authors: utheim tp. Int J Mol Sci. 2022 Mar 28;23(7):3714. doi: 10.3390/ijms23073714. Int J Mol Sci. 2022. PMID: 35409074 Free PMC article.
Patients with head and neck cancer (HNC) and patients with primary Sjogren's syndrome (pSS) may exhibit similar symptoms of dry mouth and dry eyes, as a result of radiotherapy (RT) or a consequence of disease progression. ...In conclusion, the similarities and diffe …
Patients with head and neck cancer (HNC) and patients with primary Sjogren's syndrome (pSS) may exhibit similar symptoms of dry mouth …
Dry eye disease and proteomics.
Jackson CJ, Gundersen KG, Tong L, Utheim TP. Jackson CJ, et al. Among authors: utheim tp. Ocul Surf. 2022 Apr;24:119-128. doi: 10.1016/j.jtos.2022.03.001. Epub 2022 Mar 9. Ocul Surf. 2022. PMID: 35278720 Review.
Dry eye disease (DED) is a highly prevalent disease worldwide mostly associated with age, though other factors such as screen use and contact lens wear explain why it is increasingly diagnosed in younger people. ...
Dry eye disease (DED) is a highly prevalent disease worldwide mostly associated with age, though other factors such as screen use and …
In-office thermal systems for the treatment of dry eye disease.
Beining MW, Magnø MS, Moschowits E, Olafsson J, Vehof J, Dartt DA, Utheim TP. Beining MW, et al. Among authors: utheim tp. Surv Ophthalmol. 2022 Sep-Oct;67(5):1405-1418. doi: 10.1016/j.survophthal.2022.02.007. Epub 2022 Feb 19. Surv Ophthalmol. 2022. PMID: 35192836 Free article. Review.
Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, thickening of the meibum, obstruction of term …
Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dys …
Morphology of Meibomian Glands in a 65-Year-Old Norwegian Population without Dry Eye Disease.
Chen X, Badian RA, Hynne H, Tashbayev B, Hove LH, Jensen JL, Utheim TP. Chen X, et al. Among authors: utheim tp. J Clin Med. 2022 Jan 20;11(3):527. doi: 10.3390/jcm11030527. J Clin Med. 2022. PMID: 35159978 Free PMC article.
In the current study, meibography of the upper and lower eyelids of 117 65-year-old residents in Oslo, Norway, who did not fulfil the diagnosis of dry eye disease (DED) were analysed. Meibomian gland (MG) dropout and tarsal areas were measured semi-automatically using Imag …
In the current study, meibography of the upper and lower eyelids of 117 65-year-old residents in Oslo, Norway, who did not fulfil the diagno …
Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or Sjogren's Syndrome.
Hynne H, Sandås EM, Elgstøen KBP, Rootwelt H, Utheim TP, Galtung HK, Jensen JL. Hynne H, et al. Among authors: utheim tp. Cells. 2022 Jan 19;11(3):323. doi: 10.3390/cells11030323. Cells. 2022. PMID: 35159133 Free PMC article.
The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary Sjogren's syndrome (pSS) share many of the same symptoms despite different causes. ...This finding may indicate that purinergic signaling plays …
The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary Sjog …
Video display terminal use and dry eye: preventive measures and future perspectives.
Kamøy B, Magno M, Nøland ST, Moe MC, Petrovski G, Vehof J, Utheim TP. Kamøy B, et al. Among authors: utheim tp. Acta Ophthalmol. 2022 Nov;100(7):723-739. doi: 10.1111/aos.15105. Epub 2022 Feb 4. Acta Ophthalmol. 2022. PMID: 35122403 Free PMC article. Review.
BACKGROUND: Dry eye disease (DED) is a common cause of ocular pain and discomfort. Dry eye disease (DED) stems from a loss-of-tear film homeostasis and is frequently seen in video display terminal (VDT) users. ...METHODS: Studies were found using PubMed and Embase w …
BACKGROUND: Dry eye disease (DED) is a common cause of ocular pain and discomfort. Dry eye disease (DED) stems from a loss-of- …
The Relationship Between Caffeine Intake and Dry Eye Disease.
Magno MS, Utheim TP, Morthen MK, Snieder H, Jansonius NM, Hammond CJ, Vehof J. Magno MS, et al. Among authors: utheim tp. Cornea. 2023 Feb 1;42(2):186-193. doi: 10.1097/ICO.0000000000002979. Epub 2022 Jan 26. Cornea. 2023. PMID: 35081066 Free PMC article.
PURPOSE: The aim of this study was to determine the association between caffeine intake and dry eye disease (DED) in the large, population-based LifeLines cohort in the Netherlands. METHODS: DED was cross-sectionally assessed in 85,302 participants (59% female participants …
PURPOSE: The aim of this study was to determine the association between caffeine intake and dry eye disease (DED) in the large, popul …
Meibomian gland dysfunction is highly prevalent among first-time visitors at a Norwegian dry eye specialist clinic.
Badian RA, Utheim TP, Chen X, Utheim ØA, Ræder S, Ystenæs AE, Aakre BM, Sundling V. Badian RA, et al. Among authors: utheim tp. Sci Rep. 2021 Dec 3;11(1):23412. doi: 10.1038/s41598-021-02738-6. Sci Rep. 2021. PMID: 34862425 Free PMC article.
Additionally, to explore the accuracy of the ocular surface disease index score (OSDI) as an extensively applied tool to assess the severity of dry eye symptoms and MGD diagnosis. Patients with subjective dry eye-related complaints (n = 900) attending the clinic for …
Additionally, to explore the accuracy of the ocular surface disease index score (OSDI) as an extensively applied tool to assess the severity …
Artificial intelligence in dry eye disease.
Storås AM, Strümke I, Riegler MA, Grauslund J, Hammer HL, Yazidi A, Halvorsen P, Gundersen KG, Utheim TP, Jackson CJ. Storås AM, et al. Among authors: utheim tp. Ocul Surf. 2022 Jan;23:74-86. doi: 10.1016/j.jtos.2021.11.004. Epub 2021 Nov 27. Ocul Surf. 2022. PMID: 34843999 Review.
Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. ...
Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. .. …
Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer.
Chen X, Badian RA, Hynne H, Amdal CD, Herlofson BB, Utheim ØA, Westgaard KL, Fineide F, Jensen JL, Utheim TP. Chen X, et al. Among authors: utheim tp. Sci Rep. 2021 Nov 17;11(1):22419. doi: 10.1038/s41598-021-01844-9. Sci Rep. 2021. PMID: 34789830 Free PMC article.
Twenty-seven patients (64.7 9.8 years) and 30 age-matched controls (61.4 11.0 years) underwent a comprehensive dry eye work-up. Compared to the control group, the patients had more lid margin abnormalities, and worse meibum quality. ...Patients treated with IMRT for head a …
Twenty-seven patients (64.7 9.8 years) and 30 age-matched controls (61.4 11.0 years) underwent a comprehensive dry eye work-up. Compa …
TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial.
Olafsson J, Lai X, Landsend ECS, Olafsson S, Parissi E, Utheim ØA, Raeder S, Badian RA, Lagali N, Dartt DA, Utheim TP. Olafsson J, et al. Among authors: utheim tp. Sci Rep. 2021 Nov 17;11(1):22386. doi: 10.1038/s41598-021-01899-8. Sci Rep. 2021. PMID: 34789807 Free PMC article. Clinical Trial.
Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED). In this study, we aimed to compare the effects of eyelid warming treatment using either TheraPearl Eye Mask (Bausch & Lomb Inc., New York, USA) or Blephasteam (Spectrum Thea Pharmaceut …
Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED). In this study, we aimed to compare the effects o …
Chambered warm moist air eyelid warming devices - a review.
Magno MS, Olafsson J, Beining M, Moschowits E, Lagali N, Wolffsohn JS, Craig JP, Dartt DA, Vehof J, Utheim TP. Magno MS, et al. Among authors: utheim tp. Acta Ophthalmol. 2022 Aug;100(5):499-510. doi: 10.1111/aos.15052. Epub 2021 Nov 8. Acta Ophthalmol. 2022. PMID: 34750979 Free article. Review.
The search term was '(warm OR heat OR steam OR goggle OR spectacle OR moist air) AND (meibomian OR MGD OR blepharitis OR eyelid OR dry eye OR DED)'. All relevant articles with available English full text were included. ...Further well-conducted RCTs comparing moist and …
The search term was '(warm OR heat OR steam OR goggle OR spectacle OR moist air) AND (meibomian OR MGD OR blepharitis OR eyelid OR dry …
The vision-related burden of dry eye.
Morthen MK, Magno MS, Utheim TP, Snieder H, Jansonius N, Hammond CJ, Vehof J. Morthen MK, et al. Among authors: utheim tp. Ocul Surf. 2022 Jan;23:207-215. doi: 10.1016/j.jtos.2021.10.007. Epub 2021 Oct 28. Ocul Surf. 2022. PMID: 34743866 Free article.
PURPOSE: To investigate the relationship between dry eye disease (DED) and vision-related quality of life (VR-QoL) at population level. ...
PURPOSE: To investigate the relationship between dry eye disease (DED) and vision-related quality of life (VR-QoL) at population leve …
The association between visual display terminal use and dry eye: a review.
Fjaervoll H, Fjaervoll K, Magno M, Moschowits E, Vehof J, Dartt DA, Utheim TP. Fjaervoll H, et al. Among authors: utheim tp. Acta Ophthalmol. 2022 Jun;100(4):357-375. doi: 10.1111/aos.15049. Epub 2021 Oct 25. Acta Ophthalmol. 2022. PMID: 34697901 Free article. Review.
BACKGROUND: Dry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. ...
BACKGROUND: Dry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. ...
Therapeutic Strategies for Dry Mouth Management with Emphasis on Electrostimulation as a Treatment Option.
Tulek A, Mulic A, Hogset M, Utheim TP, Sehic A. Tulek A, et al. Among authors: utheim tp. Int J Dent. 2021 Oct 22;2021:6043488. doi: 10.1155/2021/6043488. eCollection 2021. Int J Dent. 2021. PMID: 34691182 Free PMC article. Review.
OBJECTIVES: Xerostomia is a subjective sensation of dry mouth. It is commonly associated with salivary gland hypofunction. Both changes in the composition of the saliva and a reduction in the quantity secreted may be an objective finding of dry mouth. Although there …
OBJECTIVES: Xerostomia is a subjective sensation of dry mouth. It is commonly associated with salivary gland hypofunction. Both chang …
Characterization of Lipids in Saliva, Tears and Minor Salivary Glands of Sjögren's Syndrome Patients Using an HPLC/MS-Based Approach.
Fineide F, Chen X, Bjellaas T, Vitelli V, Utheim TP, Jensen JL, Galtung HK. Fineide F, et al. Among authors: utheim tp. Int J Mol Sci. 2021 Aug 20;22(16):8997. doi: 10.3390/ijms22168997. Int J Mol Sci. 2021. PMID: 34445702 Free PMC article.
We believe a comprehensive elucidation of the changes in lipid composition in saliva, tears and minor salivary glands in pSS patients may be the key to detecting pSS-related dry mouth and dry eyes at an early stage. The identified differences may illuminate the path …
We believe a comprehensive elucidation of the changes in lipid composition in saliva, tears and minor salivary glands in pSS patients may be …
Eye Make-up Products and Dry Eye Disease: A Mini Review.
Yazdani M, Elgstøen KBP, Utheim TP. Yazdani M, et al. Among authors: utheim tp. Curr Eye Res. 2022 Jan;47(1):1-11. doi: 10.1080/02713683.2021.1966476. Epub 2021 Sep 19. Curr Eye Res. 2022. PMID: 34365876 Review.
Dry eye disease (DED), a multifactorial condition of the tear film and ocular surface, is one of the leading reasons for patients seeking eye care. ...
Dry eye disease (DED), a multifactorial condition of the tear film and ocular surface, is one of the leading reasons for patients see …
Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands.
Wolpert LE, Snieder H, Jansonius NM, Utheim TP, Hammond CJ, Vehof J. Wolpert LE, et al. Among authors: utheim tp. Ocul Surf. 2021 Oct;22:1-12. doi: 10.1016/j.jtos.2021.06.009. Epub 2021 Jun 23. Ocul Surf. 2021. PMID: 34171471
Logistic regression was used to assess the risk of the 59 most-used therapeutic/pharmacological subgroups and the 99 most-used individual drugs (all n > 200) on dry eye symptoms, correcting for age, sex, body mass index, and 48 comorbidities associated with dry e …
Logistic regression was used to assess the risk of the 59 most-used therapeutic/pharmacological subgroups and the 99 most-used individual dr …
The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants.
Morthen MK, Magno MS, Utheim TP, Snieder H, Hammond CJ, Vehof J. Morthen MK, et al. Among authors: utheim tp. Ocul Surf. 2021 Jul;21:107-117. doi: 10.1016/j.jtos.2021.05.006. Epub 2021 May 24. Ocul Surf. 2021. PMID: 34044135 Free article.
PURPOSE: This large cross-sectional population-based study investigated the relationship between dry eye disease (DED) and health-related quality of life (HR-QoL). METHODS: Dry eye and HR-QoL were assessed in 78,165 participants (19-94 yrs, 59.2% female) from the Du …
PURPOSE: This large cross-sectional population-based study investigated the relationship between dry eye disease (DED) and health-rel …
The relationship between alcohol consumption and dry eye.
Magno MS, Daniel T, Morthen MK, Snieder H, Jansonius N, Utheim TP, Hammond CJ, Vehof J. Magno MS, et al. Among authors: utheim tp. Ocul Surf. 2021 Jul;21:87-95. doi: 10.1016/j.jtos.2021.05.005. Epub 2021 May 21. Ocul Surf. 2021. PMID: 34029755 Free article.
RESULTS: Overall, 30.0% of participants had symptomatic dry eye. Alcohol use significantly increased the risk of symptomatic dry eye in females (odds ratio [OR] 1.095, 95%CI 1.045-1.148), but not in males (OR 0.988, 95%CI 0.900-1.084). ...Alcohol use and intake had …
RESULTS: Overall, 30.0% of participants had symptomatic dry eye. Alcohol use significantly increased the risk of symptomatic dry …
Tear Film Break-Up Time and Dry Eye Disease Severity in a Large Norwegian Cohort.
Yazdani M, Fiskådal J, Chen X, Utheim ØA, Ræder S, Vitelli V, Utheim TP. Yazdani M, et al. Among authors: utheim tp. J Clin Med. 2021 Feb 22;10(4):884. doi: 10.3390/jcm10040884. J Clin Med. 2021. PMID: 33671667 Free PMC article.
This study evaluated to what extent tear film break-up time (TFBUT) could discriminate pathological scores for other clinical tests and explore the associations between them. Dry eye patients (n = 2094) were examined for ocular surface disease index (OSDI), tear film osmol …
This study evaluated to what extent tear film break-up time (TFBUT) could discriminate pathological scores for other clinical tests and expl …
Oral and ocular late effects in head and neck cancer patients treated with radiotherapy.
Westgaard KL, Hynne H, Amdal CD, Young A, Singh PB, Chen X, Rykke M, Hove LH, Aqrawi LA, Utheim TP, Herlofson BB, Jensen JL. Westgaard KL, et al. Among authors: utheim tp. Sci Rep. 2021 Feb 17;11(1):4026. doi: 10.1038/s41598-021-83635-w. Sci Rep. 2021. PMID: 33597629 Free PMC article.
After completing several questionnaires: Oral Health Impact Profile-14 (OHIP-14), Shortened Xerostomia Inventory (SXI), Ocular Surface Disease Index (OSDI) and McMonnies Dry Eye questionnaire (MDEQ), participants underwent oral and ocular examinations. Oral examination inc …
After completing several questionnaires: Oral Health Impact Profile-14 (OHIP-14), Shortened Xerostomia Inventory (SXI), Ocular Surface Disea …
The relationship between dry eye and sleep quality.
Magno MS, Utheim TP, Snieder H, Hammond CJ, Vehof J. Magno MS, et al. Among authors: utheim tp. Ocul Surf. 2021 Apr;20:13-19. doi: 10.1016/j.jtos.2020.12.009. Epub 2021 Jan 6. Ocul Surf. 2021. PMID: 33421635 Free article.
This study aimed to clarify the association between dry eye and sleep quality using a large population-based cohort. METHODS: 71,761 participants (19-94 yrs, 59.4% female) from the Lifelines cohort in the Netherlands were assessed for dry eye using the Women's Healt …
This study aimed to clarify the association between dry eye and sleep quality using a large population-based cohort. METHODS: 71,761 …
Intraductal meibomian gland probing and its efficacy in the treatment of meibomian gland dysfunction.
Magno M, Moschowits E, Arita R, Vehof J, Utheim TP. Magno M, et al. Among authors: utheim tp. Surv Ophthalmol. 2021 Jul-Aug;66(4):612-622. doi: 10.1016/j.survophthal.2020.11.005. Epub 2021 Jan 29. Surv Ophthalmol. 2021. PMID: 33352147 Free article. Review.
Meibomian gland dysfunction (MGD) is a major cause of dry eye, affecting millions worldwide. Intraductal meibomian gland probing (MGP) aims to open obstructed meibomian glands using a small probe to promote meibum secretion. MGP has received increasing interest since 2010, …
Meibomian gland dysfunction (MGD) is a major cause of dry eye, affecting millions worldwide. Intraductal meibomian gland probing (MGP …
Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients.
Tellefsen Nøland S, Badian RA, Utheim TP, Utheim ØA, Stojanovic A, Tashbayev B, Raeder S, Dartt DA, Chen X. Tellefsen Nøland S, et al. Among authors: utheim tp. Ocul Surf. 2021 Jan;19:68-73. doi: 10.1016/j.jtos.2020.11.009. Epub 2020 Nov 24. Ocul Surf. 2021. PMID: 33246035
PURPOSE: To investigate sex and age differences in symptoms and signs in a Norwegian clinic-based cohort of patients with dry eye disease (DED). METHODS: Visitors at the Norwegian Dry Eye Clinic were examined using Ocular Surface Disease Index (OSDI) questionnaire s …
PURPOSE: To investigate sex and age differences in symptoms and signs in a Norwegian clinic-based cohort of patients with dry eye dis …
Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjogren's syndrome.
Vehof J, Utheim TP, Bootsma H, Hammond CJ. Vehof J, et al. Among authors: utheim tp. Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):301-309. Epub 2020 Sep 25. Clin Exp Rheumatol. 2020. PMID: 33025899 Free article. Review.
The uses and pitfalls of commonly-used diagnostic tests for dry eye are reviewed, as well as the increasing number of new imaging technologies and biomarkers to refine diagnosis. ...All these aspects make the management of dry eye in Sjogren's syndrome challenging.. …
The uses and pitfalls of commonly-used diagnostic tests for dry eye are reviewed, as well as the increasing number of new imaging tec …
Dry eye disease treatment: the role of tear substitutes, their future, and an updated classification.
Barabino S, Benitez-Del-Castillo JM, Fuchsluger T, Labetoulle M, Malachkova N, Meloni M, Utheim TP, Rolando M. Barabino S, et al. Among authors: utheim tp. Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):8642-8652. doi: 10.26355/eurrev_202009_22801. Eur Rev Med Pharmacol Sci. 2020. PMID: 32964952 Free article. Review.
OBJECTIVE: The aim of this review is to summarize the results of a consensus meeting held by a group of experts in dry eye disease (DED) to discuss the importance of tear substitutes in the treatment of DED. ...MATERIALS AND METHODS: A literature search was conducted using …
OBJECTIVE: The aim of this review is to summarize the results of a consensus meeting held by a group of experts in dry eye disease (D …
Cytokines Explored in Saliva and Tears from Radiated Cancer Patients Correlate with Clinical Manifestations, Influencing Important Immunoregulatory Cellular Pathways.
Aqrawi LA, Chen X, Hynne H, Amdal C, Reppe S, Aass HCD, Rykke M, Hove LH, Young A, Herlofson BB, Westgaard KL, Utheim TP, Galtung HK, Jensen JL. Aqrawi LA, et al. Among authors: utheim tp. Cells. 2020 Sep 8;9(9):2050. doi: 10.3390/cells9092050. Cells. 2020. PMID: 32911805 Free PMC article.
TFOS European Ambassador meeting: Unmet needs and future scientific and clinical solutions for ocular surface diseases.
Erickson S, Sullivan AG, Barabino S, Begovic E, Benitez-Del-Castillo JM, Bonini S, Borges JS, Brzheskiy V, Bulat N, Cerim A, Craig JP, Cușnir V, Cușnir V Jr, Cușnir V, Doan S, Dülger E, Farrant S, Geerling G, Goldblum D, Golubev S, Gomes JAP, González-Méijome JM, Grupcheva CN, Gündüz ÖU, Horwath-Winter J, Källmark F, Karanadze N, Karcic HH, Karcic S, Kontadakis G, Messmer EM, Mrugacz M, Murphy C, O'Leary OE, Procopciuc V, Pult H, Raus P, Şahin A, Setälä N, Stanila A, Stanila DM, Utheim TP, Vehof J, Versura P, Villani E, Willcox MDP, Wolffsohn JS, Zagórski Z, Zoega GM, Sullivan DA. Erickson S, et al. Among authors: utheim tp. Ocul Surf. 2020 Oct;18(4):936-962. doi: 10.1016/j.jtos.2020.05.006. Epub 2020 Jun 3. Ocul Surf. 2020. PMID: 32504856
Aberrant HLA-DR expression in the conjunctival epithelium after autologous serum treatment in patients with graft-versus-host disease or Sjögren's syndrome.
Jirsova K, Seidler Stangova P, Palos M, Mahelkova G, Kalasova S, Rybickova I, Utheim TP, Vesela V. Jirsova K, et al. Among authors: utheim tp. PLoS One. 2020 Apr 21;15(4):e0231473. doi: 10.1371/journal.pone.0231473. eCollection 2020. PLoS One. 2020. PMID: 32315325 Free PMC article.
The aim of this study was to determine the effect of autologous serum (AS) eye drops on the density of human leucocyte antigen (HLA)-DR-positive epithelial cells and Langerhans cells on the ocular surface of patients with bilateral severe dry eye disease (DED) due to graft …
The aim of this study was to determine the effect of autologous serum (AS) eye drops on the density of human leucocyte antigen (HLA)-DR-posi …
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease.
Tashbayev B, Utheim TP, Utheim ØA, Ræder S, Jensen JL, Yazdani M, Lagali N, Vitelli V, Dartt DA, Chen X. Tashbayev B, et al. Among authors: utheim tp. Sci Rep. 2020 Mar 26;10(1):5542. doi: 10.1038/s41598-020-62583-x. Sci Rep. 2020. PMID: 32218518 Free PMC article.
The prevalence of dry eye disease is high worldwide and poses a great burden on patients' daily lives. ...Moreover, in the receiver operating characteristics curve analyses tear osmolarity measurement could not discriminate dry eye disease pathological scores. There …
The prevalence of dry eye disease is high worldwide and poses a great burden on patients' daily lives. ...Moreover, in the receiver o …
Diagnostic Test Efficacy of Meibomian Gland Morphology and Function.
Xiao J, Adil MY, Olafsson J, Chen X, Utheim ØA, Ræder S, Lagali NS, Dartt DA, Utheim TP. Xiao J, et al. Among authors: utheim tp. Sci Rep. 2019 Nov 22;9(1):17345. doi: 10.1038/s41598-019-54013-4. Sci Rep. 2019. PMID: 31758085 Free PMC article.
Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD severity. This retrospective, cross-sectional stud …
Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose …
Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity.
Xiao J, Adil MY, Chen X, Utheim ØA, Ræder S, Tønseth KA, Lagali NS, Dartt DA, Utheim TP. Xiao J, et al. Among authors: utheim tp. Am J Ophthalmol. 2020 Jan;209:160-167. doi: 10.1016/j.ajo.2019.09.005. Epub 2019 Sep 14. Am J Ophthalmol. 2020. PMID: 31526799 Free article.
PURPOSE: To classify subtypes of meibomian gland dysfunction (MGD) and evaluate the dependency of dry eye signs, symptoms, and parameters on MGD subtype. DESIGN: Cross-sectional study. ...Furthermore, nonobvious MGD cannot be diagnosed using conventional dry eye tes …
PURPOSE: To classify subtypes of meibomian gland dysfunction (MGD) and evaluate the dependency of dry eye signs, symptoms, and parame …
[Dry eye disease - diagnosis and treatment].
Ræder S, Klyve P, Utheim TP. Ræder S, et al. Among authors: utheim tp. Tidsskr Nor Laegeforen. 2019 Aug 8;139(11). doi: 10.4045/tidsskr.18.0752. Print 2019 Aug 20. Tidsskr Nor Laegeforen. 2019. PMID: 31429248 Free article. Review. Norwegian.
Dry eye disease is a frequent reason for patients to seek help. In our experience, it is an underdiagnosed and undertreated condition....
Dry eye disease is a frequent reason for patients to seek help. In our experience, it is an underdiagnosed and undertreated condition …
Tear Metabolomics in Dry Eye Disease: A Review.
Yazdani M, Elgstøen KBP, Rootwelt H, Shahdadfar A, Utheim ØA, Utheim TP. Yazdani M, et al. Among authors: utheim tp. Int J Mol Sci. 2019 Aug 1;20(15):3755. doi: 10.3390/ijms20153755. Int J Mol Sci. 2019. PMID: 31374809 Free PMC article. Review.
Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. ...
Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear …
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers.
Aqrawi LA, Galtung HK, Guerreiro EM, Øvstebø R, Thiede B, Utheim TP, Chen X, Utheim ØA, Palm Ø, Skarstein K, Jensen JL. Aqrawi LA, et al. Among authors: utheim tp. Arthritis Res Ther. 2019 Jul 31;21(1):181. doi: 10.1186/s13075-019-1961-4. Arthritis Res Ther. 2019. PMID: 31366407 Free PMC article.
Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells.
Botten N, Hodges RR, Li D, Bair JA, Shatos MA, Utheim TP, Serhan CN, Dartt DA. Botten N, et al. Among authors: utheim tp. FASEB J. 2019 Jul;33(7):8468-8478. doi: 10.1096/fj.201802467R. Epub 2019 Apr 23. FASEB J. 2019. PMID: 31013438 Free PMC article.
Thus RvD2 likely assists in the maintenance of the mucous layer of the tear film to sustain ocular surface homeostasis and has potential as a novel treatment for dry eye disease.-Botten, N., Hodges, R. R., Li, D., Bair, J. A., Shatos, M. A., Utheim, T. ...
Thus RvD2 likely assists in the maintenance of the mucous layer of the tear film to sustain ocular surface homeostasis and has potential as …
Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients.
Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Hua Y, Eidet JR, Stojanovic A, Dartt DA, Utheim TP. Yazdani M, et al. Among authors: utheim tp. Curr Eye Res. 2019 Sep;44(9):941-947. doi: 10.1080/02713683.2019.1604972. Epub 2019 Apr 29. Curr Eye Res. 2019. PMID: 30955380
Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test (ST), meibum expressibility (ME), me …
Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear fi …
Meibomian Gland Morphology Is a Sensitive Early Indicator of Meibomian Gland Dysfunction.
Adil MY, Xiao J, Olafsson J, Chen X, Lagali NS, Ræder S, Utheim ØA, Dartt DA, Utheim TP. Adil MY, et al. Among authors: utheim tp. Am J Ophthalmol. 2019 Apr;200:16-25. doi: 10.1016/j.ajo.2018.12.006. Epub 2018 Dec 20. Am J Ophthalmol. 2019. PMID: 30578784
PURPOSE: To investigate the relationship between meibomian gland (MG) morphology and clinical dry eye tests in patients with meibomian gland dysfunction (MGD). DESIGN: Cross-sectional study. ...Compensatory mechanisms such as increased aqueous tear production and dilation …
PURPOSE: To investigate the relationship between meibomian gland (MG) morphology and clinical dry eye tests in patients with meibomia …
Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjogren's syndrome.
Aqrawi LA, Chen X, Jensen JL, Morthen MK, Thiede B, Utheim ØA, Palm Ø, Tashbayev B, Utheim TP, Galtung HK. Aqrawi LA, et al. Among authors: utheim tp. PLoS One. 2018 Oct 12;13(10):e0205762. doi: 10.1371/journal.pone.0205762. eCollection 2018. PLoS One. 2018. PMID: 30312344 Free PMC article.
Ocular dryness is a characteristic feature of primary Sjogren's syndrome (pSS). This may result in dry eye disease (DED), leading to damage of the ocular surface. Additional, non-invasive diagnostic techniques are needed when evaluating pSS patients. ...In this study we fu …
Ocular dryness is a characteristic feature of primary Sjogren's syndrome (pSS). This may result in dry eye disease (DED), leading to …
Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort.
Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Lagali N, Stojanovic A, Dartt DA, Utheim TP. Yazdani M, et al. Among authors: utheim tp. Curr Eye Res. 2018 Dec;43(12):1465-1470. doi: 10.1080/02713683.2018.1514055. Epub 2018 Sep 5. Curr Eye Res. 2018. PMID: 30183390
PURPOSE: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear production. ...Classification of dry ey …
PURPOSE: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegi …
The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction.
Landsend ECS, Utheim ØA, Pedersen HR, Aass HCD, Lagali N, Dartt DA, Baraas RC, Utheim TP. Landsend ECS, et al. Among authors: utheim tp. Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2197-2204. doi: 10.1167/iovs.18-24027. Invest Ophthalmol Vis Sci. 2018. PMID: 29801153
Eyes of all participants were examined with tests for dry eye disease, including evaluation of meibomian glands (meibography). Differences in cytokine levels between the two groups were analyzed, and correlations between cytokine concentrations and ophthalmologic findings …
Eyes of all participants were examined with tests for dry eye disease, including evaluation of meibomian glands (meibography). Differ …
Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia.
Landsend ECS, Pedersen HR, Utheim ØA, Xiao J, Adil MY, Tashbayev B, Lagali N, Dartt DA, Baraas RC, Utheim TP. Landsend ECS, et al. Among authors: utheim tp. Br J Ophthalmol. 2019 Jan;103(1):119-124. doi: 10.1136/bjophthalmol-2017-310927. Epub 2018 Mar 8. Br J Ophthalmol. 2019. PMID: 29519880
AIMS: To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. METHODS: Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 healthy controls were examined. All subjects under …
AIMS: To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital anirid …
Meibomian gland features in a Norwegian cohort of patients with primary Sjögren´s syndrome.
Chen X, Utheim ØA, Xiao J, Adil MY, Stojanovic A, Tashbayev B, Jensen JL, Utheim TP. Chen X, et al. Among authors: utheim tp. PLoS One. 2017 Sep 8;12(9):e0184284. doi: 10.1371/journal.pone.0184284. eCollection 2017. PLoS One. 2017. PMID: 28886085 Free PMC article.
After completion of Ocular Surface Disease Index (OSDI) questionnaire and McMonnies Dry Eye Questionaire, participants underwent measurements of tear osmolarity, tear break-up time (TBUT), ocular surface and corneal staining, Schirmer I test, corneal sensitivity, MG expres …
After completion of Ocular Surface Disease Index (OSDI) questionnaire and McMonnies Dry Eye Questionaire, participants underwent meas …
Interdisciplinary, Comprehensive Oral and Ocular Evaluation of Patients with Primary Sjögren's Syndrome.
Tashbayev B, Rusthen S, Young A, Herlofson BB, Hove LH, Singh PB, Rykke M, Aqrawi LA, Chen X, Utheim ØA, Utheim TP, Palm Ø, Jensen JL. Tashbayev B, et al. Among authors: utheim tp. Sci Rep. 2017 Sep 7;7(1):10761. doi: 10.1038/s41598-017-10809-w. Sci Rep. 2017. PMID: 28883442 Free PMC article.
Oral (Summated Xerostomia Inventory, SXI) and ocular (McMonnies Dry Eye questionnaire, MDEIS, and Ocular Surface Disease Index, OSDI) subjective complaints were recorded. ...
Oral (Summated Xerostomia Inventory, SXI) and ocular (McMonnies Dry Eye questionnaire, MDEIS, and Ocular Surface Disease Index, OSDI) …
Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy.
Fostad IG, Eidet JR, Lagali NS, Dartt DA, Ræder S, Messelt EB, Utheim TP. Fostad IG, et al. Among authors: utheim tp. Microsc Microanal. 2017 Feb;23(1):88-96. doi: 10.1017/S1431927617000022. Epub 2017 Feb 6. Microsc Microanal. 2017. PMID: 28162126
The purpose of this work was to determine whether the morphology of the oral mucosa epithelium (OME) of patients with xerostomia differ from patients without xerostomia. In total, 34 patients with dry eye disease (DED) with or without xerostomia were examined at The Norweg …
The purpose of this work was to determine whether the morphology of the oral mucosa epithelium (OME) of patients with xerostomia differ from …
Identification of potential saliva and tear biomarkers in primary Sjögren's syndrome, utilising the extraction of extracellular vesicles and proteomics analysis.
Aqrawi LA, Galtung HK, Vestad B, Øvstebø R, Thiede B, Rusthen S, Young A, Guerreiro EM, Utheim TP, Chen X, Utheim ØA, Palm Ø, Jensen JL. Aqrawi LA, et al. Among authors: utheim tp. Arthritis Res Ther. 2017 Jan 25;19(1):14. doi: 10.1186/s13075-017-1228-x. Arthritis Res Ther. 2017. PMID: 28122643 Free PMC article.
Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility.
Fostad IG, Eidet JR, Utheim TP, Ræder S, Lagali NS, Messelt EB, Dartt DA. Fostad IG, et al. Among authors: utheim tp. PLoS One. 2016 May 5;11(5):e0155214. doi: 10.1371/journal.pone.0155214. eCollection 2016. PLoS One. 2016. PMID: 27148875 Free PMC article.
The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies were consecutively included in the s …
The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease …