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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1979 1
1981 2
1982 2
1983 5
1984 6
1985 6
1986 6
1987 10
1988 9
1989 15
1990 30
1991 23
1992 47
1993 27
1994 42
1995 29
1996 35
1997 37
1998 35
1999 37
2000 49
2001 37
2002 46
2003 44
2004 39
2005 53
2006 48
2007 49
2008 47
2009 51
2010 60
2011 75
2012 57
2013 67
2014 71
2015 78
2016 70
2017 71
2018 69
2019 76
2020 73
2021 55
2022 58
2023 47
2024 64
2025 89
2026 49

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1,842 results

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Page 1
High throughput analysis of vacuolar acidification.
Zhang C, Balutowski A, Feng Y, Calderin JD, Fratti RA. Zhang C, et al. Anal Biochem. 2022 Dec 1;658:114927. doi: 10.1016/j.ab.2022.114927. Epub 2022 Sep 24. Anal Biochem. 2022. PMID: 36167157
Thus, each compartment becomes more acidic as maturation proceeds. Lysosome acidification is essential for the breakdown of macromolecules delivered from endosomes as well as cargo from different autophagic pathways, and dysregulation of this process is linked to various d …
Thus, each compartment becomes more acidic as maturation proceeds. Lysosome acidification is essential for the breakdown of macromole …
Mitochondria-lysosome coupling contributes to lysosome acidification and aging.
Liu Q, Yoo S, Zhang ZA, Li L, Su H, Vannur L, Wooldredge AC, Hughes JB, Desprez PY, Hao N, Lithgow G, Andersen JK, Hansen M, Campisi J, Zhou C. Liu Q, et al. Mol Cell. 2026 Jun 18;86(12):2425-2442.e10. doi: 10.1016/j.molcel.2026.05.004. Epub 2026 May 29. Mol Cell. 2026. PMID: 42214330 Free PMC article.
Here, we uncovered a conserved lysosome/vacuole acidification mechanism from yeast to human involving lysosomal/vacuolar uptake of H(+) pumped out by mitochondrial electron transport chain through mitochondria-lysosomes/vacuoles membrane contacts. ...These fi …
Here, we uncovered a conserved lysosome/vacuole acidification mechanism from yeast to human involving lysosomal/vacuolar uptak …
A viral protein disrupts vacuolar acidification to facilitate virus infection in plants.
Yang M, Ismayil A, Jiang Z, Wang Y, Zheng X, Yan L, Hong Y, Li D, Liu Y. Yang M, et al. EMBO J. 2022 Dec 17;41(2):e108713. doi: 10.15252/embj.2021108713. Epub 2021 Dec 9. EMBO J. 2022. PMID: 34888888 Free PMC article.
Vacuolar acidification is essential for vacuoles in diverse physiological functions. However, its role in plant defense, and whether and how pathogens affect vacuolar acidification to promote infection remain unknown. ...Interestingly, multiple …
Vacuolar acidification is essential for vacuoles in diverse physiological functions. However, its role in plant defense …
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases.
Song Q, Meng B, Xu H, Mao Z. Song Q, et al. Transl Neurodegener. 2020 May 11;9(1):17. doi: 10.1186/s40035-020-00196-0. Transl Neurodegener. 2020. PMID: 32393395 Free PMC article. Review.
Lysosome pH gradients are mainly maintained by the vacuolar (H(+)) ATPase (or V-ATPase), which pumps protons into lysosomal lumen by consuming ATP. Dysfunction of V-ATPase affects lysosomal acidification, which disrupts the clearance of substrates and leads to many …
Lysosome pH gradients are mainly maintained by the vacuolar (H(+)) ATPase (or V-ATPase), which pumps protons into lysosomal lumen by …
Arabidopsis phospholipase Dzeta2 facilitates vacuolar acidification and autophagy under phosphorus starvation by interacting with VATD.
Guan B, Xie KX, Du XQ, Bai YX, Hao PC, Lin WH, Friml J, Xue HW. Guan B, et al. Cell Rep. 2025 Jul 22;44(7):116024. doi: 10.1016/j.celrep.2025.116024. Epub 2025 Jul 15. Cell Rep. 2025. PMID: 40668679 Free article.
The key factors regulating vacuolar acidification and underlying mechanisms remain unclear. Here, we report that Arabidopsis phospholipase Dzeta2 (PLDzeta2) promotes the acidification of the vacuolar lumen to stimulate autophagic degradation under phos …
The key factors regulating vacuolar acidification and underlying mechanisms remain unclear. Here, we report that Arabidopsis p …
Plant virus infection disrupts vacuolar acidification and autophagic degradation for the effective infection.
Yang M, Wang Y, Li D, Liu Y. Yang M, et al. Autophagy. 2022 Mar;18(3):705-706. doi: 10.1080/15548627.2022.2027194. Epub 2022 Jan 14. Autophagy. 2022. PMID: 35030068 Free PMC article.
Vacuolar acidification is essential for vacuoles in various physiological functions. However, its role in plant defense, and whether and how pathogens affect vacuolar acidification to promote infection have never been reported. In this autophagy …
Vacuolar acidification is essential for vacuoles in various physiological functions. However, its role in plant defense …
The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification.
Gluck SL. Gluck SL. J Bioenerg Biomembr. 1992 Aug;24(4):351-9. doi: 10.1007/BF00762528. J Bioenerg Biomembr. 1992. PMID: 1400280 Review.
Vacuolar H+ ATPases participate in renal hydrogen ion secretion in both the proximal and distal nephron. These plasma membrane forms of the vacuolar H+ ATPase are regulated physiologically to maintain the acid-base balance of the organism. ...
Vacuolar H+ ATPases participate in renal hydrogen ion secretion in both the proximal and distal nephron. These plasma membrane forms …
Regulation of vacuolar acidification.
Forgac M. Forgac M. Soc Gen Physiol Ser. 1996;51:121-32. Soc Gen Physiol Ser. 1996. PMID: 8809938 Review. No abstract available.
The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPase.
Kane PM. Kane PM. Microbiol Mol Biol Rev. 2006 Mar;70(1):177-91. doi: 10.1128/MMBR.70.1.177-191.2006. Microbiol Mol Biol Rev. 2006. PMID: 16524922 Free PMC article. Review.
All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in organelle acidification. Not only is the structure of V-ATPases highly conserved among eukaryotes, but there are also many regulatory mechanisms that are similar between fungi and …
All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in organelle acidification. Not only is th …
Regulation of vacuolar proton pumping ATPase-dependent luminal acidification in the epididymis.
Da Silva N, Shum WW, Breton S. Da Silva N, et al. Asian J Androl. 2007 Jul;9(4):476-82. doi: 10.1111/j.1745-7262.2007.00299.x. Asian J Androl. 2007. PMID: 17589784 Free article. Review.
Luminal acidification in the epididymis is an important process for the regulation of male fertility. ...Clear cells express very high levels of the vacuolar proton pumping ATPase (V-ATPase) in their apical membrane and are responsible for the bulk of proton secreti …
Luminal acidification in the epididymis is an important process for the regulation of male fertility. ...Clear cells express very hig …
1,842 results