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1979 1
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Page 1
Breast and endometrial safety of micronised progesterone versus norethisterone acetate in menopausal hormone therapy (PROBES): study protocol of a double-blind randomised controlled trial.
Lundell C, Stergiopoulos N, Blomberg L, Ujvari D, Schuppe-Koistinen I, Kopp-Kallner H, Iliadis SI, Skalkidou A, Hirschberg AL. Lundell C, et al. BMJ Open. 2024 Oct 23;14(10):e082749. doi: 10.1136/bmjopen-2023-082749. BMJ Open. 2024. PMID: 39448218 Free PMC article.
INTRODUCTION: Data suggest that micronised progesterone (mP) in menopausal hormone therapy is safer for the breast than synthetic progestins, while protection of the endometrium appears to be less effective. However, comparative randomised trial data are lacking. Th …
INTRODUCTION: Data suggest that micronised progesterone (mP) in menopausal hormone therapy is safer for the breast than synthetic pro …
Endometrial response to a cyclic regimen of percutaneous 17beta-estradiol and low-dose vaginal micronized progesterone in women with mild-to-moderate hypertension.
Vilodre LC, Osório Wender MC, Sisson de Castro JA, dos Reis FM, Ruschel S, Magalhães JA, Spritzer PM. Vilodre LC, et al. Gynecol Endocrinol. 2003 Aug;17(4):323-8. Gynecol Endocrinol. 2003. PMID: 14503977 Clinical Trial.
Endometrial response to natural estradiol and low-dose vaginal progesterone replacement therapy was evaluated in 20 postmenopausal women with chronic, mild-to-moderate hypertension. A cyclic hormone replacement therapy (HRT) regimen was used (21/28 day
Endometrial response to natural estradiol and low-dose vaginal progesterone replacement therapy was evaluated in 20 pos
Hormone replacement therapy in postmenopausal women.
Yasui T, Uemura H, Takikawa M, Irahara M. Yasui T, et al. J Med Invest. 2003 Aug;50(3-4):136-45. J Med Invest. 2003. PMID: 13678382 Review.
Hormone replacement therapy (HRT) is effective for relieving vasomotor symptoms such as hot flash and vaginal atrophy and for preventing bone loss in postmenopausal and bilaterally ovariectomized women. ...Moreover, low-dose regimens of CEE (conjugated equine estrog …
Hormone replacement therapy (HRT) is effective for relieving vasomotor symptoms such as hot flash and vaginal atrophy and for …
Endometrial carcinoma on continuous combined HRT: case report and literature review.
Di Spiezio Sardo A, Radhakrishnan S. Di Spiezio Sardo A, et al. Maturitas. 2004 Jun 15;48(2):171-5. doi: 10.1016/j.maturitas.2004.02.002. Maturitas. 2004. PMID: 15172092 Review.
Moreover, when given on a daily basis, progestin is thought to be more protective against the development of endometrial carcinoma. CASE REPORT: We describe the case of a 59-year-old woman, diagnosed with endometrial carcinoma while on continuous combined …
Moreover, when given on a daily basis, progestin is thought to be more protective against the development of endometrial carci …
Progestins and menopause: epidemiological studies of risks of endometrial and breast cancer.
Pike MC, Ross RK. Pike MC, et al. Steroids. 2000 Oct-Nov;65(10-11):659-64. doi: 10.1016/s0039-128x(00)00122-7. Steroids. 2000. PMID: 11108873
This may provide an explanation of why endometrial cancer risk increases so sharply with age in young women even in countries where obesity-associated anovulation is very uncommon; extended periods of unopposed estrogen is not an explanation but less than 10 days of an 'ad …
This may provide an explanation of why endometrial cancer risk increases so sharply with age in young women even in countries where o …
Hormone replacement therapy in the menopause.
Sarrel PM. Sarrel PM. Int J Fertil Womens Med. 1997 Mar-Apr;42(2):78-84. Int J Fertil Womens Med. 1997. PMID: 9160217 Review.
The failure of follicular development that characterizes the menopause leads to a marked reduction in serum levels of estradiol and progesterone. As a result, the majority of women develop symptoms, including hot flushes, sleep disturbance, and vaginal dryness. ...E …
The failure of follicular development that characterizes the menopause leads to a marked reduction in serum levels of estradiol and proge
Effect of chronic estradiol plus progesterone treatment on experimental arterial and venous thrombosis in mouse.
Valéra MC, Noirrit-Esclassan E, Dupuis M, Buscato M, Vinel A, Guillaume M, Briaux A, Garcia C, Benoit T, Lairez O, Fontaine C, Payrastre B, Arnal JF. Valéra MC, et al. PLoS One. 2017 May 9;12(5):e0177043. doi: 10.1371/journal.pone.0177043. eCollection 2017. PLoS One. 2017. PMID: 28486478 Free PMC article.
Postmenopausal hormone replacement therapy (HRT) with estrogen plus progestogens is the first line therapy to treat menopausal symptoms. ...We previously reported that chronic subcutaneous 17alpha-estradiol (E2) in mice decreases platelet responsiveness, prolongs the tail- …
Postmenopausal hormone replacement therapy (HRT) with estrogen plus progestogens is the first line therapy to treat menopausal sympto …
[Authors' experience with transvaginal administration of progestagens].
Cataldi U, Tridente V, Pazienza S, Brizzi C, Serrao L, Proia L, Quattrini MJ. Cataldi U, et al. Clin Ter. 1997 Apr;148(4):165-72. Clin Ter. 1997. PMID: 9377851 Italian.
The authors, after a short introducing on the most used kinds of progestins in Hormonal Replacement Therapy (HRT), report this own clinical experience on the efficacy of a micronized progestin treatment given by the vaginal route in comparison with oral somministrat …
The authors, after a short introducing on the most used kinds of progestins in Hormonal Replacement Therapy (HRT), report this own cl …
A prospective, controlled trial of six forms of hormone replacement therapy given to postmenopausal women.
Lind T, Cameron EC, Hunter WM, Leon C, Moran PF, Oxley A, Gerrard J, Lind UC. Lind T, et al. Br J Obstet Gynaecol. 1979;86 Suppl 3:1-29. doi: 10.1111/j.1471-0528.1979.tb16232.x. Br J Obstet Gynaecol. 1979. PMID: 393299 Clinical Trial.
From the data the following broad conclusions can be drawn: (i) some women have classic symptoms of hot flushes and sweating despite high endogenous oestrogen concentrations; (ii) vaginal cytology is a relatively poor indicator of endogenous oestrogen status; (iii) while f …
From the data the following broad conclusions can be drawn: (i) some women have classic symptoms of hot flushes and sweating despite high en …