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Page 1
Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial.
Stavrakis S, Chakraborty P, Farhat K, Whyte S, Morris L, Abideen Asad ZU, Karfonta B, Anjum J, Matlock HG, Cai X, Yu X. Stavrakis S, et al. JACC Clin Electrophysiol. 2024 Feb;10(2):346-355. doi: 10.1016/j.jacep.2023.10.015. Epub 2023 Nov 22. JACC Clin Electrophysiol. 2024. PMID: 37999672 Free PMC article. Clinical Trial.
BACKGROUND: Low-level transcutaneous stimulation of the auricular branch of the vagus nerve at the tragus is antiarrhythmic and anti-inflammatory in animals and humans. Preliminary studies show that transcutaneous vagus nerve stimulation (tVNS) is bene …
BACKGROUND: Low-level transcutaneous stimulation of the auricular branch of the vagus nerve at the tragus is antiarrhythmic an …
Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome.
Chakraborty P, Farhat K, Morris L, Whyte S, Yu X, Stavrakis S. Chakraborty P, et al. Arrhythm Electrophysiol Rev. 2023 Dec 13;12:e31. doi: 10.15420/aer.2023.20. eCollection 2023. Arrhythm Electrophysiol Rev. 2023. PMID: 38173801 Free PMC article. Review.
Other than postural tachycardia, symptoms of POTS include a spectrum of non-cardiac, systemic and neuropsychiatric features. Despite the availability of widespread pharmacological and non-pharmacological therapeutic options, the management of POTS remains challengin …
Other than postural tachycardia, symptoms of POTS include a spectrum of non-cardiac, systemic and neuropsychiatric features. Despite …
Non-invasive Vagus Nerve Stimulation as an Adjunct Treatment for Inappropriate Sinus Tachycardia.
Houff A, Gros B, Blitshteyn S, Guido R, Fries D. Houff A, et al. J Innov Card Rhythm Manag. 2025 Mar 15;16(3):6231-6234. doi: 10.19102/icrm.2025.16037. eCollection 2025 Mar. J Innov Card Rhythm Manag. 2025. PMID: 40125494 Free PMC article.
Due to persistent symptoms consistent with IST, she was started on non-invasive vagal nerve stimulation (n-VNS) therapy. Following 2 months of n-VNS applied twice daily over the carotid artery, the patient noted near-complete relief of her tachycardia and other debilitatin …
Due to persistent symptoms consistent with IST, she was started on non-invasive vagal nerve stimulation (n-VNS) therapy. Following 2 …
Noninvasive Vagal Nerve Stimulation for the Treatment of Postural Orthostatic Tachycardia Syndrome: A Comprehensive Review.
Tran HH, Thu A, Fuertes A, Radha Twayan A, Mehta KA, Basta M, Mahadevaiah A, Islek D, Weissman S, Frishman WH, Aronow WS. Tran HH, et al. Cardiol Rev. 2025 May 22. doi: 10.1097/CRD.0000000000000953. Online ahead of print. Cardiol Rev. 2025. PMID: 40401908
Postural orthostatic tachycardia syndrome (POTS) is a complex and heterogeneous autonomic disorder with limited effective treatment options. Noninvasive neuromodulation, particularly transcutaneous vagus nerve stimulation (tVNS), has recently emerged as a pro …
Postural orthostatic tachycardia syndrome (POTS) is a complex and heterogeneous autonomic disorder with limited effective treatment o …
Transcutaneous vagus nerve stimulation attenuates autoantibody-mediated cardiovagal dysfunction and inflammation in a rabbit model of postural tachycardia syndrome.
Deng J, Li H, Guo Y, Zhang G, Fischer H, Stavrakis S, Yu X. Deng J, et al. J Interv Card Electrophysiol. 2023 Mar;66(2):291-300. doi: 10.1007/s10840-022-01144-w. Epub 2022 Feb 4. J Interv Card Electrophysiol. 2023. PMID: 35118574 Free PMC article.
PURPOSE: Previous studies demonstrated M2 muscarinic acetylcholine receptor-activating autoantibodies (M2R-AAb) were present in some patients with postural tachycardia syndrome (POTS). This study examines how these autoantibodies might contribute to the pathophysiology of …
PURPOSE: Previous studies demonstrated M2 muscarinic acetylcholine receptor-activating autoantibodies (M2R-AAb) were present in some patient …
Short and long term effects of a two-week transcutaneous vagus nerve stimulation in hyperadrenergic postural orthostatic tachycardia syndrome: a proof-of-concept trial.
Shiffer D, Rigo S, Minonzio M, Yarsuvat DT, Tobaldini E, Furlan L, Montano N, Cairo B, Porta A, Zamunér AR, Bonovas S, Urechie V, Biaggioni I, Diedrich A, Furlan R. Shiffer D, et al. Eur J Intern Med. 2026 Jan;143:106529. doi: 10.1016/j.ejim.2025.106529. Epub 2025 Sep 27. Eur J Intern Med. 2026. PMID: 41016890
BACKGROUND AND AIMS: Hyperadrenergic POTS (Hyper-POTS) is characterized by excessive central sympathetic activity and impaired cardiovagal modulation. A single transcutaneous vagus nerve stimulation (tVNS) rebalanced cardiovascular autonomic control in …
BACKGROUND AND AIMS: Hyperadrenergic POTS (Hyper-POTS) is characterized by excessive central sympathetic activity and impaired …
Low-level tragus stimulation improves autoantibody-induced hyperadrenergic postural tachycardia syndrome in rabbits.
Guo Y, Li H, Deng J, Zhang G, Fischer H, Stavrakis S, Yu X. Guo Y, et al. Heart Rhythm O2. 2022 Dec 14;4(2):127-133. doi: 10.1016/j.hroo.2022.12.001. eCollection 2023 Feb. Heart Rhythm O2. 2022. PMID: 36873318 Free PMC article.
BACKGROUND: Recent studies have demonstrated that antiadrenergic autoantibodies are involved in the pathophysiology of postural orthostatic tachycardia syndrome (POTS). OBJECTIVE: The purpose of this study was to test the hypothesis that transcutaneous low-level tragus sti …
BACKGROUND: Recent studies have demonstrated that antiadrenergic autoantibodies are involved in the pathophysiology of postural orthostatic …
Vagal and Sympathetic Function in Neuropathic Postural Tachycardia Syndrome.
Jacob G, Diedrich L, Sato K, Brychta RJ, Raj SR, Robertson D, Biaggioni I, Diedrich A. Jacob G, et al. Hypertension. 2019 May;73(5):1087-1096. doi: 10.1161/HYPERTENSIONAHA.118.11803. Hypertension. 2019. PMID: 30879357 Free PMC article.
Vagal indices of heart rate variability, HF(RRI) (430 130 versus 1680 900; P=0.04), PNN50, and root mean squared of successive differences were lower in POTS. Patients showed a decrease in vagal baroreflex sensitivity (VM2e; P=0.04). In POTS, integrated muscle sympa …
Vagal indices of heart rate variability, HF(RRI) (430 130 versus 1680 900; P=0.04), PNN50, and root mean squared of successive differences w …
How COVID-19 can cause autonomic dysfunctions and postural orthostatic syndrome? A Review of mechanisms and evidence.
Hassani M, Fathi Jouzdani A, Motarjem S, Ranjbar A, Khansari N. Hassani M, et al. Neurol Clin Neurosci. 2021 Nov;9(6):434-442. doi: 10.1111/ncn3.12548. Epub 2021 Oct 26. Neurol Clin Neurosci. 2021. PMID: 34909198 Free PMC article. Review.
In this study, we focused on the effect of COVID-19 on the autonomic system and syndromes associated with it, such as postural orthostatic syndrome (POTS)....
In this study, we focused on the effect of COVID-19 on the autonomic system and syndromes associated with it, such as postural orthostatic s …
18 results