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Year Number of Results
1993 1
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2005 2
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2007 2
2008 1
2009 3
2010 1
2011 3
2012 3
2013 3
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131 results

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Page 1
Evaluation of Safety of Treatment With Anti-Epidermal Growth Factor Receptor Antibody Drug Conjugate MRG003 in Patients With Advanced Solid Tumors: A Phase 1 Nonrandomized Clinical Trial.
Qiu MZ, Zhang Y, Guo Y, Guo W, Nian W, Liao W, Xu Z, Zhang W, Zhao HY, Wei X, Xue L, Tang W, Wu Y, Ren G, Wang L, Xi J, Jin Y, Li H, Hu C, Xu RH. Qiu MZ, et al. JAMA Oncol. 2022 Jul 1;8(7):1042-1046. doi: 10.1001/jamaoncol.2022.0503. JAMA Oncol. 2022. PMID: 35511148 Free PMC article. Clinical Trial.
IMPORTANCE: The antibody drug conjugate drug MRG003 comprises an anti-epidermal growth factor receptor (EGFR) humanized immunoglobulin G1 monoclonal antibody that is conjugated with monomethyl auristatin E via a valine-citrulline linker. There is currently insufficient evi …
IMPORTANCE: The antibody drug conjugate drug MRG003 comprises an anti-epidermal growth factor receptor (EGFR) humanized immunoglobulin G1 mo …
An Enzymatically Cleavable Tripeptide Linker for Maximizing the Therapeutic Index of Antibody-Drug Conjugates.
Ha SYY, Anami Y, Yamazaki CM, Xiong W, Haase CM, Olson SD, Lee J, Ueno NT, Zhang N, An Z, Tsuchikama K. Ha SYY, et al. Mol Cancer Ther. 2022 Sep 6;21(9):1449-1461. doi: 10.1158/1535-7163.MCT-22-0362. Mol Cancer Ther. 2022. PMID: 35793453 Free PMC article.
Valine-citrulline is a protease-cleavable linker commonly used in many drug delivery systems, including antibody-drug conjugates (ADC) for cancer therapy. ...This linker technology could substantially broaden the therapeutic windows of ADCs and other drug delivery agents, …
Valine-citrulline is a protease-cleavable linker commonly used in many drug delivery systems, including antibody-drug conjugates (ADC …
Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study.
Loggers ET, Chugh R, Federman N, Hartner L, Riedel RF, Cho S, Hyslop D, Lim A, Oton AB, Oktay KH. Loggers ET, et al. Cancer. 2024 Aug 15;130(16):2812-2821. doi: 10.1002/cncr.35324. Epub 2024 May 4. Cancer. 2024. PMID: 38703010 Free article. Clinical Trial.
In the phase 3 DeFi study (NCT03785964) of nirogacestat, ovarian toxicity (OT) was identified as a safety signal among females of reproductive potential (FORP). ...RESULTS: Of 92 randomized females, 73 in the safety population were FORP (n = 36 nirogacestat, …
In the phase 3 DeFi study (NCT03785964) of nirogacestat, ovarian toxicity (OT) was identified as a safety signal among females …
FZ-AD005, a Novel DLL3-Targeted Antibody-Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models.
Guo Q, Gao B, Song R, Li W, Zhu S, Xie Q, Lou S, Wang L, Shen J, Zhao T, Zhang Y, Wu J, Lu W, Yang T. Guo Q, et al. Mol Cancer Ther. 2024 Oct 1;23(10):1367-1377. doi: 10.1158/1535-7163.MCT-23-0701. Mol Cancer Ther. 2024. PMID: 38940283 Free PMC article.
In this study, we developed a novel DLL3-targeted ADC, FZ-AD005, by using DXd with potent cytotoxicity and a relatively better safety profile to maximize the therapeutic index. FZ-AD005 was generated by a novel anti-DLL3 antibody, FZ-A038, and a valine-alanine (Val- …
In this study, we developed a novel DLL3-targeted ADC, FZ-AD005, by using DXd with potent cytotoxicity and a relatively better safety …
Dihydrolipoamide Dehydrogenase Deficiency.
Quinonez SC, Thoene JG. Quinonez SC, et al. 2014 Jul 17 [updated 2021 Sep 30]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2014 Jul 17 [updated 2021 Sep 30]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 25032271 Free Books & Documents. Review.
Surveillance: Measurement of growth parameters and evaluation of nutritional status and safety of oral intake at each visit; full amino acid profile (from plasma or filter paper) weekly or twice weekly in rapidly growing infants and routinely in older individuals; at least …
Surveillance: Measurement of growth parameters and evaluation of nutritional status and safety of oral intake at each visit; full ami …
Safety Assessment of L-beta-Aminoisobutyric Acid (L-BAIBA): Subchronic Toxicity Study in Sprague Dawley Rats.
Shanmugasundaram D, Fan Q, Wang M, Yi R, Wang O. Shanmugasundaram D, et al. Int J Toxicol. 2022 Aug;41(4):329-346. doi: 10.1177/10915818221094487. Epub 2022 May 13. Int J Toxicol. 2022. PMID: 35549583
L-3-Aminoisobutyric acid (L-BAIBA) is an endogenous compound in human metabolism when thymine and valine undergo catabolism. L-BAIBA represents one of the two isomers of BAIBA in biological systems. ...The present study was designed to evaluate the safety and tox …
L-3-Aminoisobutyric acid (L-BAIBA) is an endogenous compound in human metabolism when thymine and valine undergo catabolism. L-BAIBA …
Safety and efficacy of l-valine produced by fermentation using Corynebacterium glutamicumCGMCC 7.358 as a feed additive for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Cocconcelli PS, Glandorf B, Herman L, Maradona MP, Saarela M, Anguita M, Holczknecht O, Galobart J, Manini P, Pettenati E, Pizzo F, Tarrés-Call J. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), et al. EFSA J. 2020 Nov 12;18(11):e06286. doi: 10.2903/j.efsa.2020.6286. eCollection 2020 Nov. EFSA J. 2020. PMID: 33209151 Free PMC article.
The production strain meets the qualifications for the qualified presumption of safety (QPS) approach to safety assessment and is considered safe. l-Valine produced using C. glutamicum CGMCC 7.358 is safe for the target species when supplemented in appropriat …
The production strain meets the qualifications for the qualified presumption of safety (QPS) approach to safety assessment and …
Safety and efficacy of a feed additive consisting of l-valine produced by Corynebacterium glutamicum CGMCC 7.366 for all animal species (Ningxia Eppen Biotech Co., Ltd.).
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Cocconcelli PS, Glandorf B, Prieto Maradona M, Saarela M, Brozzi R, Pettenati E, Tarrés-Call J. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), et al. EFSA J. 2021 Apr 19;19(4):e06521. doi: 10.2903/j.efsa.2021.6521. eCollection 2021 Apr. EFSA J. 2021. PMID: 33897860 Free PMC article.
The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concludes that l-valine produced using C. glutamicum CGMCC 7.366 is safe for the target species when supplemented in app …
The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The …
Safety and efficacy of a feed additive consisting of l-valine produced by Escherichia coli CCTCC M2020321 for all animal species (Kempex Holland BV).
EFSA Panel on Additives, Products or Substances used in Animal Feed (FEEDAP); Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Galobart J, Pettenati E, Tarrés-Call J. EFSA Panel on Additives, Products or Substances used in Animal Feed (FEEDAP), et al. EFSA J. 2022 Feb 23;20(2):e07163. doi: 10.2903/j.efsa.2022.7163. eCollection 2022 Feb. EFSA J. 2022. PMID: 35228852 Free PMC article.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-valine as a nutritional additive for all animal species. The production strain and its DNA were not detected in the final additive. ...Th …
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-v …
Generation and Characterization of Iduronidase-Cleavable ADCs.
Jäger S, Könning D, Rasche N, Hart F, Sensbach J, Krug C, Raab-Westphal S, Richter K, Unverzagt C, Hecht S, Anderl J, Schröter C. Jäger S, et al. Bioconjug Chem. 2023 Dec 20;34(12):2221-2233. doi: 10.1021/acs.bioconjchem.3c00363. Epub 2023 Dec 6. Bioconjug Chem. 2023. PMID: 38054705
The generated iduronide-exatecan ADC showed high serum stability and similar target-dependent tumor cell killing in the subnanomolar range but reduced toxicity on nonmalignant cells compared to an analogous cathepsin B-activatable valine-citrulline-exatecan ADC. ... …
The generated iduronide-exatecan ADC showed high serum stability and similar target-dependent tumor cell killing in the subnanomolar range b …
131 results