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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 2
1977 2
1978 2
1979 2
1980 4
1981 2
1982 3
1983 3
1984 4
1985 4
1986 1
1987 1
1988 4
1989 4
1990 2
1991 7
1992 11
1993 10
1994 14
1995 8
1996 20
1997 25
1998 7
1999 15
2000 24
2001 12
2002 20
2003 24
2004 30
2005 38
2006 29
2007 37
2008 32
2009 40
2010 35
2011 47
2012 44
2013 41
2014 32
2015 25
2016 38
2017 30
2018 31
2019 36
2020 23
2021 25
2022 28
2023 23
2024 14
2025 6

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826 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Risk of valproic acid-related alopecia: A systematic review and meta-analysis.
Wang X, Wang H, Xu D, Zhu L, Liu L. Wang X, et al. Seizure. 2019 Jul;69:61-69. doi: 10.1016/j.seizure.2019.04.003. Epub 2019 Apr 5. Seizure. 2019. PMID: 30981051 Free article.
PURPOSE: We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy. METHODS: We retrieved relevant publications and gathered data on alopecia in patients taking VPA and …
PURPOSE: We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing v
Efficacy and safety of valproic acid in dementia: A systematic review with meta-analysis.
Liu J, Wang LN. Liu J, et al. Arch Gerontol Geriatr. 2020 Jul-Aug;89:104091. doi: 10.1016/j.archger.2020.104091. Epub 2020 May 4. Arch Gerontol Geriatr. 2020. PMID: 32413690
Valproic acid is generally well-tolerated in patients with dementia, even in long-term therapy for 24 months. ...The anticipations for a success in the trial of valproic acid for dementia in the future look not optimistic based on the available evidenc
Valproic acid is generally well-tolerated in patients with dementia, even in long-term therapy for 24 months. ...The anticipat
Effects of valproic acid on bone mineral density and bone metabolism: A meta-analysis.
Fan D, Miao J, Fan X, Wang Q, Sun M. Fan D, et al. Seizure. 2019 Dec;73:56-63. doi: 10.1016/j.seizure.2019.10.017. Epub 2019 Oct 31. Seizure. 2019. PMID: 31756600 Free article. Review.
PURPOSE: Numerous studies have shown that the risk of fracture is increased by long-term antiepileptic drugs (AEDs). Valproic acid (VPA) is one of the most commonly used AEDs. In this meta-analysis, we aimed to assess the effects of VPA on bone mineral density (BMD) …
PURPOSE: Numerous studies have shown that the risk of fracture is increased by long-term antiepileptic drugs (AEDs). Valproic acid
Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial.
Sharshar T, Porcher R, Asfar P, Grimaldi L, Jabot J, Argaud L, Lebert C, Bollaert PE, Harlay ML, Chillet P, Maury E, Santoli F, Blanc P, Sonneville R, Vu DC, Rohaut B, Mazeraud A, Alvarez JC, Navarro V, Clair B, Outin H; Valse investigators and for the Groupe d’Explorations Neurologiques en Reanimation (GENER). Sharshar T, et al. Crit Care. 2023 Jan 9;27(1):8. doi: 10.1186/s13054-022-04292-7. Crit Care. 2023. PMID: 36624526 Free PMC article. Clinical Trial.
The objective was to determine whether valproic acid (VPA) as complementary treatment to the stepwise strategy improves the outcomes of patients with de novo established GCSE. ...
The objective was to determine whether valproic acid (VPA) as complementary treatment to the stepwise strategy improves the ou …
Valproic acid-induced oxidative stress: Systematic review, meta-analysis and network pharmacology highlights disruption in antioxidant pathways in rodents.
Asghar MA, Tang S, Wan B, Chen Y, Zhang X, Zhao Q. Asghar MA, et al. Toxicol Appl Pharmacol. 2025 Jan;494:117160. doi: 10.1016/j.taap.2024.117160. Epub 2024 Nov 17. Toxicol Appl Pharmacol. 2025. PMID: 39557347
Valproic acid (VPA) is a widely used antiepileptic drug, but its effects on oxidative stress in rodent models have not been systematically reviewed. ...
Valproic acid (VPA) is a widely used antiepileptic drug, but its effects on oxidative stress in rodent models have not been sy
Valproic acid for agitation in dementia.
Lonergan ET, Cameron M, Luxenberg J. Lonergan ET, et al. Cochrane Database Syst Rev. 2004;(2):CD003945. doi: 10.1002/14651858.CD003945.pub2. Cochrane Database Syst Rev. 2004. Update in: Cochrane Database Syst Rev. 2009 Jul 08;(3):CD003945. doi: 10.1002/14651858.CD003945.pub3. PMID: 15106227 Updated. Review.
The current study examines three randomized, placebo-controlled trials of the effect of valproic acid on older people with dementia who were agitated. OBJECTIVES: To determine whether evidence supports the use of valproic acid in the treatment of agita …
The current study examines three randomized, placebo-controlled trials of the effect of valproic acid on older people with dem …
Efficacy and Safety of Valproic Acid for Spinal Muscular Atrophy: A Systematic Review and Meta-Analysis.
Elshafay A, Hieu TH, Doheim MF, Kassem MAM, ELdoadoa MF, Holloway SK, Abo-Elghar H, Hirayama K, Huy NT. Elshafay A, et al. CNS Drugs. 2019 Mar;33(3):239-250. doi: 10.1007/s40263-019-00606-6. CNS Drugs. 2019. PMID: 30796634
Early onset is correlated with a higher mortality rate, mainly due to respiratory complications. Valproic acid (VPA) is a histone deacetylase (HDAC) inhibitor that has shown positive results on SMA both in experimental and cohort studies. ...
Early onset is correlated with a higher mortality rate, mainly due to respiratory complications. Valproic acid (VPA) is a hist …
Effects of Valproic Acid Therapy on Rats with Spinal Cord Injury: A Systematic Review and Meta-Analysis.
Yang Q, Zhang H, Jin Z, Zhang B, Wang Y. Yang Q, et al. World Neurosurg. 2024 Feb;182:12-28. doi: 10.1016/j.wneu.2023.10.135. Epub 2023 Nov 3. World Neurosurg. 2024. PMID: 37923014 Review.
OBJECTIVE: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the risk of clinical conversion and provide a valuable reference for future animal and clinical studies. ...
OBJECTIVE: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the …
Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis.
Yoon HY, Ahn MH, Yee J, Lee N, Han JM, Gwak HS. Yoon HY, et al. Eur J Clin Pharmacol. 2020 Aug;76(8):1053-1058. doi: 10.1007/s00228-020-02872-6. Epub 2020 May 8. Eur J Clin Pharmacol. 2020. PMID: 32385545
PURPOSE: Cytochrome P450 (CYP) is involved in the metabolism of valproic acid (VPA). Specifically, CYP2C9 and CYP2A6 are the main enzymes responsible for VPA metabolism. ...
PURPOSE: Cytochrome P450 (CYP) is involved in the metabolism of valproic acid (VPA). Specifically, CYP2C9 and CYP2A6 are the m …
Effect of UGT2B7 genotypes on plasma concentration of valproic acid: a meta-analysis.
Wang P, Lin XQ, Cai WK, Xu GL, Zhou MD, Yang M, He GH. Wang P, et al. Eur J Clin Pharmacol. 2018 Apr;74(4):433-442. doi: 10.1007/s00228-017-2395-z. Epub 2017 Dec 14. Eur J Clin Pharmacol. 2018. PMID: 29243113 Review.
PURPOSE: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. Recently, increasing evidence suggested that polymorphisms in UGT2B7 gene were associated with VPA pharmacokinetics, but results remained controversial. ...
PURPOSE: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. Recently, increasing evidence suggested that …
826 results