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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 2
1977 2
1978 2
1979 2
1980 4
1981 2
1982 3
1983 3
1984 4
1985 4
1986 1
1987 1
1988 4
1989 4
1990 2
1991 7
1992 11
1993 10
1994 14
1995 8
1996 20
1997 25
1998 7
1999 15
2000 24
2001 12
2002 20
2003 24
2004 30
2005 38
2006 29
2007 37
2008 32
2009 40
2010 35
2011 48
2012 44
2013 42
2014 32
2015 25
2016 39
2017 30
2018 31
2019 36
2020 23
2021 24
2022 27
2023 23
2024 4

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815 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial.
Sharshar T, Porcher R, Asfar P, Grimaldi L, Jabot J, Argaud L, Lebert C, Bollaert PE, Harlay ML, Chillet P, Maury E, Santoli F, Blanc P, Sonneville R, Vu DC, Rohaut B, Mazeraud A, Alvarez JC, Navarro V, Clair B, Outin H; Valse investigators and for the Groupe d’Explorations Neurologiques en Reanimation (GENER). Sharshar T, et al. Crit Care. 2023 Jan 9;27(1):8. doi: 10.1186/s13054-022-04292-7. Crit Care. 2023. PMID: 36624526 Free PMC article. Clinical Trial.
However, GCSE is uncontrolled in 20-40% patients and is associated with protracted hospitalisation, disability, and mortality. The objective was to determine whether valproic acid (VPA) as complementary treatment to the stepwise strategy improves the outcomes of pat …
However, GCSE is uncontrolled in 20-40% patients and is associated with protracted hospitalisation, disability, and mortality. The objective …
Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults.
Gill D, Derry S, Wiffen PJ, Moore RA. Gill D, et al. Cochrane Database Syst Rev. 2011 Oct 5;2011(10):CD009183. doi: 10.1002/14651858.CD009183.pub2. Cochrane Database Syst Rev. 2011. PMID: 21975791 Free PMC article. Review.
BACKGROUND: Valproic acid and its sodium salt (sodium valproate) are antiepileptic drugs that are sometimes used to treat chronic neuropathic pain and fibromyalgia, although they are not licensed for this use. OBJECTIVES: To evaluate the analgesic efficacy and adver …
BACKGROUND: Valproic acid and its sodium salt (sodium valproate) are antiepileptic drugs that are sometimes used to treat chro …
Valproic acid for agitation in dementia.
Lonergan ET, Cameron M, Luxenberg J. Lonergan ET, et al. Cochrane Database Syst Rev. 2004;(2):CD003945. doi: 10.1002/14651858.CD003945.pub2. Cochrane Database Syst Rev. 2004. PMID: 15106227 Updated. Review.
BACKGROUND: Agitation affects up to 70% of older people with dementia. Valproic acid has been used for the past 10 years to control agitation in dementia, but no systematic review of the effectiveness of this drug has been published to date. The current study examin …
BACKGROUND: Agitation affects up to 70% of older people with dementia. Valproic acid has been used for the past 10 years to co …
Effects of valproic acid on bone mineral density and bone metabolism: A meta-analysis.
Fan D, Miao J, Fan X, Wang Q, Sun M. Fan D, et al. Seizure. 2019 Dec;73:56-63. doi: 10.1016/j.seizure.2019.10.017. Epub 2019 Oct 31. Seizure. 2019. PMID: 31756600 Free article. Review.
PURPOSE: Numerous studies have shown that the risk of fracture is increased by long-term antiepileptic drugs (AEDs). Valproic acid (VPA) is one of the most commonly used AEDs. In this meta-analysis, we aimed to assess the effects of VPA on bone mineral density (BMD) …
PURPOSE: Numerous studies have shown that the risk of fracture is increased by long-term antiepileptic drugs (AEDs). Valproic acid
The dolutegravir/valproic acid drug-drug interaction is primarily based on protein displacement.
Bollen PDJ, Prins HAB, Colbers A, Velthoven-Graafland K, Rijnders BJA, de Vries-Sluijs TEMS, van Nood E, Nouwen J, Bax H, de Mendonca Melo M, Verbon A, Burger DM, Rokx C. Bollen PDJ, et al. J Antimicrob Chemother. 2021 Apr 13;76(5):1273-1276. doi: 10.1093/jac/dkab021. J Antimicrob Chemother. 2021. PMID: 33544819 Clinical Trial.
Total and unbound dolutegravir concentrations were measured on day 0 (before intake of valproic acid and 6 h after intake of valproic acid) and on days 1, 7, 14 and 42. ...We observed a parallel increase in unbound dolutegravir fractions ranging from 0 …
Total and unbound dolutegravir concentrations were measured on day 0 (before intake of valproic acid and 6 h after intake of …
Effect of UGT2B7 genotypes on plasma concentration of valproic acid: a meta-analysis.
Wang P, Lin XQ, Cai WK, Xu GL, Zhou MD, Yang M, He GH. Wang P, et al. Eur J Clin Pharmacol. 2018 Apr;74(4):433-442. doi: 10.1007/s00228-017-2395-z. Epub 2017 Dec 14. Eur J Clin Pharmacol. 2018. PMID: 29243113 Review.
PURPOSE: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. ...
PURPOSE: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. ...
Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults.
Linde M, Mulleners WM, Chronicle EP, McCrory DC. Linde M, et al. Cochrane Database Syst Rev. 2013 Jun 24;2013(6):CD010611. doi: 10.1002/14651858.CD010611. Cochrane Database Syst Rev. 2013. PMID: 23797677 Free PMC article. Review.
OBJECTIVES: To describe and assess the evidence from controlled trials on the efficacy and tolerability of valproate (valproic acid or sodium valproate or a combination of the two) for preventing migraine attacks in adult patients with episodic migraine. ...Data fro …
OBJECTIVES: To describe and assess the evidence from controlled trials on the efficacy and tolerability of valproate (valproic aci
Effects of Valproic Acid Therapy on Rats with Spinal Cord Injury: A Systematic Review and Meta-Analysis.
Yang Q, Zhang H, Jin Z, Zhang B, Wang Y. Yang Q, et al. World Neurosurg. 2024 Feb;182:12-28. doi: 10.1016/j.wneu.2023.10.135. Epub 2023 Nov 3. World Neurosurg. 2024. PMID: 37923014 Review.
OBJECTIVE: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the risk of clinical conversion and provide a valuable reference for future animal and clinical studies. ...
OBJECTIVE: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the …
Efficacy and safety of valproic acid in dementia: A systematic review with meta-analysis.
Liu J, Wang LN. Liu J, et al. Arch Gerontol Geriatr. 2020 Jul-Aug;89:104091. doi: 10.1016/j.archger.2020.104091. Epub 2020 May 4. Arch Gerontol Geriatr. 2020. PMID: 32413690
Valproic acid is generally well-tolerated in patients with dementia, even in long-term therapy for 24 months. ...The anticipations for a success in the trial of valproic acid for dementia in the future look not optimistic based on the available evidenc
Valproic acid is generally well-tolerated in patients with dementia, even in long-term therapy for 24 months. ...The anticipat
Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells.
Kowalski TW, Lord VO, Sgarioni E, Gomes JDA, Mariath LM, Recamonde-Mendoza M, Vianna FSL. Kowalski TW, et al. Eur Neuropsychopharmacol. 2022 Jul;60:76-88. doi: 10.1016/j.euroneuro.2022.04.008. Epub 2022 May 27. Eur Neuropsychopharmacol. 2022. PMID: 35635998
Valproic acid (VPA) is a widely used antiepileptic drug not recommended in pregnancy because it is teratogenic. ...
Valproic acid (VPA) is a widely used antiepileptic drug not recommended in pregnancy because it is teratogenic. ...
815 results