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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 1
1980 1
1981 2
1982 1
1983 6
1984 6
1985 5
1986 4
1987 3
1988 6
1989 10
1990 10
1991 10
1992 16
1993 23
1994 21
1995 28
1996 42
1997 33
1998 44
1999 60
2000 69
2001 58
2002 67
2003 95
2004 96
2005 107
2006 97
2007 116
2008 103
2009 99
2010 97
2011 84
2012 103
2013 84
2014 97
2015 73
2016 93
2017 77
2018 70
2019 51
2020 67
2021 66
2022 57
2023 62
2024 22

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2,137 results

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Page 1
Does valproic acid warrant therapeutic drug monitoring in bipolar affective disorder?
Haymond J, Ensom MH. Haymond J, et al. Ther Drug Monit. 2010 Feb;32(1):19-29. doi: 10.1097/FTD.0b013e3181c13a30. Ther Drug Monit. 2010. PMID: 19901867 Review.
To review the pharmacokinetic literature regarding valproic acid (VPA) in patients with bipolar affective disorder to evaluate the appropriateness of routine therapeutic drug monitoring (TDM) of VPA in this population. Embase, Medline, Biosis, Cumulated Index …
To review the pharmacokinetic literature regarding valproic acid (VPA) in patients with bipolar affective disorder to e …
The pharmacogenomics of valproic acid.
Zhu MM, Li HL, Shi LH, Chen XP, Luo J, Zhang ZL. Zhu MM, et al. J Hum Genet. 2017 Dec;62(12):1009-1014. doi: 10.1038/jhg.2017.91. Epub 2017 Sep 7. J Hum Genet. 2017. PMID: 28878340 Review.
Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. ...During valproic acid treatment, it is difficult for prescribers to predict its individual response. ...
Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar di
Population pharmacokinetics of valproic acid in adult Chinese patients with bipolar disorder.
Zang YN, Guo W, Niu MX, Bao S, Wang Q, Wang Y, Dong F, Li AN, Ruan CJ. Zang YN, et al. Eur J Clin Pharmacol. 2022 Mar;78(3):405-418. doi: 10.1007/s00228-021-03246-2. Epub 2021 Dec 2. Eur J Clin Pharmacol. 2022. PMID: 34854947
PURPOSE: To develop and validate a population pharmacokinetic (PPK) model of valproic acid (VPA) in adult Chinese patients with bipolar disorder, and provide guidance for individualized therapy in this population. ...CONCLUSIONS: A qualified PPK model of VPA …
PURPOSE: To develop and validate a population pharmacokinetic (PPK) model of valproic acid (VPA) in adult Chinese patients wit …
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder.
Chiu CT, Wang Z, Hunsberger JG, Chuang DM. Chiu CT, et al. Pharmacol Rev. 2013 Jan 8;65(1):105-42. doi: 10.1124/pr.111.005512. Print 2013 Jan. Pharmacol Rev. 2013. PMID: 23300133 Free PMC article. Review.
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency. ...
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe me …
Valproic Acid: second generation.
Bialer M, Yagen B. Bialer M, et al. Neurotherapeutics. 2007 Jan;4(1):130-7. doi: 10.1016/j.nurt.2006.11.007. Neurotherapeutics. 2007. PMID: 17199028 Free PMC article. Review.
Valproic acid is one of the four most widely prescribed antiepileptic drugs (AEDs) and is effective (and regularly approved) in migraine prophylaxis and in the treatment of bipolar disorders. Valproic acid is also currently undergoing clinical t
Valproic acid is one of the four most widely prescribed antiepileptic drugs (AEDs) and is effective (and regularly approved) i
Effect of valproic acid on dementia onset in patients with bipolar disorder.
Tsai PS, Liu IC, Chiu CH, Huang CJ, Wang MY. Tsai PS, et al. J Affect Disord. 2016 Sep 1;201:131-6. doi: 10.1016/j.jad.2016.05.010. Epub 2016 May 10. J Affect Disord. 2016. PMID: 27208500
BACKGROUND: Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. This study investigated the effect of VPA on the risk of dementia in patients with bipolar disorder. METH …
BACKGROUND: Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse eff …
Kidney tubular injury induced by valproic acid: systematic literature review.
Anguissola G, Leu D, Simonetti GD, Simonetti BG, Lava SAG, Milani GP, Bianchetti MG, Scoglio M. Anguissola G, et al. Pediatr Nephrol. 2023 Jun;38(6):1725-1731. doi: 10.1007/s00467-022-05869-8. Epub 2023 Jan 16. Pediatr Nephrol. 2023. PMID: 36645492 Free PMC article. Review.
BACKGROUND: Valproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches. ...CONCLUSIONS: Valproic acid may induce an overt kidney tubular injury, which is associated with a proximal tubular mitochondri …
BACKGROUND: Valproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches. .. …
Long-term use of valproic acid reduced mortality in bipolar disorder patients in a Taiwanese population: An association analysis using the national health insurance research database (NHIRD).
Hsieh TC, Lin CC, Wu LS. Hsieh TC, et al. J Psychiatr Res. 2022 May;149:339-343. doi: 10.1016/j.jpsychires.2021.11.021. Epub 2021 Nov 8. J Psychiatr Res. 2022. PMID: 34785038
OBJECTIVE: Valproic acid (VPA) is used for the treatment of epilepsy and bipolar disorder (BD). ...
OBJECTIVE: Valproic acid (VPA) is used for the treatment of epilepsy and bipolar disorder (BD). ...
2,137 results