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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 1
1980 1
1981 2
1982 1
1983 6
1984 6
1985 5
1986 4
1987 3
1988 6
1989 10
1990 10
1991 10
1992 16
1993 23
1994 21
1995 28
1996 42
1997 33
1998 44
1999 60
2000 69
2001 58
2002 67
2003 95
2004 96
2005 107
2006 97
2007 116
2008 103
2009 99
2010 97
2011 84
2012 103
2013 85
2014 97
2015 73
2016 92
2017 77
2018 69
2019 44
2020 28
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1,912 results
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Page 1
The pharmacogenomics of valproic acid.
Zhu MM, Li HL, Shi LH, Chen XP, Luo J, Zhang ZL. Zhu MM, et al. J Hum Genet. 2017 Dec;62(12):1009-1014. doi: 10.1038/jhg.2017.91. Epub 2017 Sep 7. J Hum Genet. 2017. PMID: 28878340 Review.
Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. ...During valproic acid treatment, it is difficult for prescribers to predict its individual response. Recent advances
Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar di
Hyperammonemia associated with valproic acid concentrations.
Vázquez M, Fagiolino P, Maldonado C, Olmos I, Ibarra M, Alvariza S, Guevara N, Magallanes L, Olano I. Vázquez M, et al. Biomed Res Int. 2014;2014:217269. doi: 10.1155/2014/217269. Epub 2014 Apr 29. Biomed Res Int. 2014. PMID: 24868521 Free PMC article.
Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. ...As a high correlation between sali
Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum an
Population Pharmacokinetics of Valproic Acid in Patients with Mania: Implication for Individualized Dosing Regimens.
Methaneethorn J. Methaneethorn J. Clin Ther. 2017 Jun;39(6):1171-1181. doi: 10.1016/j.clinthera.2017.04.005. Epub 2017 May 5. Clin Ther. 2017. PMID: 28483293
FINDINGS: Valproic acid data were adequately described by a 1-compartment model. Significant predictors for valproic acid clearance included valproic acid dose and weight. ...Valproic acid clearance could be predicted from …
FINDINGS: Valproic acid data were adequately described by a 1-compartment model. Significant predictors for valproic
A randomized controlled trial comparing lithium plus valproic acid versus lithium plus carbamazepine in young patients with type 1 bipolar disorder: the LICAVAL study.
Missio G, Moreno DH, Demetrio FN, Soeiro-de-Souza MG, Dos Santos Fernandes F, Barros VB, Moreno RA. Missio G, et al. Trials. 2019 Oct 26;20(1):608. doi: 10.1186/s13063-019-3655-2. Trials. 2019. PMID: 31655626 Free PMC article. Clinical Trial.
BACKGROUND: Treatment of bipolar disorder (BD) usually requires drug combinations. Combinations of lithium plus valproic acid (Li/VPA) and lithium plus carbamazepine (Li/CBZ) are used in clinical practice but were not previously compared in a head-to-head tri …
BACKGROUND: Treatment of bipolar disorder (BD) usually requires drug combinations. Combinations of lithium plus valproic ac
Serum Valproic Acid Levels During Initial Conversion of Antituberculoid Therapy in Bipolar Mania: A Case Report and Literature Review.
DeLucia B, Mahon J. DeLucia B, et al. Psychosomatics. 2017 Jul-Aug;58(4):446-449. doi: 10.1016/j.psym.2017.02.009. Epub 2017 Feb 20. Psychosomatics. 2017. PMID: 28413090 Review. No abstract available.
Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies.
Rashid M, Kashyap A, Undela K. Rashid M, et al. Int J Dermatol. 2019 Sep;58(9):1014-1022. doi: 10.1111/ijd.14411. Epub 2019 Feb 27. Int J Dermatol. 2019. PMID: 30809807
Valproic acid (VPA) is a commonly used antiepileptic drug (AED). Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are the rare but fatal cutaneous adverse drug reactions for VPA. ...It is essential for healthcare professionals to be aware of the importa
Valproic acid (VPA) is a commonly used antiepileptic drug (AED). Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis
Effect of valproic acid on dementia onset in patients with bipolar disorder.
Tsai PS, Liu IC, Chiu CH, Huang CJ, Wang MY. Tsai PS, et al. J Affect Disord. 2016 Sep 1;201:131-6. doi: 10.1016/j.jad.2016.05.010. Epub 2016 May 10. J Affect Disord. 2016. PMID: 27208500
BACKGROUND: Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. ...CONCLUSION: Treating bipolar disorder with VPA increases the risk of dementia by 73-95%....
BACKGROUND: Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse eff …
[Use of valproic acid in long stay units of psychiatry].
Martínez-Lazcano MT, Esplá-González S, Herraiz-Robles P, Hernández-Pérez P, Chillerón-Cuenca R, Pol-Yanguas E. Martínez-Lazcano MT, et al. Farm Hosp. 2015 Mar 1;39(2):92-101. doi: 10.7399/fh.2015.39.2.8460. Farm Hosp. 2015. PMID: 25817088 Free article. Spanish.
Demographics, valproic acid treatment, posology and associated drug treatment, monitoring safety parameters, interactions and valproic acid concentrations. RESULTS: Valproic acid is prescribed in 1 of 3 patients of the center. It was used …
Demographics, valproic acid treatment, posology and associated drug treatment, monitoring safety parameters, interactions and …
Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes.
Praena B, Bello-Morales R, de Castro F, López-Guerrero JA. Praena B, et al. Antiviral Res. 2019 Aug;168:91-99. doi: 10.1016/j.antiviral.2019.05.006. Epub 2019 May 25. Antiviral Res. 2019. PMID: 31132386 Free article.
In the present study, we assessed two amidic derivatives of valproic acid (VPA) - valpromide (VPD) and valnoctamide (VCD) - which are already used in clinic treatments, as feasible HSV-1 antivirals in glial cells. Both VPD and VCD have exhibited increased efficacy i …
In the present study, we assessed two amidic derivatives of valproic acid (VPA) - valpromide (VPD) and valnoctamide (VCD) - wh …
Does valproic acid warrant therapeutic drug monitoring in bipolar affective disorder?
Haymond J, Ensom MH. Haymond J, et al. Ther Drug Monit. 2010 Feb;32(1):19-29. doi: 10.1097/FTD.0b013e3181c13a30. Ther Drug Monit. 2010. PMID: 19901867 Review.
To review the pharmacokinetic literature regarding valproic acid (VPA) in patients with bipolar affective disorder to evaluate the appropriateness of routine therapeutic drug monitoring (TDM) of VPA in this population. Embase, Medline, Biosis, Cumulated Index …
To review the pharmacokinetic literature regarding valproic acid (VPA) in patients with bipolar affective disorder to e …
1,912 results
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