Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.
Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4. doi: 10.1006/bbrc.1999.0224.
Biochem Biophys Res Commun. 1999.
PMID: 10049736