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Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates.
van Geel R, Wijdeven MA, Heesbeen R, Verkade JM, Wasiel AA, van Berkel SS, van Delft FL. van Geel R, et al. Among authors: van delft fl, van berkel ss. Bioconjug Chem. 2015 Nov 18;26(11):2233-42. doi: 10.1021/acs.bioconjchem.5b00224. Epub 2015 Jun 10. Bioconjug Chem. 2015. PMID: 26061183 Free article.
Metal-free triazole formation as a tool for bioconjugation.
van Berkel SS, Dirks AT, Debets MF, van Delft FL, Cornelissen JJ, Nolte RJ, Rutjes FP. van Berkel SS, et al. Among authors: van delft fl. Chembiochem. 2007 Sep 3;8(13):1504-8. doi: 10.1002/cbic.200700278. Chembiochem. 2007. PMID: 17631666 No abstract available.
Complementary chemoenzymatic routes to both enantiomers of febrifugine.
Wijdeven MA, van den Berg RJ, Wijtmans R, Botman PN, Blaauw RH, Schoemaker HE, van Delft FL, Rutjes FP. Wijdeven MA, et al. Among authors: van delft fl, van den berg rj. Org Biomol Chem. 2009 Jul 21;7(14):2976-80. doi: 10.1039/b901670h. Epub 2009 Jun 4. Org Biomol Chem. 2009. PMID: 19582308
A macrocyclic coumarin-containing tripeptide via CuAAC chemistry.
van Berkel SS, van der Lee B, van Delft FL, Rutjes FP. van Berkel SS, et al. Among authors: van delft fl, van der lee b. Chem Commun (Camb). 2009 Jul 28;(28):4272-4. doi: 10.1039/b906762k. Epub 2009 Jun 9. Chem Commun (Camb). 2009. PMID: 19585044
Bioconjugation with strained alkenes and alkynes.
Debets MF, van Berkel SS, Dommerholt J, Dirks AT, Rutjes FP, van Delft FL. Debets MF, et al. Among authors: van delft fl, van berkel ss. Acc Chem Res. 2011 Sep 20;44(9):805-15. doi: 10.1021/ar200059z. Epub 2011 Jul 18. Acc Chem Res. 2011. PMID: 21766804
105 results