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PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells.
Prostate. 2006 May 15;66(7):749-60. doi: 10.1002/pros.20398.
Prostate. 2006.
PMID: 16425184
Tumor heterogeneity, aggressiveness, and immune cell composition in a novel syngeneic PSA-targeted Pten knockout mouse prostate cancer (MuCaP) model.
van Duijn PW, Marques RB, Ziel-van der Made ACJ, van Zoggel HJAA, Aghai A, Berrevoets C, Debets R, Jenster G, Trapman J, van Weerden WM.
van Duijn PW, et al.
Prostate. 2018 Sep;78(13):1013-1023. doi: 10.1002/pros.23659. Epub 2018 May 29.
Prostate. 2018.
PMID: 30133757
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PTEN-mediated G1 cell-cycle arrest in LNCaP prostate cancer cells is associated with altered expression of cell-cycle regulators.
van Duijn PW, Ziel-van der Made AC, van der Korput JA, Trapman J.
van Duijn PW, et al.
Prostate. 2010 Feb 1;70(2):135-46. doi: 10.1002/pros.21045.
Prostate. 2010.
PMID: 19784964
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Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.
Ma X, Ziel-van der Made AC, Autar B, van der Korput HA, Vermeij M, van Duijn P, Cleutjens KB, de Krijger R, Krimpenfort P, Berns A, van der Kwast TH, Trapman J.
Ma X, et al.
Cancer Res. 2005 Jul 1;65(13):5730-9. doi: 10.1158/0008-5472.CAN-04-4519.
Cancer Res. 2005.
PMID: 15994948
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Characterization of Heterogeneous Prostate Tumors in Targeted Pten Knockout Mice.
Korsten H, Ziel-van der Made AC, van Weerden WM, van der Kwast T, Trapman J, Van Duijn PW.
Korsten H, et al. Among authors: van duijn pw.
PLoS One. 2016 Jan 25;11(1):e0147500. doi: 10.1371/journal.pone.0147500. eCollection 2016.
PLoS One. 2016.
PMID: 26807730
Free PMC article.
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours.
Närhi K, Nagaraj AS, Parri E, Turkki R, van Duijn PW, Hemmes A, Lahtela J, Uotinen V, Mäyränpää MI, Salmenkivi K, Räsänen J, Linder N, Trapman J, Rannikko A, Kallioniemi O, Af Hällström TM, Lundin J, Sommergruber W, Anders S, Verschuren EW.
Närhi K, et al. Among authors: van duijn pw.
J Pathol. 2018 May;245(1):101-113. doi: 10.1002/path.5059. Epub 2018 Apr 2.
J Pathol. 2018.
PMID: 29443392
Free PMC article.
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The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion.
Verhagen PC, van Duijn PW, Hermans KG, Looijenga LH, van Gurp RJ, Stoop H, van der Kwast TH, Trapman J.
Verhagen PC, et al. Among authors: van duijn pw.
J Pathol. 2006 Apr;208(5):699-707. doi: 10.1002/path.1929.
J Pathol. 2006.
PMID: 16402365
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