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Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM. Kaufman AC, et al. Among authors: van dyck ch. Ann Neurol. 2015 Jun;77(6):953-71. doi: 10.1002/ana.24394. Epub 2015 Mar 21. Ann Neurol. 2015. PMID: 25707991 Free PMC article.
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC; GERAD Consortium; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetic Consortium (ADGC); Goate AM. Cruchaga C, et al. Neuron. 2013 Apr 24;78(2):256-68. doi: 10.1016/j.neuron.2013.02.026. Epub 2013 Apr 4. Neuron. 2013. PMID: 23562540 Free PMC article.
Fyn kinase inhibition as a novel therapy for Alzheimer's disease.
Nygaard HB, van Dyck CH, Strittmatter SM. Nygaard HB, et al. Among authors: van dyck ch. Alzheimers Res Ther. 2014 Feb 5;6(1):8. doi: 10.1186/alzrt238. eCollection 2014. Alzheimers Res Ther. 2014. PMID: 24495408 Free PMC article. Review.
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.
Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH. Nygaard HB, et al. Among authors: van dyck ch. Alzheimers Res Ther. 2015 Apr 14;7(1):35. doi: 10.1186/s13195-015-0119-0. eCollection 2015. Alzheimers Res Ther. 2015. PMID: 25874001 Free PMC article.
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.
Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS; Alzheimer's Disease Cooperative Study. Turner RS, et al. Among authors: van dyck ch. Neurology. 2015 Oct 20;85(16):1383-91. doi: 10.1212/WNL.0000000000002035. Epub 2015 Sep 11. Neurology. 2015. PMID: 26362286 Free PMC article. Clinical Trial.
A phase 3 trial of IV immunoglobulin for Alzheimer disease.
Relkin NR, Thomas RG, Rissman RA, Brewer JB, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS; Alzheimer's Disease Cooperative Study. Relkin NR, et al. Among authors: van dyck ch. Neurology. 2017 May 2;88(18):1768-1775. doi: 10.1212/WNL.0000000000003904. Epub 2017 Apr 5. Neurology. 2017. PMID: 28381506 Free PMC article. Clinical Trial.
PET imaging of mGluR5 in Alzheimer's disease.
Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. Mecca AP, et al. Among authors: van dyck ch. Alzheimers Res Ther. 2020 Jan 18;12(1):15. doi: 10.1186/s13195-020-0582-0. Alzheimers Res Ther. 2020. PMID: 31954399 Free PMC article.
383 results