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Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.
Maring JG, van Kuilenburg AB, Haasjes J, Piersma H, Groen HJ, Uges DR, Van Gennip AH, De Vries EG. Maring JG, et al. Br J Cancer. 2002 Apr 8;86(7):1028-33. doi: 10.1038/sj.bjc.6600208. Br J Cancer. 2002. PMID: 11953843 Free PMC article.
Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.
Raida M, Schwabe W, Häusler P, Van Kuilenburg AB, Van Gennip AH, Behnke D, Höffken K. Raida M, et al. Clin Cancer Res. 2001 Sep;7(9):2832-9. Clin Cancer Res. 2001. PMID: 11555601
Pyrimidine degradation defects and severe 5-fluorouracil toxicity.
van Kuilenburg AB, Meinsma R, van Gennip AH. van Kuilenburg AB, et al. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1371-5. doi: 10.1081/NCN-200027624. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15571261 Review.
Pharmacokinetics of bolus 5-fluorouracil: relationship between dose, plasma concentrations, area-under-the-curve and toxicity.
Codacci-Pisanelli G, Pinedo HM, Lankelma J, Van Groeningen CJ, Van Kuilenburg AB, Van Gennip AH, Peters GJ. Codacci-Pisanelli G, et al. Among authors: van gennip ah. J Chemother. 2005 Jun;17(3):315-20. doi: 10.1179/joc.2005.17.3.315. J Chemother. 2005. PMID: 16038526 Clinical Trial.
Activity of pyrimidine degradation enzymes in normal tissues.
van Kuilenburg AB, van Lenthe H, van Gennip AH. van Kuilenburg AB, et al. Among authors: van gennip ah. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1211-4. doi: 10.1080/15257770600894576. Nucleosides Nucleotides Nucleic Acids. 2006. PMID: 17065093
Genetic analysis of the first 4 patients with beta-ureidopropionase deficiency.
van Kuilenburg AB, Meinsma R, Assman B, Hoffman GF, Voit T, Ribes A, Lorente I, Busch R, Mayatepek E, Abeling NG, Wevers RA, Rutsch F, van Gennip AH. van Kuilenburg AB, et al. Among authors: van gennip ah. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1093-8. doi: 10.1080/15257770600956870. Nucleosides Nucleotides Nucleic Acids. 2006. PMID: 17065070
A pivotal role for beta-aminoisobutyric acid and oxidative stress in dihydropyrimidine dehydrogenase deficiency?
van Kuilenburg AB, Stroomer AE, Abeling NG, van Gennip AH. van Kuilenburg AB, et al. Among authors: van gennip ah. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1103-6. doi: 10.1080/15257770600894097. Nucleosides Nucleotides Nucleic Acids. 2006. PMID: 17065072
Dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil associated toxicity.
van Kuilenburg AB, Haasjes J, Van Lenthe H, Zoetekouw L, Waterham HR, Vreken P, van Gennip AH. van Kuilenburg AB, et al. Adv Exp Med Biol. 2000;486:251-5. doi: 10.1007/0-306-46843-3_49. Adv Exp Med Biol. 2000. PMID: 11783494 No abstract available.
Identification of a cDNA encoding an isoform of human CTP synthetase.
van Kuilenburg AB, Meinsma R, Vreken P, Waterham HR, van Gennip AH. van Kuilenburg AB, et al. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):548-52. doi: 10.1016/s0167-4781(00)00141-x. Biochim Biophys Acta. 2000. PMID: 10899599
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