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Functional Homologous Recombination (HR) Screening Shows the Majority of BRCA1/2-Mutant Breast and Ovarian Cancer Cell Lines Are HR-Proficient.
Meijer TG, Martens JWM, Prager-van der Smissen WJC, Verkaik NS, Beaufort CM, van Herk S, Robert-Finestra T, Hoogenboezem RM, Ruigrok-Ritstier K, Paul MW, Gribnau J, Bindels EMJ, Kanaar R, Jager A, van Gent DC, Hollestelle A. Meijer TG, et al. Among authors: van gent dc. Cancers (Basel). 2024 Feb 10;16(4):741. doi: 10.3390/cancers16040741. Cancers (Basel). 2024. PMID: 38398132 Free PMC article.
Ex vivo radiation sensitivity assessment for individual head and neck cancer patients using deep learning-based automated nuclei and DNA damage foci detection.
Lauwers I, Pachler KS, Capala ME, Sijtsema ND, Van Gent DC, Rovituso M, Hoogeman MS, Verduijn GM, Petit SF. Lauwers I, et al. Among authors: van gent dc. Clin Transl Radiat Oncol. 2024 Jan 30;45:100735. doi: 10.1016/j.ctro.2024.100735. eCollection 2024 Mar. Clin Transl Radiat Oncol. 2024. PMID: 38380115 Free PMC article.
Ex Vivo Functional Assay for Evaluating Treatment Response in Tumor Tissue of Head and Neck Squamous Cell Carcinoma.
Capala ME, Pachler KS, Lauwers I, de Korte MA, Verkaik NS, Mast H, Jonker BP, Sewnaik A, Hardillo JA, Keereweer S, Monserez D, Koljenovic S, Mostert B, Verduijn GM, Petit S, van Gent DC. Capala ME, et al. Among authors: van gent dc. Cancers (Basel). 2023 Jan 12;15(2):478. doi: 10.3390/cancers15020478. Cancers (Basel). 2023. PMID: 36672427 Free PMC article.
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.
van Ruiten MS, van Gent D, Sedeño Cacciatore Á, Fauster A, Willems L, Hekkelman ML, Hoekman L, Altelaar M, Haarhuis JHI, Brummelkamp TR, de Wit E, Rowland BD. van Ruiten MS, et al. Among authors: van gent d. Nat Struct Mol Biol. 2022 Jun;29(6):586-591. doi: 10.1038/s41594-022-00773-z. Epub 2022 Jun 16. Nat Struct Mol Biol. 2022. PMID: 35710836 Free PMC article.
Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests.
Meijer TG, Nguyen L, Van Hoeck A, Sieuwerts AM, Verkaik NS, Ladan MM, Ruigrok-Ritstier K, van Deurzen CHM, van de Werken HJG, Lips EH, Linn SC, Memari Y, Davies H, Nik-Zainal S, Kanaar R, Martens JWM, Cuppen E, Jager A, van Gent DC. Meijer TG, et al. Among authors: van gent dc. Oncogene. 2022 Jun;41(26):3498-3506. doi: 10.1038/s41388-022-02363-1. Epub 2022 Jun 3. Oncogene. 2022. PMID: 35662281 Free PMC article.
The COMPLETE trial: HolistiC early respOnse assessMent for oroPharyngeaL cancEr paTiEnts; Protocol for an observational study.
Verduijn GM, Capala ME, Sijtsema ND, Lauwers I, Hernandez Tamames JA, Heemsbergen WD, Sewnaik A, Hardillo JA, Mast H, van Norden Y, Jansen MPHM, van der Lugt A, van Gent DC, Hoogeman MS, Mostert B, Petit SF. Verduijn GM, et al. Among authors: van gent dc. BMJ Open. 2022 May 18;12(5):e059345. doi: 10.1136/bmjopen-2021-059345. BMJ Open. 2022. PMID: 35584883 Free PMC article.
123 results