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Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by beta-catenin.
van Gijn ME, Snel F, Cleutjens JP, Smits JF, Blankesteijn WM. van Gijn ME, et al. Exp Cell Res. 2001 Apr 15;265(1):46-53. doi: 10.1006/excr.2001.5174. Exp Cell Res. 2001. PMID: 11281642
Wnt signalling induces maturation of Paneth cells in intestinal crypts.
van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T, Taketo MM, Clevers H. van Es JH, et al. Among authors: van gijn me, van den born m. Nat Cell Biol. 2005 Apr;7(4):381-6. doi: 10.1038/ncb1240. Epub 2005 Mar 20. Nat Cell Biol. 2005. PMID: 15778706
The wnt-frizzled cascade in cardiovascular disease.
van Gijn ME, Daemen MJ, Smits JF, Blankesteijn WM. van Gijn ME, et al. Cardiovasc Res. 2002 Jul;55(1):16-24. doi: 10.1016/s0008-6363(02)00221-3. Cardiovasc Res. 2002. PMID: 12062705 Review. No abstract available.
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H. van der Flier LG, et al. Among authors: van gijn me, van den born m, van es jh, van de wetering m. Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031. Cell. 2009. PMID: 19269367
Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse.
van Gijn ME, Blankesteijn WM, Smits JF, Hierck B, Gittenberger-de Groot AC. van Gijn ME, et al. Anat Embryol (Berl). 2001 Mar;203(3):185-92. doi: 10.1007/s004290000152. Anat Embryol (Berl). 2001. PMID: 11303904
Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction.
Blankesteijn WM, van Gijn ME, Essers-Janssen YP, Daemen MJ, Smits JF. Blankesteijn WM, et al. Among authors: van gijn me. Am J Pathol. 2000 Sep;157(3):877-83. doi: 10.1016/s0002-9440(10)64601-9. Am J Pathol. 2000. PMID: 10980127 Free PMC article.
The Intestinal Wnt/TCF Signature.
Van der Flier LG, Sabates-Bellver J, Oving I, Haegebarth A, De Palo M, Anti M, Van Gijn ME, Suijkerbuijk S, Van de Wetering M, Marra G, Clevers H. Van der Flier LG, et al. Among authors: van gijn me, van de wetering m. Gastroenterology. 2007 Feb;132(2):628-32. doi: 10.1053/j.gastro.2006.08.039. Epub 2006 Aug 18. Gastroenterology. 2007. PMID: 17320548
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. van Es JH, et al. Among authors: van gijn me, van den born m. Nature. 2005 Jun 16;435(7044):959-63. doi: 10.1038/nature03659. Nature. 2005. PMID: 15959515
A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation.
Wienke J, Janssen W, Scholman R, Spits H, van Gijn M, Boes M, van Montfrans J, Moes N, de Roock S. Wienke J, et al. Oncotarget. 2015 Aug 21;6(24):20037-42. doi: 10.18632/oncotarget.5042. Oncotarget. 2015. PMID: 26343524 Free PMC article.
Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study.
Kempers MJ, Kuiper RP, Ockeloen CW, Chappuis PO, Hutter P, Rahner N, Schackert HK, Steinke V, Holinski-Feder E, Morak M, Kloor M, Büttner R, Verwiel ET, van Krieken JH, Nagtegaal ID, Goossens M, van der Post RS, Niessen RC, Sijmons RH, Kluijt I, Hogervorst FB, Leter EM, Gille JJ, Aalfs CM, Redeker EJ, Hes FJ, Tops CM, van Nesselrooij BP, van Gijn ME, Gómez García EB, Eccles DM, Bunyan DJ, Syngal S, Stoffel EM, Culver JO, Palomares MR, Graham T, Velsher L, Papp J, Oláh E, Chan TL, Leung SY, van Kessel AG, Kiemeney LA, Hoogerbrugge N, Ligtenberg MJ. Kempers MJ, et al. Among authors: van nesselrooij bp, van gijn me, van krieken jh, van kessel ag, van der post rs. Lancet Oncol. 2011 Jan;12(1):49-55. doi: 10.1016/S1470-2045(10)70265-5. Epub 2010 Dec 8. Lancet Oncol. 2011. PMID: 21145788 Free PMC article.
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