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A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females.
Klok MD, Giltay EJ, Van der Does AJ, Geleijnse JM, Antypa N, Penninx BW, de Geus EJ, Willemsen G, Boomsma DI, van Leeuwen N, Zitman FG, de Kloet ER, DeRijk RH. Klok MD, et al. Among authors: van der does aj, van leeuwen n. Transl Psychiatry. 2011 Dec 13;1(12):e62. doi: 10.1038/tp.2011.59. Transl Psychiatry. 2011. PMID: 22832354 Free PMC article.
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Leal Rodríguez C, Brasas V, Webel H, Benros ME, Pedersen AG, Chmura PJ, Jacobsen UP, Mari A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Hong MG, Musholt PB, De Masi F, Vogt J, Pedersen HK, Gudmundsdottir V, Jones A, Kennedy G, Bell J, Thomas EL, Frost G, Thomsen H, Hansen E, Hansen TH, Vestergaard H, Muilwijk M, Blom MT, 't Hart LM, Pattou F, Raverdy V, Brage S, Kokkola T, Heggie A, McEvoy D, Mourby M, Kaye J, Hattersley A, McDonald T, Ridderstråle M, Walker M, Forgie I, Giordano GN, Pavo I, Ruetten H, Pedersen O, Hansen T, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, McCarthy MI, Pearson E, Banasik K, Rasmussen S, Brunak S; IMI DIRECT Consortium. Allesøe RL, et al. Nat Biotechnol. 2023 Mar;41(3):399-408. doi: 10.1038/s41587-022-01520-x. Epub 2023 Jan 2. Nat Biotechnol. 2023. PMID: 36593394 Free PMC article.
The functional c.-2G>C variant of the mineralocorticoid receptor modulates blood pressure, renin, and aldosterone levels.
van Leeuwen N, Caprio M, Blaya C, Fumeron F, Sartorato P, Ronconi V, Giacchetti G, Mantero F, Fernandes-Rosa FL, Simian C, Peyrard S, Zitman FG, Penninx BW, de Kloet ER, Azizi M, Jeunemaitre X, Derijk RH, Zennaro MC. van Leeuwen N, et al. Hypertension. 2010 Nov;56(5):995-1002. doi: 10.1161/HYPERTENSIONAHA.110.155630. Epub 2010 Sep 20. Hypertension. 2010. PMID: 20855654
Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men.
van Raalte DH, van Leeuwen N, Simonis-Bik AM, Nijpels G, van Haeften TW, Schafer SA, Boomsma DI, Kramer MH, J Heine R, Maassen JA, Staiger H, Machicao F, Häring HU, Slagboom PE, Willemsen G, de Geus EJ, Dekker JM, Fritsche A, Eekhoff EM, Diamant M, 't Hart LM. van Raalte DH, et al. Among authors: van haeften tw, van leeuwen n. Diabet Med. 2012 Aug;29(8):e211-6. doi: 10.1111/j.1464-5491.2012.03690.x. Diabet Med. 2012. PMID: 22507373
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway.
't Hart LM, Fritsche A, Nijpels G, van Leeuwen N, Donnelly LA, Dekker JM, Alssema M, Fadista J, Carlotti F, Gjesing AP, Palmer CN, van Haeften TW, Herzberg-Schäfer SA, Simonis-Bik AM, Houwing-Duistermaat JJ, Helmer Q, Deelen J, Guigas B, Hansen T, Machicao F, Willemsen G, Heine RJ, Kramer MH, Holst JJ, de Koning EJ, Häring HU, Pedersen O, Groop L, de Geus EJ, Slagboom PE, Boomsma DI, Eekhoff EM, Pearson ER, Diamant M. 't Hart LM, et al. Among authors: van haeften tw, van leeuwen n. Diabetes. 2013 Sep;62(9):3275-81. doi: 10.2337/db13-0227. Epub 2013 May 14. Diabetes. 2013. PMID: 23674605 Free PMC article. Clinical Trial.
Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.
Guigas B, de Leeuw van Weenen JE, van Leeuwen N, Simonis-Bik AM, van Haeften TW, Nijpels G, Houwing-Duistermaat JJ, Beekman M, Deelen J, Havekes LM, Penninx BW, Vogelzangs N, van 't Riet E, Dehghan A, Hofman A, Witteman JC, Uitterlinden AG, Grarup N, Jørgensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Hottenga J, Romijn JA, Diamant M, Kramer MH, Heine RJ, Willemsen G, Dekker JM, Eekhoff EM, Pijl H, de Geus EJ, Slagboom PE, 't Hart LM. Guigas B, et al. Among authors: van t riet e, van haeften tw, van leeuwen n. Diabet Med. 2014 Aug;31(8):1001-8. doi: 10.1111/dme.12464. Epub 2014 May 2. Diabet Med. 2014. PMID: 24724616
146 results