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Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function.
van Meurs M, Kurniati NF, Wulfert FM, Asgeirsdottir SA, de Graaf IA, Satchell SC, Mathieson PW, Jongman RM, Kümpers P, Zijlstra JG, Heeringa P, Molema G. van Meurs M, et al. Am J Physiol Renal Physiol. 2009 Aug;297(2):F272-81. doi: 10.1152/ajprenal.00137.2009. Epub 2009 Jun 10. Am J Physiol Renal Physiol. 2009. PMID: 19515812
Hemorrhagic shock-induced endothelial cell activation in a spontaneous breathing and a mechanical ventilation hemorrhagic shock model is induced by a proinflammatory response and not by hypoxia.
van Meurs M, Wulfert FM, Jongman RM, Schipper M, Houwertjes MC, Vaneker M, Scheffer GJ, Teppema LJ, Aarts LP, Heeringa P, Zijlstra JG, Molema G. van Meurs M, et al. Anesthesiology. 2011 Sep;115(3):474-82. doi: 10.1097/ALN.0b013e318229a640. Anesthesiology. 2011. PMID: 21778876
MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation.
Asgeirsdóttir SA, van Solingen C, Kurniati NF, Zwiers PJ, Heeringa P, van Meurs M, Satchell SC, Saleem MA, Mathieson PW, Banas B, Kamps JA, Rabelink TJ, van Zonneveld AJ, Molema G. Asgeirsdóttir SA, et al. Among authors: van solingen c, van zonneveld aj, van meurs m. Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1630-9. doi: 10.1152/ajprenal.00400.2011. Epub 2012 Mar 14. Am J Physiol Renal Physiol. 2012. PMID: 22419694
We previously showed that during hemorrhagic shock, VCAM-1 protein was expressed primarily in extraglomerular compartments of the kidney, while E-selectin protein was highly induced in glomeruli only (van Meurs M, Wulfert FM, Knol AJ, de Haes A, Houwertjes …
We previously showed that during hemorrhagic shock, VCAM-1 protein was expressed primarily in extraglomerular compartments of the kidney, wh …
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