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Optimality in the development of intestinal crypts.
Itzkovitz S, Blat IC, Jacks T, Clevers H, van Oudenaarden A. Itzkovitz S, et al. Among authors: van oudenaarden a. Cell. 2012 Feb 3;148(3):608-19. doi: 10.1016/j.cell.2011.12.025. Cell. 2012. PMID: 22304925 Free PMC article.
Slug and Sox9 cooperatively determine the mammary stem cell state.
Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA. Guo W, et al. Among authors: van oudenaarden a. Cell. 2012 Mar 2;148(5):1015-28. doi: 10.1016/j.cell.2012.02.008. Cell. 2012. PMID: 22385965 Free PMC article.
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.
van Es JH, Haegebarth A, Kujala P, Itzkovitz S, Koo BK, Boj SF, Korving J, van den Born M, van Oudenaarden A, Robine S, Clevers H. van Es JH, et al. Among authors: van den born m, van oudenaarden a. Mol Cell Biol. 2012 May;32(10):1918-27. doi: 10.1128/MCB.06288-11. Epub 2012 Mar 5. Mol Cell Biol. 2012. PMID: 22393260 Free PMC article.
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H. Muñoz J, et al. Among authors: van oudenaarden a, van es jh, van de wetering m. EMBO J. 2012 Jun 12;31(14):3079-91. doi: 10.1038/emboj.2012.166. EMBO J. 2012. PMID: 22692129 Free PMC article.
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.
van Es JH, Sato T, van de Wetering M, Lyubimova A, Yee Nee AN, Gregorieff A, Sasaki N, Zeinstra L, van den Born M, Korving J, Martens ACM, Barker N, van Oudenaarden A, Clevers H. van Es JH, et al. Among authors: van den born m, van oudenaarden a, van de wetering m. Nat Cell Biol. 2012 Oct;14(10):1099-1104. doi: 10.1038/ncb2581. Epub 2012 Sep 23. Nat Cell Biol. 2012. PMID: 23000963 Free PMC article.
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