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31 results
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Isolation of a family of organic anion transporters from human liver and kidney.
Sun W, Wu RR, van Poelje PD, Erion MD. Sun W, et al. Among authors: van poelje pd. Biochem Biophys Res Commun. 2001 May 4;283(2):417-22. doi: 10.1006/bbrc.2001.4774. Biochem Biophys Res Commun. 2001. PMID: 11327718
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.
Reddy KR, Matelich MC, Ugarkar BG, Gómez-Galeno JE, DaRe J, Ollis K, Sun Z, Craigo W, Colby TJ, Fujitaki JM, Boyer SH, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: van poelje pd. J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173234
Liver-targeted drug delivery using HepDirect prodrugs.
Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM, Linemeyer DL, Bullough DA. Erion MD, et al. Among authors: van poelje pd. J Pharmacol Exp Ther. 2005 Feb;312(2):554-60. doi: 10.1124/jpet.104.075903. Epub 2004 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 15340017
Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates.
Dang Q, Brown BS, van Poelje PD, Colby TJ, Erion MD. Dang Q, et al. Among authors: van poelje pd. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1505-10. doi: 10.1016/s0960-894x(99)00239-5. Bioorg Med Chem Lett. 1999. PMID: 10386925
Liver targeting of hepatitis-B antiviral lamivudine using the HepDirect prodrug technology.
Reddy KR, Colby TJ, Fujitaki JM, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: van poelje pd. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):375-81. doi: 10.1081/ncn-200059781. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247954
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
Dang Q, Liu Y, Cashion DK, Kasibhatla SR, Jiang T, Taplin F, Jacintho JD, Li H, Sun Z, Fan Y, DaRe J, Tian F, Li W, Gibson T, Lemus R, van Poelje PD, Potter SC, Erion MD. Dang Q, et al. Among authors: van poelje pd. J Med Chem. 2011 Jan 13;54(1):153-65. doi: 10.1021/jm101035x. Epub 2010 Dec 2. J Med Chem. 2011. PMID: 21126019
Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist.
Fujitaki JM, Cable EE, Ito BR, Zhang BH, Hou J, Yang C, Bullough DA, Ferrero JL, van Poelje PD, Linemeyer DL, Erion MD. Fujitaki JM, et al. Among authors: van poelje pd. Drug Metab Dispos. 2008 Nov;36(11):2393-403. doi: 10.1124/dmd.108.021642. Epub 2008 Aug 14. Drug Metab Dispos. 2008. PMID: 18703645
Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors.
Dang Q, Kasibhatla SR, Jiang T, Fan K, Liu Y, Taplin F, Schulz W, Cashion DK, Reddy KR, van Poelje PD, Fujitaki JM, Potter SC, Erion MD. Dang Q, et al. Among authors: van poelje pd. J Med Chem. 2008 Jul 24;51(14):4331-9. doi: 10.1021/jm8001235. Epub 2008 Jun 21. J Med Chem. 2008. PMID: 18570362
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.
Erion MD, van Poelje PD, Dang Q, Kasibhatla SR, Potter SC, Reddy MR, Reddy KR, Jiang T, Lipscomb WN. Erion MD, et al. Among authors: van poelje pd. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5. doi: 10.1073/pnas.0502983102. Epub 2005 May 23. Proc Natl Acad Sci U S A. 2005. PMID: 15911772 Free PMC article.
Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist.
Cable EE, Finn PD, Stebbins JW, Hou J, Ito BR, van Poelje PD, Linemeyer DL, Erion MD. Cable EE, et al. Among authors: van poelje pd. Hepatology. 2009 Feb;49(2):407-17. doi: 10.1002/hep.22572. Hepatology. 2009. PMID: 19072834
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