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The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.
Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MAWH, Kloosterhuis NJ, Melki R, van Cruchten RTP, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TPJ, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH. Kakkar V, et al. Among authors: van waarde mawh. Mol Cell. 2016 Apr 21;62(2):272-283. doi: 10.1016/j.molcel.2016.03.017. Epub 2016 Apr 14. Mol Cell. 2016. PMID: 27151442 Free article.
Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.
Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE, Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, Morelli FF, Carra S, Weihl CC, Bergink S, Gestwicki JE, Kampinga HH. Meister-Broekema M, et al. Among authors: van waarde mawh. Nat Commun. 2018 Dec 17;9(1):5342. doi: 10.1038/s41467-018-07718-5. Nat Commun. 2018. PMID: 30559338 Free PMC article.
Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones.
Serlidaki D, van Waarde MAWH, Rohland L, Wentink AS, Dekker SL, Kamphuis MJ, Boertien JM, Brunsting JF, Nillegoda NB, Bukau B, Mayer MP, Kampinga HH, Bergink S. Serlidaki D, et al. Among authors: van waarde mawh. J Biol Chem. 2020 May 22;295(21):7301-7316. doi: 10.1074/jbc.RA119.012449. Epub 2020 Apr 13. J Biol Chem. 2020. PMID: 32284329 Free PMC article.
19 results