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How important is intestinal cytochrome P450 3A metabolism?
van Herwaarden AE, van Waterschoot RA, Schinkel AH. van Herwaarden AE, et al. Among authors: van waterschoot ra. Trends Pharmacol Sci. 2009 May;30(5):223-7. doi: 10.1016/j.tips.2009.02.003. Epub 2009 Mar 28. Trends Pharmacol Sci. 2009. PMID: 19328560
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.
Lagas JS, van Waterschoot RA, van Tilburg VA, Hillebrand MJ, Lankheet N, Rosing H, Beijnen JH, Schinkel AH. Lagas JS, et al. Among authors: van tilburg va, van waterschoot ra. Clin Cancer Res. 2009 Apr 1;15(7):2344-51. doi: 10.1158/1078-0432.CCR-08-2253. Epub 2009 Mar 10. Clin Cancer Res. 2009. PMID: 19276246
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