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Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.
Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS. Keedy DA, et al. Among authors: van benschoten ah, van den bedem h. Elife. 2015 Sep 30;4:e07574. doi: 10.7554/eLife.07574. Elife. 2015. PMID: 26422513 Free PMC article.
Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis.
Dasgupta M, Budday D, de Oliveira SHP, Madzelan P, Marchany-Rivera D, Seravalli J, Hayes B, Sierra RG, Boutet S, Hunter MS, Alonso-Mori R, Batyuk A, Wierman J, Lyubimov A, Brewster AS, Sauter NK, Applegate GA, Tiwari VK, Berkowitz DB, Thompson MC, Cohen AE, Fraser JS, Wall ME, van den Bedem H, Wilson MA. Dasgupta M, et al. Among authors: van den bedem h. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25634-25640. doi: 10.1073/pnas.1901864116. Epub 2019 Dec 4. Proc Natl Acad Sci U S A. 2019. PMID: 31801874 Free PMC article.
134 results