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Challenges in maturation and integration of kidney organoids for stem cell-based renal replacement therapy.
van den Berg CW, Dumas SJ, Little MH, Rabelink TJ. van den Berg CW, et al. Kidney Int. 2025 Feb;107(2):262-270. doi: 10.1016/j.kint.2024.10.028. Epub 2024 Nov 19. Kidney Int. 2025. PMID: 39571903 Free article. Review.
Human pluripotent stem cell-derived kidney organoids hold promise for future applications in regenerative medicine. ...
Human pluripotent stem cell-derived kidney organoids hold promise for future applications in regenerative medicine. ...
Good Manufacturing Practice-compliant human induced pluripotent stem cells: from bench to putative clinical products.
Novoa JJ, Westra IM, Steeneveld E, Fonseca Neves N, Arendzen CH, Rajaei B, Grundeken E, Yildiz M, van der Valk W, Salvador A, Carlotti F, Dijkers PF, Locher H, van den Berg CW, Raymond KI, Kirkeby A, Mummery CL, Rabelink TJ, Freund C, Meij P, Wieles B. Novoa JJ, et al. Among authors: van den berg cw. Cytotherapy. 2024 Jun;26(6):556-566. doi: 10.1016/j.jcyt.2024.02.021. Epub 2024 Mar 5. Cytotherapy. 2024. PMID: 38483359 Free article.
BACKGROUND AIMS: Few human induced pluripotent stem cell (hiPSC) lines are Good Manufacturing Practice (GMP)-compliant, limiting the clinical use of hiPSC-derived products. ...
BACKGROUND AIMS: Few human induced pluripotent stem cell (hiPSC) lines are Good Manufacturing Practice (GMP)-compliant, limiting the …
Ultrastructural characterization of maturing iPSC-derived nephron structures upon transplantation.
Wiersma LE, Avramut MC, Koster AJ, van den Berg CW, Rabelink TJ. Wiersma LE, et al. Among authors: van den berg cw. Microsc Res Tech. 2024 Mar;87(3):495-505. doi: 10.1002/jemt.24447. Epub 2023 Nov 6. Microsc Res Tech. 2024. PMID: 37929605
Pluripotent stem cell-derived kidney organoids hold great promise as a potential auxiliary transplant tissue for individuals with end-stage renal disease and as a platform for studying kidney diseases and drug discovery. ...
Pluripotent stem cell-derived kidney organoids hold great promise as a potential auxiliary transplant tissue for individuals with end …
T-Cell Mediated Immune Rejection of Beta-2-Microglobulin Knockout Induced Pluripotent Stem Cell-Derived Kidney Organoids.
Gaykema LH, van Nieuwland RY, Lievers E, Moerkerk WBJ, de Klerk JA, Dumas SJ, Kers J, Zaldumbide A, van den Berg CW, Rabelink TJ. Gaykema LH, et al. Among authors: van den berg cw. Stem Cells Transl Med. 2024 Jan 12;13(1):69-82. doi: 10.1093/stcltm/szad069. Stem Cells Transl Med. 2024. PMID: 37843402 Free PMC article.
Immune evasive induced pluripotent stem cell (iPSC)-derived kidney organoids, known as "stealth" organoids, hold promise for clinical transplantation. ...
Immune evasive induced pluripotent stem cell (iPSC)-derived kidney organoids, known as "stealth" organoids, hold promise for clinical …
Heart and kidney organoids maintain organ-specific function in a microfluidic system.
Gabbin B, Meraviglia V, Angenent ML, Ward-van Oostwaard D, Sol W, Mummery CL, Rabelink TJ, van Meer BJ, van den Berg CW, Bellin M. Gabbin B, et al. Among authors: van den berg cw. Mater Today Bio. 2023 Sep 25;23:100818. doi: 10.1016/j.mtbio.2023.100818. eCollection 2023 Dec. Mater Today Bio. 2023. PMID: 37810749 Free PMC article.
Cardiac microtissues (cMTs) and kidney organoids (kOs) derived from human induced pluripotent stem cells (hiPSCs) were generated and loaded into two separated communicating chambers of a perfusion chip. ...
Cardiac microtissues (cMTs) and kidney organoids (kOs) derived from human induced pluripotent stem cells (hiPSCs) were generated and …
Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos.
Koning M, Lievers E, Jaffredo T, van den Berg CW, Rabelink TJ. Koning M, et al. Among authors: van den berg cw. J Vis Exp. 2023 Feb 17;(192). doi: 10.3791/65090. J Vis Exp. 2023. PMID: 36876942
Kidney organoids derived from human induced pluripotent stem cells contain nephron-like structures that resemble those in the adult kidney to a certain degree. ...
Kidney organoids derived from human induced pluripotent stem cells contain nephron-like structures that resemble those in the adult k …
Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential.
van Amerongen RA, Morton LT, Chaudhari UG, Remst DFG, Hagedoorn RS, van den Berg CW, Freund C, Falkenburg JHF, Heemskerk MHM. van Amerongen RA, et al. Among authors: van den berg cw. Mol Ther Methods Clin Dev. 2023 Jan 20;28:249-261. doi: 10.1016/j.omtm.2023.01.005. eCollection 2023 Mar 9. Mol Ther Methods Clin Dev. 2023. PMID: 36816758 Free PMC article.
Here, we set up preclinical models with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, epicardial cells, and kidney organoids to investigate toxicity risks of tumor-specific T cells more thoroughly. ...
Here, we set up preclinical models with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, epicardial cells, and kid …
Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids.
Gaykema LH, van Nieuwland RY, Dekkers MC, van Essen MF, Heidt S, Zaldumbide A, van den Berg CW, Rabelink TJ, van Kooten C. Gaykema LH, et al. Among authors: van den berg cw. Front Immunol. 2023 Jan 12;13:1058763. doi: 10.3389/fimmu.2022.1058763. eCollection 2022. Front Immunol. 2023. PMID: 36713440 Free PMC article.
In this study we investigate whether inhibition of the complement system in human induced pluripotent stem cells (iPSC) could provide protection from such immune injury. To this end we created knock-in iPSC lines of the membrane bound complement inhibitor CD55 to create a …
In this study we investigate whether inhibition of the complement system in human induced pluripotent stem cells (iPSC) could provide …
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation.
Wang G, Heijs B, Kostidis S, Rietjens RGJ, Koning M, Yuan L, Tiemeier GL, Mahfouz A, Dumas SJ, Giera M, Kers J, Chuva de Sousa Lopes SM, van den Berg CW, van den Berg BM, Rabelink TJ. Wang G, et al. Among authors: van den berg cw. Cell Stem Cell. 2022 Nov 3;29(11):1580-1593.e7. doi: 10.1016/j.stem.2022.10.008. Cell Stem Cell. 2022. PMID: 36332571 Free article.
Vasculogenesis in kidney organoids upon transplantation.
Koning M, Dumas SJ, Avramut MC, Koning RI, Meta E, Lievers E, Wiersma LE, Borri M, Liang X, Xie L, Liu P, Chen F, Lin L, Luo Y, Mulder J, Spijker HS, Jaffredo T, van den Berg BM, Carmeliet P, van den Berg CW, Rabelink TJ. Koning M, et al. Among authors: van den berg cw. NPJ Regen Med. 2022 Aug 19;7(1):40. doi: 10.1038/s41536-022-00237-4. NPJ Regen Med. 2022. PMID: 35986027 Free PMC article.
Human induced pluripotent stem cell-derived kidney organoids have potential for disease modeling and to be developed into clinically transplantable auxiliary tissue. ...
Human induced pluripotent stem cell-derived kidney organoids have potential for disease modeling and to be developed into clinically …
24 results