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ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.
Groen EJ, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, van den Heuvel DM, Koppers M, van Diggelen F, van Heest J, Demmers JA, Kirby J, Shaw PJ, Aronica E, Spliet WG, Veldink JH, van den Berg LH, Pasterkamp RJ. Groen EJ, et al. Among authors: van den heuvel dm. Hum Mol Genet. 2013 Sep 15;22(18):3690-704. doi: 10.1093/hmg/ddt222. Epub 2013 May 15. Hum Mol Genet. 2013. PMID: 23681068
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways.
Blokhuis AM, Koppers M, Groen EJN, van den Heuvel DMA, Dini Modigliani S, Anink JJ, Fumoto K, van Diggelen F, Snelting A, Sodaar P, Verheijen BM, Demmers JAA, Veldink JH, Aronica E, Bozzoni I, den Hertog J, van den Berg LH, Pasterkamp RJ. Blokhuis AM, et al. Among authors: van den heuvel dma. Acta Neuropathol. 2016 Aug;132(2):175-196. doi: 10.1007/s00401-016-1575-8. Epub 2016 May 10. Acta Neuropathol. 2016. PMID: 27164932 Free PMC article.
Getting connected in the dopamine system.
Van den Heuvel DM, Pasterkamp RJ. Van den Heuvel DM, et al. Prog Neurobiol. 2008 May;85(1):75-93. doi: 10.1016/j.pneurobio.2008.01.003. Epub 2008 Jan 20. Prog Neurobiol. 2008. PMID: 18304718 Review.
Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.
Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ. Kolk SM, et al. Among authors: van den heuvel dm. J Neurosci. 2009 Oct 7;29(40):12542-57. doi: 10.1523/JNEUROSCI.2521-09.2009. J Neurosci. 2009. PMID: 19812329 Free PMC article.
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malinauskaite L, Brignani S, van den Munkhof MH, Düdükcü Ö, De Ruiter AA, Van den Heuvel DMA, Bishop B, Elegheert J, Aricescu AR, Pasterkamp RJ, Siebold C. Robinson RA, et al. Among authors: van den heuvel dma. Cell. 2021 Apr 15;184(8):2103-2120.e31. doi: 10.1016/j.cell.2021.02.045. Epub 2021 Mar 18. Cell. 2021. PMID: 33740419 Free PMC article.
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ. van Erp S, et al. Among authors: van den heuvel dma. Dev Cell. 2015 Dec 7;35(5):537-552. doi: 10.1016/j.devcel.2015.11.008. Dev Cell. 2015. PMID: 26651291 Free article.
Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer.
Hurkmans DP, Verdegaal EME, Hogan SA, de Wijn R, Hovestad L, van den Heuvel DMA, Ruijtenbeek R, Welters MJP, van Brakel M, Basak EA, Pinedo HM, Lamers CHJ, van de Werken HJG, Groten JP, Debets R, Levesque MP, Dummer R, Kapiteijn E, Mathijssen RHJ, Aerts JGJV, van der Burg SH. Hurkmans DP, et al. Among authors: van den heuvel dma. J Immunother Cancer. 2020 Dec;8(2):e001607. doi: 10.1136/jitc-2020-001607. J Immunother Cancer. 2020. PMID: 33427690 Free PMC article.
22 results