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Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.
Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, Cupo A, van der Woude P, Golabek M, Sliepen K, Blane T, Kootstra N, van Breemen MJ, Pritchard LK, Stanfield RL, Crispin M, Ward AB, Stamatatos L, Klasse PJ, Moore JP, Nemazee D, Nussenzweig MC, Wilson IA, Sanders RW. Medina-Ramírez M, et al. Among authors: van den kerkhof tlgm. J Exp Med. 2017 Sep 4;214(9):2573-2590. doi: 10.1084/jem.20161160. Epub 2017 Aug 28. J Exp Med. 2017. PMID: 28847869 Free PMC article.
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
de Taeye SW, Ozorowski G, Torrents de la Peña A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW. de Taeye SW, et al. Cell. 2015 Dec 17;163(7):1702-15. doi: 10.1016/j.cell.2015.11.056. Cell. 2015. PMID: 26687358 Free PMC article.
The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype.
Cornelissen M, Euler Z, van den Kerkhof TL, van Gils MJ, Boeser-Nunnink BD, Kootstra NA, Zorgdrager F, Schuitemaker H, Prins JM, Sanders RW, van der Kuyl AC. Cornelissen M, et al. AIDS Res Hum Retroviruses. 2016 Oct/Nov;32(10-11):1135-1142. doi: 10.1089/aid.2015.0324. Epub 2016 Feb 24. AIDS Res Hum Retroviruses. 2016. PMID: 26910384
Natural infection as a blueprint for rational HIV vaccine design.
van Haaren MM, van den Kerkhof TL, van Gils MJ. van Haaren MM, et al. Hum Vaccin Immunother. 2017 Jan 2;13(1):229-236. doi: 10.1080/21645515.2016.1232785. Epub 2016 Sep 20. Hum Vaccin Immunother. 2017. PMID: 27649455 Free PMC article. Review.
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.
van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW. van Gils MJ, et al. Nat Microbiol. 2016 Nov 14;2:16199. doi: 10.1038/nmicrobiol.2016.199. Nat Microbiol. 2016. PMID: 27841852 Free PMC article.
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