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Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Chelliah V, Lazarou G, Bhatnagar S, Gibbs JP, Nijsen M, Ray A, Stoll B, Thompson RA, Gulati A, Soukharev S, Yamada A, Weddell J, Sayama H, Oishi M, Wittemer-Rump S, Patel C, Niederalt C, Burghaus R, Scheerans C, Lippert J, Kabilan S, Kareva I, Belousova N, Rolfe A, Zutshi A, Chenel M, Venezia F, Fouliard S, Oberwittler H, Scholer-Dahirel A, Lelievre H, Bottino D, Collins SC, Nguyen HQ, Wang H, Yoneyama T, Zhu AZX, van der Graaf PH, Kierzek AM. Chelliah V, et al. Among authors: van der graaf ph. Clin Pharmacol Ther. 2021 Mar;109(3):605-618. doi: 10.1002/cpt.1987. Epub 2020 Aug 14. Clin Pharmacol Ther. 2021. PMID: 32686076 Free PMC article. Review.
FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective.
Bai JPF, Schmidt BJ, Gadkar KG, Damian V, Earp JC, Friedrich C, van der Graaf PH, Madabushi R, Musante CJ, Naik K, Rogge M, Zhu H. Bai JPF, et al. Among authors: van der graaf ph. AAPS J. 2021 Apr 30;23(3):60. doi: 10.1208/s12248-021-00585-x. AAPS J. 2021. PMID: 33931790
The Pharmacological War Against and With Opioids.
van der Graaf PH. van der Graaf PH. Clin Pharmacol Ther. 2021 Mar;109(3):557-559. doi: 10.1002/cpt.2157. Clin Pharmacol Ther. 2021. PMID: 33615454 No abstract available.
Biomarker-Guided Individualization of Antibiotic Therapy.
Aulin LBS, de Lange DW, Saleh MAA, van der Graaf PH, Völler S, van Hasselt JGC. Aulin LBS, et al. Among authors: van der graaf ph. Clin Pharmacol Ther. 2021 Feb 9. doi: 10.1002/cpt.2194. Online ahead of print. Clin Pharmacol Ther. 2021. PMID: 33559152
Toward Replacement of Thorough QT Studies.
van der Graaf PH. van der Graaf PH. Clin Pharmacol Ther. 2021 Feb;109(2):281-282. doi: 10.1002/cpt.2136. Clin Pharmacol Ther. 2021. PMID: 33469967 No abstract available.
Anti-tuberculosis effect of isoniazid scales accurately from zebrafish to humans.
van Wijk RC, Hu W, Dijkema SM, van den Berg DJ, Liu J, Bahi R, Verbeek FJ, Simonsson USH, Spaink HP, van der Graaf PH, Krekels EHJ. van Wijk RC, et al. Among authors: van der graaf ph. Br J Pharmacol. 2020 Dec;177(24):5518-5533. doi: 10.1111/bph.15247. Epub 2020 Nov 3. Br J Pharmacol. 2020. PMID: 32860631 Free PMC article.
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