van der Ley P - Search Results

1

Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity.

van der Ley P, Steeghs L, Hamstra HJ, ten Hove J, Zomer B, van Alphen L. van der Ley P, et al. Among authors: van alphen l. Infect Immun. 2001 Oct;69(10):5981-90. doi: 10.1128/IAI.69.10.5981-5990.2001. Infect Immun. 2001. PMID: 11553534 Free PMC article.

2

Relative immunogenicity of PorA subtypes in a multivalent Neisseria meningitidis vaccine is not dependent on presentation form.

Luijkx TA, van Dijken H, Hamstra HJ, Kuipers B, van der Ley P, van Alphen L, van den Dobbelsteen G. Luijkx TA, et al. Among authors: van alphen l, van der ley p, van dijken h, van den dobbelsteen g. Infect Immun. 2003 Nov;71(11):6367-71. doi: 10.1128/IAI.71.11.6367-6371.2003. Infect Immun. 2003. PMID: 14573657 Free PMC article.

3

Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of Bordetella pertussis.

Geurtsen J, Steeghs L, Hamstra HJ, Ten Hove J, de Haan A, Kuipers B, Tommassen J, van der Ley P. Geurtsen J, et al. Among authors: van der ley p. Infect Immun. 2006 Oct;74(10):5574-85. doi: 10.1128/IAI.00834-06. Infect Immun. 2006. PMID: 16988232 Free PMC article.

4

Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis.

Steeghs L, Keestra AM, van Mourik A, Uronen-Hansson H, van der Ley P, Callard R, Klein N, van Putten JP. Steeghs L, et al. Among authors: van putten jp, van mourik a, van der ley p. Infect Immun. 2008 Aug;76(8):3801-7. doi: 10.1128/IAI.00005-08. Epub 2008 May 19. Infect Immun. 2008. PMID: 18490457 Free PMC article.

5

Identification of a novel lipopolysaccharide core biosynthesis gene cluster in Bordetella pertussis, and influence of core structure and lipid A glucosamine substitution on endotoxic activity.

Geurtsen J, Dzieciatkowska M, Steeghs L, Hamstra HJ, Boleij J, Broen K, Akkerman G, El Hassan H, Li J, Richards JC, Tommassen J, van der Ley P. Geurtsen J, et al. Among authors: van der ley p. Infect Immun. 2009 Jul;77(7):2602-11. doi: 10.1128/IAI.00033-09. Epub 2009 Apr 13. Infect Immun. 2009. PMID: 19364841 Free PMC article.

6

The structure of Neisseria meningitidis lipid A determines outcome in experimental meningococcal disease.

Fransen F, Hamstra HJ, Boog CJ, van Putten JP, van den Dobbelsteen GP, van der Ley P. Fransen F, et al. Among authors: van putten jp, van den dobbelsteen gp, van der ley p. Infect Immun. 2010 Jul;78(7):3177-86. doi: 10.1128/IAI.01311-09. Epub 2010 May 3. Infect Immun. 2010. PMID: 20439476 Free PMC article.

7

Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity.

Steeghs L, Berns M, ten Hove J, de Jong A, Roholl P, van Alphen L, Tommassen J, van der Ley P. Steeghs L, et al. Among authors: van alphen l, van der ley p. Cell Microbiol. 2002 Sep;4(9):599-611. doi: 10.1046/j.1462-5822.2002.00214.x. Cell Microbiol. 2002. PMID: 12390352

8

Lessons from an LPS-deficient Neisseria meningitidis mutant.

van der Ley P, Steeghs L. van der Ley P, et al. J Endotoxin Res. 2003;9(2):124-8. doi: 10.1179/096805103125001522. J Endotoxin Res. 2003. PMID: 12803887

9

Isolation and characterization of the Neisseria meningitidis lpxD-fabZ-lpxA gene cluster involved in lipid A biosynthesis.

Steeghs L, Jennings MP, Poolman JT, van der Ley P. Steeghs L, et al. Among authors: van der ley p. Gene. 1997 May 6;190(2):263-70. doi: 10.1016/s0378-1119(97)00005-x. Gene. 1997. PMID: 9197543

10

Immunogenicity of outer membrane proteins in a lipopolysaccharide-deficient mutant of Neisseria meningitidis: influence of adjuvants on the immune response.

Steeghs L, Kuipers B, Hamstra HJ, Kersten G, van Alphen L, van der Ley P. Steeghs L, et al. Among authors: van alphen l, van der ley p. Infect Immun. 1999 Oct;67(10):4988-93. doi: 10.1128/IAI.67.10.4988-4993.1999. Infect Immun. 1999. PMID: 10496868 Free PMC article.

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