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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2001 3
2002 20
2003 30
2004 30
2005 29
2006 36
2007 34
2008 42
2009 42
2010 34
2011 36
2012 32
2013 43
2014 41
2015 50
2016 48
2017 44
2018 29
2019 38
2020 32
2021 58
2022 44
2023 2
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712 results
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Page 1
Artificial Intelligence for Early Sepsis Detection - A Word of Caution.
Schinkel M, van der Poll T, Wiersinga WJ. Schinkel M, et al. Among authors: van der poll t. Am J Respir Crit Care Med. 2023 Feb 1. doi: 10.1164/rccm.202212-2284VP. Online ahead of print. Am J Respir Crit Care Med. 2023. PMID: 36724366 No abstract available.
ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol.
Kotsaki A, Pickkers P, Bauer M, Calandra T, Lupse M, Wiersinga WJ, Meylan S, Bloos F, van der Poll T, Slim MA, van Mourik N, Müller MCA, van Vught L, Vlaar APJ, de Nooijer A, Bakkerus L, Weis S, Antonakos N, Netea MG, Giamarellos-Bourboulis EJ. Kotsaki A, et al. Among authors: van der poll t. BMJ Open. 2022 Dec 20;12(12):e067251. doi: 10.1136/bmjopen-2022-067251. BMJ Open. 2022. PMID: 36600424 Free PMC article.
Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the  phase 2 PANAMO trial.
Lim EHT, Vlaar APJ, Bos LDJ, van Vught LA, Boer AMT, Dujardin RWG, Habel M, Xu Z, Brouwer MC, van de Beek D, de Bruin S; Amsterdam UMC COVID-19 Biobank Investigators. Lim EHT, et al. Respir Res. 2022 Dec 24;23(1):375. doi: 10.1186/s12931-022-02278-1. Respir Res. 2022. PMID: 36566174 Free PMC article. Clinical Trial.
Association between age and the host response in critically ill patients with sepsis.
Michels EHA, Butler JM, Reijnders TDY, Cremer OL, Scicluna BP, Uhel F, Peters-Sengers H, Schultz MJ, Knight JC, van Vught LA, van der Poll T; MARS consortium. Michels EHA, et al. Among authors: van der poll t. Crit Care. 2022 Dec 13;26(1):385. doi: 10.1186/s13054-022-04266-9. Crit Care. 2022. PMID: 36514130 Free PMC article.
Immunopathophysiology of human sepsis.
Wiersinga WJ, van der Poll T. Wiersinga WJ, et al. Among authors: van der poll t. EBioMedicine. 2022 Dec;86:104363. doi: 10.1016/j.ebiom.2022.104363. Epub 2022 Dec 2. EBioMedicine. 2022. PMID: 36470832 Free PMC article. Review.
An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.
Cano-Gamez E, Burnham KL, Goh C, Allcock A, Malick ZH, Overend L, Kwok A, Smith DA, Peters-Sengers H, Antcliffe D; GAinS Investigators; McKechnie S, Scicluna BP, van der Poll T, Gordon AC, Hinds CJ, Davenport EE, Knight JC, Webster N, Galley H, Taylor J, Hall S, Addison J, Roughton S, Tennant H, Guleri A, Waddington N, Arawwawala D, Durcan J, Short A, Swan K, Williams S, Smolen S, Mitchell-Inwang C, Gordon T, Errington E, Templeton M, Venatesh P, Ward G, McCauley M, Baudouin S, Higham C, Soar J, Grier S, Hall E, Brett S, Kitson D, Wilson R, Mountford L, Moreno J, Hall P, Hewlett J, McKechnie S, Garrard C, Millo J, Young D, Hutton P, Parsons P, Smiths A, Faras-Arraya R, Soar J, Raymode P, Thompson J, Bowrey S, Kazembe S, Rich N, Andreou P, Hales D, Roberts E, Fletcher S, Rosbergen M, Glister G, Cuesta JM, Bion J, Millar J, Perry EJ, Willis H, Mitchell N, Ruel S, Carrera R, Wilde J, Nilson A, Lees S, Kapila A, Jacques N, Atkinson J, Brown A, Prowse H, Krige A, Bland M, Bullock L, Harrison D, Mills G, Humphreys J, Armitage K, Laha S, Baldwin J, Walsh A, Doherty N, Drage S, Ortiz-Ruiz de Gordoa L, Lowes S, Higham C, Walsh H, Calder V, Swan C, Payne H, Higgins D, Andrews S, Mappleback S, Hind C, Garrard C, Watson D, McLees E, Purdy A, Stotz M, Ochelli-Okpue A, Bonner S, Whitehead I, Hugil K, Goodridge V, Cawthor L, Kuper M, Pahary S, Bellingan G, Marshall R, Montgomery H, Ryu JH, Bercades G, Boluda S, Bentley A, Mccalman K, Jefferies F, Knight J, Davenport E, Burnham K, Maugeri N, Radhakrishnan J, Mi Y, Allcock A, Goh C. Cano-Gamez E, et al. Among authors: van der poll t. Sci Transl Med. 2022 Nov 2;14(669):eabq4433. doi: 10.1126/scitranslmed.abq4433. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322631 Free PMC article.
Microglial response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice after systemic stimulation with Escherichia coli.
Hoogland ICM, Yik J, Westhoff D, Engelen-Lee JY, Valls Seron M, Man WK, Houben-Weerts JHPM, Tanck MW, van Westerloo DJ, van der Poll T, van Gool WA, van de Beek D. Hoogland ICM, et al. Among authors: van der poll t. Neurosci Lett. 2022 Nov 1;790:136894. doi: 10.1016/j.neulet.2022.136894. Epub 2022 Sep 29. Neurosci Lett. 2022. PMID: 36183964 Free article.
The Azithromycin Pro-Drug CSY5669 Boosts Bacterial Killing While Attenuating Lung Inflammation Associated with Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus.
Saris A, Qin W, van Linge CCA, Reijnders TDY, Florquin S, Burnet M, Strass S, de Vos AF, van der Poll T. Saris A, et al. Among authors: van der poll t. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0229821. doi: 10.1128/aac.02298-21. Epub 2022 Aug 16. Antimicrob Agents Chemother. 2022. PMID: 35972289 Free PMC article.
Intracellular pyruvate levels positively correlate with cytokine production capacity in tolerant monocytes from patients with pneumonia.
Otto NA, Butler JM, Schuurman AR, Brands X, Haak BW, Klarenbeek AM, van Weeghel M, Houtkooper RH, Jakobs ME, Faber DR, de Vos AF, Wiersinga WJ, Scicluna BP, van der Poll T. Otto NA, et al. Among authors: van der poll t. Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1;1868(11):166519. doi: 10.1016/j.bbadis.2022.166519. Epub 2022 Aug 12. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35964875 Free article.
The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes.
Malmström E, Khan HN, Veer CV', Stunnenberg M, Meijer MT, Matsumoto H, Otto NA, Geijtenbeek TBH, de Vos AF, van der Poll T, Scicluna BP. Malmström E, et al. Among authors: van der poll t. Front Cell Infect Microbiol. 2022 Jul 12;12:934313. doi: 10.3389/fcimb.2022.934313. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35903199 Free PMC article.
Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients.
de Brabander J, Duijvelaar E, Schippers JR, Smeele PJ, Peters-Sengers H, Duitman JW, Aman J, Bogaard HJ, van der Poll T, Bos LDJ; CounterCOVID Study Group. de Brabander J, et al. Among authors: van der poll t. Eur Respir J. 2022 Dec 15;60(6):2200780. doi: 10.1183/13993003.00780-2022. Print 2022 Dec. Eur Respir J. 2022. PMID: 35896211 Free PMC article. Clinical Trial.
Human alveolar macrophages do not rely on glucose metabolism upon activation by lipopolysaccharide.
Pereverzeva L, van Linge CCA, Schuurman AR, Klarenbeek AM, Ramirez Moral I, Otto NA, Peters-Sengers H, Butler JM, Schomakers BV, van Weeghel M, Houtkooper RH, Wiersinga WJ, Bonta PI, Annema JT, de Vos AF, van der Poll T. Pereverzeva L, et al. Among authors: van der poll t. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166488. doi: 10.1016/j.bbadis.2022.166488. Epub 2022 Jul 11. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35835414 Free article.
Redefining critical illness.
Maslove DM, Tang B, Shankar-Hari M, Lawler PR, Angus DC, Baillie JK, Baron RM, Bauer M, Buchman TG, Calfee CS, Dos Santos CC, Giamarellos-Bourboulis EJ, Gordon AC, Kellum JA, Knight JC, Leligdowicz A, McAuley DF, McLean AS, Menon DK, Meyer NJ, Moldawer LL, Reddy K, Reilly JP, Russell JA, Sevransky JE, Seymour CW, Shapiro NI, Singer M, Summers C, Sweeney TE, Thompson BT, van der Poll T, Venkatesh B, Walley KR, Walsh TS, Ware LB, Wong HR, Zador ZE, Marshall JC. Maslove DM, et al. Among authors: van der poll t. Nat Med. 2022 Jun;28(6):1141-1148. doi: 10.1038/s41591-022-01843-x. Epub 2022 Jun 17. Nat Med. 2022. PMID: 35715504 Review.
The host response in different aetiologies of community-acquired pneumonia.
Schuurman AR, Reijnders TDY, van Engelen TSR, Léopold V, de Brabander J, van Linge C, Schinkel M, Pereverzeva L, Haak BW, Brands X, Kanglie MMNP, van den Berk IAH, Douma RA, Faber DR, Nanayakkara PWB, Stoker J, Prins JM, Scicluna BP, Wiersinga WJ, van der Poll T. Schuurman AR, et al. Among authors: van der poll t. EBioMedicine. 2022 Jul;81:104082. doi: 10.1016/j.ebiom.2022.104082. Epub 2022 Jun 1. EBioMedicine. 2022. PMID: 35660785 Free PMC article.
Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward.
de Brabander J, Michels EHA, van Linge CCA, Chouchane O, Douma RA, Reijnders TDY, Schuurman AR, van Engelen TSR; Amsterdam UMC COVID-19 biobank study group; Wiersinga WJ, van der Poll T. de Brabander J, et al. Among authors: van der poll t. Respir Res. 2022 Jun 3;23(1):145. doi: 10.1186/s12931-022-02060-3. Respir Res. 2022. PMID: 35659223 Free PMC article.
Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome.
Kullberg RFJ, de Brabander J, Boers LS, Biemond JJ, Nossent EJ, Heunks LMA, Vlaar APJ, Bonta PI, van der Poll T, Duitman J, Bos LDJ, Wiersinga WJ; ArtDECO Consortium and the Amsterdam UMC COVID-19 Biobank Study Group. Kullberg RFJ, et al. Among authors: van der poll t. Am J Respir Crit Care Med. 2022 Oct 1;206(7):846-856. doi: 10.1164/rccm.202202-0274OC. Am J Respir Crit Care Med. 2022. PMID: 35616585 Free PMC article.
Personalised immunotherapy in sepsis: a scoping review protocol.
Slim MA, van Mourik N, Dionne JC, Oczkowski SJW, Netea MG, Pickkers P, Giamarellos-Bourboulis EJ, Müller MCA, van der Poll T, Wiersinga WJ, Vlaar APJ, van Vught LA. Slim MA, et al. Among authors: van der poll t. BMJ Open. 2022 May 9;12(5):e060411. doi: 10.1136/bmjopen-2021-060411. BMJ Open. 2022. PMID: 35534059 Free PMC article.
Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.
Hoogland ICM, Yik J, Westhoff D, Engelen-Lee JY, Valls Seron M, Man WK, Houben-Weerts JHPM, Tanck MWT, van Westerloo DJ, van der Poll T, van Gool WA, van de Beek D. Hoogland ICM, et al. Among authors: van der poll t. J Neuroinflammation. 2022 Apr 12;19(1):94. doi: 10.1186/s12974-022-02452-8. J Neuroinflammation. 2022. PMID: 35413868 Free PMC article.
Association of Hyperferritinemia With Distinct Host Response Aberrations in Patients With Community-Acquired Pneumonia.
Brands X, van Engelen TSR, de Vries FMC, Haak BW, Klarenbeek AM, Kanglie MMNP, van den Berk IAH, Schuurman AR, Peters-Sengers H, Otto NA, Faber DR, Lutter R, Scicluna BP, Stoker J, Prins JM, Joost Wiersinga W, van der Poll T. Brands X, et al. Among authors: van der poll t. J Infect Dis. 2022 Jun 1;225(11):2023-2032. doi: 10.1093/infdis/jiac013. J Infect Dis. 2022. PMID: 35100411 Free PMC article.
A guide to immunotherapy for COVID-19.
van de Veerdonk FL, Giamarellos-Bourboulis E, Pickkers P, Derde L, Leavis H, van Crevel R, Engel JJ, Wiersinga WJ, Vlaar APJ, Shankar-Hari M, van der Poll T, Bonten M, Angus DC, van der Meer JWM, Netea MG. van de Veerdonk FL, et al. Among authors: van der poll t. Nat Med. 2022 Jan;28(1):39-50. doi: 10.1038/s41591-021-01643-9. Epub 2022 Jan 21. Nat Med. 2022. PMID: 35064248 Review.
The Immune Response to Respiratory Viruses: From Start to Memory.
Reijnders TDY, Schuurman AR, van der Poll T. Reijnders TDY, et al. Among authors: van der poll t. Semin Respir Crit Care Med. 2021 Dec;42(6):759-770. doi: 10.1055/s-0041-1736459. Epub 2021 Dec 16. Semin Respir Crit Care Med. 2021. PMID: 34918319 Review.
HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis.
Matsumoto H, Scicluna BP, Jim KK, Falahi F, Qin W, Gürkan B, Malmström E, Meijer MT, Butler JM, Khan HN, Takagi T, Ishii S, Schultz MJ, van de Beek D, de Vos AF, van 't Veer C, van der Poll T. Matsumoto H, et al. Among authors: van der poll t. Front Immunol. 2021 Nov 5;12:744358. doi: 10.3389/fimmu.2021.744358. eCollection 2021. Front Immunol. 2021. PMID: 34804025 Free PMC article.
Etiology of Myocardial Injury in Critically Ill Patients with Sepsis: A Cohort Study.
Frencken JF, van Smeden M, van de Groep K, Ong DSY, Klein Klouwenberg PMC, Juffermans N, Bonten MJM, van der Poll T, Cremer OL; MARS Consortium. Frencken JF, et al. Among authors: van der poll t. Ann Am Thorac Soc. 2022 May;19(5):773-780. doi: 10.1513/AnnalsATS.202106-689OC. Ann Am Thorac Soc. 2022. PMID: 34784496
The immunology of sepsis.
van der Poll T, Shankar-Hari M, Wiersinga WJ. van der Poll T, et al. Immunity. 2021 Nov 9;54(11):2450-2464. doi: 10.1016/j.immuni.2021.10.012. Immunity. 2021. PMID: 34758337 Free article. Review.
Sepsis-Induced Immunosuppression.
Torres LK, Pickkers P, van der Poll T. Torres LK, et al. Among authors: van der poll t. Annu Rev Physiol. 2022 Feb 10;84:157-181. doi: 10.1146/annurev-physiol-061121-040214. Epub 2021 Oct 27. Annu Rev Physiol. 2022. PMID: 34705481 Review.
Rectal bacteriome and virome signatures and clinical outcomes in community-acquired pneumonia: An exploratory study.
Kullberg RFJ, Hugenholtz F, Brands X, Kinsella CM, Peters-Sengers H, Butler JM, Deijs M, Klein M, Faber DR, Scicluna BP, Van der Poll T, Van der Hoek L, Wiersinga WJ, Haak BW. Kullberg RFJ, et al. Among authors: van der poll t. EClinicalMedicine. 2021 Aug 12;39:101074. doi: 10.1016/j.eclinm.2021.101074. eCollection 2021 Sep. EClinicalMedicine. 2021. PMID: 34611613 Free PMC article.
Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
Writing Committee for the REMAP-CAP Investigators; Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Bégin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chassé M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. Writing Committee for the REMAP-CAP Investigators, et al. JAMA. 2021 Nov 2;326(17):1690-1702. doi: 10.1001/jama.2021.18178. JAMA. 2021. PMID: 34606578 Free PMC article. Clinical Trial.
Combined Transcriptome and Proteome Leukocyte's Profiling Reveals Up-Regulated Module of Genes/Proteins Related to Low Density Neutrophils and Impaired Transcription and Translation Processes in Clinical Sepsis.
Leite GGF, Ferreira BL, Tashima AK, Nishiduka ES, Cunha-Neto E, Brunialti MKC, Assuncao M, Azevedo LCP, Freitas F, van der Poll T, Scicluna BP, Salomão R. Leite GGF, et al. Among authors: van der poll t. Front Immunol. 2021 Sep 10;12:744799. doi: 10.3389/fimmu.2021.744799. eCollection 2021. Front Immunol. 2021. PMID: 34594344 Free PMC article.
Bruton's Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia.
de Porto AP, Liu Z, de Beer R, Florquin S, Roelofs JJTH, de Boer OJ, den Haan JMM, Hendriks RW, van 't Veer C, van der Poll T, de Vos AF. de Porto AP, et al. Among authors: van der poll t. Front Immunol. 2021 Sep 6;12:723967. doi: 10.3389/fimmu.2021.723967. eCollection 2021. Front Immunol. 2021. PMID: 34552589 Free PMC article.
712 results