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Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice.
Koomen M, Cheng NC, van de Vrugt HJ, Godthelp BC, van der Valk MA, Oostra AB, Zdzienicka MZ, Joenje H, Arwert F. Koomen M, et al. Hum Mol Genet. 2002 Feb 1;11(3):273-81. doi: 10.1093/hmg/11.3.273. Hum Mol Genet. 2002. PMID: 11823446
GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.
Westerman BA, Blom M, Tanger E, van der Valk M, Song JY, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J, Prosser HM, Uren A, Aronica E, van Lohuizen M. Westerman BA, et al. PLoS One. 2012;7(5):e35943. doi: 10.1371/journal.pone.0035943. Epub 2012 May 4. PLoS One. 2012. PMID: 22574128 Free PMC article.
Fancf-deficient mice are prone to develop ovarian tumours.
Bakker ST, van de Vrugt HJ, Visser JA, Delzenne-Goette E, van der Wal A, Berns MA, van de Ven M, Oostra AB, de Vries S, Kramer P, Arwert F, van der Valk M, de Winter JP, te Riele H. Bakker ST, et al. J Pathol. 2012 Jan;226(1):28-39. doi: 10.1002/path.2992. Epub 2011 Nov 14. J Pathol. 2012. PMID: 21915857
Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.
Dannenberg JH, Schuijff L, Dekker M, van der Valk M, te Riele H. Dannenberg JH, et al. Genes Dev. 2004 Dec 1;18(23):2952-62. doi: 10.1101/gad.322004. Genes Dev. 2004. PMID: 15574596 Free PMC article.
Synergy of Nf2 and p53 mutations in development of malignant tumours of neural crest origin.
Robanus-Maandag E, Giovannini M, van der Valk M, Niwa-Kawakita M, Abramowski V, Antonescu C, Thomas G, Berns A. Robanus-Maandag E, et al. Oncogene. 2004 Aug 26;23(39):6541-7. doi: 10.1038/sj.onc.1207858. Oncogene. 2004. PMID: 15221010
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.
Krimpenfort P, Ijpenberg A, Song JY, van der Valk M, Nawijn M, Zevenhoven J, Berns A. Krimpenfort P, et al. Nature. 2007 Aug 23;448(7156):943-6. doi: 10.1038/nature06084. Nature. 2007. PMID: 17713536
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.
van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, van der Valk M, Deschamps J, Sofroniew M, van Lohuizen M, et al. van der Lugt NM, et al. Genes Dev. 1994 Apr 1;8(7):757-69. doi: 10.1101/gad.8.7.757. Genes Dev. 1994. PMID: 7926765
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