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2020 11
2021 17
2022 17
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COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants.
Jalkanen P, Kolehmainen P, Häkkinen HK, Huttunen M, Tähtinen PA, Lundberg R, Maljanen S, Reinholm A, Tauriainen S, Pakkanen SH, Levonen I, Nousiainen A, Miller T, Välimaa H, Ivaska L, Pasternack A, Naves R, Ritvos O, Österlund P, Kuivanen S, Smura T, Hepojoki J, Vapalahti O, Lempainen J, Kakkola L, Kantele A, Julkunen I. Jalkanen P, et al. Nat Commun. 2021 Jun 28;12(1):3991. doi: 10.1038/s41467-021-24285-4. Nat Commun. 2021. PMID: 34183681 Free PMC article.
As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under development or in clinical use. ...The vaccinees' neutralization titres exceeded those of recovered non-hospitalized COVID-19 patients. Our work provides …
As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under development or in clinical u …
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Cantuti-Castelvetri L, et al. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20. Science. 2020. PMID: 33082293 Free PMC article.
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ...Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed …
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (S
A serological assay to detect SARS-CoV-2 seroconversion in humans.
Amanat F, Stadlbauer D, Strohmeier S, Nguyen THO, Chromikova V, McMahon M, Jiang K, Arunkumar GA, Jurczyszak D, Polanco J, Bermudez-Gonzalez M, Kleiner G, Aydillo T, Miorin L, Fierer DS, Lugo LA, Kojic EM, Stoever J, Liu STH, Cunningham-Rundles C, Felgner PL, Moran T, García-Sastre A, Caplivski D, Cheng AC, Kedzierska K, Vapalahti O, Hepojoki JM, Simon V, Krammer F. Amanat F, et al. Nat Med. 2020 Jul;26(7):1033-1036. doi: 10.1038/s41591-020-0913-5. Epub 2020 May 12. Nat Med. 2020. PMID: 32398876 Free PMC article.
Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in seru …
Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2
Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients.
Kortela E, Kirjavainen V, Ahava MJ, Jokiranta ST, But A, Lindahl A, Jääskeläinen AE, Jääskeläinen AJ, Järvinen A, Jokela P, Kallio-Kokko H, Loginov R, Mannonen L, Ruotsalainen E, Sironen T, Vapalahti O, Lappalainen M, Kreivi HR, Jarva H, Kurkela S, Kekäläinen E. Kortela E, et al. PLoS One. 2021 May 21;16(5):e0251661. doi: 10.1371/journal.pone.0251661. eCollection 2021. PLoS One. 2021. PMID: 34019562 Free PMC article.
BACKGROUND: Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the COVID-19 pandemic and it has implications for patient management. ...In addition to examining the first RT-PCR test of repeat-te …
BACKGROUND: Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the …
Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response.
Lin JW, Tang C, Wei HC, Du B, Chen C, Wang M, Zhou Y, Yu MX, Cheng L, Kuivanen S, Ogando NS, Levanov L, Zhao Y, Li CL, Zhou R, Li Z, Zhang Y, Sun K, Wang C, Chen L, Xiao X, Zheng X, Chen SS, Zhou Z, Yang R, Zhang D, Xu M, Song J, Wang D, Li Y, Lei S, Zeng W, Yang Q, He P, Zhang Y, Zhou L, Cao L, Luo F, Liu H, Wang L, Ye F, Zhang M, Li M, Fan W, Li X, Li K, Ke B, Xu J, Yang H, He S, Pan M, Yan Y, Zha Y, Jiang L, Yu C, Liu Y, Xu Z, Li Q, Jiang Y, Sun J, Hong W, Wei H, Lu G, Vapalahti O, Luo Y, Wei Y, Connor T, Tan W, Snijder EJ, Smura T, Li W, Geng J, Ying B, Chen L. Lin JW, et al. Cell Host Microbe. 2021 Mar 10;29(3):489-502.e8. doi: 10.1016/j.chom.2021.01.015. Epub 2021 Jan 29. Cell Host Microbe. 2021. PMID: 33548198 Free PMC article.
The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. ...
The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. ...
New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic.
Salmi H, Heinonen S, Hästbacka J, Lääperi M, Rautiainen P, Miettinen PJ, Vapalahti O, Hepojoki J, Knip M. Salmi H, et al. Arch Dis Child. 2022 Feb;107(2):180-185. doi: 10.1136/archdischild-2020-321220. Epub 2021 May 27. Arch Dis Child. 2022. PMID: 34045208 Free PMC article.
BACKGROUND: Viral infections may trigger type 1 diabetes (T1D), and recent reports suggest an increased incidence of paediatric T1D and/or diabetic ketoacidosis (DKA) during the COVID-19 pandemic. OBJECTIVE: To study whether the number of children admitted to the pa …
BACKGROUND: Viral infections may trigger type 1 diabetes (T1D), and recent reports suggest an increased incidence of paediatric T1D and/or d …
Performance of six SARS-CoV-2 immunoassays in comparison with microneutralisation.
Jääskeläinen AJ, Kuivanen S, Kekäläinen E, Ahava MJ, Loginov R, Kallio-Kokko H, Vapalahti O, Jarva H, Kurkela S, Lappalainen M. Jääskeläinen AJ, et al. J Clin Virol. 2020 Aug;129:104512. doi: 10.1016/j.jcv.2020.104512. Epub 2020 Jun 15. J Clin Virol. 2020. PMID: 32563180 Free PMC article.
We compared the performance of six commercial immunoassays for the detection of SARS-COV-2 IgG, IgA and IgM antibodies, including four automated assays [Abbott SARS-COV-2 IgG (CE marked), Diasorin Liaison SARS-COV-2 S …
We compared the performance of six commercial immunoassays for the detection of SARS-COV-2 IgG, IgA and IgM antibodies, …
A 10-Minute "Mix and Read" Antibody Assay for SARS-CoV-2.
Rusanen J, Kareinen L, Levanov L, Mero S, Pakkanen SH, Kantele A, Amanat F, Krammer F, Hedman K, Vapalahti O, Hepojoki J. Rusanen J, et al. Viruses. 2021 Jan 20;13(2):143. doi: 10.3390/v13020143. Viruses. 2021. PMID: 33498157 Free PMC article.
The major targets of human antibody response in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the spike glycoprotein (SP) and nucleocapsid protein (NP). ...In conclusion, this study demonstrates the applicability of LFRET, a 10-min " …
The major targets of human antibody response in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …
Effects of Environmental Factors on Severity and Mortality of COVID-19.
Kifer D, Bugada D, Villar-Garcia J, Gudelj I, Menni C, Sudre C, Vučković F, Ugrina I, Lorini LF, Posso M, Bettinelli S, Ughi N, Maloberti A, Epis O, Giannattasio C, Rossetti C, Kalogjera L, Peršec J, Ollivere L, Ollivere BJ, Yan H, Cai T, Aithal GP, Steves CJ, Kantele A, Kajova M, Vapalahti O, Sajantila A, Wojtowicz R, Wierzba W, Krol Z, Zaczynski A, Zycinska K, Postula M, Lukšić I, Čivljak R, Markotić A, Brachmann J, Markl A, Mahnkopf C, Murray B, Ourselin S, Valdes AM, Horcajada JP, Castells X, Pascual J, Allegri M, Primorac D, Spector TD, Barrios C, Lauc G. Kifer D, et al. Front Med (Lausanne). 2021 Jan 20;7:607786. doi: 10.3389/fmed.2020.607786. eCollection 2020. Front Med (Lausanne). 2021. PMID: 33553204 Free PMC article.
Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. ...The …
Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented …
Evaluation of commercial and automated SARS-CoV-2 IgG and IgA ELISAs using coronavirus disease (COVID-19) patient samples.
Jääskeläinen AJ, Kekäläinen E, Kallio-Kokko H, Mannonen L, Kortela E, Vapalahti O, Kurkela S, Lappalainen M. Jääskeläinen AJ, et al. Euro Surveill. 2020 May;25(18):2000603. doi: 10.2807/1560-7917.ES.2020.25.18.2000603. Euro Surveill. 2020. PMID: 32400364 Free PMC article.
Antibody-screening methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) need to be validated. We evaluated SARS-CoV-2 IgG and IgA ELISAs in conjunction with the EUROLabworkstation (Euroimmun, Lubeck, Germa …
Antibody-screening methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) need to be val …
41 results