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The following term was not found in PubMed: obracovic
Page 1
Did you mean vdr leukemia obradovic (1 results)?
Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.
Khazan N, Quarato ER, Singh NA, Snyder CWA, Moore T, Miller JP, Yasui M, Teramoto Y, Goto T, Reshi S, Hong J, Zhang N, Pandey D, Srivastava P, Morell A, Kawano H, Kawano Y, Conley T, Sahasrabudhe DM, Yano N, Miyamoto H, Aljitawi O, Liesveld J, Becker MW, Calvi LM, Zhovmer AS, Tabdanov ED, Dokholyan NV, Linehan DC, Hansen JN, Gerber SA, Sharon A, Khera MK, Jurutka PW, Rochel N, Kim KK, Rowswell-Turner RB, Singh RK, Moore RG. Khazan N, et al. Cancers (Basel). 2023 Jun 30;15(13):3432. doi: 10.3390/cancers15133432. Cancers (Basel). 2023. PMID: 37444542 Free PMC article.
In this study, using chromatin immunoprecipitation (ChIP) assay and siRNA, we demonstrate that vitamin D/VDR regulates PD-L1 expression in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells. We have examined whether a VDR antagonist, MeTC7, …
In this study, using chromatin immunoprecipitation (ChIP) assay and siRNA, we demonstrate that vitamin D/VDR regulates PD-L1 expressi …
A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy.
Sun L, Yang N, Chen B, Bei Y, Kang Z, Zhang C, Zhang N, Xu P, Yang W, Wei J, Ke J, Sun W, Li X, Shen P. Sun L, et al. Acta Pharm Sin B. 2023 Jul;13(7):3027-3042. doi: 10.1016/j.apsb.2023.05.007. Epub 2023 May 16. Acta Pharm Sin B. 2023. PMID: 37521858 Free PMC article.
Interestingly, the generation and release of NE-packaged EVs could be dramatically increased by vitamin D receptor (VDR) activation in UC-MSC. Chemical activation of VDR by using its agonist 1alpha,25-dihydroxyvitamin D3 efficiently enhanced the pro-differentiation …
Interestingly, the generation and release of NE-packaged EVs could be dramatically increased by vitamin D receptor (VDR) activation i …
Human myeloid differentiation by BMP4 signaling through the VDR pathway in acute myeloid leukemia.
Zylbersztejn F, Byelinska I, Jeanpierre S, Barral L, Geistlich K, Flores-Violante M, Voeltzel T, Paubelle E, Heiblig M, Alcazer V, Le Meur G, Fossard G, Belhabri A, Cruz-Moura I, Hermine O, Lefort S, Maguer-Satta V. Zylbersztejn F, et al. Cell Death Discov. 2024 Jul 16;10(1):325. doi: 10.1038/s41420-024-02090-4. Cell Death Discov. 2024. PMID: 39013874 Free PMC article. No abstract available.
Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D.
Gleba JJ, Kłopotowska D, Banach J, Turlej E, Mielko KA, Gębura K, Bogunia-Kubik K, Kutner A, Wietrzyk J. Gleba JJ, et al. Cancers (Basel). 2022 Jan 13;14(2):387. doi: 10.3390/cancers14020387. Cancers (Basel). 2022. PMID: 35053549 Free PMC article.
The study aimed to determine whether polymorphism of VDR is responsible for the sensitivity of human leukemia and lymphoma cells to calcitriol and tacalcitol. ...Subsequently, the levels of the VDR and 1,25D(3)-MARRS proteins of calcitriol and tacalcitol bind …
The study aimed to determine whether polymorphism of VDR is responsible for the sensitivity of human leukemia and lymphoma cel …
Nuclear Receptors as Potential Therapeutic Targets for Myeloid Leukemia.
Pan P, Chen X. Pan P, et al. Cells. 2020 Aug 19;9(9):1921. doi: 10.3390/cells9091921. Cells. 2020. PMID: 32824945 Free PMC article. Review.
The nuclear receptor (NR) superfamily has been studied extensively in many solid tumors and some receptors have been targeted to develop therapies. However, their roles in leukemia are less clear and vary considerably among different types of leukemia. Some NRs part …
The nuclear receptor (NR) superfamily has been studied extensively in many solid tumors and some receptors have been targeted to develop the …
Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1.
Iriani A, Rachman A, Fatina MK, Gemilang RK, Trisnandi A, Nugraha MFI. Iriani A, et al. Mol Biol Rep. 2024 Apr 17;51(1):526. doi: 10.1007/s11033-024-09432-6. Mol Biol Rep. 2024. PMID: 38632160
BACKGROUND: Vitamin D deficiency is prevalent among the Indonesian population, particularly in individuals diagnosed with leukemia-lymphoma. The regulation of vitamin D metabolism is influenced by the expression of several enzymes, such as CYP2R1, CYP24A1, and the vitamin …
BACKGROUND: Vitamin D deficiency is prevalent among the Indonesian population, particularly in individuals diagnosed with leukemia-ly …
Loss of the vitamin D receptor triggers senescence in chronic myeloid leukemia via DDIT4-mediated DNA damage.
Xu Y, Qi W, Zheng C, Li Y, Lu Z, Guan J, Lu C, Zhao B. Xu Y, et al. J Mol Cell Biol. 2024 Apr 4;15(10):mjad066. doi: 10.1093/jmcb/mjad066. J Mol Cell Biol. 2024. PMID: 37880985 Free PMC article.
Here, we revealed the requirement of the vitamin D receptor (VDR) in the progression of CML. VDR was upregulated by BCR::ABL1 and highly expressed in CML cells. ...Mechanistically, VDR transcriptionally regulated DDIT4 expression; reduced DDIT4 levels upon …
Here, we revealed the requirement of the vitamin D receptor (VDR) in the progression of CML. VDR was upregulated by BCR::ABL1 …
Vitamin D receptor polymorphisms and cancer.
Gandini S, Gnagnarella P, Serrano D, Pasquali E, Raimondi S. Gandini S, et al. Adv Exp Med Biol. 2014;810:69-105. doi: 10.1007/978-1-4939-0437-2_5. Adv Exp Med Biol. 2014. PMID: 25207361 Review.
It was suggested that vitamin D levels influence cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. In fact It has been hypothesized that polymorphisms in the VDR gene affect cancer risk and the relevance of …
It was suggested that vitamin D levels influence cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellu …
A chemically adjustable BMP6-IL6 axis in mesenchymal stem cells drives acute myeloid leukemia cell differentiation.
Sun L, Rao S, Kerim K, Lu J, Li H, Zhao S, Shen P, Sun W. Sun L, et al. Biochem Pharmacol. 2024 Jul;225:116262. doi: 10.1016/j.bcp.2024.116262. Epub 2024 May 3. Biochem Pharmacol. 2024. PMID: 38705535
Chemotherapy alone or in combination with allogeneic stem cell transplantation has been the standard of care for acute myeloid leukemia (AML) for decades. Leukemia relapse with limited treatment options remains the main cause of treatment failure. ...Mesenchymal ste …
Chemotherapy alone or in combination with allogeneic stem cell transplantation has been the standard of care for acute myeloid leukemia …
201 results