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519 results

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Page 1
Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential.
Ren Y, DeRose K, Li L, Gallucci JC, Yu J, Douglas Kinghorn A. Ren Y, et al. Bioorg Med Chem. 2023 Sep 7;92:117439. doi: 10.1016/j.bmc.2023.117439. Epub 2023 Aug 9. Bioorg Med Chem. 2023. PMID: 37579526 Free PMC article. Review.
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and treatment of cerebrovascular disorders and insufficiencies. ...Also, discussed herein are the design of the potential vincamine-based …
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and t …
Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice.
Xu JW, Xu X, Ling Y, Wang YC, Huang YJ, Yang JZ, Wang JY, Shen X. Xu JW, et al. Acta Pharmacol Sin. 2023 Dec;44(12):2388-2403. doi: 10.1038/s41401-023-01135-1. Epub 2023 Aug 14. Acta Pharmacol Sin. 2023. PMID: 37580494 Free PMC article.
G-protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells, but also in spinal dorsal horn and dorsal root ganglion (DRG) neurons, regulating neuropathic pain. We previously have reported that vincamine (Vin), a monoterpenoid indole alkaloid …
G-protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells, but also in spinal dorsal horn and dorsal root ga …
Evaluation of vincamine against Acetylcholinesterase enzyme.
Syed Sayeed Ahmad, Khatoon A, Sajid Khan M, Khalid M, Alharbi AM, Siddiqui MH. Syed Sayeed Ahmad, et al. Cell Mol Biol (Noisy-le-grand). 2022 Jul 31;68(7):14-21. doi: 10.14715/cmb/2022.68.7.3. Cell Mol Biol (Noisy-le-grand). 2022. PMID: 36495525
Computationally, it confirmed the interaction between vincamine and AChE at an indistinguishable locus from that of substrate AChI (-3.94 kcal/mol) but with much higher binding energy. ...Thus, the present computational and enzyme kinetics studies conclude that vincamin …
Computationally, it confirmed the interaction between vincamine and AChE at an indistinguishable locus from that of substrate AChI (- …
Vincamine Mitigates Methotrexate-Induced Liver Fibrosis Model.
Ürün YY, Güner G, Bora ES, Taşkın AB, Ürün M, Erbaş O. Ürün YY, et al. Turk J Gastroenterol. 2025 Jun 23;36(10):641-648. doi: 10.5152/tjg.2025.24716. Turk J Gastroenterol. 2025. PMID: 41084779 Free PMC article.
This study examined the hepatoprotective properties of vincamine and its potential therapeutic application in treating liver damage caused by methotrexate in rats. ...Vincamine treatment effectively protected against liver injury, and histopathological examination o …
This study examined the hepatoprotective properties of vincamine and its potential therapeutic application in treating liver damage c …
Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats.
Parlar Köprülü RE, Okur ME, Kolbaşi B, Keskin İ, Ozbek H. Parlar Köprülü RE, et al. Iran J Pharm Res. 2023 Jan 20;21(1):e132265. doi: 10.5812/ijpr-132265. eCollection 2022 Dec. Iran J Pharm Res. 2023. PMID: 36942057 Free PMC article.
METHODS: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). ...In the vincamine 20 mg/kg group, s …
METHODS: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-trea …
Vincamine ameliorates hepatic fibrosis via inhibiting S100A4-mediated farnesoid X receptor activation: based on liver microenvironment and enterohepatic circulation dependence.
Jiang YC, Guo J, Liu SH, Dai X, Wang CY, Lian LH, Cui ZY, Nan JX, Wu YL. Jiang YC, et al. Br J Pharmacol. 2025 Jun;182(11):2447-2465. doi: 10.1111/bph.17471. Epub 2025 Feb 12. Br J Pharmacol. 2025. PMID: 39940076
BACKGROUND AND PURPOSE: Vincamine has extensive biological and pharmaceutical activity. We examined the hepatoprotective effects and mechanisms by which vincamine suppresses hepatic fibrosis. ...Vincamine decreased inflammatory factors e.g. caspase 1 and IL-1 …
BACKGROUND AND PURPOSE: Vincamine has extensive biological and pharmaceutical activity. We examined the hepatoprotective effects and …
Vincamine Ameliorates Epithelial-Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis in Rats; Targeting TGF-beta/MAPK/Snai1 Pathway.
Alaaeldin R, Mohyeldin RH, Bekhit AA, Gomaa W, Zhao QL, Fathy M. Alaaeldin R, et al. Molecules. 2023 Jun 9;28(12):4665. doi: 10.3390/molecules28124665. Molecules. 2023. PMID: 37375218 Free PMC article.
SOD and GPX were also increased following vincamine treatment, while MDA levels were decreased. Additionally, vincamine suppressed the expression of p53, Bax, TWIST, Snail, and Slug genes as well as the expression of factors such as TGF-beta1, p/t p38 MAPK, p/t ERK1 …
SOD and GPX were also increased following vincamine treatment, while MDA levels were decreased. Additionally, vincamine suppre …
Vincamine, a safe natural alkaloid, represents a novel anticancer agent.
Al-Rashed S, Baker A, Ahmad SS, Syed A, Bahkali AH, Elgorban AM, Khan MS. Al-Rashed S, et al. Bioorg Chem. 2021 Feb;107:104626. doi: 10.1016/j.bioorg.2021.104626. Epub 2021 Jan 7. Bioorg Chem. 2021. PMID: 33450545
Vincamine was also found to quench hydroxyl free radicals and deplete iron ions in cancer cells. As a dietary supplement, vincamine is almost non-toxic in BEAS-2B and 3T3-L1 cells. Therefore, we propose that vincamine represents a safe anticancer agent in lun …
Vincamine was also found to quench hydroxyl free radicals and deplete iron ions in cancer cells. As a dietary supplement, vincamin …
Vincamine, an active constituent of Vinca rosea ameliorates experimentally induced acute lung injury in Swiss albino mice through modulation of Nrf-2/NF-kappaB signaling cascade.
Patangrao Renushe A, Kumar Banothu A, Kumar Bharani K, Mekala L, Mahesh Kumar J, Neeradi D, Durga Veera Hanuman D, Gadige A, Khurana A. Patangrao Renushe A, et al. Int Immunopharmacol. 2022 Jul;108:108773. doi: 10.1016/j.intimp.2022.108773. Epub 2022 Apr 20. Int Immunopharmacol. 2022. PMID: 35453074
It was observed that vincamine at the dose of 40 mg/kg, significantly reduced LPS induced inflammatory cell count in blood and in bronchoalveolar lavage (BAL) fluid. ...Interestingly, histological changes were reversed in vincamine treated groups in a dose-dependent …
It was observed that vincamine at the dose of 40 mg/kg, significantly reduced LPS induced inflammatory cell count in blood and in bro …
Pharmacokinetics and metabolism of vincamine and related compounds.
Vereczkey L. Vereczkey L. Eur J Drug Metab Pharmacokinet. 1985 Apr-Jun;10(2):89-103. doi: 10.1007/BF03189702. Eur J Drug Metab Pharmacokinet. 1985. PMID: 3899662 Review.
The pharmacokinetics and metabolism of vincamine, vinpocetine, methylene-methoxy-apovincaminic acid ester and eburnamine have been reviewed. ...Vincamine and its derivatives show significant differences in metabolic pathway and their elimination is rapid in the spec …
The pharmacokinetics and metabolism of vincamine, vinpocetine, methylene-methoxy-apovincaminic acid ester and eburnamine have been re …
519 results