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36 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Vinpocetine, cognition, and epilepsy.
Meador KJ, Leeman-Markowski B, Medina AE, Illamola SM, Seliger J, Novak G, Lin C, Ivanisevic M, Razavi B, Marino S, Boyd A, Loring DW. Meador KJ, et al. Epilepsy Behav. 2021 Jun;119:107988. doi: 10.1016/j.yebeh.2021.107988. Epub 2021 May 3. Epilepsy Behav. 2021. PMID: 33957389 Clinical Trial.
No appreciable side effects occurred. Vinpocetine and AVA levels were lower in humans than animals. CONCLUSIONS: Vinpocetine was well tolerated, but was not associated with positive cognitive effects. ...This suggests that higher dosages are needed in humans to asse …
No appreciable side effects occurred. Vinpocetine and AVA levels were lower in humans than animals. CONCLUSIONS: Vinpocetine w …
Vinpocetine for cognitive impairment and dementia.
Szatmari SZ, Whitehouse PJ. Szatmari SZ, et al. Cochrane Database Syst Rev. 2003;2003(1):CD003119. doi: 10.1002/14651858.CD003119. Cochrane Database Syst Rev. 2003. PMID: 12535455 Free PMC article.
BACKGROUND: Vinpocetine is a synthetic ethyl ester of apovincamine, a vinca alkaloid obtained from the leaves of the Lesser Periwinkle (Vinca minor) and discovered in the late 1960s. ...The manufacturers of vinpocetine were asked for information on trials of vinp …
BACKGROUND: Vinpocetine is a synthetic ethyl ester of apovincamine, a vinca alkaloid obtained from the leaves of the Lesser Periwinkl …
Safety and Efficacy of Vinpocetine as a Neuroprotective Agent in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
Panda PK, Ramachandran A, Panda P, Sharawat IK. Panda PK, et al. Neurocrit Care. 2022 Aug;37(1):314-325. doi: 10.1007/s12028-022-01499-y. Epub 2022 Apr 29. Neurocrit Care. 2022. PMID: 35488169 Free PMC article.
BACKGROUND: Vinpocetine as a neuroprotective agent is effective in acute ischemic stroke in some randomized controlled trials (RCTs). ...RESULTS: Four placebo-controlled RCTs enrolling a total of 601 and 236 patients in vinpocetine and placebo groups, respectively, …
BACKGROUND: Vinpocetine as a neuroprotective agent is effective in acute ischemic stroke in some randomized controlled trials (RCTs). …
Extended-release vinpocetine: a possible adjuvant treatment for focal onset epileptic seizures.
Garza-Morales S, Briceño-González E, Ceja-Moreno H, Ruiz-Sandoval JL, Góngora-Rivera F, Rodríguez-Leyva I, Alonso-Rivera CG. Garza-Morales S, et al. Bol Med Hosp Infant Mex. 2019;76(5):215-224. doi: 10.24875/BMHIM.19000056. Bol Med Hosp Infant Mex. 2019. PMID: 31536041 Clinical Trial. English.
No significant differences in the presence of adverse effects in patients treated with vinpocetine compared to those treated with placebo were observed. The most frequent adverse events observed with vinpocetine were headache (7.9%) and diplopia (5.2%). ...Vinpoc …
No significant differences in the presence of adverse effects in patients treated with vinpocetine compared to those treated with pla …
Combination of Vinpocetine and Dexamethasone Alleviates Cognitive Impairment in Nasopharyngeal Carcinoma Patients following Radiation Injury.
Zhang P, Cao Y, Chen S, Shao L. Zhang P, et al. Pharmacology. 2021;106(1-2):37-44. doi: 10.1159/000506777. Epub 2020 Apr 15. Pharmacology. 2021. PMID: 32294652 Clinical Trial.
Principally, toll-like receptors (TLRs) could regulate the inflammatory/anti-inflammatory balance in patients with radiation-induced brain injury. Vinpocetine has an anti-inflammatory effect as shown in both animal and in vitro studies. ...Thus, it is important to test whe …
Principally, toll-like receptors (TLRs) could regulate the inflammatory/anti-inflammatory balance in patients with radiation-induced brain i …
Vinpocetine treatment in acute ischaemic stroke: a pilot single-blind randomized clinical trial.
Feigin VL, Doronin BM, Popova TF, Gribatcheva EV, Tchervov DV. Feigin VL, et al. Eur J Neurol. 2001 Jan;8(1):81-5. doi: 10.1046/j.1468-1331.2001.00181.x. Eur J Neurol. 2001. PMID: 11509086 Clinical Trial.

The patients were randomly allocated to receive either low-molecular weight dextran alone or in combination with vinpocetine. Poor outcome was defined as being dead or having a Barthel index of < 70 or a Rankin score of 3--5. ...This pilot study shows that a full-scale

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The patients were randomly allocated to receive either low-molecular weight dextran alone or in combination with vinpocetine. Poor ou …
Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders-a randomized controlled clinical study.
Alkuraishy HM, Al-Gareeb AI, Albuhadilly AK. Alkuraishy HM, et al. Biomed Res Int. 2014;2014:324307. doi: 10.1155/2014/324307. Epub 2014 Dec 7. Biomed Res Int. 2014. PMID: 25548768 Free PMC article. Clinical Trial.

Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosit

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Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine …
Efficacy and tolerance of vinpocetine in ambulant patients suffering from mild to moderate organic psychosyndromes.
Hindmarch I, Fuchs HH, Erzigkeit H. Hindmarch I, et al. Int Clin Psychopharmacol. 1991 Spring;6(1):31-43. doi: 10.1097/00004850-199100610-00005. Int Clin Psychopharmacol. 1991. PMID: 2071888 Clinical Trial.
Vinpocetine was also superior to placebo in ratings of the "severity of illness". This study demonstrates the usefulness and efficacy of vinpocetine in the management of patients with moderate organic psychosyndromes. An apparently greater therapeutic efficacy of 3 …
Vinpocetine was also superior to placebo in ratings of the "severity of illness". This study demonstrates the usefulness and efficacy …
Efficacy and Safety of Vinpocetine as Part of Treatment for Acute Cerebral Infarction: A Randomized, Open-Label, Controlled, Multicenter CAVIN (Chinese Assessment for Vinpocetine in Neurology) Trial.
Zhang W, Huang Y, Li Y, Tan L, Nao J, Hu H, Zhang J, Li C, Kong Y, Song Y. Zhang W, et al. Clin Drug Investig. 2016 Sep;36(9):697-704. doi: 10.1007/s40261-016-0415-x. Clin Drug Investig. 2016. PMID: 27283947 Clinical Trial.
Importantly, such effects of vinpocetine were maintained over time. In addition, TCD monitoring showed significantly increased cerebral blood flow associated with vinpocetine versus control. ...Vinpocetine could be an effective and safe component of treatment …
Importantly, such effects of vinpocetine were maintained over time. In addition, TCD monitoring showed significantly increased cerebr …
Acute and chronic effects of vinpocetine on cerebral hemodynamics and neuropsychological performance in multi-infarct patients.
Kemény V, Molnár S, Andrejkovics M, Makai A, Csiba L. Kemény V, et al. J Clin Pharmacol. 2005 Sep;45(9):1048-54. doi: 10.1177/0091270005279363. J Clin Pharmacol. 2005. PMID: 16100299 Clinical Trial.
No serious side effect was found in the vinpocetine group. The flow velocities were significantly lower in the acute phase after breath holding in the vinpocetine group than in the placebo group. Three months later, the vinpocetine patients did not show any s …
No serious side effect was found in the vinpocetine group. The flow velocities were significantly lower in the acute phase after brea …
36 results