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39 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Antivenom therapy of carpet viper (Echis ocellatus) envenoming: effectiveness and strategies for delivery in West Africa.
Habib AG, Warrell DA. Habib AG, et al. Toxicon. 2013 Jul;69:82-9. doi: 10.1016/j.toxicon.2013.01.002. Epub 2013 Jan 20. Toxicon. 2013. PMID: 23339853 Review.
Mortality more than doubled during times when stocks of reliable antivenoms ran out, with Relative Risk (95% CI)] of 2.33 (1.26-4.06). Serum kinetics of venom antigen/antivenom levels also confirmed that decline of venom antigen levels coincided with resolution of c …
Mortality more than doubled during times when stocks of reliable antivenoms ran out, with Relative Risk (95% CI)] of 2.33 (1.26-4.06). Serum …
Systematic review and meta-analysis on the efficacy of Indian polyvalent antivenom against the Indian snakes of clinical significance.
Gopal G, Selvaraj H, Venkataramanan SK, Venkataraman S, Saravanan K, Bibina C, Ambi SV. Gopal G, et al. Arch Toxicol. 2024 Feb;98(2):375-393. doi: 10.1007/s00204-023-03643-9. Epub 2023 Dec 28. Arch Toxicol. 2024. PMID: 38153416 Review.
Indian polyvalent antivenom, a scientifically validated medicine for treating the toxic effects of snakebites, is available against the venom of the so-called Big Four snakes namely Spectacled cobra (Naja naja), Saw-scaled viper (Echis carinatus), Russell's viper …
Indian polyvalent antivenom, a scientifically validated medicine for treating the toxic effects of snakebites, is available against the v …
Crotalidae polyvalent immune Fab: in patients with North American crotaline envenomation.
Keating GM. Keating GM. BioDrugs. 2011 Apr 1;25(2):69-76. doi: 10.2165/11207250-000000000-00000. BioDrugs. 2011. PMID: 21443271 Review.
Crotalidae polyvalent immune Fab is produced using four North American snake venoms: Crotalus atrox, Crotalus adamanteus, Crotalus scutulatus, and Agkistrodon piscivorus. ...Despite treatment with crotalidae polyvalent immune Fab, patients may experience delayed-onset or r …
Crotalidae polyvalent immune Fab is produced using four North American snake venoms: Crotalus atrox, Crotalus adamanteus, Crotalus sc …
Clinical study of anti-snake venom blockade in the treatment of local tissue necrosis caused by Chinese cobra (Naja atra) bites.
Zeng L, Hou J, Ge C, Li Y, Gao J, Zhang C, Huang P, Du J, Mo Z, Liu Y, Zeng Z. Zeng L, et al. PLoS Negl Trop Dis. 2022 Dec 16;16(12):e0010997. doi: 10.1371/journal.pntd.0010997. eCollection 2022 Dec. PLoS Negl Trop Dis. 2022. PMID: 36525460 Free PMC article. Clinical Trial.
OBJECTIVE: This study aimed to evaluate the clinical therapeutic efficacy of anti-snake venom serum blockade in treating local tissue necrosis caused by Chinese cobra (Naja atra) bites. ...The experimental group received regular as well as anti-snake venom serum blo …
OBJECTIVE: This study aimed to evaluate the clinical therapeutic efficacy of anti-snake venom serum blockade in treating local tissue …
Subacute coagulopathy in a randomized, comparative trial of Fab and F(ab')2 antivenoms.
Boyer LV, Chase PB, Degan JA, Figge G, Buelna-Romero A, Luchetti C, Alagón A. Boyer LV, et al. Toxicon. 2013 Nov;74:101-8. doi: 10.1016/j.toxicon.2013.07.018. Epub 2013 Aug 13. Toxicon. 2013. PMID: 23948058 Clinical Trial.
CONCLUSIONS: Following the acute phase of presentation and treatment for pit viper envenomation, there appears to be a roughly 2-week subacute phase of the disease during which ongoing presence of venom may result in serious delayed or recurrent coagulation defects. …
CONCLUSIONS: Following the acute phase of presentation and treatment for pit viper envenomation, there appears to be a roughly 2-week …
A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming.
Isbister GK, Jayamanne S, Mohamed F, Dawson AH, Maduwage K, Gawarammana I, Lalloo DG, de Silva HJ, Scorgie FE, Lincz LF, Buckley NA. Isbister GK, et al. J Thromb Haemost. 2017 Apr;15(4):645-654. doi: 10.1111/jth.13628. Epub 2017 Feb 16. J Thromb Haemost. 2017. PMID: 28106331 Free PMC article. Clinical Trial.
Essentials Russell's viper envenoming is a major health issue in South Asia and causes coagulopathy. We studied the effect of fresh frozen plasma and two antivenom doses on correcting coagulopathy. ...Low-dose antivenom did not worsen coagulopathy. SUMMARY: Background Russ …
Essentials Russell's viper envenoming is a major health issue in South Asia and causes coagulopathy. We studied the effect of fresh f …
Recovery from Copperhead Snake Envenomation: Role of Age, Sex, Bite Location, Severity, and Treatment.
Lavonas EJ, Burnham RI, Schwarz J, Quackenbush E, Lewis B, Rose SR, Greene S, Toschlog EA, Charlton NP, Mullins ME, Schwartz R, Denning D, Sharma K, Kleinschmidt K, Bush SP, Anderson VE, Ginde AA, Gerardo CJ. Lavonas EJ, et al. J Med Toxicol. 2020 Jan;16(1):17-23. doi: 10.1007/s13181-019-00733-y. Epub 2019 Sep 3. J Med Toxicol. 2020. PMID: 31482319 Free PMC article. Clinical Trial.
INTRODUCTION: Few data exist to understand the recovery phase of pit viper envenomation. A recently published placebo-controlled clinical trial affords this opportunity. ...
INTRODUCTION: Few data exist to understand the recovery phase of pit viper envenomation. A recently published placebo-controlled clin …
Comparison of Montanide adjuvants, IMS 3012 (Nanoparticle), ISA 206 and ISA 35 (Emulsion based) along with incomplete Freund's adjuvant for hyperimmunization of equines used for production of polyvalent snake antivenom.
Waghmare A, Deopurkar RL, Salvi N, Khadilkar M, Kalolikar M, Gade SK. Waghmare A, et al. Vaccine. 2009 Feb 11;27(7):1067-72. doi: 10.1016/j.vaccine.2008.11.103. Epub 2008 Dec 25. Vaccine. 2009. PMID: 19100805 Clinical Trial.
The present study was conducted in 33 new horses, randomly divided into four groups and hyperimmunized using crude mixture of snake venoms, viz.; Cobra venom (CV), Russell's viper venom (RV), Krait venom (KV) and Saw-scaled viper (EV) alo …
The present study was conducted in 33 new horses, randomly divided into four groups and hyperimmunized using crude mixture of snake venom …
A randomized, double-blind, placebo-controlled trial of antivenom for local effects of green pit viper bites.
Rojnuckarin P, Chanthawibun W, Noiphrom J, Pakmanee N, Intragumtornchai T. Rojnuckarin P, et al. Trans R Soc Trop Med Hyg. 2006 Sep;100(9):879-84. doi: 10.1016/j.trstmh.2005.10.006. Epub 2006 Feb 8. Trans R Soc Trop Med Hyg. 2006. PMID: 16466758 Clinical Trial.
Although systemic administration of antivenom can promptly reverse coagulopathy, efficacy on local effects of viper venom remains to be determined. Currently, there has been no proven specific treatment for snakebite patients with severe local effects. ...The reduct …
Although systemic administration of antivenom can promptly reverse coagulopathy, efficacy on local effects of viper venom rema …
A Randomized Controlled Trial to Optimize Antivenom Therapy for Carpet Viper (Echis romani)-Envenomed Children in Nigeria.
Hamman NA, Ibrahim AD, Hamza M, Jahun MG, Micah M, Lawal HA, Abubakar SB, Iliyasu G, Chedi BAZ, Mohammed I, Harrison RA, Gutiérrez JM, Habib AG. Hamman NA, et al. Am J Trop Med Hyg. 2024 Aug 6;111(4):904-910. doi: 10.4269/ajtmh.24-0222. Print 2024 Oct 2. Am J Trop Med Hyg. 2024. PMID: 39106853 Clinical Trial.
In an open randomized controlled trial, we compared one vial (10 mL) to two vials (20 mL) of EchiTAb-plus-ICP (EPI) antivenom among children with systemic carpet viper (Echis romani) envenoming of moderate severity in northeastern Nigeria. Systemic envenoming, presenting w …
In an open randomized controlled trial, we compared one vial (10 mL) to two vials (20 mL) of EchiTAb-plus-ICP (EPI) antivenom among children …
39 results