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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1905 1
1909 1
1910 1
1911 1
1912 1
1913 1
1914 2
1915 2
1917 1
1918 1
1920 4
1921 3
1922 4
1923 1
1924 4
1925 2
1926 7
1927 6
1928 4
1930 6
1931 2
1932 2
1933 2
1936 4
1937 2
1938 1
1939 1
1940 2
1942 1
1944 1
1945 1
1946 6
1947 3
1948 5
1949 2
1950 3
1951 3
1952 8
1953 9
1954 8
1955 11
1956 29
1957 18
1958 20
1959 18
1960 5
1961 7
1962 2
1963 13
1964 10
1965 36
1966 87
1967 165
1968 173
1969 242
1970 394
1971 448
1972 291
1973 290
1974 274
1975 393
1976 303
1977 263
1978 283
1979 298
1980 335
1981 346
1982 430
1983 524
1984 642
1985 718
1986 696
1987 761
1988 819
1989 987
1990 1129
1991 1224
1992 1370
1993 1385
1994 1533
1995 1642
1996 1671
1997 1805
1998 2010
1999 2176
2000 2523
2001 2813
2002 2902
2003 3391
2004 3602
2005 3854
2006 4166
2007 4329
2008 4435
2009 4756
2010 5362
2011 6437
2012 6603
2013 6096
2014 5949
2015 6280
2016 6471
2017 6900
2018 7245
2019 7518
2020 8726
2021 8513
2022 6229
2023 5485
2024 6973
2025 9142
2026 4489

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163,669 results

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Page 1
Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes.
Hafner L, Gadin E, Huang L, Frouin A, Laporte F, Gaultier C, Vieira A, Maudet C, Varet H, Moura A, Bracq-Dieye H, Tessaud-Rita N, Maury M, Dazas M, Legendre R, Gastineau P, Tsai YH, Coppée JY, Charlier C, Patin E, Chikhi R, Rocha EPC, Leclercq A, Disson O, Aschard H, Lecuit M. Hafner L, et al. Nat Microbiol. 2024 Dec;9(12):3345-3361. doi: 10.1038/s41564-024-01859-8. Epub 2024 Nov 22. Nat Microbiol. 2024. PMID: 39578578
Microbial pathogenesis is mediated by the expression of virulence genes. However, as microbes with identical virulence gene content can differ in their pathogenic potential, other virulence determinants must be involved. ...The tuning of SigB pathway r …
Microbial pathogenesis is mediated by the expression of virulence genes. However, as microbes with identical virulence gene co …
Spike gene variability in porcine epidemic diarrhea virus as a determinant for virulence.
Li W, Hangalapura BN, van den Elzen P, van den Born E, van Kuppeveld FJM, Rottier PJM, Bosch B-J. Li W, et al. J Virol. 2025 Mar 18;99(3):e0216524. doi: 10.1128/jvi.02165-24. Epub 2025 Feb 26. J Virol. 2025. PMID: 40001283 Free PMC article.
In this study, we explored the impact of spike gene variability on PEDV pathogenicity. Using targeted RNA recombination, we generated recombinant PEDV (rPEDV) variants carrying spike genes from contemporary strains (moderately virulent strain UU and highly virule …
In this study, we explored the impact of spike gene variability on PEDV pathogenicity. Using targeted RNA recombination, we generated …
Adaptation and Virulence of Enterovirus-A71.
Kobayashi K, Koike S. Kobayashi K, et al. Viruses. 2021 Aug 21;13(8):1661. doi: 10.3390/v13081661. Viruses. 2021. PMID: 34452525 Free PMC article. Review.
Outbreaks with many fatalities have occurred sporadically in the Asia-Pacific region and have become a serious public health concern. It is hypothesized that virulent mutations in the EV-A71 genome cause these occasional outbreaks. Analysis of EV-A71 neurovirulence …
Outbreaks with many fatalities have occurred sporadically in the Asia-Pacific region and have become a serious public health concern. It is …
The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China.
Jin Y, Zhou W, Yin Z, Zhang S, Chen Y, Shen P, Ji J, Chen W, Zheng B, Xiao Y. Jin Y, et al. Emerg Microbes Infect. 2021 Dec;10(1):1052-1064. doi: 10.1080/22221751.2021.1914516. Emerg Microbes Infect. 2021. PMID: 33823746 Free PMC article.
To address this issue, here, we described thirteen ST338 CA-MRSA strains isolated from severe bloodstream infection cases, and focused on their epidemiology, genetic features and virulence potential. Phylogenetic analysis showed the earliest isolated strain of this …
To address this issue, here, we described thirteen ST338 CA-MRSA strains isolated from severe bloodstream infection cases, and focused on th …
Genetic and structural analysis of a virulence determinant in polyomavirus VP1.
Bauer PH, Bronson RT, Fung SC, Freund R, Stehle T, Harrison SC, Benjamin TL. Bauer PH, et al. J Virol. 1995 Dec;69(12):7925-31. doi: 10.1128/JVI.69.12.7925-7931.1995. J Virol. 1995. PMID: 7494305 Free PMC article.
By constructing and assaying LID-PTA recombinant viruses and by DNA sequencing, the determinant of virulence in LID was mapped to the major viral capsid protein, VP1. The VP1s of LID and PTA differed at two positions: at 185, LID has phenylalanine and PTA has tyrosi …
By constructing and assaying LID-PTA recombinant viruses and by DNA sequencing, the determinant of virulence in LID was mapped …
Novel swine virulence determinant in the left variable region of the African swine fever virus genome.
Neilan JG, Zsak L, Lu Z, Kutish GF, Afonso CL, Rock DL. Neilan JG, et al. J Virol. 2002 Apr;76(7):3095-104. doi: 10.1128/jvi.76.7.3095-3104.2002. J Virol. 2002. PMID: 11884534 Free PMC article.
Our recent observations that NL gene deletion mutants of two additional pathogenic ASFV isolates, Malawi Lil-20/1 and Pr4, remained highly virulent in swine (100% mortality) suggested that these isolates encoded an additional virulence determinant(s) that was …
Our recent observations that NL gene deletion mutants of two additional pathogenic ASFV isolates, Malawi Lil-20/1 and Pr4, remained highly …
Evolutionary insights into the emergence of virulent Leptospira spirochetes.
Giraud-Gatineau A, Nieves C, Harrison LB, Benaroudj N, Veyrier FJ, Picardeau M. Giraud-Gatineau A, et al. PLoS Pathog. 2024 Jul 17;20(7):e1012161. doi: 10.1371/journal.ppat.1012161. eCollection 2024 Jul. PLoS Pathog. 2024. PMID: 39018329 Free PMC article.
Here, we use a recently described lineage of environmental-adapted leptospires, which are evolutionarily the closest relatives of the highly virulent Leptospira species, to explore the key phenotypic traits and genetic determinants of Leptospira virulence. .. …
Here, we use a recently described lineage of environmental-adapted leptospires, which are evolutionarily the closest relatives of the highly …
Cryptosporidium virulence determinants--are we there yet?
Okhuysen PC, Chappell CL. Okhuysen PC, et al. Int J Parasitol. 2002 May;32(5):517-25. doi: 10.1016/s0020-7519(01)00356-3. Int J Parasitol. 2002. PMID: 11943224 Review.
To date, no specific virulence factors have been unequivocally shown to individually cause direct or indirect damage to host tissues nor have mutant strains been produced that could prove that particular deletions result in less virulent strains. ...Here, we review …
To date, no specific virulence factors have been unequivocally shown to individually cause direct or indirect damage to host tissues …
Advances in the quest for virulence factors of Haemophilus parasuis.
Costa-Hurtado M, Aragon V. Costa-Hurtado M, et al. Vet J. 2013 Dec;198(3):571-6. doi: 10.1016/j.tvjl.2013.08.027. Epub 2013 Sep 4. Vet J. 2013. PMID: 24084037 Review.
Understanding the pathogenicity of H. parasuis is essential for determining how this bacterium produces disease and to better distinguish between virulent and non-virulent strains. ...This review provides an overview of the current knowledge of viru …
Understanding the pathogenicity of H. parasuis is essential for determining how this bacterium produces disease and to better …
Global virulence regulation networks in phytopathogenic bacteria.
Mole BM, Baltrus DA, Dangl JL, Grant SR. Mole BM, et al. Trends Microbiol. 2007 Aug;15(8):363-71. doi: 10.1016/j.tim.2007.06.005. Epub 2007 Jul 12. Trends Microbiol. 2007. PMID: 17627825 Review.
Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulation networks. We dissect the global regulation of four distantly related model phytopathogens to evaluate large-scale events and mechanisms …
Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulat …
163,669 results
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