vitamin AND cardiovascular - Search Results

Year	Number of Results
1940	1
1945	5
1946	17
1947	16
1948	19
1949	27
1950	43
1951	33
1952	48
1953	53
1954	57
1955	46
1956	49
1957	39
1958	38
1959	50
1960	47
1961	34
1962	53
1963	111
1964	140
1965	96
1966	103
1967	144
1968	160
1969	203
1970	172
1971	197
1972	166
1973	141
1974	191
1975	145
1976	96
1977	109
1978	95
1979	105
1980	110
1981	118
1982	132
1983	147
1984	173
1985	173
1986	162
1987	183
1988	174
1989	207
1990	197
1991	249
1992	245
1993	275
1994	311
1995	373
1996	375
1997	421
1998	464
1999	537
2000	638
2001	659
2002	648
2003	709
2004	742
2005	786
2006	810
2007	834
2008	874
2009	909
2010	1032
2011	1107
2012	1181
2013	1256
2014	1383
2015	1433
2016	1352
2017	1376
2018	1434
2019	1423
2020	1557
2021	1509
2022	1445
2023	1270
2024	1316
2025	1404
2026	758

1

Vitamin D status and cardiovascular outcome.

Saponaro F, Marcocci C, Zucchi R. Saponaro F, et al. J Endocrinol Invest. 2019 Nov;42(11):1285-1290. doi: 10.1007/s40618-019-01057-y. Epub 2019 Jun 6. J Endocrinol Invest. 2019. PMID: 31172459 Review.

INTRODUCTION: Vitamin D is classically involved in maintaining bone and mineral health, but it has been shown to exert many extraskeletal functions, including pleiotropic effects on cardiovascular system. MATERIALS AND METHOD: This review aims to summarize ev …

INTRODUCTION: Vitamin D is classically involved in maintaining bone and mineral health, but it has been shown to exert many extraskel …

2

Vitamin K(2)-a neglected player in cardiovascular health: a narrative review.

Hariri E, Kassis N, Iskandar JP, Schurgers LJ, Saad A, Abdelfattah O, Bansal A, Isogai T, Harb SC, Kapadia S. Hariri E, et al. Open Heart. 2021 Nov;8(2):e001715. doi: 10.1136/openhrt-2021-001715. Open Heart. 2021. PMID: 34785587 Free PMC article. Review.

Vitamin K(2) serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. ...

Vitamin K(2) serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the …

3

Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke.

Muscogiuri G, Annweiler C, Duval G, Karras S, Tirabassi G, Salvio G, Balercia G, Kimball S, Kotsa K, Mascitelli L, Bhattoa HP, Colao A. Muscogiuri G, et al. Int J Cardiol. 2017 Mar 1;230:577-584. doi: 10.1016/j.ijcard.2016.12.053. Epub 2016 Dec 26. Int J Cardiol. 2017. PMID: 28043680 Review.

There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). ...Thus, the goal of this review is to provide an updated review of the literature on the basic science of how …

There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiova …

4

Vitamin D and cardiovascular disease: is the evidence solid?

Al Mheid I, Patel RS, Tangpricha V, Quyyumi AA. Al Mheid I, et al. Eur Heart J. 2013 Dec;34(48):3691-8. doi: 10.1093/eurheartj/eht166. Epub 2013 Jun 9. Eur Heart J. 2013. PMID: 23751422 Free PMC article. Review.

Low 25-OH D levels are associated with left ventricular hypertrophy, vascular dysfunction, and renin-angiotensin system activation. Despite a large body of experimental, cross-sectional, and prospective evidence implicating vitamin D deficiency in the pathogenesis o …

Low 25-OH D levels are associated with left ventricular hypertrophy, vascular dysfunction, and renin-angiotensin system activation. D …

5

Cardiovascular Diseases and Fat Soluble Vitamins: Vitamin D and Vitamin K.

Tsugawa N. Tsugawa N. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S170-2. doi: 10.3177/jnsv.61.S170. J Nutr Sci Vitaminol (Tokyo). 2015. PMID: 26598844 Free article. Review.

Recently, the associations between insufficiency of fat soluble vitamins and cardiovascular diseases (CVDs) have been reported. Vitamin D affects the cardiovascular system via several pathways, such as suppression of parathyroid hormone, the ren …

Recently, the associations between insufficiency of fat soluble vitamins and cardiovascular diseases (CVDs) have been reported …

6

Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases.

Pál É, Ungvári Z, Benyó Z, Várbíró S. Pál É, et al. Nutrients. 2023 Jan 9;15(2):334. doi: 10.3390/nu15020334. Nutrients. 2023. PMID: 36678205 Free PMC article. Review.

Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects approximately 24% to 40% of the population of the Western world. ...This brief overview focuses on the cardiovascular and cerebrovascular effects of VitD and the cellular, mo …

Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects approximately 24% to 40% of the populatio …

7

[Vitamin D deficiency and cardiovascular diseases].

Mascitelli L, Goldstein MR, Pezzetta F. Mascitelli L, et al. Recenti Prog Med. 2010 May;101(5):202-11. Recenti Prog Med. 2010. PMID: 20590017 Review. Italian.

However, it has become evident that adequate vitamin D status is important for optimal function of many organs and tissues throughout the body, including the cardiovascular system. ...The relationship between baseline vitamin D status, dose of vitam …

However, it has become evident that adequate vitamin D status is important for optimal function of many organs and tissues throughout …

8

Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients.

Cianciolo G, Cappuccilli M, Tondolo F, Gasperoni L, Zappulo F, Barbuto S, Iacovella F, Conte D, Capelli I, La Manna G. Cianciolo G, et al. Nutrients. 2021 Apr 25;13(5):1453. doi: 10.3390/nu13051453. Nutrients. 2021. PMID: 33922902 Free PMC article. Review.

This condition is further worsened by the compromised response of CKD patients to high-dose cholecalciferol supplementation due to the defective activation of renal hydroxylation of vitamin D. Currently, the literature lacks large and interventional studies on the so-calle …

This condition is further worsened by the compromised response of CKD patients to high-dose cholecalciferol supplementation due to the defec …

9

Putting cardiovascular disease and vitamin D insufficiency into perspective.

Zittermann A, Schleithoff SS, Koerfer R. Zittermann A, et al. Br J Nutr. 2005 Oct;94(4):483-92. doi: 10.1079/bjn20051544. Br J Nutr. 2005. PMID: 16197570 Free article. Review.

Interestingly, all these factors also have an influence on human UVB exposure and thus on vitamin D status. Several mechanisms might be responsible for a protective role of vitamin D in CVD. These mechanisms include the inhibition of vascular smooth muscle prolifera …

Interestingly, all these factors also have an influence on human UVB exposure and thus on vitamin D status. Several mechanisms might …

10

The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond.

AlMatar M, AlMandeal H, Makky EA, Kayar B, Yarar E, Var I, Koksal F. AlMatar M, et al. Curr Drug Metab. 2017;18(3):207-224. doi: 10.2174/1389200217666161207161212. Curr Drug Metab. 2017. PMID: 27928943 Review.

Notably, vitamin D status is more likely to be used as a lifestyle biomarker, since poor and unhealthy lifestyles are correlated with the deficiency of vitamin D, a feature which may result in cardiovascular complications. Moreover, recent reports revealed th …

Notably, vitamin D status is more likely to be used as a lifestyle biomarker, since poor and unhealthy lifestyles are correlated with …

11

Vitamin D and heart.

Camici M, Galetta F, Franzoni F, Carpi A, Zangeneh F. Camici M, et al. Intern Emerg Med. 2013 Apr;8 Suppl 1:S5-9. doi: 10.1007/s11739-013-0926-x. Intern Emerg Med. 2013. PMID: 23462894 Review.

The authors briefly review the biological effects of vitamin D on the heart and discuss the experimental and clinical studies related to the potential protective effect of vitamin D on the cardiovascular system. Experimental and observational studies i …

The authors briefly review the biological effects of vitamin D on the heart and discuss the experimental and clinical studies related …

12

Epimeric vitamin D and cardiovascular structure and function in advanced CKD and after kidney transplantation.

Arroyo E, Leber CA, Burney HN, Li Y, Li X, Lu TS, Jones G, Kaufmann M, Ting SMS, Hiemstra TF, Zehnder D, Lim K. Arroyo E, et al. Nephrol Dial Transplant. 2024 Jan 31;39(2):264-276. doi: 10.1093/ndt/gfad168. Nephrol Dial Transplant. 2024. PMID: 37468453 Free PMC article.

BACKGROUND: 25-hydroxyvitamin D can undergo C-3 epimerization to produce 3-epi-25(OH)D3. 3-epi-25(OH)D3 levels decline in chronic kidney disease (CKD), but its role in regulating the cardiovascular system is unknown. Herein, we examined the relationship between 3-ep …

BACKGROUND: 25-hydroxyvitamin D can undergo C-3 epimerization to produce 3-epi-25(OH)D3. 3-epi-25(OH)D3 levels decline in chronic kidney dis …

13

Vitamin neurotoxicity.

Snodgrass SR. Snodgrass SR. Mol Neurobiol. 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. Mol Neurobiol. 1992. PMID: 1463588 Review.

Because vitamin A and analogs enter the CNS better than most vitamins, and because retinoids have many effects on enzyme activity and gene expression, Vitamin A neurotoxicity is more likely than that of most, perhaps all other vitamins. Megadose vit …

Because vitamin A and analogs enter the CNS better than most vitamins, and because retinoids have many effects on enzyme activ …

14

Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.

Rozemeijer S, Hemilä H, van Baaren M, de Man AME. Rozemeijer S, et al. BMC Cardiovasc Disord. 2023 Sep 21;23(1):475. doi: 10.1186/s12872-023-03459-6. BMC Cardiovasc Disord. 2023. PMID: 37735625 Free PMC article.

RESULTS: We found seven controlled trials which included 872 patients. All included trials administered vitamin C intravenously, with a range from 1 to 16 g/day, and all initiated vitamin administration prior to the procedure. ...Vitamin C also significantly …

RESULTS: We found seven controlled trials which included 872 patients. All included trials administered vitamin C intravenously, with …

15

Assessment of vitamin B12 levels and cardiovascular risk factors in metformin- and non-metformin-treated type 2 diabetic patients.

Ilona Nyulas K, Cornelia Tilinca M, Pál S, Fogarasi EM, Croitoru MD, Gabriel Tripon R, Preg Z, Germán-Salló M, Simon-Szabó Z, Nemes-Nagy E. Ilona Nyulas K, et al. Pak J Pharm Sci. 2023 Sep;36(5):1399-1405. Pak J Pharm Sci. 2023. PMID: 37869915

Negative correlation occured between serum vitamin B(12) and HC, this vitamin's level was significantly lower and serum zinc was significantly higher in patients on metformin. ...Elevated hs-CRP and homocysteine represent raised cardiovascular risk. In …

Negative correlation occured between serum vitamin B(12) and HC, this vitamin's level was significantly lower and serum …

16

Supplemental calcium and vitamin D and long-term mortality in aortic stenosis.

Kassis N, Hariri EH, Karrthik AK, Ahuja KR, Layoun H, Saad AM, Gad MM, Kaur M, Bazarbashi N, Griffin BP, Popovic ZB, Harb SC, Desai MY, Kapadia SR. Kassis N, et al. Heart. 2022 May 25;108(12):964-972. doi: 10.1136/heartjnl-2021-320215. Heart. 2022. PMID: 35470234

Groups were stratified into no supplementation, supplementation with vitamin D alone and supplementation with calcium vitamin D. The primary outcomes were mortality (all-cause, cardiovascular (CV) and non-CV) and aortic valve replacement (AVR), and the second …

Groups were stratified into no supplementation, supplementation with vitamin D alone and supplementation with calcium vitamin …

17

Thiamine and Cardiovascular Disease: A Literature Review.

DiNicolantonio JJ, Liu J, O'Keefe JH. DiNicolantonio JJ, et al. Prog Cardiovasc Dis. 2018 May-Jun;61(1):27-32. doi: 10.1016/j.pcad.2018.01.009. Epub 2018 Jan 31. Prog Cardiovasc Dis. 2018. PMID: 29360523 Review.

Thiamine is a water-soluble vitamin that plays an important role in the energy metabolism in the human body. Deficiency in thiamine can lead to neurological abnormalities and congestive heart failure (HF), known as dry beriberi and wet beriberi respectively. ...This articl …

Thiamine is a water-soluble vitamin that plays an important role in the energy metabolism in the human body. Deficiency in thiamine c …

18

The Mutual Relationship among Cardiovascular Diseases and COVID-19: Focus on Micronutrients Imbalance.

Severino P, D'Amato A, Prosperi S, Myftari V, Labbro Francia A, Önkaya M, Notari C, Papisca I, Canuti ES, Yarden Revivo M, Birtolo LI, Celli P, Galardo G, Maestrini V, d'Ettorre G, Mancone M, Fedele F. Severino P, et al. Nutrients. 2022 Aug 21;14(16):3439. doi: 10.3390/nu14163439. Nutrients. 2022. PMID: 36014944 Free PMC article. Review.

The relationship between cardiovascular diseases and COVID-19 is mutual: the latter triggers cardiovascular disease onset and worsening while patients with previous cardiovascular disease may develop a more severe form of COVID-19. In addition to the well-kno …

The relationship between cardiovascular diseases and COVID-19 is mutual: the latter triggers cardiovascular disease onset and …

19

Vitamin C revisited.

Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Oudemans-van Straaten HM, et al. Crit Care. 2014 Aug 6;18(4):460. doi: 10.1186/s13054-014-0460-x. Crit Care. 2014. PMID: 25185110 Free PMC article. Review.

High-dose vitamin C, however, provides a cheap, strong and multifaceted antioxidant, especially robust for resuscitation of the circulation. Vitamin C given as early as possible after the injurious event, or before if feasible, seems most effective. ...

High-dose vitamin C, however, provides a cheap, strong and multifaceted antioxidant, especially robust for resuscitation of the circu …

20

Vitamin D deficiency and coronary artery disease: a review of the evidence.

Kunadian V, Ford GA, Bawamia B, Qiu W, Manson JE. Kunadian V, et al. Am Heart J. 2014 Mar;167(3):283-91. doi: 10.1016/j.ahj.2013.11.012. Epub 2013 Dec 19. Am Heart J. 2014. PMID: 24576510 Review.

Older patients are at particularly high risk of poor outcomes following acute coronary syndrome and impaired nutrition, including low vitamin D levels, may play a role. The extraskeletal effects of vitamin D, in particular, its role in maintaining a healthy cardi …

Older patients are at particularly high risk of poor outcomes following acute coronary syndrome and impaired nutrition, including low vit …

21

Association between vitamin D and cardioprotection in adult patients.

Ferraz GC, Andrade RR, Reis FMP, Oliveira Neto OB, Omena CO, Jucá MJ, Sousa-Rodrigues CF, Barbosa FT. Ferraz GC, et al. Rev Assoc Med Bras (1992). 2020 Oct;66(10):1444-1448. doi: 10.1590/1806-9282.66.10.1444. Rev Assoc Med Bras (1992). 2020. PMID: 33174941 Free article. Review.

RESULTS: Twenty-three articles were identified from the electronic search that reported on physiological mechanisms relating the vitamin D axis and the cardiovascular system through receptors. Of the ten studies that evaluated the therapeutic effect of vit …

RESULTS: Twenty-three articles were identified from the electronic search that reported on physiological mechanisms relating the vitamin …

22

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach.

Hill A, Wendt S, Benstoem C, Neubauer C, Meybohm P, Langlois P, Adhikari NK, Heyland DK, Stoppe C. Hill A, et al. Nutrients. 2018 Jul 27;10(8):974. doi: 10.3390/nu10080974. Nutrients. 2018. PMID: 30060468 Free PMC article. Review.

The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative s …

The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. …

23

Effects of vitamin supplements on clinical cardiovascular outcomes: Time to move on! - A comprehensive review.

Simsek B, Selte A, Egeli BH, Çakatay U. Simsek B, et al. Clin Nutr ESPEN. 2021 Apr;42:1-14. doi: 10.1016/j.clnesp.2021.02.014. Epub 2021 Feb 25. Clin Nutr ESPEN. 2021. PMID: 33745562 Free PMC article. Review.

METHODS: A thorough PubMed search with the phrase: "Vitamin supplements and cardiovascular health" was performed. In the present review, focus was maintained on the evidence for the use of vitamin supplements in the prevention of major cardiovascular e …

METHODS: A thorough PubMed search with the phrase: "Vitamin supplements and cardiovascular health" was performed. In the prese …

24

Association between dietary vitamin C and abdominal aortic calcification among the US adults.

Jia J, Zhang J, He Q, Wang M, Liu Q, Wang T, Chen X, Wang W, Xu H. Jia J, et al. Nutr J. 2023 Nov 15;22(1):58. doi: 10.1186/s12937-023-00889-y. Nutr J. 2023. PMID: 37964312 Free PMC article.

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality, and vascular calcification has been highly correlated with CVD events. ...However, the relationship of vitamin C supplements with AAC was not identified. CONCLUSIONS: The study revealed that …

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality, and vascular calcification has been highly correlated wit …

25

Blood-brain barrier dysfunction and folate and vitamin B12 levels in first-episode schizophrenia-spectrum psychosis: a retrospective chart review.

Campana M, Löhrs L, Strauß J, Münz S, Oviedo-Salcedo T, Fernando P, Maurus I, Raabe F, Moussiopoulou J, Eichhorn P, Falkai P, Hasan A, Wagner E. Campana M, et al. Eur Arch Psychiatry Clin Neurosci. 2023 Dec;273(8):1693-1701. doi: 10.1007/s00406-023-01572-3. Epub 2023 Mar 4. Eur Arch Psychiatry Clin Neurosci. 2023. PMID: 36869234 Free PMC article.

Vitamin deficiency syndromes and blood-brain barrier (BBB) dysfunction are frequent phenomena in psychiatric conditions. ...This retrospective analysis contributes to the discussion on the impact of vitamin deficiency syndromes in FEP. Although decreased vitamin …

Vitamin deficiency syndromes and blood-brain barrier (BBB) dysfunction are frequent phenomena in psychiatric conditions. ...This retr …

26

Comparison of the cardiovascular system, clinical condition, and laboratory results in COVID-19 patients with and without vitamin D insufficiency.

Kazemi E, Mansoursamaei A, Rohani-Rasaf M, Sheibani H. Kazemi E, et al. BMC Infect Dis. 2022 May 7;22(1):441. doi: 10.1186/s12879-022-07438-8. BMC Infect Dis. 2022. PMID: 35525957 Free PMC article.

RESULTS: The patients were divided into three groups based on their vitamin D level: 127 cases in the insufficient vitamin D group, 53 cases in the normal vitamin D group, and 22 cases in the high vitamin D group. ...The distribution of this group was …

RESULTS: The patients were divided into three groups based on their vitamin D level: 127 cases in the insufficient vitamin D g …

27

Vitamins, Vascular Health and Disease.

Ayoub G. Ayoub G. Nutrients. 2025 Sep 15;17(18):2955. doi: 10.3390/nu17182955. Nutrients. 2025. PMID: 41010482 Free PMC article. Review.

Endothelial dysfunction, often aggravated by inadequate vitamin absorption, contributes to a spectrum of clinical disorders, including cardiovascular disease, cerebrovascular disease, peripheral artery disease, age-related macular degeneration, lymphedema, and chron …

Endothelial dysfunction, often aggravated by inadequate vitamin absorption, contributes to a spectrum of clinical disorders, includin …

28

[Homocysteine, endothelial dysfunction and cardiovascular risk: pathomechanisms and therapeutic options].

Sydow K, Böger RH. Sydow K, et al. Z Kardiol. 2001 Jan;90(1):1-11. doi: 10.1007/s003920170206. Z Kardiol. 2001. PMID: 11220081 Review. German.

Oxidative mechanisms and decreased biological activity of endothelium-derived nitric oxide (NO) may also contribute to homocyst(e)ine-associated endothelial dysfunction. B vitamins are essential cofactors in the metabolism of homocyst(e)ine to methionine via the remethylat …

Oxidative mechanisms and decreased biological activity of endothelium-derived nitric oxide (NO) may also contribute to homocyst(e)ine-associ …

29

Calciotrophic hormones and hyperglycemia modulate vitamin D receptor and 25 hydroxyy vitamin D 1-alpha hydroxylase mRNA expression in human vascular smooth muscle cells.

Somjen D, Knoll E, Sharon O, Many A, Stern N. Somjen D, et al. J Steroid Biochem Mol Biol. 2015 Apr;148:210-3. doi: 10.1016/j.jsbmb.2014.11.007. Epub 2014 Nov 13. J Steroid Biochem Mol Biol. 2015. PMID: 25448744 Review.

Estrogen receptors (ERalpha and ERbeta), the vitamin D receptor (VDR) and 25 hydroxyy vitamin D 1-alpha hydroxylase (1OHase) mRNA are expressed in vascular smooth muscle cells (VSMC). ...In conclusion, calcitrophic hormones modify VSMC growth and concomitantly affec …

Estrogen receptors (ERalpha and ERbeta), the vitamin D receptor (VDR) and 25 hydroxyy vitamin D 1-alpha hydroxylase (1OHase) m …

30

Modulatory effects of melatonin and vitamin C on oxidative stress-mediated haemolytic anaemia and associated cardiovascular dysfunctions in rats.

Ajibade TO, Oyagbemi AA, Durotoye LA, Omóbòwálé TO, Asenuga ER, Olayemi FO. Ajibade TO, et al. J Complement Integr Med. 2017 Mar 1;14(1):/j/jcim.2017.14.issue-1/jcim-2015-0082/jcim-2015-0082.xml. doi: 10.1515/jcim-2015-0082. J Complement Integr Med. 2017. PMID: 28237973

Pathology of the heart and kidney was also observed in PHE treated group. However, treatment with MLT and vitamin C improved enzymic and non-enzymic antioxidant system together with the restoration of SBP, DBP and MABP to near normal. The architectural anarchy obser …

Pathology of the heart and kidney was also observed in PHE treated group. However, treatment with MLT and vitamin C improved enzymic …

31

What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review.

Łykowska-Szuber L, Rychter AM, Dudek M, Ratajczak AE, Szymczak-Tomczak A, Zawada A, Eder P, Lesiak M, Dobrowolska A, Krela-Kaźmierczak I. Łykowska-Szuber L, et al. Nutrients. 2021 Jul 30;13(8):2661. doi: 10.3390/nu13082661. Nutrients. 2021. PMID: 34444821 Free PMC article. Review.

Several studies have shown increased rates of cardiovascular disease (CVD) in patients suffering from inflammatory bowel disease (IBD), particularly in cases of early atherosclerosis and myocardial infarction. ...Thus, it is essential to investigate the factors responsible …

Several studies have shown increased rates of cardiovascular disease (CVD) in patients suffering from inflammatory bowel disease (IBD …

32

An update on vitamin E, tocopherol and tocotrienol-perspectives.

Colombo ML. Colombo ML. Molecules. 2010 Mar 24;15(4):2103-13. doi: 10.3390/molecules15042103. Molecules. 2010. PMID: 20428030 Free PMC article. Review.

Vitamin E, like tocotrienols and tocopherols, is constituted of compounds essential for animal cells. ...From a health point of view, at the moment there is a great interest in the natural forms of tocochromanols, because they are considered promising compounds able to mai …

Vitamin E, like tocotrienols and tocopherols, is constituted of compounds essential for animal cells. ...From a health point of view, …

33

Effects of Gender and Vitamin D on Vascular Reactivity of the Carotid Artery on a Testosterone-Induced PCOS Model.

Süli A, Magyar P, Vezér M, Bányai B, Szekeres M, Sipos M, Mátrai M, Hetthéssy JR, Dörnyei G, Ács N, Horváth EM, Nádasy GL, Várbíró S, Török M. Süli A, et al. Int J Mol Sci. 2023 Nov 21;24(23):16577. doi: 10.3390/ijms242316577. Int J Mol Sci. 2023. PMID: 38068901 Free PMC article.

The negative cardiovascular effects of polycystic ovary syndrome (PCOS) and vitamin D deficiency (VDD) have been discussed previously; however, the sex differences between PCOS females and males are not yet known. ...Both VDD and PCOS result in a dysfunctional vascu …

The negative cardiovascular effects of polycystic ovary syndrome (PCOS) and vitamin D deficiency (VDD) have been discussed pre …

34

Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium.

Gibson CC, Davis CT, Zhu W, Bowman-Kirigin JA, Walker AE, Tai Z, Thomas KR, Donato AJ, Lesniewski LA, Li DY. Gibson CC, et al. PLoS One. 2015 Oct 15;10(10):e0140370. doi: 10.1371/journal.pone.0140370. eCollection 2015. PLoS One. 2015. PMID: 26469335 Free PMC article.

Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be largely mediated by the metabolite 1,25(OH)2D3. ...We further demonstrate that this phenomenon is appa …

Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vit …

35

Vitamin E and vitamin C attenuate Di-(2-ethylhexyl) phthalate-induced blood-testis barrier disruption by p38 MAPK in immature SD rats.

Shen L, Tang X, Wei Y, Long C, Tan B, Wu S, Sun M, Zhou Y, Cao X, Wei G. Shen L, et al. Reprod Toxicol. 2018 Oct;81:17-27. doi: 10.1016/j.reprotox.2018.06.015. Epub 2018 Jun 27. Reprod Toxicol. 2018. PMID: 29940330

Therefore, we sought to investigate this mechanism and determine whether vitamin C and vitamin E administration would attenuate the BTB impairment induced by DEHP in vivo and by Mono-(2-Ethylhexyl) Phthalate (MEHP) in vitro, respectively. ...In summary, vitamin …

Therefore, we sought to investigate this mechanism and determine whether vitamin C and vitamin E administration would attenuat …

36

Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders.

Mohan A, Kumar R, Kumar V, Yadav M. Mohan A, et al. Curr Cardiol Rev. 2023;19(4):e090223213539. doi: 10.2174/1573403X19666230209111854. Curr Cardiol Rev. 2023. PMID: 36757031 Free PMC article.

However, the long-term effects of sub-medical deficiency have not been thoroughly studied, but they may have a negative impact on the cardiovascular system, pregnancy outcomes, and vascular, renal, cognitive, bone, and eye health. ...Another approach is related to t …

However, the long-term effects of sub-medical deficiency have not been thoroughly studied, but they may have a negative impact on the car …

37

Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice.

Babaev VR, Li L, Shah S, Fazio S, Linton MF, May JM. Babaev VR, et al. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1751-7. doi: 10.1161/ATVBAHA.110.209502. Epub 2010 Jun 17. Arterioscler Thromb Vasc Biol. 2010. PMID: 20558818 Free PMC article.

OBJECTIVE: To assess the role of combined deficiencies of vitamins C and E on the earliest stages of atherosclerosis (an inflammatory condition associated with oxidative stress), 4 combinations of vitamin supplementation (low C/low E, low C/high E, high C/low E, and …

OBJECTIVE: To assess the role of combined deficiencies of vitamins C and E on the earliest stages of atherosclerosis (an inflammatory …

38

Vitamin D and macrophage polarization in epicardial adipose tissue of atherosclerotic swine.

Gunasekar P, Swier VJ, Fleegel JP, Boosani CS, Radwan MM, Agrawal DK. Gunasekar P, et al. PLoS One. 2018 Oct 8;13(10):e0199411. doi: 10.1371/journal.pone.0199411. eCollection 2018. PLoS One. 2018. PMID: 30296271 Free PMC article.

Significant difference in the number of CCR7+ cells was observed in the EAT from vitamin D-deficient swine compared to vitamin D-sufficient or -supplemented swine. Expression of CD206 correlated with high levels of serum 25(OH)D indicating a significant increase in …

Significant difference in the number of CCR7+ cells was observed in the EAT from vitamin D-deficient swine compared to vitamin …

39

[Atherosclerosis].

Yamada N. Yamada N. Nihon Rinsho. 1999 Oct;57(10):2345-8. Nihon Rinsho. 1999. PMID: 10540884 Review. Japanese.

In the presence of excessive amounts of low-density lipoprotein (LDL), denatured LDL modified by oxidation or other reactions on the vascular wall is taken up by macrophages via scavenger receptors, resulting in the formation of foam cells and accumulation of cholesterol esters. …

In the presence of excessive amounts of low-density lipoprotein (LDL), denatured LDL modified by oxidation or other reactions on the vascula …

40

A brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019.

Cereda E, Bogliolo L, de Stefano L, Caccialanza R. Cereda E, et al. Curr Opin Clin Nutr Metab Care. 2021 Jan;24(1):102-107. doi: 10.1097/MCO.0000000000000701. Curr Opin Clin Nutr Metab Care. 2021. PMID: 33003119 Review.

PURPOSE OF REVIEW: Vitamin D exerts extraskeletal functions, including immunomodulatory activity, protection against respiratory tract infections and pleiotropic effects on the cardiovascular system. ...However, the pandemic progression and the increased know …

PURPOSE OF REVIEW: Vitamin D exerts extraskeletal functions, including immunomodulatory activity, protection against respiratory trac …

41

High-fat diets and cardiovascular disease: are nutritional supplements useful?

Freedman JE. Freedman JE. J Am Coll Cardiol. 2003 May 21;41(10):1750-2. doi: 10.1016/s0735-1097(03)00303-6. J Am Coll Cardiol. 2003. PMID: 12767659 Free article. No abstract available.

42

Folate and homocysteine.

Young IS, Woodside JV. Young IS, et al. Curr Opin Clin Nutr Metab Care. 2000 Nov;3(6):427-32. doi: 10.1097/00075197-200011000-00003. Curr Opin Clin Nutr Metab Care. 2000. PMID: 11085827 Review.

Hyperhomocysteinaemia has been identified from epidemiological studies as an independent risk factor for cardiovascular disease. Plasma total homocysteine is elevated in renal impairment, which may be a consequence of cardiovascular disease. ...The results of clinic …

Hyperhomocysteinaemia has been identified from epidemiological studies as an independent risk factor for cardiovascular disease. Plas …

43

Differential effect of basal vitamin D status in monocrotaline induced pulmonary arterial hypertension in normal and vitamin D deficient rats: Possible involvement of eNOS/TGF-beta/alpha-SMA signaling pathways.

Shah S, Vishwakarma VK, Arava SK, Mridha AR, Yadav RK, Seth S, Bhatia J, Hote MP, Arya DS, Yadav HN. Shah S, et al. J Nutr Biochem. 2023 Mar;113:109246. doi: 10.1016/j.jnutbio.2022.109246. Epub 2022 Dec 7. J Nutr Biochem. 2023. PMID: 36496061

Rats were fed a VDD diet and exposed to filtered fluorescent light to deplete vitamin D. Normal rats were pretreated with vitamin D 100 IU/d and treated with vitamin D 100 and 200 IU/d, while VDD rats received vitamin D 100 IU/d. ...Vitamin D 10 …

Rats were fed a VDD diet and exposed to filtered fluorescent light to deplete vitamin D. Normal rats were pretreated with vitamin …

44

Aberrant endothelial expression of hnRNPC1/C2 and VDR and reduced maternal vitamin D levels in women with preeclampsia.

Gu Y, Lin S, Morgan JA, Lewis DF, Wang Y. Gu Y, et al. J Steroid Biochem Mol Biol. 2022 Sep;222:106155. doi: 10.1016/j.jsbmb.2022.106155. Epub 2022 Jul 20. J Steroid Biochem Mol Biol. 2022. PMID: 35868598

Vitamin D deficiency is a widespread health problem globally and vitamin D deficiency/ insufficiency in pregnancy is a risk factor for preeclampsia, a hypertensive disorder in human pregnancy. ...Reduced VDR expression was relevant to low maternal antenatal and post …

Vitamin D deficiency is a widespread health problem globally and vitamin D deficiency/ insufficiency in pregnancy is a risk fa …

45

New cardiovascular risk factors: homocysteine and vitamins involved in homocysteine metabolism.

De Caterina R, Zampolli A, Madonna R, Fioretti P, Vanuzzo D. De Caterina R, et al. Ital Heart J. 2004 Jun;5 Suppl 6:19S-24S. Ital Heart J. 2004. PMID: 15185912 Review.

There are also, however, suggestions from the literature that group B vitamins, and in particular vitamin B6 (pyridoxine/pyridoxal-phosphate), are modulators of cardiovascular risk independent of homocysteine. The results of a recent study of ours, with a lon …

There are also, however, suggestions from the literature that group B vitamins, and in particular vitamin B6 (pyridoxine/pyrid …

46

Long-term vitamin-K antagonist use and coronary artery calcification.

Ünlü S, Şahinarslan A, Kılıç HK, Gökalp G, Sezenöz B, Erbaş G, Yalçın RM, Araç M. Ünlü S, et al. Herz. 2020 Sep;45(6):580-585. doi: 10.1007/s00059-018-4760-9. Epub 2018 Oct 1. Herz. 2020. PMID: 30276478 English.

BACKGROUND: The aim of this study was to investigate the impact of vitamin K antagonist (VKA) therapy on coronary artery calcification (CAC) by comparing long-term VKA users with metallic prosthetic valves (MPVs) and VKA-free patients undergoing coronary calcium scoring fo …

BACKGROUND: The aim of this study was to investigate the impact of vitamin K antagonist (VKA) therapy on coronary artery calcificatio …

47

Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. SUpplementation en VItamines et Mineraux AntioXydants Study.

Hercberg S, Galan P, Preziosi P, Roussel AM, Arnaud J, Richard MJ, Malvy D, Paul-Dauphin A, Briançon S, Favier A. Hercberg S, et al. Int J Vitam Nutr Res. 1998;68(1):3-20. Int J Vitam Nutr Res. 1998. PMID: 9503043 Review.

The "SUpplementation en VItamines et MinerauxAntioXydants" (SU.VI.MAX) study is a randomized double-blind, placebo-controlled, primary prevention trial designed to test the efficacy of daily supplementation with antioxidant vitamins (vitamin C, 120 mg; vit …

The "SUpplementation en VItamines et MinerauxAntioXydants" (SU.VI.MAX) study is a randomized double-blind, placebo-controlled, primar …

48

Oral vitamin C restores endothelial function during acute inflammation in young and older adults.

Lefferts EC, Hibner BA, Lefferts WK, Lima NS, Baynard T, Haus JM, Lane-Cordova AD, Phillips SA, Fernhall B. Lefferts EC, et al. Physiol Rep. 2021 Nov;9(21):e15104. doi: 10.14814/phy2.15104. Physiol Rep. 2021. PMID: 34762777 Free PMC article.

In conclusion, oral vitamin C restored endothelial function during acute inflammation in young and older adults, with no effect on aortic stiffness. The effect of vitamin C on endothelial function did not appear to be due to reductions in inflammatory markers. ...

In conclusion, oral vitamin C restored endothelial function during acute inflammation in young and older adults, with no effect on ao …

49

Effects of moderate exercise and a multiple vitamin and mineral complex on the arterial wall.

Potoră CS, Tache S, Albu A, Nagy AL. Potoră CS, et al. Rom J Morphol Embryol. 2018;59(1):249-256. Rom J Morphol Embryol. 2018. PMID: 29940635 Free article.

Its beneficial role may be due to a decrease in oxidative stress. The association of vitamin and mineral supplements to exercise determined contradictory effects on arterial wall and oxidative stress parameters. The aim of this experimental study was to evaluate the effect …

Its beneficial role may be due to a decrease in oxidative stress. The association of vitamin and mineral supplements to exercise dete …

50

Vitamin K supplementation and progression of coronary artery calcium in older men and women.

Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL. Shea MK, et al. Am J Clin Nutr. 2009 Jun;89(6):1799-807. doi: 10.3945/ajcn.2008.27338. Epub 2009 Apr 22. Am J Clin Nutr. 2009. PMID: 19386744 Free PMC article. Clinical Trial.

BACKGROUND: Coronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent cal …

BACKGROUND: Coronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitam …

51

Menopause and risk of cardiovascular disease.

Gensini GF, Micheli S, Prisco D, Abbate R. Gensini GF, et al. Thromb Res. 1996 Oct 1;84(1):1-19. doi: 10.1016/0049-3848(96)00143-0. Thromb Res. 1996. PMID: 8885143 Review. No abstract available.

52

Antioxidants and atherosclerotic heart disease.

Diaz MN, Frei B, Vita JA, Keaney JF Jr. Diaz MN, et al. N Engl J Med. 1997 Aug 7;337(6):408-16. doi: 10.1056/NEJM199708073370607. N Engl J Med. 1997. PMID: 9241131 Review.

Epidemiologic studies have provided evidence of an inverse relation between coronary artery disease and antioxidant intake, and vitamin E supplementation in particular. The oxidative-modification hypothesis implies that reduced atherosclerosis is a result of the production …

Epidemiologic studies have provided evidence of an inverse relation between coronary artery disease and antioxidant intake, and vitamin …

53

Different vitamin D receptor agonists exhibit differential effects on endothelial function and aortic gene expression in 5/6 nephrectomized rats.

Wu-Wong JR, Li X, Chen YW. Wu-Wong JR, et al. J Steroid Biochem Mol Biol. 2015 Apr;148:202-9. doi: 10.1016/j.jsbmb.2014.12.002. Epub 2014 Dec 10. J Steroid Biochem Mol Biol. 2015. PMID: 25500070 Review.

Endothelial dysfunction, common in chronic kidney disease (CKD), significantly increases cardiovascular disease risk in CKD patients. This study investigates whether different vitamin D receptor agonists exhibit different effects on endothelial function and on aorti …

Endothelial dysfunction, common in chronic kidney disease (CKD), significantly increases cardiovascular disease risk in CKD patients. …

54

Vitamin-D Deficiency and Supplementation Altered the Network of the Coronary Arteries in a Rodent Model-In Situ Video Microscopic Technique.

Dalloul H, Hainzl T, Monori-Kiss A, Hadjadj L, Nádasy GL, Török M, Várbíró S. Dalloul H, et al. Nutrients. 2022 May 13;14(10):2041. doi: 10.3390/nu14102041. Nutrients. 2022. PMID: 35631182 Free PMC article.

The aim of our study was to identify whether vitamin-D deficiency (VDD) can alter the geometry of the coronary-resistance-artery system. ...In VD- rats, 150-200 and 300 m units were almost missing at higher flow distances from the orifice. Serum vitamin-D al …

The aim of our study was to identify whether vitamin-D deficiency (VDD) can alter the geometry of the coronary-resistance-artery s …

55

Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats.

Hajiluian G, Nameni G, Shahabi P, Mesgari-Abbasi M, Sadigh-Eteghad S, Farhangi MA. Hajiluian G, et al. Int J Obes (Lond). 2017 Apr;41(4):639-644. doi: 10.1038/ijo.2017.10. Epub 2017 Jan 17. Int J Obes (Lond). 2017. PMID: 28093570

Vitamin D supplementation in the HFD group significantly reduced body weight, NF-kappaB concentrations, BBB permeability and increased BDNF concentrations in the hippocampus. CONCLUSIONS: Vitamin D reversed HFD-induced cognitive impairments by reduction of the NF-ka …

Vitamin D supplementation in the HFD group significantly reduced body weight, NF-kappaB concentrations, BBB permeability and increase …

56

Vitamin D as therapeutic modulator in cerebrovascular diseases: a mechanistic perspectives.

Rihal V, Khan H, Kaur A, Singh TG. Rihal V, et al. Crit Rev Food Sci Nutr. 2023;63(25):7772-7794. doi: 10.1080/10408398.2022.2050349. Epub 2022 Mar 14. Crit Rev Food Sci Nutr. 2023. PMID: 35285752 Review.

Vitamin D deficiency has been linked to several major chronic diseases, such as cardiovascular and neurodegenerative diseases, diabetes, and cancer, linked to oxidative stress, inflammation, and aging. Vitamin D deficiency appears to be particularly harmful t …

Vitamin D deficiency has been linked to several major chronic diseases, such as cardiovascular and neurodegenerative diseases, …

57

The virtues of vitamin D--but how much is too much?

Shroff R, Knott C, Rees L. Shroff R, et al. Pediatr Nephrol. 2010 Sep;25(9):1607-20. doi: 10.1007/s00467-010-1499-9. Pediatr Nephrol. 2010. PMID: 20393752 Review.

Most tissues in the body have a vitamin D receptor and the enzymatic machinery to convert 'nutritional' 25-hydroxyvitamin D to the active form 1,25-dihydroxyvitamin D; it is estimated that 3% of the human genome is regulated by the vitamin D endocrine system. …

Most tissues in the body have a vitamin D receptor and the enzymatic machinery to convert 'nutritional' 25-hydroxyvitamin D to the ac …

58

Iloprost and vitamin C attenuates acute myocardial injury induced by suprarenal aortic ischemia-reperfusion in rabbits.

Iriz E, Iriz A, Take G, Ozgul H, Oktar L, Demirtas H, Helvacioglu F, Arslan M. Iriz E, et al. Bratisl Lek Listy. 2015;116(10):627-31. doi: 10.4149/bll_2015_121. Bratisl Lek Listy. 2015. PMID: 26531875

These groups are control group, sham group, iloprost group, and iloprost+vitamin C group. Suprarenal aorta was occluded with a vascular clamp. Following 30 minutes of ischemia, the vascular clamp was removed. ...Myocardial edema was significantly alleviated by iloprost and …

These groups are control group, sham group, iloprost group, and iloprost+vitamin C group. Suprarenal aorta was occluded with a vascul …

59

Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat.

Papparella I, Ceolotto G, Berto L, Cavalli M, Bova S, Cargnelli G, Ruga E, Milanesi O, Franco L, Mazzoni M, Petrelli L, Nussdorfer GG, Semplicini A. Papparella I, et al. Cardiovasc Res. 2007 Jan 15;73(2):432-8. doi: 10.1016/j.cardiores.2006.10.010. Epub 2006 Oct 20. Cardiovasc Res. 2007. PMID: 17123493

All of these effects were prevented by vitamin C. CONCLUSION: Chronic AZT administration increases blood pressure and promotes cardiovascular damage through a NAD(P)H oxidase-dependent mechanism that involves PKC delta. Vitamin C antagonizes these adverse eff …

All of these effects were prevented by vitamin C. CONCLUSION: Chronic AZT administration increases blood pressure and promotes car …

60

[Peculiarities of vitamin status in men and women with cardiovascular disease and obesity].

Baturin AK, Pogozheva AV, Akol'zina SE, Kodentsova VM, Vrzhesinskaia OA, Beketova NA, Pereverzeva OG. Baturin AK, et al. Vopr Pitan. 2012;81(4):58-64. Vopr Pitan. 2012. PMID: 23156053 Russian.

We explored the characteristics of the vitamin status in 471 patients with cardiovascular diseases, according to sex, and BMI values. ...These data suggest that the rate of supply of vitamins are reliable markers to assess the adequacy of the diet consumed by …

We explored the characteristics of the vitamin status in 471 patients with cardiovascular diseases, according to sex, and BMI …

61

Evaluation of the relationship between vitamin D level during pregnancy and the rate of fetal heart problems: a cross-sectional study.

Rastegar M, Fateh M, Rahnama A, Sheybani-Arani M, Salimi Asl A, Rajaei S. Rastegar M, et al. Clin Nutr ESPEN. 2022 Oct;51:262-266. doi: 10.1016/j.clnesp.2022.08.018. Epub 2022 Aug 31. Clin Nutr ESPEN. 2022. PMID: 36184213

Heart problems increased in fetuses of mothers with lower serum vitamin D levels. No abnormality was also observed in the fetal heart of mothers with normal vitamin D levels. ...Vitamin D deficiency in the mother can also be considered an indication of fetal …

Heart problems increased in fetuses of mothers with lower serum vitamin D levels. No abnormality was also observed in the fetal heart …

62

Safety of Vitamin K in mechanical heart valve patients with supratherapeutic INR: A systematic review and meta-analysis.

Sapapsap B, Srisawat C, Suthumpoung P, Luengrungkiat O, Leelakanok N, Saokaew S, Kanchanasurakit S. Sapapsap B, et al. Medicine (Baltimore). 2022 Sep 9;101(36):e30388. doi: 10.1097/MD.0000000000030388. Medicine (Baltimore). 2022. PMID: 36086772 Free PMC article.

BACKGROUND: Patients who had mechanical heart valves and an international normalized ratio (INR) of >5.0 should be managed by temporary cessation of vitamin K antagonist. This study aimed to investigate the safety of low-dose vitamin K1 in patients with mechanica …

BACKGROUND: Patients who had mechanical heart valves and an international normalized ratio (INR) of >5.0 should be managed by temporary c …

63

Effect of Combined Treatment With Folic Acid, Vitamin B(6), and Vitamin B(12) on Plasma Biomarkers of Inflammation and Endothelial Dysfunction in Women.

Christen WG, Cook NR, Van Denburgh M, Zaharris E, Albert CM, Manson JE. Christen WG, et al. J Am Heart Assoc. 2018 May 18;7(11):e008517. doi: 10.1161/JAHA.117.008517. J Am Heart Assoc. 2018. PMID: 29776960 Free PMC article. Clinical Trial.

BACKGROUND: The aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment with folic acid, vitamin B(6), and vitamin B(12) alters plasma biomarkers of inflammation and endothelial dysfunction in women a …

BACKGROUND: The aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment wi …

64

Glucose transporter 10 and arterial tortuosity syndrome: the vitamin C connection.

Segade F. Segade F. FEBS Lett. 2010 Jul 16;584(14):2990-4. doi: 10.1016/j.febslet.2010.06.011. Epub 2010 Jun 12. FEBS Lett. 2010. PMID: 20547159 Review.

65

Atherosclerosis and oxidant stress: the end of the road for antioxidant vitamin treatment?

Thomson MJ, Puntmann V, Kaski JC. Thomson MJ, et al. Cardiovasc Drugs Ther. 2007 Jun;21(3):195-210. doi: 10.1007/s10557-007-6027-1. Cardiovasc Drugs Ther. 2007. PMID: 17484034 Review.

Extensive experimental data have revealed a central role for oxidative stress in atherogenesis and suggested a potential role for 'antioxidant' treatment in cardiovascular disease (CVD) [1-11]. Experimental data, however, have not translated into clinical benefit: most ant …

Extensive experimental data have revealed a central role for oxidative stress in atherogenesis and suggested a potential role for 'antioxida …

66

Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.

Montero D, Walther G, Stehouwer CD, Houben AJ, Beckman JA, Vinet A. Montero D, et al. Obes Rev. 2014 Feb;15(2):107-16. doi: 10.1111/obr.12114. Epub 2013 Oct 7. Obes Rev. 2014. PMID: 24118784

Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus (T2DM) subjects. The aim of this study was to systematically review and quantify the effect of antioxidant vitamin …

Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type …

67

Vitamin D deficiency attenuates endothelial function by reducing antioxidant activity and vascular eNOS expression in the rat microcirculation.

Wee CL, Mokhtar SS, Banga Singh KK, Rasool AHG. Wee CL, et al. Microvasc Res. 2021 Nov;138:104227. doi: 10.1016/j.mvr.2021.104227. Epub 2021 Jul 27. Microvasc Res. 2021. PMID: 34324883

This study examined the effects of vitamin D deficiency on vascular function and tissue oxidative status in the microcirculation; and whether or not these effects can be ameliorated with calcitriol, the active vitamin D metabolite. ...Calcitriol supplementation to …

This study examined the effects of vitamin D deficiency on vascular function and tissue oxidative status in the microcirculation; and …

68

Vitamin D and osteogenic differentiation in the artery wall.

Hsu JJ, Tintut Y, Demer LL. Hsu JJ, et al. Clin J Am Soc Nephrol. 2008 Sep;3(5):1542-7. doi: 10.2215/CJN.01220308. Epub 2008 Jun 18. Clin J Am Soc Nephrol. 2008. PMID: 18562594 Free PMC article.

Recent epidemiologic evidence suggests that there is a narrow range of vitamin D levels in which vascular function is optimized. Levels above or below this range seem to confer a significant increase in risk for cardiovascular disease. ...These findings raise intere …

Recent epidemiologic evidence suggests that there is a narrow range of vitamin D levels in which vascular function is optimized. Leve …

69

Antioxidant vitamin status and carotid atherosclerosis in the elderly.

Gale CR, Ashurst HE, Powers HJ, Martyn CN. Gale CR, et al. Am J Clin Nutr. 2001 Sep;74(3):402-8. doi: 10.1093/ajcn/74.3.402. Am J Clin Nutr. 2001. PMID: 11522566

BACKGROUND: The oxidative modification of LDL is thought to play a crucial role in the initiation of atherosclerosis. Antioxidant vitamins can protect LDL from oxidation, and high intakes or blood concentrations of these vitamins have been linked with a reduced risk …

BACKGROUND: The oxidative modification of LDL is thought to play a crucial role in the initiation of atherosclerosis. Antioxidant vitamin …

70

Calcium, phosphorus and vitamin D as factors regulating the integrity of the cardiovascular system.

GILBERT C, GILLMAN J. GILBERT C, et al. Exp Med Surg. 1956;14(2-3):136-68. Exp Med Surg. 1956. PMID: 13365610 No abstract available.

71

Protective effect of vitamin B5 (dexpanthenol) on cardiovascular damage induced by streptozocin in rats.

Demirci B, Demir O, Dost T, Birincioglu M. Demirci B, et al. Bratisl Lek Listy. 2014;115(4):190-6. doi: 10.4149/bll_2014_040. Bratisl Lek Listy. 2014. PMID: 24797592

OBJECTIVES: This study investigated whether Dexpanthenol (DEX) improves diabetic cardiovascular function and cardiac performance by regulating total oxidant and antioxidant status. ...

OBJECTIVES: This study investigated whether Dexpanthenol (DEX) improves diabetic cardiovascular function and cardiac performance by r …

72

Potential of vitamin D in treating diabetic cardiomyopathy.

Lee TW, Lee TI, Chang CJ, Lien GS, Kao YH, Chao TF, Chen YJ. Lee TW, et al. Nutr Res. 2015 Apr;35(4):269-79. doi: 10.1016/j.nutres.2015.02.005. Epub 2015 Feb 24. Nutr Res. 2015. PMID: 25770692 Review.

Currently, effective treatments for diabetic cardiomyopathy are limited. Vitamin D exerts pleiotropic effects on the cardiovascular system and is associated with DM. The purpose of this review was to evaluate published research on vitamin D in diabetic …

Currently, effective treatments for diabetic cardiomyopathy are limited. Vitamin D exerts pleiotropic effects on the cardiovascula …

73

Vitamin activities in human portal, hepatic and femoral blood after vitamin ingestion.

Baker H, tenHove W, Baker E, Frank O. Baker H, et al. Int J Vitam Nutr Res. 1994;64(1):60-7. Int J Vitam Nutr Res. 1994. PMID: 8200751

All water-soluble vitamins proved elevated after vitamin ingestion principally in portal blood within 10 minutes as compared with hepatic and femoral blood. ...In contrast, ingestion of the fat-soluble vitamins A and E evoked no elevated vitamin activi …

All water-soluble vitamins proved elevated after vitamin ingestion principally in portal blood within 10 minutes as compared w …

74

Effect of vitamin D deficiency and replacement on endothelial functions in Behcet's disease.

Can M, Gunes M, Haliloglu OA, Haklar G, Inanç N, Yavuz DG, Direskeneli H. Can M, et al. Clin Exp Rheumatol. 2012 May-Jun;30(3 Suppl 72):S57-61. Epub 2012 Sep 27. Clin Exp Rheumatol. 2012. PMID: 23020973

Endothelial function was evaluated by brachial artery flow mediated dilatation (FMD) and CIMT with B-Mode ultrasound. The vitamin D-deficient BD patients received 1000 IU Vitamin D3 daily for 3 months. RESULTS: Less than 50 nmol/L levels of 25(OH) Vit D3 were presen …

Endothelial function was evaluated by brachial artery flow mediated dilatation (FMD) and CIMT with B-Mode ultrasound. The vitamin D-d …

75

Modulatory effects of vitamin C on biochemical and oxidative changes induced by acute exposure to diazinon in rat various tissues: Prophylactic and therapeutic roles.

Khazaie S, Jafari M, Heydari J, Asgari A, Tahmasebi K, Salehi M, Abedini MS. Khazaie S, et al. J Anim Physiol Anim Nutr (Berl). 2019 Sep;103(5):1619-1628. doi: 10.1111/jpn.13144. Epub 2019 Jun 19. J Anim Physiol Anim Nutr (Berl). 2019. PMID: 31218763

The aim of the present study was to investigate prophylactic and therapeutic effects of vitamin C against oxidative stress caused by DZN in various tissues of male Wistar rats. Thirty rats were divided into five groups: control group received corn oil as DZN solvent, DZN g …

The aim of the present study was to investigate prophylactic and therapeutic effects of vitamin C against oxidative stress caused by …

76

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition.

González-Lamuño D, Arrieta-Blanco FJ, Fuentes ED, Forga-Visa MT, Morales-Conejo M, Peña-Quintana L, Vitoria-Miñana I. González-Lamuño D, et al. Nutrients. 2023 Dec 30;16(1):135. doi: 10.3390/nu16010135. Nutrients. 2023. PMID: 38201964 Free PMC article. Review.

A nutritional approach to HHcy management involves implementing dietary strategies and targeted supplementation, emphasizing key nutrients like vitamin B6, B12, and folate that are crucial for Hcy conversion. Adequate intake of these vitamins, along with betaine sup …

A nutritional approach to HHcy management involves implementing dietary strategies and targeted supplementation, emphasizing key nutrients l …

77

Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice.

Schmidt N, Brandsch C, Schutkowski A, Hirche F, Stangl GI. Schmidt N, et al. J Nutr. 2014 May;144(5):638-46. doi: 10.3945/jn.113.189118. Epub 2014 Mar 19. J Nutr. 2014. PMID: 24647396 Free article.

Vitamin D insufficiency is highly associated with cardiovascular morbidity and mortality. We have demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR(-/-)) mice fed a diet low in vitamin D. This study aimed to investigate the impact of …

Vitamin D insufficiency is highly associated with cardiovascular morbidity and mortality. We have demonstrated enhanced vascul …

78

Folate, homocysteine, endothelial function and cardiovascular disease. What is the link?

Ashfield-Watt PA, Moat SJ, Doshi SN, McDowell IF. Ashfield-Watt PA, et al. Biomed Pharmacother. 2001 Oct;55(8):425-33. doi: 10.1016/s0753-3322(01)00125-1. Biomed Pharmacother. 2001. PMID: 11686575 Review.

Elevated plasma homocysteine concentrations are associated with an increased risk of cardiovascular disease, but the relationship has not been proven to be causal. Folate is the strongest nutritional and pharmacological determinant of plasma homocysteine concentrations, wh …

Elevated plasma homocysteine concentrations are associated with an increased risk of cardiovascular disease, but the relationship has …

79

Impact of vitamin D3 on cardiovascular responses to glucocorticoid excess.

Ahmed MA. Ahmed MA. J Physiol Biochem. 2013 Jun;69(2):267-76. doi: 10.1007/s13105-012-0209-4. Epub 2012 Sep 19. J Physiol Biochem. 2013. PMID: 22991185

Although the cardiovascular system is not a classical target for 1,25-dihydroxyvitamin D3, both cardiac myocytes and vascular smooth muscle cells respond to this hormone. ...These changes were markedly improved by vitamin D3 treatment. In conclusion, vitam …

Although the cardiovascular system is not a classical target for 1,25-dihydroxyvitamin D3, both cardiac myocytes and vascular …

80

Teratogenic effects of diabetic conditions in chick heart in ovo and in micromass culture may be prevented by addition of vitamin C and folic acid.

Memon S, Pratten MK. Memon S, et al. Reprod Toxicol. 2013 Jan;35:117-24. doi: 10.1016/j.reprotox.2012.10.007. Epub 2012 Oct 23. Reprod Toxicol. 2013. PMID: 23099339

Day 3 chick embryos in ovo were injected with glucose+hydroxybutyrate or a combination of these and vitamins. Diabetic conditions caused gross and histological malformations, but these effects were abrogated by vitamin supplement. Teratogenic effects on heart develo …

Day 3 chick embryos in ovo were injected with glucose+hydroxybutyrate or a combination of these and vitamins. Diabetic conditions cau …

81

The effects of some antioxidant vitamin- and trace element-supplemented diets on activities of SOD, CAT, GSH-Px and LPO levels in chicken tissues.

Oztürk-Urek R, Bozkaya LA, Tarhan L. Oztürk-Urek R, et al. Cell Biochem Funct. 2001 Jun;19(2):125-32. doi: 10.1002/cbf.905. Cell Biochem Funct. 2001. PMID: 11335937

Chickens, 45 weeks of age were divided into six groups: control group, Cu group (13.2 mg Cu kg(-1) diet); Se group (0.07 mg Se kg(-l) diet); vitamin E group (70 mg DL-alpha-tocopherol acetate kg(-1) diet) and a constant level vitamin C, 200 mg kg(-1) diet); vitam …

Chickens, 45 weeks of age were divided into six groups: control group, Cu group (13.2 mg Cu kg(-1) diet); Se group (0.07 mg Se kg(-l) diet); …

82

Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases.

Mullins AP, Arjmandi BH. Mullins AP, et al. Nutrients. 2021 Feb 5;13(2):519. doi: 10.3390/nu13020519. Nutrients. 2021. PMID: 33562498 Free PMC article. Review.

Cardiovascular disease (CVD) is the leading cause of death worldwide, claiming over 650,000 American lives annually. ...Inclusion of beans as part of a plant-based dietary strategy imparts cardiovascular, metabolic, and colon protective effects; improves obesity, lo …

Cardiovascular disease (CVD) is the leading cause of death worldwide, claiming over 650,000 American lives annually. ...Inclusion of …

83

Response to: Rapid response by Diehl on 'Supplemental calcium and vitamin D and long-term mortality in aortic stenosis'.

Kassis N, Hariri E, Kapadia S. Kassis N, et al. Heart. 2022 Aug 11;108(17):1415. doi: 10.1136/heartjnl-2022-321395. Heart. 2022. PMID: 35725299 No abstract available.

84

[Vitamin C in blood and effect of various vitamins on its dynamics in cardiovascular diseases].

BELIAEV MI. BELIAEV MI. Klin Med (Mosk). 1952 Jan;30(1):83. Klin Med (Mosk). 1952. PMID: 14898687 Undetermined Language. No abstract available.

85

Vitamin D induces increased systolic arterial pressure via vascular reactivity and mechanical properties.

Santos PP, Rafacho BP, Gonçalves Ade F, Jaldin RG, Nascimento TB, Silva MA, Cau SB, Roscani MG, Azevedo PS, Minicucci MF, Tostes Rde C, Zornoff LA, Paiva SA. Santos PP, et al. PLoS One. 2014 Jun 12;9(6):e98895. doi: 10.1371/journal.pone.0098895. eCollection 2014. PLoS One. 2014. PMID: 24921930 Free PMC article.

METHODS: Male Wistar rats were divided into three groups: 1) Control group (C, n = 20), with no supplementation of vitamin D, 2) VD3 (n = 19), supplemented with 3,000 IU vitamin D/kg of chow; 3) VD10 (n = 21), supplemented with 10,000 IU vitamin D/kg of chow. …

METHODS: Male Wistar rats were divided into three groups: 1) Control group (C, n = 20), with no supplementation of vitamin D, 2) VD3 …

86

The Role of Brain Barriers in Maintaining Brain Vitamin Levels.

Tiani KA, Stover PJ, Field MS. Tiani KA, et al. Annu Rev Nutr. 2019 Aug 21;39:147-173. doi: 10.1146/annurev-nutr-082018-124235. Epub 2019 May 31. Annu Rev Nutr. 2019. PMID: 31150592 Free PMC article. Review.

It is increasingly recognized that tissue-specific nutrient deficiencies can exist in the absence of whole-body deficiency and that these deficiencies may result from disease or disease-related physiological processes. Brain and central nervous system tissues require adequ …

It is increasingly recognized that tissue-specific nutrient deficiencies can exist in the absence of whole-body deficiency and that these de …

87

Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses.

Carlson D, Maass DL, White DJ, Tan J, Horton JW. Carlson D, et al. Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2779-89. doi: 10.1152/ajpheart.01258.2005. Epub 2006 Jul 14. Am J Physiol Heart Circ Physiol. 2006. PMID: 16844910 Free article.

This study examined the effects of antioxidant vitamins on several aspects of sepsis-related myocardial signaling cascades. Sprague-Dawley rats were divided into four groups: group 1, vehicle-treated shams; group 2, sham-operated rats given antioxidant vitamins ( …

This study examined the effects of antioxidant vitamins on several aspects of sepsis-related myocardial signaling cascades. Sprague-D …

88

Vitamin D and the heart: why we need large-scale clinical trials.

Manson JE. Manson JE. Cleve Clin J Med. 2010 Dec;77(12):903-10. doi: 10.3949/ccjm.77gr.10004. Cleve Clin J Med. 2010. PMID: 21147944 Free article.

Although vitamin D supplementation appears to be a promising intervention for reducing risks of cancer, cardiovascular disease, and other chronic diseases, existing evidence on its benefits and risks is limited and inconclusive. Recruitment is now under way for the …

Although vitamin D supplementation appears to be a promising intervention for reducing risks of cancer, cardiovascular disease …

89

Dysregulation of vitamin D metabolism in the brain and myocardium of rats following prolonged exposure to dexamethasone.

Jiang P, Xue Y, Li HD, Liu YP, Cai HL, Tang MM, Zhang LH. Jiang P, et al. Psychopharmacology (Berl). 2014 Sep;231(17):3445-51. doi: 10.1007/s00213-014-3440-6. Epub 2014 Jan 22. Psychopharmacology (Berl). 2014. PMID: 24448902

RATIONALE: Chronic stress or hypercortisolism may increase the risks of depression, cardiac disorders, and osteoporosis, which are also associated with vitamin D (VD) deficiency. Both glucocorticoid receptor (GR) and vitamin D receptor (VDR) are widely distributed a …

RATIONALE: Chronic stress or hypercortisolism may increase the risks of depression, cardiac disorders, and osteoporosis, which are also asso …

90

Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice.

Zhou J, Møller J, Ritskes-Hoitinga M, Larsen ML, Austin RC, Falk E. Zhou J, et al. Atherosclerosis. 2003 Jun;168(2):255-62. doi: 10.1016/s0021-9150(03)00138-2. Atherosclerosis. 2003. PMID: 12801608

Six-week-old female apoE(-/-) mice were divided into seven groups: vitamin-defined purified chow diet alone (control), or same diet supplemented with either D,L-homocysteine (upward arrow Hcy) or L-homocystine (upward arrow Hcy-Hcy), or diet high in L-methionine (upward ar …

Six-week-old female apoE(-/-) mice were divided into seven groups: vitamin-defined purified chow diet alone (control), or same diet s …

91

The Biological Role of Vitamins in Athletes' Muscle, Heart and Microbiota.

Brancaccio M, Mennitti C, Cesaro A, Fimiani F, Vano M, Gargiulo B, Caiazza M, Amodio F, Coto I, D'Alicandro G, Mazzaccara C, Lombardo B, Pero R, Terracciano D, Limongelli G, Calabrò P, D'Argenio V, Frisso G, Scudiero O. Brancaccio M, et al. Int J Environ Res Public Health. 2022 Jan 23;19(3):1249. doi: 10.3390/ijerph19031249. Int J Environ Res Public Health. 2022. PMID: 35162272 Free PMC article. Review.

Vitamins are introduced to the diet because the human body is unable to produce these micronutrients. The aim of this review is to highlight the fundamental role of vitamin supplementation in physical activity. Above all, we focus on the roles of vitamins A, …

Vitamins are introduced to the diet because the human body is unable to produce these micronutrients. The aim of this review is to hi …

92

Association of Vitamin Deficiency With Pulmonary Arterial Hypertension: A Review.

Jin Y, Ding L, Fan M, Kong N. Jin Y, et al. Nutr Rev. 2026 Jun 1;84(6):1227-1238. doi: 10.1093/nutrit/nuaf119. Nutr Rev. 2026. PMID: 40644452 Review.

However, a comprehensive characterization of vitamin deficiencies in patients with PAH and their potential roles remains lacking. Consequently, this review aims to synthesize existing literature on the roles of vitamins in PAH, encompassing the epidemiology of vi …

However, a comprehensive characterization of vitamin deficiencies in patients with PAH and their potential roles remains lacking. Con …

93

Pretreatment of vitamin D3 ameliorates lung and muscle injury induced by reperfusion of bilateral femoral vessels in a rat model.

Shih PK, Chen YC, Huang YC, Chang YT, Chen JX, Cheng CM. Shih PK, et al. J Surg Res. 2011 Nov;171(1):323-8. doi: 10.1016/j.jss.2010.03.008. Epub 2010 Mar 31. J Surg Res. 2011. PMID: 20462603

Compared with the saline + I/R group, there was a significant decrease in plasma IL-6 level, muscle and lung wet/dry weight ratio in both vitamin D3 + sham and vitamin D3 + I/R groups, and leukocyte HO-1 expression in vitamin D3 + sham group (P < 0.05). Co

…

Compared with the saline + I/R group, there was a significant decrease in plasma IL-6 level, muscle and lung wet/dry weight ratio in both …

94

Treating endothelial dysfunction with vitamin D in chronic kidney disease: a meta-analysis.

Lundwall K, Jacobson SH, Jörneskog G, Spaak J. Lundwall K, et al. BMC Nephrol. 2018 Sep 25;19(1):247. doi: 10.1186/s12882-018-1042-y. BMC Nephrol. 2018. PMID: 30253741 Free PMC article.

BACKGROUND: Vitamin D deficiency is common in patients with chronic kidney disease (CKD), and is associated with endothelial dysfunction and cardiovascular disease. ...CONCLUSIONS: Short term intervention with vitamin D is associated with improvements in endo …

BACKGROUND: Vitamin D deficiency is common in patients with chronic kidney disease (CKD), and is associated with endothelial dysfunct …

95

The molecular biology and pathophysiology of vascular calcification.

McCarty MF, DiNicolantonio JJ. McCarty MF, et al. Postgrad Med. 2014 Mar;126(2):54-64. doi: 10.3810/pgm.2014.03.2740. Postgrad Med. 2014. PMID: 24685968 Review.

Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for cardiovascular events and mortality. Calcification of the arterial media and of heart valves clearly plays a mediating role in this …

Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for …

96

Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N'-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke.

Mnafgui K, Khdhiri E, Ghazouani L, Ncir M, Zaafouri Z, Allouche N, Elfeki A, Ammar H, Abid S, Hajji R. Mnafgui K, et al. Arch Physiol Biochem. 2021 Dec;127(6):527-540. doi: 10.1080/13813455.2019.1657900. Epub 2019 Aug 30. Arch Physiol Biochem. 2021. PMID: 31469295

97

Cardiovascular calcification in patients with end-stage renal disease: a century-old phenomenon.

Qunibi WY, Nolan CA, Ayus JC. Qunibi WY, et al. Kidney Int Suppl. 2002 Dec;(82):S73-80. doi: 10.1046/j.1523-1755.62.s82.15.x. Kidney Int Suppl. 2002. PMID: 12410860 Free article. Review.

Recently, a number of the dialysis-specific risk factors have been implicated in the pathogenesis of cardiovascular calcification. These include: hyperphosphatemia, high calcium-phosphate (Ca x P) product, elevated parathyroid hormone levels, duration of dialysis, and trea …

Recently, a number of the dialysis-specific risk factors have been implicated in the pathogenesis of cardiovascular calcification. Th …

98

Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia.

Mandell E, Seedorf G, Gien J, Abman SH. Mandell E, et al. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1;306(5):L420-8. doi: 10.1152/ajplung.00344.2013. Epub 2014 Jan 10. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24414254 Free PMC article.

Vitamin D (vit D) has anti-inflammatory properties and modulates lung growth, but whether vit D can prevent lung injury after exposure to antenatal inflammation is unknown. ...

Vitamin D (vit D) has anti-inflammatory properties and modulates lung growth, but whether vit D can prevent lung injury after exposur …

99

Diet-induced hypertension and cardiovascular lesions in mice.

Smith-Vaniz GT, Ashburn AD, Williams WL. Smith-Vaniz GT, et al. Yale J Biol Med. 1970 Oct;43(2):61-70. Yale J Biol Med. 1970. PMID: 4099269 Free PMC article. No abstract available.

100

Biomarkers of Key Biological Pathways in CVD.

Jenny NS, Olson NC, Allison MA, Rifkin DE, Daniels LB, de Boer IH, Wassel CL, Tracy RP. Jenny NS, et al. Glob Heart. 2016 Sep;11(3):327-336.e3. doi: 10.1016/j.gheart.2016.07.003. Glob Heart. 2016. PMID: 27741979 Free PMC article. Review.

The contributions of MESA biomarkers to our knowledge of these key pathways in the development and progression of atherosclerosis, cardiovascular disease, diabetes, kidney disease, and pulmonary disease are highlighted, as are the contributions of MESA to recommendations f …

The contributions of MESA biomarkers to our knowledge of these key pathways in the development and progression of atherosclerosis, cardio …

101

How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?

Brecht P, Dring JC, Yanez F, Styczeń A, Mertowska P, Mertowski S, Grywalska E. Brecht P, et al. Nutrients. 2023 Jul 24;15(14):3264. doi: 10.3390/nu15143264. Nutrients. 2023. PMID: 37513682 Free PMC article. Review.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, far ahead of cancer. ...This review aimed to draw attention to the role of selected minerals and vitamins in health and the development and progression of CVDs in adults and children. Particula …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, far ahead of cancer. ...This review aimed to draw attention …

102

Vitamin CNa enhances the antioxidant ability of chicken myocardium cells and induces heat shock proteins to relieve heat stress injury.

Yin B, Di L, Tang S, Bao E. Yin B, et al. Res Vet Sci. 2020 Dec;133:124-130. doi: 10.1016/j.rvsc.2020.09.008. Epub 2020 Sep 11. Res Vet Sci. 2020. PMID: 32977120

In order to explore the function of vitamin C (VC) and VC-Na in the relief of heat stress injury in chicken cardiomyocytes, 150 30-day-old specific-pathogen-free chickens were randomly divided into a control group (fed normal drinking water), a VC group (50 mug/mL VC in dr …

In order to explore the function of vitamin C (VC) and VC-Na in the relief of heat stress injury in chicken cardiomyocytes, 150 30-da …

103

[Antioxidant vitamin supplementation in the prevention of cardiovascular disease].

Yuen B, Furrer L, Ballmer PE. Yuen B, et al. Ther Umsch. 2005 Sep;62(9):615-8. doi: 10.1024/0040-5930.62.9.615. Ther Umsch. 2005. PMID: 16218497 Review. German.

Various observational epidemiological studies have suggested that antioxidant vitamin intake is associated with reduced cardiovascular morbidity and mortality. Also, experimental studies in animals have demonstrated that antioxidant vitamins slow the progress …

Various observational epidemiological studies have suggested that antioxidant vitamin intake is associated with reduced cardiovasc …

104

[Cardiovascular complications of desoxycorticosterone acetate and vitamin C in therapeutic doses].

MIRCOLI D, CAZZOLA R. MIRCOLI D, et al. Rass Clin Sci. 1951 Jun;27(6):174-7. Rass Clin Sci. 1951. PMID: 14864889 Undetermined Language. No abstract available.

105

Relationship between vitamin D status and left ventricular geometry in a healthy population: results from the Baltimore Longitudinal Study of Aging.

Ameri P, Canepa M, Milaneschi Y, Spallarossa P, Leoncini G, Giallauria F, Strait JB, Lakatta EG, Brunelli C, Murialdo G, Ferrucci L. Ameri P, et al. J Intern Med. 2013 Mar;273(3):253-62. doi: 10.1111/joim.12007. Epub 2012 Nov 12. J Intern Med. 2013. PMID: 23061475 Free PMC article.

OBJECTIVES: The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We investigated the relation between vitamin D status and left ventricular (LV) structure and function in community-dwelling subjects wi …

OBJECTIVES: The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We …

106

A significant correlation between the plasma levels of coenzyme Q10 and vitamin B-6 and a reduced risk of coronary artery disease.

Lee BJ, Yen CH, Hsu HC, Lin JY, Hsia S, Lin PT. Lee BJ, et al. Nutr Res. 2012 Oct;32(10):751-6. doi: 10.1016/j.nutres.2012.09.003. Epub 2012 Oct 12. Nutr Res. 2012. PMID: 23146771

Subjects with CAD had significantly lower plasma levels of coenzyme Q10 and vitamin B-6 compared to the control group. The plasma coenzyme Q10 concentration (beta = 1.06, P = .02) and the ratio of coenzyme Q10 to total cholesterol (beta = .28, P = .01) were positively corr …

Subjects with CAD had significantly lower plasma levels of coenzyme Q10 and vitamin B-6 compared to the control group. The plasma coe …

107

Heart muscle and plasma vitamin Q with heart transplantation.

Karlsson J, Semb B. Karlsson J, et al. Can J Cardiol. 1997 Feb;13(2):147-52. Can J Cardiol. 1997. PMID: 9070166

OBJECTIVE: To study variations in heart muscle septum and plasma vitamin Q (Q, ubiquinone, n = 9) and plasma vitamin E (E, alpha-tocopherol, n = 4) in heart transplant patients. ...

OBJECTIVE: To study variations in heart muscle septum and plasma vitamin Q (Q, ubiquinone, n = 9) and plasma vitamin E (E, alp …

108

Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver homogenates.

Zarei M, Fakher S, Tabei SM, Javanbakht MH, Derakhshanian H, Farahbakhsh-Farsi P, Sadeghi MR, Mostafavi E, Djalali M. Zarei M, et al. Singapore Med J. 2016 Mar;57(3):153-6. doi: 10.11622/smedj.2015102. Singapore Med J. 2016. PMID: 26996784 Free PMC article.

INTRODUCTION: This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus. ...No significant change …

INTRODUCTION: This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty …

109

Impact evidence of the vitamin D status in hypertensive patients in Morocco.

Azmi H, Lamsisi M, Ait Faraji S, El Mzibri M, Ennaji MM. Azmi H, et al. Cell Mol Biol (Noisy-le-grand). 2022 Dec 31;68(12):21-25. doi: 10.14715/cmb/2022.68.12.5. Cell Mol Biol (Noisy-le-grand). 2022. PMID: 37130186

Vitamin D deficiency is a hot topic as it affects about 50% of the world's population. Beyond its extra-osseous effects, notably on the cardiovascular system. In recent years many epidemiological studies have looked at the role of vitamin D status in m …

Vitamin D deficiency is a hot topic as it affects about 50% of the world's population. Beyond its extra-osseous effects, notably on t …

110

Vitamins C and P in cardiovascular and cerebrovascular disease.

GALE ET, THEWLIS MW. GALE ET, et al. Geriatrics. 1953 Feb;8(2):80-7. Geriatrics. 1953. PMID: 13034044 No abstract available.

111

N-acetylcysteine modulates doxorubicin-induced oxidative stress and antioxidant vitamin concentrations in liver of rats.

Koçkar MC, Nazıroğlu M, Celik O, Tola HT, Bayram D, Koyu A. Koçkar MC, et al. Cell Biochem Funct. 2010 Dec 2;28(8):673-7. doi: 10.1002/cbf.1707. Epub 2010 Nov 8. Cell Biochem Funct. 2010. PMID: 21104935

The most common side effect of DOX was indicated on cardiovascular system by experimental studies. There are some studies suggesting oxidative stress-induced toxic changes on liver related to DOX administration. ...Lipid peroxidation (LP) levels were higher in the D …

The most common side effect of DOX was indicated on cardiovascular system by experimental studies. There are some studies sugg …

112

The Possible Influence of Vitamin D Levels on the Development of Atrial Fibrillation-An Update.

Graczyk S, Grzeczka A, Pasławska U, Kordowitzki P. Graczyk S, et al. Nutrients. 2023 Jun 12;15(12):2725. doi: 10.3390/nu15122725. Nutrients. 2023. PMID: 37375629 Free PMC article. Review.

Atrial fibrillation (AF) is a severe and most common supraventricular arrhythmia in humans, which, if left untreated or treated ineffectively, can lead to ischemic stroke or heart failure. It has been suggested that serum vitamin D (VitD) deficiency may be one of the criti …

Atrial fibrillation (AF) is a severe and most common supraventricular arrhythmia in humans, which, if left untreated or treated ineffectivel …

113

CAPILLARY fragility, vitamin P and rutin.

[No authors listed] [No authors listed] Chem Drug. 1948 Jan 24;149(3544):112-5. Chem Drug. 1948. PMID: 18921366 No abstract available.

114

Endothelial relaxation mechanisms and nitrative stress are partly restored by Vitamin D3 therapy in a rat model of polycystic ovary syndrome.

Masszi G, Benko R, Csibi N, Horvath EM, Tokes AM, Novak A, Beres NJ, Tarszabo R, Buday A, Repas C, Bekesi G, Patocs A, Nadasy GL, Hamar P, Benyo Z, Varbiro S. Masszi G, et al. Life Sci. 2013 Aug 6;93(4):133-8. doi: 10.1016/j.lfs.2013.05.003. Epub 2013 May 14. Life Sci. 2013. PMID: 23685132

AIMS: In polycystic ovary syndrome (PCOS), metabolic and cardiovascular dysfunction is related to hyperandrogenic status and insulin resistance, however, Vitamin D3 has a beneficial effect partly due to its anti-oxidant capacity. Nitrative stress is a major factor i …

AIMS: In polycystic ovary syndrome (PCOS), metabolic and cardiovascular dysfunction is related to hyperandrogenic status and insulin …

115

Is oxidative stress a therapeutic target in cardiovascular disease?

Münzel T, Gori T, Bruno RM, Taddei S. Münzel T, et al. Eur Heart J. 2010 Nov;31(22):2741-8. doi: 10.1093/eurheartj/ehq396. Epub 2010 Oct 25. Eur Heart J. 2010. PMID: 20974801 Review.

Despite this sound biological rationale and a number of pre-clinical and clinical lines of evidence, studies testing the effects of classical antioxidants such as vitamin C, vitamin E, or folic acid in combination with vitamin E have been disappointing. Rathe …

Despite this sound biological rationale and a number of pre-clinical and clinical lines of evidence, studies testing the effects of classica …

116

[New observations of vitamin therapy A and E in cardiovascular diseases].

AGADJANIAN N. AGADJANIAN N. J Med Paris. 1948 Mar;68(3):48. J Med Paris. 1948. PMID: 18858665 French. No abstract available.

117

Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study.

Nanayakkara PW, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD. Nanayakkara PW, et al. Arch Intern Med. 2007 Jun 25;167(12):1262-70. doi: 10.1001/archinte.167.12.1262. Arch Intern Med. 2007. PMID: 17592099 Clinical Trial.

BACKGROUND: Patients with chronic kidney disease have an increased risk of cardiovascular disease. Oxidative stress has been proposed to play a role in the development of cardiovascular disease among these patients. ...The treatment group received a regimen of prava …

BACKGROUND: Patients with chronic kidney disease have an increased risk of cardiovascular disease. Oxidative stress has been proposed …

118

Effects of vitamin-mineral supplementation on cardiac marker and radical scavenging enzymes, and MDA levels in young swimmers.

Cavas L, Tarhan L. Cavas L, et al. Int J Sport Nutr Exerc Metab. 2004 Apr;14(2):133-46. doi: 10.1123/ijsnem.14.2.133. Int J Sport Nutr Exerc Metab. 2004. PMID: 15118188 Clinical Trial.

The relationship among the enzyme activities of cardiac markers, the antioxidant defense system, and erythrocyte membrane malonyldialdehyde (MDA) levels related to vitamin-mineral supplementation in swim exercise was investigated. ...Antioxidant enzyme activity incr …

The relationship among the enzyme activities of cardiac markers, the antioxidant defense system, and erythrocyte membrane malonyldial …

119

The effect of vitamin D supplementation on endothelial function: An umbrella review of interventional meta-analyses.

Chen Y, Chen D, Peng Y, Wang M, Wang W, Shi F, Wang Y, Hua L. Chen Y, et al. Nutr Metab Cardiovasc Dis. 2025 Jul;35(7):103871. doi: 10.1016/j.numecd.2025.103871. Epub 2025 Jan 25. Nutr Metab Cardiovasc Dis. 2025. PMID: 39986938

AIMS: There is no consensus in the existing literature regarding the effect of vitamin D supplementation on endothelial function. This umbrella review aimed to assess meta-analyses of randomized controlled trials (RCTs) conducted in this field. ...CONCLUSION: These finding …

AIMS: There is no consensus in the existing literature regarding the effect of vitamin D supplementation on endothelial function. Thi …

120

Effect of calcifediol treatment on cardiovascular outcomes in patients with acute coronary syndrome and percutaneous revascularization.

Navarro-Valverde C, Quesada-Gómez JM, Pérez-Cano R, Fernández-Palacín A, Pastor-Torres LF. Navarro-Valverde C, et al. Med Clin (Barc). 2018 Nov 9;151(9):345-352. doi: 10.1016/j.medcli.2017.11.033. Epub 2018 Jan 3. Med Clin (Barc). 2018. PMID: 29306481 Clinical Trial. English, Spanish.

BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been consistently linked with cardiovascular diseases. However, results of intervention studies are contradictory. The aim of this study was to evaluate the effect of treatment with calcifediol (25(OH)D(3)) on the …

BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been consistently linked with cardiovascular diseases. However, results of …

121

Additive effect of homocysteine- and cholesterol-lowering therapy on endothelium-dependent vasodilation in patients with cardiovascular disease.

Wustmann K, Klaey M, Burow A, Shaw SG, Hess OM, Allemann Y. Wustmann K, et al. Cardiovasc Ther. 2012 Oct;30(5):277-86. doi: 10.1111/j.1755-5922.2011.00272.x. Epub 2011 Jul 31. Cardiovasc Ther. 2012. PMID: 21884007 Free article. Clinical Trial.

Thus, we evaluated the effect of rosuvastatin, B-group vitamins and their combination on endothelial function in high-risk cardiovascular patients. ...CONCLUSIONS: In conclusion, both treatments, rosuvastatin and B-group vitamin supplementation, improved endo …

Thus, we evaluated the effect of rosuvastatin, B-group vitamins and their combination on endothelial function in high-risk cardiov …

122

Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using (18)F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design.

Peeters FECM, van Mourik MJW, Meex SJR, Bucerius J, Schalla SM, Gerretsen SC, Mihl C, Dweck MR, Schurgers LJ, Wildberger JE, Crijns HJGM, Kietselaer BLJH. Peeters FECM, et al. Nutrients. 2018 Mar 21;10(4):386. doi: 10.3390/nu10040386. Nutrients. 2018. PMID: 29561783 Free PMC article.

BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) on imaging measurements of calcification in the bicuspid aortic valve (BAV) and calcific aortic valve stenosis (CAVS). ...Matrix Gla protei …

BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) …

123

Effects of dietary vitamin E and C supplementation on heart failure in fast growing commercial broiler chickens.

Nain S, Wojnarowicz C, Laarveld B, Olkowski AA. Nain S, et al. Br Poult Sci. 2008 Nov;49(6):697-704. doi: 10.1080/00071660802415658. Br Poult Sci. 2008. PMID: 19093242 Clinical Trial.

The present study examines the effects of supplementation of these vitamins on incidence of CHF and prevention of oxidative stress in the myocardium. 2. Commercial male broilers were randomly allocated to three experimental groups and, respectively, offered commercial broi …

The present study examines the effects of supplementation of these vitamins on incidence of CHF and prevention of oxidative stress in …

124

Late administration of antenatal vitamin A promotes pulmonary structural maturation and improves ventilation in the lamb model of congenital diaphragmatic hernia.

Lewis NA, Holm BA, Rossman J, Swartz D, Glick PL. Lewis NA, et al. Pediatr Surg Int. 2011 Feb;27(2):119-24. doi: 10.1007/s00383-010-2790-3. Pediatr Surg Int. 2011. PMID: 21153554

Group 1 lambs (CDH, n = 5) were untreated. In group 2 (CDH + vitamin A, n = 6) and group 3 lambs (control + vitamin A, n = 3) right jugular venous catheters were inserted at 118-120 days and retinyl palmitate (vitamin A) was administered until 135 days. ...In …

Group 1 lambs (CDH, n = 5) were untreated. In group 2 (CDH + vitamin A, n = 6) and group 3 lambs (control + vitamin A, n = 3) …

125

ADAM10 modulates calcitriol-regulated RAGE in cardiomyocytes.

Lee TW, Kao YH, Lee TI, Chen YJ. Lee TW, et al. Eur J Clin Invest. 2017 Sep;47(9):675-683. doi: 10.1111/eci.12789. Epub 2017 Aug 7. Eur J Clin Invest. 2017. PMID: 28722189

BACKGROUND: Receptor for advanced glycation end products (RAGE) signalling plays a critical role in the pathogenesis of cardiovascular disease. Calcitriol modulates cardiac RAGE expression. This study explored the mechanisms underlying the effect of calcitriol on RAGE and …

BACKGROUND: Receptor for advanced glycation end products (RAGE) signalling plays a critical role in the pathogenesis of cardiovascular …

126

Antioxidant therapy in critical care--is the microcirculation the primary target?

Biesalski HK, McGregor GP. Biesalski HK, et al. Crit Care Med. 2007 Sep;35(9 Suppl):S577-83. doi: 10.1097/01.CCM.0000278598.95294.C5. Crit Care Med. 2007. PMID: 17713412

Parenteral high-dose vitamin C inhibits endotoxin-induced endothelial dysfunction and vasohyporeactivity in humans and reverses sepsis-induced suppression of microcirculatory control in rodents. In severe burn injury, in both animals and patients, parenteral high-dose v …

Parenteral high-dose vitamin C inhibits endotoxin-induced endothelial dysfunction and vasohyporeactivity in humans and reverses sepsi …

127

Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review.

Dragan S, Buleu F, Christodorescu R, Cobzariu F, Iurciuc S, Velimirovici D, Xiao J, Luca CT. Dragan S, et al. Crit Rev Food Sci Nutr. 2019;59(6):965-981. doi: 10.1080/10408398.2018.1540398. Epub 2018 Dec 3. Crit Rev Food Sci Nutr. 2019. PMID: 30507249 Review.

128

Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis.

Marampon F, Gravina GL, Festuccia C, Popov VM, Colapietro A, Sanità P, Musio D, De Felice F, Lenzi A, Jannini EA, Di Cesare E, Tombolini V. Marampon F, et al. J Endocrinol Invest. 2016 Apr;39(4):411-22. doi: 10.1007/s40618-015-0381-9. Epub 2015 Sep 3. J Endocrinol Invest. 2016. PMID: 26335302

Here, we investigated on radioprotective properties of Vitamin D (Vit.D) on human endothelial cells (HUVEC). METHODS: HUVEC, pre-treated with Vit.D, were exposed to ionizing radiation (IR): ROS production, cellular viability, apoptosis, senescence and western blot for prot …

Here, we investigated on radioprotective properties of Vitamin D (Vit.D) on human endothelial cells (HUVEC). METHODS: HUVEC, pre-trea …

129

Vitamin C Deficiency-Induced Pulmonary Arterial Hypertension.

Gayen SK, Abdelrahman AA, Preston IR, Petit RD, Hill NS. Gayen SK, et al. Chest. 2020 Feb;157(2):e21-e23. doi: 10.1016/j.chest.2019.06.043. Chest. 2020. PMID: 32033656

We report a case of a man in his 60s who developed pulmonary arterial hypertension (PAH) in association with profound vitamin C deficiency. Decreased availability of endothelial nitric oxide and activation of the hypoxia-inducible family of transcription factors, both cons …

We report a case of a man in his 60s who developed pulmonary arterial hypertension (PAH) in association with profound vitamin C defic …

130

[Effect of vitamin C and cortisone administered at the same time as desoxycorticosterone on the cardiovascular and renal lesions provoked by the latter in the rat].

LANZA B, FRASSINETI A. LANZA B, et al. Boll Soc Ital Biol Sper. 1951 May;27(5):757-9. Boll Soc Ital Biol Sper. 1951. PMID: 14878838 Undetermined Language. No abstract available.

131

Human nutrition and blood pressure regulation: an integrated approach.

McCarron DA, Henry HJ, Morris CD. McCarron DA, et al. Hypertension. 1982 Sep-Oct;4(5 Pt 2):III2-13. doi: 10.1161/01.hyp.4.5_pt_2.iii2. Hypertension. 1982. PMID: 7049930 Review.

This review highlights the complex interactions that constitute the disciplines of nutrition and cardiovascular physiology. Nutritional factors have long been considered as critical in the pathogenesis of human hypertension. ..."Accepted" principles of nutrient interaction …

This review highlights the complex interactions that constitute the disciplines of nutrition and cardiovascular physiology. Nutrition …

132

Should hypertensive patients take vitamin D?

Wuerzner G, Burnier M, Waeber B. Wuerzner G, et al. Curr Hypertens Rep. 2012 Aug;14(4):318-23. doi: 10.1007/s11906-012-0271-x. Curr Hypertens Rep. 2012. PMID: 22648128 Review.

The prevalence of both hypertension and vitamin D deficiency is high. The discovery of the vitamin D receptor and its possible effects on components of the cardiovascular system influencing blood pressure, such as the renin angiotensin system, t …

The prevalence of both hypertension and vitamin D deficiency is high. The discovery of the vitamin D receptor and its possible …

133

Endothelial dysfunction in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementation.

Chia S, Wilson R, Ludlam CA, Webb DJ, Flapan AD, Newby DE. Chia S, et al. Clin Sci (Lond). 2005 Jan;108(1):65-72. doi: 10.1042/CS20040150. Clin Sci (Lond). 2005. PMID: 15367100 Clinical Trial.

There were no differences in substance P-induced tissue plasminogen activator release. Vitamin supplementation increased serum folate and vitamin B12 concentrations (P<0.05), but did not significantly lower homocysteine, or affect FBF or fibrinolytic responses. . …

There were no differences in substance P-induced tissue plasminogen activator release. Vitamin supplementation increased serum folate …

134

Herbal therapies and cardiac side effects.

Flattery M. Flattery M. Prog Cardiovasc Nurs. 2008 Fall;23(4):187-90. doi: 10.1111/j.1751-7117.2008.00014.x. Prog Cardiovasc Nurs. 2008. PMID: 19067984 Review. No abstract available.

135

Effects of the administration of a vitamin E concentrate and of cholesterol and bile salt on the aorta of the rat.

MARX W, MARX L, et al. MARX W, et al. Arch Pathol (Chic). 1949 May;47(5):440-5. Arch Pathol (Chic). 1949. PMID: 18131184 No abstract available.

136

Vitamin D supplementation for the improvement of vascular function in patients with chronic kidney disease: a meta-analysis of randomized controlled trials.

Dou D, Yang B, Gan H, Xie D, Lei H, Ye N. Dou D, et al. Int Urol Nephrol. 2019 May;51(5):851-858. doi: 10.1007/s11255-019-02088-3. Epub 2019 Feb 8. Int Urol Nephrol. 2019. PMID: 30737643

BACKGROUND: The efficacy of vitamin D on vascular function remains controversial in chronic kidney disease (CKD) patients. ...For phosphorus (P), systolic blood pressure (SBP), and diastolic blood pressure (DBP), there were no significant differences between the two groups …

BACKGROUND: The efficacy of vitamin D on vascular function remains controversial in chronic kidney disease (CKD) patients. ...For pho …

137

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.

Münzel T, Gori T, Keaney JF Jr, Maack C, Daiber A. Münzel T, et al. Eur Heart J. 2015 Oct 7;36(38):2555-64. doi: 10.1093/eurheartj/ehv305. Epub 2015 Jul 4. Eur Heart J. 2015. PMID: 26142467 Free PMC article. Review.

Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin-angiotensin-aldosterone system (RAAS), and with a subsequent inappropriately increased production of reactive oxygen species (ROS). .. …

Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin-a …

138

Dietary vitamin E (alpha-tocopherol acetate) and selenium supplementation from different sources: performance, ascites-related variables and antioxidant status in broilers reared at low and optimum temperatures.

Ozkan S, Malayoğlu HB, Yalçin S, Karadas F, Koçtürk S, Cabuk M, Oktay G, Ozdemir S, Ozdemir E, Ergül M. Ozkan S, et al. Br Poult Sci. 2007 Oct;48(5):580-93. doi: 10.1080/00071660701593951. Br Poult Sci. 2007. PMID: 17952730 Clinical Trial.

Diet 1, the control diet, comprised a commercial diet containing 0.15 mg/kg inorganic Se and 50 mg vitamin E/kg feed. Diet 2 was the same as diet 1, supplemented with 0.15 mg/kg inorganic Se. Diet 3 was the same as diet 2 but was supplemented with 200 mg/kg vitamin …

Diet 1, the control diet, comprised a commercial diet containing 0.15 mg/kg inorganic Se and 50 mg vitamin E/kg feed. Diet 2 was the …

139

Deficiency of B vitamins leads to cholesterol-independent atherogenic transformation of the aorta.

Almer G, Opriessnig P, Wolinski H, Sommer G, Diwoky C, Lechleitner M, Kolb D, Bubalo V, Brunner MS, Schwarz AN, Leitinger G, Schoiswohl G, Marsche G, Niedrist T, Schauer S, Oswald W, Groselj-Strele A, Paar M, Cvirn G, Hoefler G, Rechberger GN, Herrmann M, Frank S, Holzapfel GA, Kratky D, Mangge H, Hörl G, Tehlivets O. Almer G, et al. Biomed Pharmacother. 2022 Oct;154:113640. doi: 10.1016/j.biopha.2022.113640. Epub 2022 Sep 5. Biomed Pharmacother. 2022. PMID: 36081286 Free PMC article.

Atherosclerosis, the leading cause of cardiovascular disease responsible for the majority of deaths worldwide, cannot be sufficiently explained by established risk factors, including hypercholesterolemia. ...Our automated system helped to glean vital details of chol …

Atherosclerosis, the leading cause of cardiovascular disease responsible for the majority of deaths worldwide, cannot be sufficiently …

140

Americans love hogwash.

Rynearson EH. Rynearson EH. Nutr Rev. 1974 Jul;32(0):suppl 1:1-14. doi: 10.1111/j.1753-4887.1974.tb05179.x. Nutr Rev. 1974. PMID: 4367657 No abstract available.

141

Vitamin D Attenuates Loss of Endothelial Biomarker Expression in Cardio-Endothelial Cells.

Lai CC, Juang WC, Sun GC, Tseng YK, Jhong RC, Tseng CJ, Wong TY, Cheng PW. Lai CC, et al. Int J Mol Sci. 2020 Mar 22;21(6):2196. doi: 10.3390/ijms21062196. Int J Mol Sci. 2020. PMID: 32235811 Free PMC article.

Vitamin D is associated with cardiovascular health through activating the vitamin D receptor that targets genes related to cardiovascular disease (CVD). ...Based on this study, the beneficial effect of vitamin D may be insignificant; however, fu …

Vitamin D is associated with cardiovascular health through activating the vitamin D receptor that targets genes related …

142

A pilot study to assess the effect of a three-month vitamin supplementation containing L-methylfolate on systemic homocysteine plasma concentrations and retinal blood flow in patients with diabetes.

Schmidl D, Howorka K, Szegedi S, Stjepanek K, Puchner S, Bata A, Scheschy U, Aschinger G, Werkmeister RM, Schmetterer L, Garhofer G. Schmidl D, et al. Mol Vis. 2020 Apr 24;26:326-333. eCollection 2020. Mol Vis. 2020. PMID: 32355442 Free PMC article.

Retinal blood flow was measured using a custom-built dual-beam Doppler optical coherence tomography (OCT) system. In addition, flicker-induced retinal vasodilatation was assessed by means of a commercially available dynamic vessel analyzer (IMEDOS, Jena, Germany). ...

Retinal blood flow was measured using a custom-built dual-beam Doppler optical coherence tomography (OCT) system. In addition, flicke …

143

Adverse myocardial effects of B-vitamin therapy in subjects with chronic kidney disease and hyperhomocysteinaemia.

Rafeq Z, Roh JD, Guarino P, Kaufman J, Joseph J. Rafeq Z, et al. Nutr Metab Cardiovasc Dis. 2013 Sep;23(9):836-42. doi: 10.1016/j.numecd.2012.07.002. Epub 2012 Aug 16. Nutr Metab Cardiovasc Dis. 2013. PMID: 22902185 Clinical Trial.

HCY levels were inversely correlated with diastolic function (R=-0.21; p=0.038). Vitamin therapy resulted in a significant increase in left atrial size (+0.15 0.8 cm vs. -0.13 0.07 cm; p=0.0095). ...These findings suggest that high-dose B vitamin therapy may be harm …

HCY levels were inversely correlated with diastolic function (R=-0.21; p=0.038). Vitamin therapy resulted in a significant increase i …

144

Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics.

He J, Gao Z, Li X, Zhao L, Tian X, Gao B. He J, et al. Brain Res. 2025 Jul 1;1858:149656. doi: 10.1016/j.brainres.2025.149656. Epub 2025 Apr 24. Brain Res. 2025. PMID: 40286835

BACKGROUND: Vitamin D is increasingly recognized for its neuroprotective, anti-inflammatory, and immunomodulatory roles in mental health. However, its delivery to the central nervous system remains constrained by various factors. OBJECTIVE: This systematic review ev …

BACKGROUND: Vitamin D is increasingly recognized for its neuroprotective, anti-inflammatory, and immunomodulatory roles in mental hea …

145

Extracellular magnesium regulates effects of vitamin B6, B12 and folate on homocysteinemia-induced depletion of intracellular free magnesium ions in canine cerebral vascular smooth muscle cells: possible relationship to [Ca2+]i, atherogenesis and stroke.

Li W, Zheng T, Wang J, Altura BT, Altura BM. Li W, et al. Neurosci Lett. 1999 Oct 22;274(2):83-6. doi: 10.1016/s0304-3940(99)00683-7. Neurosci Lett. 1999. PMID: 10553943

Depletion of [Mg2+]i, induced by HC, was potentiated by low Mg2+. Preincubation of these cells with vitamin B6, vitamin B12, folic acid, alone, did not alter [Ca2+]i or [Mg2+]i. Likewise, concomitant addition of vitamin B6, vitamin B12, or folic acid, …

Depletion of [Mg2+]i, induced by HC, was potentiated by low Mg2+. Preincubation of these cells with vitamin B6, vitamin B12, f …

146

Transferrin-functionalized liposomes loaded with vitamin VB12 for Alzheimer's disease therapy.

Andrade S, Ramalho MJ, Loureiro JA, Pereira MC. Andrade S, et al. Int J Pharm. 2022 Oct 15;626:122167. doi: 10.1016/j.ijpharm.2022.122167. Epub 2022 Sep 6. Int J Pharm. 2022. PMID: 36075524 Free article.

Despite the efforts of the pharmaceutical and research sectors, Alzheimer's disease (AD) remains incurable, imposing the demand for new effective strategies. Vitamin B12 (VB12) has aroused interest due to its in vitro anti-amyloidogenic properties. ...

Despite the efforts of the pharmaceutical and research sectors, Alzheimer's disease (AD) remains incurable, imposing the demand for new effe …

147

Association of Vitamin B12 Deficiency with Homozygosity of the TT MTHFR C677T Genotype, Hyperhomocysteinemia, and Endothelial Cell Dysfunction.

Shiran A, Remer E, Asmer I, Karkabi B, Zittan E, Cassel A, Barak M, Rozenberg O, Karkabi K, Flugelman MY. Shiran A, et al. Isr Med Assoc J. 2015 May;17(5):288-92. Isr Med Assoc J. 2015. PMID: 26137654 Free article.

BACKGROUND: Hyperhomocysteinemia is associated with increased cardiovascular risk, but treatment with folic acid has no effect on outcome in unselected patient populations. ...Based on our findings we suggest that B12 deficiency be tested for MTHFR polymorphism in order to …

BACKGROUND: Hyperhomocysteinemia is associated with increased cardiovascular risk, but treatment with folic acid has no effect on out …

148

A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.

Kumar V, Yadav AK, Lal A, Kumar V, Singhal M, Billot L, Gupta KL, Banerjee D, Jha V. Kumar V, et al. J Am Soc Nephrol. 2017 Oct;28(10):3100-3108. doi: 10.1681/ASN.2017010003. Epub 2017 Jun 30. J Am Soc Nephrol. 2017. PMID: 28667080 Free PMC article. Clinical Trial.

Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. ...Thus, in nondiabetic patients with stage 3-4 CKD and vitamin D deficiency, vitamin D supplem …

Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovas …

149

Anabolic steroids and ergogenic aids.

Hough DO. Hough DO. Am Fam Physician. 1990 Apr;41(4):1157-64. Am Fam Physician. 1990. PMID: 2181832 Review.

150

Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium.

Wilson JX. Wilson JX. Biofactors. 2009 Jan-Feb;35(1):5-13. doi: 10.1002/biof.7. Biofactors. 2009. PMID: 19319840 Free PMC article. Review.

Circulating levels of vitamin C (ascorbate) are low in patients with sepsis. Parenteral administration of ascorbate raises plasma and tissue concentrations of the vitamin and may decrease morbidity. ...

Circulating levels of vitamin C (ascorbate) are low in patients with sepsis. Parenteral administration of ascorbate raises plasma and …

151

Disruption of Vitamin D Signaling Impairs Adaptation of Cerebrocortical Microcirculation to Carotid Artery Occlusion in Hyperandrogenic Female Mice.

Nagy D, Hricisák L, Walford GP, Lékai Á, Karácsony G, Várbíró S, Ungvári Z, Benyó Z, Pál É. Nagy D, et al. Nutrients. 2023 Sep 5;15(18):3869. doi: 10.3390/nu15183869. Nutrients. 2023. PMID: 37764653 Free PMC article.

Vitamin D deficiency contributes to the pathogenesis of age-related cerebrovascular diseases, including ischemic stroke. ...To investigate the potential interaction between sex steroids and disrupted vitamin D signaling in the cerebral microcirculation, we examined …

Vitamin D deficiency contributes to the pathogenesis of age-related cerebrovascular diseases, including ischemic stroke. ...To invest …

152

Vitamin and metabolism of heart muscle.

YAMADA K. YAMADA K. Jpn Circ J. 1962 Feb;26:128-36. doi: 10.1253/jcj.26.128. Jpn Circ J. 1962. PMID: 14002233 No abstract available.

153

Intraventricular block in malnutrition and vitamin B deficiency a report of two cases in children.

BRAUN K, ROTH I, SUESSKIND S. BRAUN K, et al. J Pediatr. 1947 Feb;30(2):177-81. doi: 10.1016/s0022-3476(47)80031-9. J Pediatr. 1947. PMID: 20284535 No abstract available.

154

Vitamin D sclerosis of the arteries and the danger of feeding extra vitamin D to older people, with a view on the development of different forms of arteriosclerosis.

DE LANGEN CD, DONATH WF. DE LANGEN CD, et al. Acta Med Scand. 1956 Dec 31;156(4):317-23. doi: 10.1111/j.0954-6820.1956.tb00089.x. Acta Med Scand. 1956. PMID: 13394179 No abstract available.

155

Vitamin homeostasis in the central nervous system.

Spector R. Spector R. N Engl J Med. 1977 Jun 16;296(24):1393-8. doi: 10.1056/NEJM197706162962409. N Engl J Med. 1977. PMID: 323714 Review. No abstract available.

156

Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti-apoptotic process.

Heydarnia E, Taghian F, Jalali Dehkordi K, Moghadasi M. Heydarnia E, et al. J Food Biochem. 2022 Oct;46(10):e14291. doi: 10.1111/jfbc.14291. Epub 2022 Jul 2. J Food Biochem. 2022. PMID: 35780321

Hence, levels of antiapoptotic mRNA were modified in the combined training/vitamin consumption group compared with other classifications. We found that regular combined exercise and vitamin consumption could reverse the apoptosis process to enhance the survival of c …

Hence, levels of antiapoptotic mRNA were modified in the combined training/vitamin consumption group compared with other classificati …

157

A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response.

Harley CB, Liu W, Flom PL, Raffaele JM. Harley CB, et al. Rejuvenation Res. 2013 Oct;16(5):386-95. doi: 10.1089/rej.2013.1430. Rejuvenation Res. 2013. PMID: 23808324 Clinical Trial.

We conclude that in addition to apparent positive immune remodeling, PattonProtocol-1 may improve markers of metabolic, bone, and cardiovascular health....

We conclude that in addition to apparent positive immune remodeling, PattonProtocol-1 may improve markers of metabolic, bone, and cardiov …

158

Increased endothelial microparticles and oxidative stress at extreme altitude.

Pichler Hefti J, Leichtle A, Stutz M, Hefti U, Geiser T, Huber AR, Merz TM. Pichler Hefti J, et al. Eur J Appl Physiol. 2016 Apr;116(4):739-48. doi: 10.1007/s00421-015-3309-3. Epub 2016 Jan 28. Eur J Appl Physiol. 2016. PMID: 26820158 Free article. Clinical Trial.

METHODS: 29 participants were randomly assigned to a treatment group (n = 14), receiving vitamin E, C, A, and N-acetylcysteine daily, and a control group (n = 15), receiving placebo. ...

METHODS: 29 participants were randomly assigned to a treatment group (n = 14), receiving vitamin E, C, A, and N-acetylcysteine daily, …

159

Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis. A case-control study. The ARIC Study Investigators. Atherosclerosis Risk in Communities.

Iribarren C, Folsom AR, Jacobs DR Jr, Gross MD, Belcher JD, Eckfeldt JH. Iribarren C, et al. Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1171-7. doi: 10.1161/01.atv.17.6.1171. Arterioscler Thromb Vasc Biol. 1997. PMID: 9194770

Oxidative modification of LDL is believed to be a crucial step in atherosclerosis. Thus, antioxidant vitamins may have a role in the prevention of coronary disease. We examined the cross-sectional association of serum vitamin levels, the susceptibility of LDL to hem …

Oxidative modification of LDL is believed to be a crucial step in atherosclerosis. Thus, antioxidant vitamins may have a role in the …

160

Proteomic analysis of rat aorta during atherosclerosis induced by high cholesterol diet and injection of vitamin D3.

Almofti MR, Huang Z, Yang P, Rui Y, Yang P. Almofti MR, et al. Clin Exp Pharmacol Physiol. 2006 Apr;33(4):305-9. doi: 10.1111/j.1440-1681.2006.04366.x. Clin Exp Pharmacol Physiol. 2006. PMID: 16620292

161

Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus.

Tousoulis D, Antoniades C, Vasiliadou C, Kourtellaris P, Koniari K, Marinou K, Charakida M, Ntarladimas I, Siasos G, Stefanadis C. Tousoulis D, et al. Heart. 2007 Feb;93(2):244-6. doi: 10.1136/hrt.2006.093112. Epub 2006 Aug 16. Heart. 2007. PMID: 16914485 Free PMC article. Clinical Trial. No abstract available.

162

The failure of histidine and vitamin C, and of ether, to improve the peripheral circulation; report of studies on subjects with normal arterial circulation and with occlusive arterial diseases.

WEISMAN SJ, ALLEN EV. WEISMAN SJ, et al. Circulation. 1950 Jan;1(1):127-31. doi: 10.1161/01.cir.1.1.127. Circulation. 1950. PMID: 15401200 No abstract available.

163

Vitamin B12 supplementation improves heart rate variability in healthy elderly Indian subjects.

Sucharita S, Thomas T, Antony B, Vaz M. Sucharita S, et al. Auton Neurosci. 2012 May 21;168(1-2):66-71. doi: 10.1016/j.autneu.2011.12.002. Epub 2012 Jan 5. Auton Neurosci. 2012. PMID: 22226502

They underwent blood sampling, anthropometry, HRV and nerve conduction assessment. Subjects were classified based on vitamin B(12) level (148 pmol/L) into deplete vitamin B(12) and replete vitamin B(12) groups. ...Supplementation with vitamin B(12) for …

They underwent blood sampling, anthropometry, HRV and nerve conduction assessment. Subjects were classified based on vitamin B(12) le …

164

Caffeinated energy drinks in the Canadian context: health risk assessment with a focus on cardiovascular effects.

La Vieille S, Gillespie Z, Bonvalot Y, Benkhedda K, Grinberg N, Rotstein J, Barber J, Krahn AD. La Vieille S, et al. Appl Physiol Nutr Metab. 2021 Sep;46(9):1019-1028. doi: 10.1139/apnm-2021-0245. Epub 2021 May 17. Appl Physiol Nutr Metab. 2021. PMID: 34000209 Free article. Review.

HC updated its assessment by reviewing new information with the focus on potential cardiovascular effects associated with the consumption of CEDs available for sale in Canada. Due to limited data on CED consumption among Canadians to derive accurate exposure information, t …

HC updated its assessment by reviewing new information with the focus on potential cardiovascular effects associated with the consump …

165

Novel aspects of erythropoietin response in renal failure patients.

Sunder-Plassmann G, Hörl WH. Sunder-Plassmann G, et al. Nephrol Dial Transplant. 2001;16 Suppl 5:40-4. doi: 10.1093/ndt/16.suppl_5.40. Nephrol Dial Transplant. 2001. PMID: 11509683 Review.

A weekly dose of 2-3 mg of folic acid and 100-150 mg of vitamin B6 is recommended for haemodialysis patients on rHuEpo therapy. The addition of 0.25 mg/month of vitamin B12 may be necessary in selected patients. Vitamin C (1-1.5 g/week) was shown to overcome …

A weekly dose of 2-3 mg of folic acid and 100-150 mg of vitamin B6 is recommended for haemodialysis patients on rHuEpo therapy. The a …

166

Natural bioactive substances in milk and colostrum: effects on the arterial blood pressure system.

Groziak SM, Miller GD. Groziak SM, et al. Br J Nutr. 2000 Nov;84 Suppl 1:S119-25. doi: 10.1017/s0007114500002348. Br J Nutr. 2000. PMID: 11242456 Review.

High blood pressure is a significant public health problem worldwide which is associated with increased risk of cardiovascular disease, stroke, and renal disease. The development of this disease is influenced by genetic and environmental factors. ...

High blood pressure is a significant public health problem worldwide which is associated with increased risk of cardiovascular diseas …

167

Hypercholesterolemia and endothelium dysfunction: role of dietary supplementation as vascular protective agents.

Boak L, Chin-Dusting JP. Boak L, et al. Curr Vasc Pharmacol. 2004 Jan;2(1):45-52. doi: 10.2174/1570161043476546. Curr Vasc Pharmacol. 2004. PMID: 15320832 Review.

There is increasing evidence that dietary supplementation, such as L-arginine, anti-oxidant vitamins, soy phytoestrogens, flavonoids and omega-3 fatty acids exert vascular protective benefits particularly in terms of restoring endothelial function in cardiovascular …

There is increasing evidence that dietary supplementation, such as L-arginine, anti-oxidant vitamins, soy phytoestrogens, flavonoids …

168

Effect of high-dose oral cholecalciferol on cardiac mechanics in children with chronic kidney disease.

Deveci M, Aytaç MB, Altun G, Kayabey Ö, Babaoğlu K. Deveci M, et al. Cardiol Young. 2017 Nov;27(9):1807-1814. doi: 10.1017/S1047951117001482. Epub 2017 Aug 3. Cardiol Young. 2017. PMID: 28770692

Cardiovascular factors are an important cause of mortality in chronic kidney disease, and vitamin-D deficiency is common in this patient population. ...Initial longitudinal and radial strain as well as strain rate values of the left ventricle were significantly lowe …

Cardiovascular factors are an important cause of mortality in chronic kidney disease, and vitamin-D deficiency is common in th …

169

Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species.

Fang J, Yang Q, Maas RGC, Buono M, Meijlink B, Lotgerink Bruinenberg D, Benavente ED, Mokry M, van Mil A, Qian L, Goumans MJ, Schiffelers R, Lei Z, Sluijter JPG. Fang J, et al. Stem Cell Res Ther. 2024 Jan 17;15(1):19. doi: 10.1186/s13287-023-03615-x. Stem Cell Res Ther. 2024. PMID: 38229180 Free PMC article.

METHODS: We screened seven factors capable of improving direct cardiac reprogramming of both mice and human fibroblasts by evaluating small molecules known to be involved in cardiomyocyte differentiation or promoting human-induced pluripotent stem cell reprogramming. RESULTS: We …

METHODS: We screened seven factors capable of improving direct cardiac reprogramming of both mice and human fibroblasts by evaluating small …

170

Plasma choline, smoking, and long-term prognosis in patients with stable angina pectoris.

Schartum-Hansen H, Pedersen ER, Svingen GF, Ueland PM, Seifert R, Ebbing M, Strand E, Bleie Ø, Nygård O. Schartum-Hansen H, et al. Eur J Prev Cardiol. 2015 May;22(5):606-14. doi: 10.1177/2047487314524867. Epub 2014 Mar 4. Eur J Prev Cardiol. 2015. PMID: 24595862 Clinical Trial.

BACKGROUND: Plasma choline has been associated with cardiovascular disease and nonalcoholic steatohepatitis. DESIGN: We sought to study relations of plasma choline and its metabolite betaine to long-term risk of acute myocardial infarction (AMI) and all-cause mortality acc …

BACKGROUND: Plasma choline has been associated with cardiovascular disease and nonalcoholic steatohepatitis. DESIGN: We sought to stu …

171

Evaluation of the Effect of Vitamin D Treatment on Cardiac Function in Non-Obese Female Adolescents with Vitamin D Deficiency in Turkiye: A Cross-Sectional Study.

Altın H, Şen E, Bozdemir ŞE, Türe E, Aktürk B, Karaca A. Altın H, et al. Niger J Clin Pract. 2024 Feb 1;27(2):194-201. doi: 10.4103/njcp.njcp_721_23. Epub 2024 Feb 26. Niger J Clin Pract. 2024. PMID: 38409147 Free article.

BACKGROUND: Vitamin D deficiency may cause adverse effects on the cardiovascular system as well as many other systems. ...AIM: To evaluate the effect of daily 2000 IU vitamin D supplementation for 12 weeks on cardiac function in non-obese adolescent gi …

BACKGROUND: Vitamin D deficiency may cause adverse effects on the cardiovascular system as well as many other systems. …

172

Multivariate Analysis of Influence of Vitamin Intake on Vascular Function Parameters by Sex in the General Spanish Population: EVA Study.

Patino-Alonso MC, Gómez Sánchez M, Gómez Sánchez L, Alonso-Domínguez R, Sánchez-Aguadero N, Sánchez Salgado B, Rodríguez Sánchez E, García Ortiz L, Gómez-Marcos MA. Patino-Alonso MC, et al. Nutrients. 2020 Feb 28;12(3):643. doi: 10.3390/nu12030643. Nutrients. 2020. PMID: 32121178 Free PMC article.

Results: The vitamins with the least adequate intake was vitamin D, less than 5%, and vitamin B(9), less than 35%. ...In women, vitamins B(2) and B(3) were related cfPWV, vitamins B(1) and B(12) with cfPWV and vitamin D with CAVI....

Results: The vitamins with the least adequate intake was vitamin D, less than 5%, and vitamin B(9), less than 35%. ...I …

173

Dietary supplementation with vitamin E ameliorates cardiac failure in type I diabetic cardiomyopathy by suppressing myocardial generation of 8-iso-prostaglandin F2alpha and oxidized glutathione.

Hamblin M, Smith HM, Hill MF. Hamblin M, et al. J Card Fail. 2007 Dec;13(10):884-92. doi: 10.1016/j.cardfail.2007.07.002. J Card Fail. 2007. PMID: 18068623 Free PMC article.

Furthermore, studies investigating antioxidant protection with vitamin E in this unique cardiac phenomenon have yet to be performed. In the present study, we sought to determine whether vitamin E supplementation can confer cardioprotective effects against diabetic c …

Furthermore, studies investigating antioxidant protection with vitamin E in this unique cardiac phenomenon have yet to be performed. …

174

[Effect of vitamin C and calcium chloride on vascular reactivity and water metabolism in nephritis].

MEL'NIKOV AA. MEL'NIKOV AA. Klin Med (Mosk). 1955 Apr;33(4):85-6. Klin Med (Mosk). 1955. PMID: 14382367 Russian. No abstract available.

175

[Vitamin C and the heart].

MENESES HOYOS J. MENESES HOYOS J. Rev Med Cienc Afines. 1951 Sep;10(110):65-6. Rev Med Cienc Afines. 1951. PMID: 14892511 Undetermined Language. No abstract available.

176

Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKalpha/Sirt1/Foxo3a signaling pathway.

Chen L, Holder R, Porter C, Shah Z. Chen L, et al. PLoS One. 2021 Jun 8;16(6):e0252816. doi: 10.1371/journal.pone.0252816. eCollection 2021. PLoS One. 2021. PMID: 34101754 Free PMC article.

The toxicity of doxorubicin to the cardiovascular system often limits its benefits and widespread use as chemotherapy. The mechanisms involved in doxorubicin-induced cardiovascular damage and possible protective interventions are not well-explored. ...These r …

The toxicity of doxorubicin to the cardiovascular system often limits its benefits and widespread use as chemotherapy. The mec …

177

Oxidative stress in critical care: is antioxidant supplementation beneficial?

Oldham KM, Bowen PE. Oldham KM, et al. J Am Diet Assoc. 1998 Sep;98(9):1001-8. doi: 10.1016/S0002-8223(98)00230-2. J Am Diet Assoc. 1998. PMID: 9739800 Review.

Only indirect measurements of ROS are available, but the presence of oxidative stress in critical illness is supported by clinical studies. In general, serum antioxidant vitamin concentrations seem to decrease and measures of oxidative stress seem to increase in critically …

Only indirect measurements of ROS are available, but the presence of oxidative stress in critical illness is supported by clinical studies. …

178

Impact of 6-year body weight change on cardiac geometry and function in ageing adults: the SUpplementation en Vitamines et Mineraux AntioXydants -2 (SU.VI.MAX-2) cardiovascular ultrasound substudy.

Monsuez JJ, Kesse-Guyot E, Fezeu L, Blacher J, Galan P, Sebbane G, Hercberg S, Czernichow S. Monsuez JJ, et al. J Hypertens. 2010 Nov;28(11):2309-15. doi: 10.1097/HJH.0b013e32833d4576. J Hypertens. 2010. PMID: 20706135

179

Capillary strength tests in scurvy and their reactions to vitamin C and vitamin P therapy.

LAZARUS S, MUNRO HN, BELL GH. LAZARUS S, et al. Clin Sci. 1948 Dec;7(2):175-84. Clin Sci. 1948. PMID: 18104744 No abstract available.

180

Deoxynucleoside and vitamin transport into the central nervous system.

Spector R, Eells J. Spector R, et al. Fed Proc. 1984 Feb;43(2):196-200. Fed Proc. 1984. PMID: 6692939

Several essential substances for the mammalian brain including certain vitamins and deoxynucleosides do not enter the brain in appreciable amounts directly through the cerebral capillaries, the blood-brain barrier; rather these substances are transported from blood into ce …

Several essential substances for the mammalian brain including certain vitamins and deoxynucleosides do not enter the brain in apprec …

181

Homocysteinemia: association of a metabolic disorder with vascular disease and thrombosis.

Rees MM, Rodgers GM. Rees MM, et al. Thromb Res. 1993 Sep 1;71(5):337-59. doi: 10.1016/0049-3848(93)90160-p. Thromb Res. 1993. PMID: 8236162 Review. No abstract available.

182

Vitamin C Regulates the Profibrotic Activity of Fibroblasts in In Vitro Replica Settings of Myocardial Infarction.

Xu Y, Zheng H, Nilcham P, Bucur O, Vogt F, Slabu I, Liehn EA, Rusu M. Xu Y, et al. Int J Mol Sci. 2023 May 6;24(9):8379. doi: 10.3390/ijms24098379. Int J Mol Sci. 2023. PMID: 37176085 Free PMC article.

Activated primary cardiac fibroblasts following myocardial infarction are extensively investigated to establish anti-fibrotic therapies to improve left ventricular remodeling. To systematically assess vitamin C functions as a potential modulator involved in collagen fibril …

Activated primary cardiac fibroblasts following myocardial infarction are extensively investigated to establish anti-fibrotic therapies to i …

183

Glutaraldehyde treated bovine pericardium: changes in calcification due to vitamins and platelet inhibitors.

Vasudev SC, Chandy T, Sharma CP. Vasudev SC, et al. Artif Organs. 1997 Sep;21(9):1007-13. doi: 10.1111/j.1525-1594.1997.tb00516.x. Artif Organs. 1997. PMID: 9288872

The purpose of the present paper is to study the possibility that some antiplatelet drugs (aspirin and persantine) and certain vitamins (vitamin C, vitamin B6, and vitamin E) and their combinations might prevent the mineralization of glutaraldehyde tre …

The purpose of the present paper is to study the possibility that some antiplatelet drugs (aspirin and persantine) and certain vitamins …

184

Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25.

Shih CK, Chen CM, Chen CY, Liu JF, Lin HW, Chou HT, Li SC. Shih CK, et al. Food Chem Toxicol. 2010 Jul;48(7):1913-8. doi: 10.1016/j.fct.2010.04.033. Epub 2010 Apr 27. Food Chem Toxicol. 2010. PMID: 20430062

Riboflavin (vitamin B2) is a water-soluble vitamin essential for normal cellular functions, growth and development. ...Mice were assigned to four groups, saline vehicle, LPS, LPS plus low dose of vitamin B2 (LB2) and LPS plus high dose of vitamin B2 (H …

Riboflavin (vitamin B2) is a water-soluble vitamin essential for normal cellular functions, growth and development. ...Mice we …

185

Tissue-Specific Transcriptomic Profiling of Vitamin-Dependent Mitochondrial Pathways in Female Buffalo.

Sadeesh EM, Lahamge MS, Singh P, Mohiddin R. Sadeesh EM, et al. Cell Biochem Biophys. 2026 Jun;84(2):2063-2085. doi: 10.1007/s12013-025-01979-w. Epub 2025 Dec 29. Cell Biochem Biophys. 2026. PMID: 41457117

This study provides a comprehensive tissue-specific transcriptomic analysis of mitochondrial genes associated with vitamin metabolism in buffalo. Using RNA-seq data from four post-pubertal female buffalo tissues (kidney, heart, brain, and ovary), we profiled 41 nuclear-enc …

This study provides a comprehensive tissue-specific transcriptomic analysis of mitochondrial genes associated with vitamin metabolism …

186

Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease.

Zhang Q, Zhang M, Wang H, Sun C, Feng Y, Zhu W, Cao D, Shao Q, Li N, Xia Y, Tang T, Wan C, Liu J, Jin B, Zhao M, Jiang C. Zhang Q, et al. Int Urol Nephrol. 2018 May;50(5):923-927. doi: 10.1007/s11255-018-1829-6. Epub 2018 Feb 26. Int Urol Nephrol. 2018. PMID: 29484540

PURPOSE: Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD pat …

PURPOSE: Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular …

187

Study on the clinical value of Vitamin D in recurrent spontaneous abortion: Revisiting the Importance of Vitamin D.

Du W, Ye C, Lin Y, Zhai H, Xia J. Du W, et al. Am J Reprod Immunol. 2024 Jan;91(1):e13810. doi: 10.1111/aji.13810. Am J Reprod Immunol. 2024. PMID: 38282601

OBJECTIVE: This study explores the possible pathogenesis of recurrent spontaneous abortion (RSA) caused by vitamin D (VD), provides evidence-based bases for prevention and treatment of RSA, improves female reproductive health. ...

OBJECTIVE: This study explores the possible pathogenesis of recurrent spontaneous abortion (RSA) caused by vitamin D (VD), provides e …

188

Clinical assay of vitamin P; relation between response and initial capillary resistance.

SCARBOROUGH H, WORKES F. SCARBOROUGH H, et al. Biochem J. 1946;40(5-6):lxv. Biochem J. 1946. PMID: 20277278 No abstract available.

189

Effect of Vitamin D on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial.

Borgi L, McMullan C, Wohlhueter A, Curhan GC, Fisher ND, Forman JP. Borgi L, et al. Am J Hypertens. 2017 Feb;30(2):124-129. doi: 10.1093/ajh/hpw135. Epub 2016 Nov 15. Am J Hypertens. 2017. PMID: 28077419 Free PMC article. Clinical Trial.

However, the effect of vitamin D supplementation on endothelial dysfunction in nonhypertensive individuals has not been examined in a rigorous fashion. ...Mean 25(OH)D levels increased from 14.9 to 30.3 in the vitamin D group and 14.4 to 17.4 in the placebo. EDV did …

However, the effect of vitamin D supplementation on endothelial dysfunction in nonhypertensive individuals has not been examined in a …

190

Acute autonomic effects of vitamins and fats in male smokers.

Wright CI, Ruediger H, Kroner CI, Janssen BJ, Draijer R. Wright CI, et al. Eur J Clin Nutr. 2009 Feb;63(2):246-52. doi: 10.1038/sj.ejcn.1602912. Epub 2007 Sep 26. Eur J Clin Nutr. 2009. PMID: 17895912 Clinical Trial.

Plasma vitamin levels did not correlate with any cardiovascular parameters. Moderate vitamins increased the vagal control of HR (+23%; P<0.05) and cream led to small increases (P<0.05) in SBP (+2 mm Hg) and HR (+2 beats min(-1)) with no change in BRS. C …

Plasma vitamin levels did not correlate with any cardiovascular parameters. Moderate vitamins increased the vagal contr …

191

Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets.

Qin F, Rounds NK, Mao W, Kawai K, Liang CS. Qin F, et al. Cardiovasc Res. 2001 Sep;51(4):736-48. doi: 10.1016/s0008-6363(01)00323-6. Cardiovasc Res. 2001. PMID: 11530107

To determine whether this change occurred in intact animals after chronic subhypertensive doses of NE, and whether the effect was mediated via oxidative stress produced by NE, we measured myocyte apoptosis and apoptotic gene proteins in ferrets receiving chronic NE with and witho …

To determine whether this change occurred in intact animals after chronic subhypertensive doses of NE, and whether the effect was mediated v …

192

Calcitriol supplementation improves endothelium-dependent vasodilation in rat hypertensive renal injury.

Takenaka T, Inoue T, Ohno Y, Miyazaki T, Nishiyama A, Ishii N, Suzuki H. Takenaka T, et al. Kidney Blood Press Res. 2014;39(1):17-27. doi: 10.1159/000355773. Epub 2014 Apr 30. Kidney Blood Press Res. 2014. PMID: 24821359 Free article.

BACKGROUND/AIMS: Vitamin D increases renal expression of klotho in normotensive rats. Klotho reduces oxidative stress. ...These results suggest that the amelioration of endothelium function by vitamin D involves free klotho....

BACKGROUND/AIMS: Vitamin D increases renal expression of klotho in normotensive rats. Klotho reduces oxidative stress. ...These resul …

193

Increased dietary intake of vitamin A promotes aortic valve calcification in vivo.

Huk DJ, Hammond HL, Kegechika H, Lincoln J. Huk DJ, et al. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):285-93. doi: 10.1161/ATVBAHA.112.300388. Epub 2012 Nov 29. Arterioscler Thromb Vasc Biol. 2013. PMID: 23202364 Free PMC article.

In this study, we investigated the effects of excess vitamin A and its metabolite RA on heart valve structure and function in vivo and examined the molecular mechanisms of RA signaling during the calcification process in vitro. ...CONCLUSIONS: Our studies demonstrate that …

In this study, we investigated the effects of excess vitamin A and its metabolite RA on heart valve structure and function in vivo an …

194

Influence of Vitamin D on the Vasoactive Effect of Estradiol in a Rat Model of Polycystic Ovary Syndrome.

Tarszabó R, Bányai B, Ruisanchez É, Péterffy B, Korsós-Novák Á, Lajtai K, Sziva RE, Gerszi D, Hosszú Á, Benkő R, Benyó Z, Horváth EM, Masszi G, Várbíró S. Tarszabó R, et al. Int J Mol Sci. 2021 Aug 30;22(17):9404. doi: 10.3390/ijms22179404. Int J Mol Sci. 2021. PMID: 34502321 Free PMC article.

We examined the vasoactive effect of estradiol in a rat model of early PCOS and the influence of vitamin D deficiency (VDD). We created a model of chronic hyperandrogenism and VDD in adolescent female Wistar rats (N = 46) with four experimental groups: vitamin D sup …

We examined the vasoactive effect of estradiol in a rat model of early PCOS and the influence of vitamin D deficiency (VDD). We creat …

195

Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease.

Aytaç MB, Deveci M, Bek K, Kayabey Ö, Ekinci Z. Aytaç MB, et al. Pediatr Nephrol. 2016 Feb;31(2):267-77. doi: 10.1007/s00467-015-3220-5. Epub 2015 Oct 2. Pediatr Nephrol. 2016. PMID: 26432706

BACKGROUND: As cardiovascular factors are the leading cause of mortality in chronic kidney disease (CKD) and as vitamin D deficiency is prevalent in this population, we aimed to examine the effect of oral cholecalciferol on cardiac parameters and biomarkers for endo …

BACKGROUND: As cardiovascular factors are the leading cause of mortality in chronic kidney disease (CKD) and as vitamin D defi …

196

A systematic review protocol examining the effect of vitamin D supplementation on endothelial function.

Alyami A, Soares MJ, Sherriff JL, Zhao Y, Hallett J, Coombes F. Alyami A, et al. BMJ Open. 2015 Jun 12;5(6):e006835. doi: 10.1136/bmjopen-2014-006835. BMJ Open. 2015. PMID: 26070793 Free PMC article.

INTRODUCTION: Vitamin D has potential benefits for extraskeletal health. These could include an anti-inflammatory effect as well as a reduction in endothelial dysfunction. We aim to provide quality evidence for the hypothesis that supplementation with vitamin D will …

INTRODUCTION: Vitamin D has potential benefits for extraskeletal health. These could include an anti-inflammatory effect as well as a …

197

Oxidative stress and vascular damage in hypertension.

Berry C, Brosnan MJ, Fennell J, Hamilton CA, Dominiczak AF. Berry C, et al. Curr Opin Nephrol Hypertens. 2001 Mar;10(2):247-55. doi: 10.1097/00041552-200103000-00014. Curr Opin Nephrol Hypertens. 2001. PMID: 11224701 Review.

198

Clinical observations on the effects of injectable rutin, esculin, adrenoxyl, and vitamin E on the capillary fragility of diabetic retinopathy.

LEVITAN BA. LEVITAN BA. Am J Med Sci. 1951 Feb;221(2):185-90. doi: 10.1097/00000441-195102000-00011. Am J Med Sci. 1951. PMID: 14799483 No abstract available.

199

[A cardiovascular effect of vitamin P].

KEYSSLER H, PARHOFER R, SCHEDEL F. KEYSSLER H, et al. Munch Med Wochenschr. 1954 Sep 10;96(37):1070-1. Munch Med Wochenschr. 1954. PMID: 13223671 German. No abstract available.

200

Cardiovascular effects of cholecalciferol treatment in dialysis patients--a randomized controlled trial.

Mose FH, Vase H, Larsen T, Kancir AS, Kosierkiewic R, Jonczy B, Hansen AB, Oczachowska-Kulik AE, Thomsen IM, Bech JN, Pedersen EB. Mose FH, et al. BMC Nephrol. 2014 Mar 24;15:50. doi: 10.1186/1471-2369-15-50. BMC Nephrol. 2014. PMID: 24661355 Free PMC article. Clinical Trial.

BACKGROUND: Patients on chronic dialysis are at increased risk of vitamin D deficiency. In observational studies plasma 25-hydroxyvitamin D (p-25(OH) D) levels are inversely correlated with plasma BNP and adverse cardiovascular outcomes. ...

BACKGROUND: Patients on chronic dialysis are at increased risk of vitamin D deficiency. In observational studies plasma 25-hydroxyvit …

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