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1949 27
1950 43
1951 33
1952 48
1953 53
1954 57
1955 46
1956 49
1957 39
1958 38
1959 50
1960 47
1961 34
1962 53
1963 111
1964 140
1965 96
1966 103
1967 144
1968 160
1969 203
1970 172
1971 197
1972 166
1973 141
1974 191
1975 145
1976 96
1977 109
1978 95
1979 105
1980 110
1981 118
1982 132
1983 147
1984 173
1985 173
1986 162
1987 183
1988 174
1989 207
1990 197
1991 249
1992 245
1993 271
1994 311
1995 373
1996 375
1997 421
1998 463
1999 537
2000 635
2001 658
2002 648
2003 709
2004 742
2005 785
2006 810
2007 834
2008 874
2009 909
2010 1032
2011 1107
2012 1181
2013 1256
2014 1383
2015 1432
2016 1353
2017 1375
2018 1433
2019 1423
2020 1558
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2022 1424
2023 1228
2024 215

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Page 1
Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial.
Thompson B, Waterhouse M, English DR, McLeod DS, Armstrong BK, Baxter C, Duarte Romero B, Ebeling PR, Hartel G, Kimlin MG, Rahman ST, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Neale RE. Thompson B, et al. BMJ. 2023 Jun 28;381:e075230. doi: 10.1136/bmj-2023-075230. BMJ. 2023. PMID: 37380191 Free PMC article. Clinical Trial.
OBJECTIVE: To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence of major cardiovascular events. DESIGN: Randomised, double blind, placebo controlled trial of monthly vitamin D (the D-Health Trial). ...The medi …
OBJECTIVE: To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence of major cardiov
Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases.
Pál É, Ungvári Z, Benyó Z, Várbíró S. Pál É, et al. Nutrients. 2023 Jan 9;15(2):334. doi: 10.3390/nu15020334. Nutrients. 2023. PMID: 36678205 Free PMC article. Review.
Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects approximately 24% to 40% of the population of the Western world. ...This brief overview focuses on the cardiovascular and cerebrovascular effects of VitD and the cellular, mo …
Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects approximately 24% to 40% of the populatio …
Vitamin D and the Skin: An Update for Dermatologists.
Kechichian E, Ezzedine K. Kechichian E, et al. Am J Clin Dermatol. 2018 Apr;19(2):223-235. doi: 10.1007/s40257-017-0323-8. Am J Clin Dermatol. 2018. PMID: 28994020 Review.
Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral i
Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproduc
Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U.S. Preventive Services Task Force.
Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Fortmann SP, et al. Ann Intern Med. 2013 Dec 17;159(12):824-34. doi: 10.7326/0003-4819-159-12-201312170-00729. Ann Intern Med. 2013. PMID: 24217421 Free article. Review.
BACKGROUND: Vitamin and mineral supplements are commonly used to prevent chronic diseases. PURPOSE: To systematically review evidence for the benefit and harms of vitamin and mineral supplements in community-dwelling, nutrient-sufficient adults for the primary preve …
BACKGROUND: Vitamin and mineral supplements are commonly used to prevent chronic diseases. PURPOSE: To systematically review evidence …
Vitamin D status and cardiovascular outcome.
Saponaro F, Marcocci C, Zucchi R. Saponaro F, et al. J Endocrinol Invest. 2019 Nov;42(11):1285-1290. doi: 10.1007/s40618-019-01057-y. Epub 2019 Jun 6. J Endocrinol Invest. 2019. PMID: 31172459 Review.
INTRODUCTION: Vitamin D is classically involved in maintaining bone and mineral health, but it has been shown to exert many extraskeletal functions, including pleiotropic effects on cardiovascular system. MATERIALS AND METHOD: This review aims to summarize ev …
INTRODUCTION: Vitamin D is classically involved in maintaining bone and mineral health, but it has been shown to exert many extraskel …
Vitamin K(2)-a neglected player in cardiovascular health: a narrative review.
Hariri E, Kassis N, Iskandar JP, Schurgers LJ, Saad A, Abdelfattah O, Bansal A, Isogai T, Harb SC, Kapadia S. Hariri E, et al. Open Heart. 2021 Nov;8(2):e001715. doi: 10.1136/openhrt-2021-001715. Open Heart. 2021. PMID: 34785587 Free PMC article. Review.
Vitamin K(2) serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. ...
Vitamin K(2) serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the
Vitamin D and Cardiovascular Disease: Controversy Unresolved.
Al Mheid I, Quyyumi AA. Al Mheid I, et al. J Am Coll Cardiol. 2017 Jul 4;70(1):89-100. doi: 10.1016/j.jacc.2017.05.031. J Am Coll Cardiol. 2017. PMID: 28662812 Free article. Review.
Serum levels of 25-hydroxyvitamin D l <20 ng/ml are diagnostic of vitamin D deficiency. Vitamin D has various cardiovascular pleiotropic effects by activating its nuclear receptor in cardiomyocytes and vascular endothelial cells and by regulating the renin …
Serum levels of 25-hydroxyvitamin D l <20 ng/ml are diagnostic of vitamin D deficiency. Vitamin D has various cardiovasc
The role of vitamin D in cardiovascular disease and COVID-19.
Driggin E, Madhavan MV, Gupta A. Driggin E, et al. Rev Endocr Metab Disord. 2022 Apr;23(2):293-297. doi: 10.1007/s11154-021-09674-w. Epub 2022 Mar 2. Rev Endocr Metab Disord. 2022. PMID: 35233703 Free PMC article. Review.
Patients with pre-existing cardiovascular disease (CVD) are at high risk for adverse outcomes with coronavirus disease 2019 (COVID-19). ...Further, given that vitamin D has important protective effects on the CV system, including augmentation of myocardial co …
Patients with pre-existing cardiovascular disease (CVD) are at high risk for adverse outcomes with coronavirus disease 2019 (COVID-19 …
Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke.
Muscogiuri G, Annweiler C, Duval G, Karras S, Tirabassi G, Salvio G, Balercia G, Kimball S, Kotsa K, Mascitelli L, Bhattoa HP, Colao A. Muscogiuri G, et al. Int J Cardiol. 2017 Mar 1;230:577-584. doi: 10.1016/j.ijcard.2016.12.053. Epub 2016 Dec 26. Int J Cardiol. 2017. PMID: 28043680 Review.
There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). ...Thus, the goal of this review is to provide an updated review of the literature on the basic science of how …
There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiova
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment.
Sunkara A, Raizner A. Sunkara A, et al. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):179-184. doi: 10.14797/mdcj-15-3-179. Methodist Debakey Cardiovasc J. 2019. PMID: 31687096 Free PMC article. Review.
Vitamins and minerals are dietary supplements used by almost half of the US adult population based on the presumption that they help prevent or treat cardiovascular disease. ...Despite extensive investigation, the evidence to date fails to support the use of exogeno
Vitamins and minerals are dietary supplements used by almost half of the US adult population based on the presumption that they help
Vitamin D, Calcium, and Cardiovascular Disease: A"D"vantageous or "D"etrimental? An Era of Uncertainty.
Chin K, Appel LJ, Michos ED. Chin K, et al. Curr Atheroscler Rep. 2017 Jan;19(1):5. doi: 10.1007/s11883-017-0637-2. Curr Atheroscler Rep. 2017. PMID: 28127710 Free PMC article. Review.
While the function of vitamin D in regulating calcium homeostasis is well established, there has been growing interest in its role in the prevention of numerous chronic diseases, including cardiovascular disease (CVD). There is mounting epidemiological evidence sugg …
While the function of vitamin D in regulating calcium homeostasis is well established, there has been growing interest in its role in …
Vitamin D in the Spectrum of Prediabetes and Cardiovascular Autonomic Dysfunction.
Dimova R, Tankova T, Chakarova N. Dimova R, et al. J Nutr. 2017 Sep;147(9):1607-1615. doi: 10.3945/jn.117.250209. Epub 2017 Aug 2. J Nutr. 2017. PMID: 28768837 Free article. Review.
Vitamin D is a fat-soluble secosteroid hormone with pleiotropic effects. 1,25-Dihydroxyvitamin D coordinates the biosynthesis of neurotransmitters in the central nervous system, which regulate cardiovascular autonomic function and may explain its putative rol
Vitamin D is a fat-soluble secosteroid hormone with pleiotropic effects. 1,25-Dihydroxyvitamin D coordinates the biosynthesis of neur
Vitamin D and cardiovascular disease: is the evidence solid?
Al Mheid I, Patel RS, Tangpricha V, Quyyumi AA. Al Mheid I, et al. Eur Heart J. 2013 Dec;34(48):3691-8. doi: 10.1093/eurheartj/eht166. Epub 2013 Jun 9. Eur Heart J. 2013. PMID: 23751422 Free PMC article. Review.
While the endocrine functions of vitamin D related to bone metabolism and mineral ion homoeostasis have been extensively studied, robust epidemiological evidence also suggests a close association between vitamin D deficiency and cardiovascular morbidity and m …
While the endocrine functions of vitamin D related to bone metabolism and mineral ion homoeostasis have been extensively studied, rob …
Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial.
Okereke OI, Reynolds CF 3rd, Mischoulon D, Chang G, Vyas CM, Cook NR, Weinberg A, Bubes V, Copeland T, Friedenberg G, Lee IM, Buring JE, Manson JE. Okereke OI, et al. JAMA. 2020 Aug 4;324(5):471-480. doi: 10.1001/jama.2020.10224. JAMA. 2020. PMID: 32749491 Free PMC article. Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: There were 18 353 men and women aged 50 years or older in the VITAL-DEP (Vitamin D and Omega-3 Trial-Depression Endpoint Prevention) ancillary study to VITAL, a randomized clinical trial of cardiovascular disease and cancer prevent …
DESIGN, SETTING, AND PARTICIPANTS: There were 18 353 men and women aged 50 years or older in the VITAL-DEP (Vitamin D and Omega-3 Tri …
Vitamin D supplementation: what's known, what to do, and what's needed.
Haines ST, Park SK. Haines ST, et al. Pharmacotherapy. 2012 Apr;32(4):354-82. doi: 10.1002/phar.1037. Pharmacotherapy. 2012. PMID: 22461123 Review.
Epidemiologic evidence links vitamin D deficiency to autoimmune disease, cancer, cardiovascular disease, depression, dementia, infectious diseases, musculoskeletal decline, and more. ...For patients who are not at risk for developing vitamin D deficiency, sen …
Epidemiologic evidence links vitamin D deficiency to autoimmune disease, cancer, cardiovascular disease, depression, dementia, …
Vitamin E and cardiovascular disease.
Saremi A, Arora R. Saremi A, et al. Am J Ther. 2010 May-Jun;17(3):e56-65. doi: 10.1097/MJT.0b013e31819cdc9a. Am J Ther. 2010. PMID: 19451807 Review.
The objective of this article is to review the role of vitamin E in cardiovascular disease. We begin by describing the general characteristics and metabolism of vitamin E and the pathogenesis of atherosclerosis as it relates to oxidation. ...The American Hear …
The objective of this article is to review the role of vitamin E in cardiovascular disease. We begin by describing the general …
Cardiovascular Diseases and Fat Soluble Vitamins: Vitamin D and Vitamin K.
Tsugawa N. Tsugawa N. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S170-2. doi: 10.3177/jnsv.61.S170. J Nutr Sci Vitaminol (Tokyo). 2015. PMID: 26598844 Free article. Review.
Recently, the associations between insufficiency of fat soluble vitamins and cardiovascular diseases (CVDs) have been reported. Vitamin D affects the cardiovascular system via several pathways, such as suppression of parathyroid hormone, the ren …
Recently, the associations between insufficiency of fat soluble vitamins and cardiovascular diseases (CVDs) have been reported …
Vitamin D and Cardiovascular Disease.
Schwarz N, Nicholls SJ, Psaltis PJ. Schwarz N, et al. Heart Lung Circ. 2018 Aug;27(8):903-906. doi: 10.1016/j.hlc.2018.05.098. Heart Lung Circ. 2018. PMID: 30047471 No abstract available.
Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients.
Cianciolo G, Cappuccilli M, Tondolo F, Gasperoni L, Zappulo F, Barbuto S, Iacovella F, Conte D, Capelli I, La Manna G. Cianciolo G, et al. Nutrients. 2021 Apr 25;13(5):1453. doi: 10.3390/nu13051453. Nutrients. 2021. PMID: 33922902 Free PMC article. Review.
This condition is further worsened by the compromised response of CKD patients to high-dose cholecalciferol supplementation due to the defective activation of renal hydroxylation of vitamin D. Currently, the literature lacks large and interventional studies on the so-calle …
This condition is further worsened by the compromised response of CKD patients to high-dose cholecalciferol supplementation due to the defec …
The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond.
AlMatar M, AlMandeal H, Makky EA, Kayar B, Yarar E, Var I, Koksal F. AlMatar M, et al. Curr Drug Metab. 2017;18(3):207-224. doi: 10.2174/1389200217666161207161212. Curr Drug Metab. 2017. PMID: 27928943 Review.
Moreover, recent reports revealed that the effect of vitamin D is to cover not only cardiovascular system but also skeletal system. OBJECTIVE: Herein, we are highlighting the recent knowledge of vitamin D roles and functions with respect to path …
Moreover, recent reports revealed that the effect of vitamin D is to cover not only cardiovascular system but also skel …
Vitamin K effects in human health: new insights beyond bone and cardiovascular health.
Fusaro M, Gallieni M, Porta C, Nickolas TL, Khairallah P. Fusaro M, et al. J Nephrol. 2020 Apr;33(2):239-249. doi: 10.1007/s40620-019-00685-0. Epub 2019 Dec 19. J Nephrol. 2020. PMID: 31858448 Free article. Review.
Vitamin K is a cofactor for the function of the enzyme gamma-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. ...This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKD
Vitamin K is a cofactor for the function of the enzyme gamma-glutamyl carboxylase, necessary for the activation of multiple vitami
Vitamin D and cardiovascular disease: potential role in health disparities.
Artaza JN, Contreras S, Garcia LA, Mehrotra R, Gibbons G, Shohet R, Martins D, Norris KC. Artaza JN, et al. J Health Care Poor Underserved. 2011;22(4 Suppl):23-38. doi: 10.1353/hpu.2011.0161. J Health Care Poor Underserved. 2011. PMID: 22102304 Free PMC article. Review.
Cardiovascular disease (CVD), which includes coronary artery disease and stroke, is the leading cause of mortality in the nation. ...We review the epidemiology of vitamin D and CVD in African Americans and the emerging biological roles of vitamin D in key CVD
Cardiovascular disease (CVD), which includes coronary artery disease and stroke, is the leading cause of mortality in the nation. ...
The role of vitamin D in dyslipidemia and cardiovascular disease.
Zittermann A, Gummert JF, Börgermann J. Zittermann A, et al. Curr Pharm Des. 2011;17(9):933-42. doi: 10.2174/138161211795428786. Curr Pharm Des. 2011. PMID: 21418036 Review.
Dyslipidemia and vascular calcification are important predictors of cardiovascular disease (CVD). Vitamin D may have an influence on these two CVD risk markers. ...The previously presumed influence of statins on circulating 25-hydroxyvitamin D levels and on cellular …
Dyslipidemia and vascular calcification are important predictors of cardiovascular disease (CVD). Vitamin D may have an influe …
Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies.
Grandi NC, Breitling LP, Brenner H. Grandi NC, et al. Prev Med. 2010 Sep-Oct;51(3-4):228-33. doi: 10.1016/j.ypmed.2010.06.013. Epub 2010 Jun 19. Prev Med. 2010. PMID: 20600257 Review.
BACKGROUND: Low serum 25-hydroxyvitamin D (25-OH-D) has recently been linked to cardiovascular diseases. This review summarizes evidence from prospective studies evaluating the prognostic value of 25-OH-D for cardiovascular disease incidence and mortality. ...Prospe …
BACKGROUND: Low serum 25-hydroxyvitamin D (25-OH-D) has recently been linked to cardiovascular diseases. This review summarizes evide …
Vitamin D and its effects on glucose homeostasis, cardiovascular function and immune function.
El-Fakhri N, McDevitt H, Shaikh MG, Halsey C, Ahmed SF. El-Fakhri N, et al. Horm Res Paediatr. 2014;81(6):363-78. doi: 10.1159/000357731. Epub 2014 Apr 26. Horm Res Paediatr. 2014. PMID: 24776698 Free article. Review.
In recent years there has been increasing interest in the non-skeletal effects of vitamin D. It has been suggested that vitamin D deficiency may influence the development of diabetes, cardiovascular dysfunction and autoimmune diseases. This review focuses on …
In recent years there has been increasing interest in the non-skeletal effects of vitamin D. It has been suggested that vitamin
The Role of Vitamin D in Diabetes and Cardiovascular Disease: An Updated Review of the Literature.
Papandreou D, Hamid ZT. Papandreou D, et al. Dis Markers. 2015;2015:580474. doi: 10.1155/2015/580474. Epub 2015 Oct 20. Dis Markers. 2015. PMID: 26576069 Free PMC article. Review.
The dietary reference values for Vitamin D were set primarily considering its role in bone health, but with the discovery of Vitamin D receptors throughout body tissues, new links with other health conditions are now studied, such as for diabetes and cardiovascul
The dietary reference values for Vitamin D were set primarily considering its role in bone health, but with the discovery of Vitam
Putting cardiovascular disease and vitamin D insufficiency into perspective.
Zittermann A, Schleithoff SS, Koerfer R. Zittermann A, et al. Br J Nutr. 2005 Oct;94(4):483-92. doi: 10.1079/bjn20051544. Br J Nutr. 2005. PMID: 16197570 Free article. Review.
Interestingly, all these factors also have an influence on human UVB exposure and thus on vitamin D status. Several mechanisms might be responsible for a protective role of vitamin D in CVD. ...The first intervention trials indicate that vitamin D may suppres …
Interestingly, all these factors also have an influence on human UVB exposure and thus on vitamin D status. Several mechanisms might …
Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1.
Pham DQ, Plakogiannis R. Pham DQ, et al. Ann Pharmacother. 2005 Nov;39(11):1870-8. doi: 10.1345/aph.1G211. Epub 2005 Sep 27. Ann Pharmacother. 2005. PMID: 16189282 Review.
OBJECTIVE: To review clinical trials evaluating the safety and efficacy of vitamin E supplementation in cardiovascular disease and cancer prevention. ...CONCLUSIONS: Available data do not support the supplementation of vitamin E in cardiovascular disea …
OBJECTIVE: To review clinical trials evaluating the safety and efficacy of vitamin E supplementation in cardiovascular disease …
Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials.
Myung SK, Ju W, Cho B, Oh SW, Park SM, Koo BK, Park BJ; Korean Meta-Analysis Study Group. Myung SK, et al. BMJ. 2013 Jan 18;346:f10. doi: 10.1136/bmj.f10. BMJ. 2013. PMID: 23335472 Free PMC article. Review.
OBJECTIVE: To assess the efficacy of vitamin and antioxidant supplements in the prevention of cardiovascular diseases. ...CONCLUSION: There is no evidence to support the use of vitamin and antioxidant supplements for prevention of cardiovascular diseas …
OBJECTIVE: To assess the efficacy of vitamin and antioxidant supplements in the prevention of cardiovascular diseases. ...CONC …
Limited evidence for a beneficial effect of vitamin C supplementation on biomarkers of cardiovascular diseases: an umbrella review of systematic reviews and meta-analyses.
Ashor AW, Brown R, Keenan PD, Willis ND, Siervo M, Mathers JC. Ashor AW, et al. Nutr Res. 2019 Jan;61:1-12. doi: 10.1016/j.nutres.2018.08.005. Epub 2018 Sep 1. Nutr Res. 2019. PMID: 30683434 Review.
Vitamin C is an essential nutrient with important antioxidant properties. Higher vitamin C intake appears to be associated with positive effects on cardiovascular risk factors in cohort studies, whereas large randomized controlled clinical trials did not conf
Vitamin C is an essential nutrient with important antioxidant properties. Higher vitamin C intake appears to be associated wit
Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 134000 Individuals in 29 Randomized Clinical Trials and 157000 Individuals in 30 Prospective Cohort Studies: An Updated Systematic Review and Meta-analysis.
Rasouli MA, Darvishzadehdaledari S, Alizadeh Z, Moradi G, Gholami F, Mahmoudian A. Rasouli MA, et al. J Res Health Sci. 2023 Dec 29;23(4):e00594. doi: 10.34172/jrhs.2023.129. Epub 2023 Dec 29. J Res Health Sci. 2023. PMID: 38315909 Free PMC article. Review.
BACKGROUND: According to the findings from observational studies and clinical trials assessing the effect of vitamin D supplements on cardiovascular diseases (CVDs), there are still contradictory results. ...However, there is a direct association between vitamin
BACKGROUND: According to the findings from observational studies and clinical trials assessing the effect of vitamin D supplements on …
Vitamin D and Heart Failure.
Brinkley DM, Ali OM, Zalawadiya SK, Wang TJ. Brinkley DM, et al. Curr Heart Fail Rep. 2017 Oct;14(5):410-420. doi: 10.1007/s11897-017-0355-7. Curr Heart Fail Rep. 2017. PMID: 28808858 Review.
PURPOSE: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascula
PURPOSE: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways thro …
[Vitamin D deficiency and cardiovascular diseases].
Mascitelli L, Goldstein MR, Pezzetta F. Mascitelli L, et al. Recenti Prog Med. 2010 May;101(5):202-11. Recenti Prog Med. 2010. PMID: 20590017 Review. Italian.
However, it has become evident that adequate vitamin D status is important for optimal function of many organs and tissues throughout the body, including the cardiovascular system. ...The relationship between baseline vitamin D status, dose of vitam
However, it has become evident that adequate vitamin D status is important for optimal function of many organs and tissues throughout …
Vitamin D and atherosclerosis.
Menezes AR, Lamb MC, Lavie CJ, DiNicolantonio JJ. Menezes AR, et al. Curr Opin Cardiol. 2014 Nov;29(6):571-7. doi: 10.1097/HCO.0000000000000108. Curr Opin Cardiol. 2014. PMID: 25144342 Review.
PURPOSE OF REVIEW: To provide an overview of the association between vitamin D deficiency and atherosclerosis. RECENT FINDINGS: Vitamin D exerts protective effects on atherosclerosis through multiple mechanisms. ...Recently, there has been mounting evidence linking …
PURPOSE OF REVIEW: To provide an overview of the association between vitamin D deficiency and atherosclerosis. RECENT FINDINGS: Vi
Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence.
Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M. Pludowski P, et al. Autoimmun Rev. 2013 Aug;12(10):976-89. doi: 10.1016/j.autrev.2013.02.004. Epub 2013 Mar 28. Autoimmun Rev. 2013. PMID: 23542507 Review.
Vitamin D deficiency/insufficiency is associated with all-cause mortality. CONCLUSIONS: Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of dis
Vitamin D deficiency/insufficiency is associated with all-cause mortality. CONCLUSIONS: Adequate vitamin D supplementation and
The vitamin D and calcium controversy: an update.
Lewis JR, Sim M, Daly RM. Lewis JR, et al. Curr Opin Rheumatol. 2019 Mar;31(2):91-97. doi: 10.1097/BOR.0000000000000584. Curr Opin Rheumatol. 2019. PMID: 30601231 Review.
There has also been high-quality evidence that vitamin D, daily or as a bolus, does not reduce the risk of cardiovascular events. ...Finally, there remain inconsistent findings for adverse cardiovascular effects of calcium supplements with or without vitam
There has also been high-quality evidence that vitamin D, daily or as a bolus, does not reduce the risk of cardiovascular even …
Thiamine and Cardiovascular Disease: A Literature Review.
DiNicolantonio JJ, Liu J, O'Keefe JH. DiNicolantonio JJ, et al. Prog Cardiovasc Dis. 2018 May-Jun;61(1):27-32. doi: 10.1016/j.pcad.2018.01.009. Epub 2018 Jan 31. Prog Cardiovasc Dis. 2018. PMID: 29360523 Review.
Thiamine is a water-soluble vitamin that plays an important role in the energy metabolism in the human body. ...This article aims to provide a review of current literature on the role of thiamine in the human body, the current scope of thiamine deficiency, and explore the …
Thiamine is a water-soluble vitamin that plays an important role in the energy metabolism in the human body. ...This article aims to …
Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence.
Dou R, Ng K, Giovannucci EL, Manson JE, Qian ZR, Ogino S. Dou R, et al. Br J Nutr. 2016 May;115(9):1643-60. doi: 10.1017/S0007114516000696. Br J Nutr. 2016. PMID: 27245104 Free PMC article. Review.
In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune resp …
In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor …
Vitamin D and heart.
Camici M, Galetta F, Franzoni F, Carpi A, Zangeneh F. Camici M, et al. Intern Emerg Med. 2013 Apr;8 Suppl 1:S5-9. doi: 10.1007/s11739-013-0926-x. Intern Emerg Med. 2013. PMID: 23462894 Review.
The authors briefly review the biological effects of vitamin D on the heart and discuss the experimental and clinical studies related to the potential protective effect of vitamin D on the cardiovascular system. Experimental and observational studies i …
The authors briefly review the biological effects of vitamin D on the heart and discuss the experimental and clinical studies related …
Supplemental calcium and vitamin D and long-term mortality in aortic stenosis.
Kassis N, Hariri EH, Karrthik AK, Ahuja KR, Layoun H, Saad AM, Gad MM, Kaur M, Bazarbashi N, Griffin BP, Popovic ZB, Harb SC, Desai MY, Kapadia SR. Kassis N, et al. Heart. 2022 May 25;108(12):964-972. doi: 10.1136/heartjnl-2021-320215. Heart. 2022. PMID: 35470234
Studies assessing the long-term safety of oral calcium and/or vitamin D in AS are scarce yet imperative given the rising use among an elderly population prone to deficiency. ...Groups were stratified into no supplementation, supplementation with vitamin D alone and …
Studies assessing the long-term safety of oral calcium and/or vitamin D in AS are scarce yet imperative given the rising use among an …
Role of vitamins in the metabolic syndrome and cardiovascular disease.
Aguilera-Méndez A, Boone-Villa D, Nieto-Aguilar R, Villafaña-Rauda S, Molina AS, Sobrevilla JV. Aguilera-Méndez A, et al. Pflugers Arch. 2022 Jan;474(1):117-140. doi: 10.1007/s00424-021-02619-x. Epub 2021 Sep 13. Pflugers Arch. 2022. PMID: 34518916 Review.
Numerous randomized preclinical and clinical trials have evaluated the use of vitamin supplementation in the prevention and treatment of metabolic syndrome and cardiovascular disease. ...In this review, we investigated chemical basics, physiological effect and recom …
Numerous randomized preclinical and clinical trials have evaluated the use of vitamin supplementation in the prevention and treatment …
Protean manifestations of vitamin D deficiency, part 3: association with cardiovascular disease and disorders of the central and peripheral nervous systems.
Bell DS. Bell DS. South Med J. 2011 May;104(5):340-4. doi: 10.1097/01.SMJ.0000397894.02150.5f. South Med J. 2011. PMID: 21606713 Review.
As a result there is an increase in cardiovascular events (CVEs) associated with vitamin D deficiency. Vitamin D deficiency itself or secondary hyperparathyroidism or both may be responsible for the increase in CVEs. ...Vitamin D deficiency is early tr …
As a result there is an increase in cardiovascular events (CVEs) associated with vitamin D deficiency. Vitamin D defici …
Comparison of the cardiovascular system, clinical condition, and laboratory results in COVID-19 patients with and without vitamin D insufficiency.
Kazemi E, Mansoursamaei A, Rohani-Rasaf M, Sheibani H. Kazemi E, et al. BMC Infect Dis. 2022 May 7;22(1):441. doi: 10.1186/s12879-022-07438-8. BMC Infect Dis. 2022. PMID: 35525957 Free PMC article.
RESULTS: The patients were divided into three groups based on their vitamin D level: 127 cases in the insufficient vitamin D group, 53 cases in the normal vitamin D group, and 22 cases in the high vitamin D group. ...CONCLUSION: The finding of the pres …
RESULTS: The patients were divided into three groups based on their vitamin D level: 127 cases in the insufficient vitamin D g …
The Mutual Relationship among Cardiovascular Diseases and COVID-19: Focus on Micronutrients Imbalance.
Severino P, D'Amato A, Prosperi S, Myftari V, Labbro Francia A, Önkaya M, Notari C, Papisca I, Canuti ES, Yarden Revivo M, Birtolo LI, Celli P, Galardo G, Maestrini V, d'Ettorre G, Mancone M, Fedele F. Severino P, et al. Nutrients. 2022 Aug 21;14(16):3439. doi: 10.3390/nu14163439. Nutrients. 2022. PMID: 36014944 Free PMC article. Review.
It has been also observed in coronavirus disease 2019 (COVID-19), particularly in most severe patients. The relationship between cardiovascular diseases and COVID-19 is mutual: the latter triggers cardiovascular disease onset and worsening while patients with previo …
It has been also observed in coronavirus disease 2019 (COVID-19), particularly in most severe patients. The relationship between cardiova
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Madeo F, et al. Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. Autophagy. 2019. PMID: 30306826 Free PMC article.
Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to countera …
Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes ove …
Niacin.
Kirkland JB, Meyer-Ficca ML. Kirkland JB, et al. Adv Food Nutr Res. 2018;83:83-149. doi: 10.1016/bs.afnr.2017.11.003. Epub 2018 Feb 1. Adv Food Nutr Res. 2018. PMID: 29477227
Insight into the role of niacin and various NAD-related diseases ranging from cancer, aging, and metabolic diseases to cardiovascular problems has shifted our view of niacin as a vitamin to current views that explore its potential as a therapeutic....
Insight into the role of niacin and various NAD-related diseases ranging from cancer, aging, and metabolic diseases to cardiovascular
Epimeric vitamin D and cardiovascular structure and function in advanced CKD and after kidney transplantation.
Arroyo E, Leber CA, Burney HN, Li Y, Li X, Lu TS, Jones G, Kaufmann M, Ting SMS, Hiemstra TF, Zehnder D, Lim K. Arroyo E, et al. Nephrol Dial Transplant. 2024 Jan 31;39(2):264-276. doi: 10.1093/ndt/gfad168. Nephrol Dial Transplant. 2024. PMID: 37468453
BACKGROUND: 25-hydroxyvitamin D can undergo C-3 epimerization to produce 3-epi-25(OH)D3. 3-epi-25(OH)D3 levels decline in chronic kidney disease (CKD), but its role in regulating the cardiovascular system is unknown. Herein, we examined the relationship between 3-ep …
BACKGROUND: 25-hydroxyvitamin D can undergo C-3 epimerization to produce 3-epi-25(OH)D3. 3-epi-25(OH)D3 levels decline in chronic kidney dis …
Effect of Vitamins and Dietary Supplements on Cardiovascular Health.
Goudarzi S, Memar Montazerin S, Najafi H, Shojaei F, Chi G. Goudarzi S, et al. Crit Pathw Cardiol. 2020 Sep;19(3):153-159. doi: 10.1097/HPC.0000000000000212. Crit Pathw Cardiol. 2020. PMID: 32053519 Review.
In contrast, vitamins and minerals have not undergone an equal level of scrutiny, and the evidence of cardiovascular benefit remains elusive. ...This review summarizes the currently available data about the effect of vitamins and other dietary supplements on …
In contrast, vitamins and minerals have not undergone an equal level of scrutiny, and the evidence of cardiovascular benefit r …
Relationship between Vitamin D and Immunity in Older People with COVID-19.
Lauretani F, Salvi M, Zucchini I, Testa C, Cattabiani C, Arisi A, Maggio M. Lauretani F, et al. Int J Environ Res Public Health. 2023 Apr 7;20(8):5432. doi: 10.3390/ijerph20085432. Int J Environ Res Public Health. 2023. PMID: 37107714 Free PMC article. Review.
Vitamin D is a group of lipophilic hormones with pleiotropic actions. ...In the pandemic era, by considering the response of the different branches of the immune system to SARS-CoV-2 infection, our aims are both to analyse, among the pleiotropic effects of vitami
Vitamin D is a group of lipophilic hormones with pleiotropic actions. ...In the pandemic era, by considering the response of the diff
Association between vitamin D and cardioprotection in adult patients.
Ferraz GC, Andrade RR, Reis FMP, Oliveira Neto OB, Omena CO, Jucá MJ, Sousa-Rodrigues CF, Barbosa FT. Ferraz GC, et al. Rev Assoc Med Bras (1992). 2020 Oct;66(10):1444-1448. doi: 10.1590/1806-9282.66.10.1444. Rev Assoc Med Bras (1992). 2020. PMID: 33174941 Free article. Review.
RESULTS: Twenty-three articles were identified from the electronic search that reported on physiological mechanisms relating the vitamin D axis and the cardiovascular system through receptors. Of the ten studies that evaluated the therapeutic effect of vit
RESULTS: Twenty-three articles were identified from the electronic search that reported on physiological mechanisms relating the vitamin
Vitamin D and chronic disease prevention.
Welsh P, Sattar N. Welsh P, et al. BMJ. 2014 Apr 1;348:g2280. doi: 10.1136/bmj.g2280. BMJ. 2014. PMID: 24690627 Free article. No abstract available.
A review of vitamin D status and CVD.
Cashman KD. Cashman KD. Proc Nutr Soc. 2014 Feb;73(1):65-72. doi: 10.1017/S0029665113003595. Epub 2013 Oct 9. Proc Nutr Soc. 2014. PMID: 24103845 Review.
Beyond the well-accepted effects on the skeleton, low vitamin D status has been linked to increased risk of several non-skeletal disease, including CVD. ...Finally, the review summarises current serum 25(OH)D concentrations within a select number of adult populations in th …
Beyond the well-accepted effects on the skeleton, low vitamin D status has been linked to increased risk of several non-skeletal dise …
Optimal Vitamin D Supplementation Levels for Cardiovascular Disease Protection.
Lugg ST, Howells PA, Thickett DR. Lugg ST, et al. Dis Markers. 2015;2015:864370. doi: 10.1155/2015/864370. Epub 2015 Sep 8. Dis Markers. 2015. PMID: 26435569 Free PMC article. Review.
First described in relation to musculoskeletal disease, there is accumulating data to suggest that vitamin D may play an important role in cardiovascular disease (CVD). ...The role of vitamin D levels as a disease marker for all-cause mortality is also discus …
First described in relation to musculoskeletal disease, there is accumulating data to suggest that vitamin D may play an important ro …
Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach.
Hill A, Wendt S, Benstoem C, Neubauer C, Meybohm P, Langlois P, Adhikari NK, Heyland DK, Stoppe C. Hill A, et al. Nutrients. 2018 Jul 27;10(8):974. doi: 10.3390/nu10080974. Nutrients. 2018. PMID: 30060468 Free PMC article. Review.
The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative s …
The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. …
Effects of vitamin supplements on clinical cardiovascular outcomes: Time to move on! - A comprehensive review.
Simsek B, Selte A, Egeli BH, Çakatay U. Simsek B, et al. Clin Nutr ESPEN. 2021 Apr;42:1-14. doi: 10.1016/j.clnesp.2021.02.014. Epub 2021 Feb 25. Clin Nutr ESPEN. 2021. PMID: 33745562 Free PMC article. Review.
METHODS: A thorough PubMed search with the phrase: "Vitamin supplements and cardiovascular health" was performed. In the present review, focus was maintained on the evidence for the use of vitamin supplements in the prevention of major cardiovascular e …
METHODS: A thorough PubMed search with the phrase: "Vitamin supplements and cardiovascular health" was performed. In the prese …
Vitamin D in burn-injured patients.
Rech MA, Colon Hidalgo D, Larson J, Zavala S, Mosier M. Rech MA, et al. Burns. 2019 Feb;45(1):32-41. doi: 10.1016/j.burns.2018.04.015. Burns. 2019. PMID: 29776863 Review.
Recently, many studies have demonstrated pleotropic effects of vitamin D, including immune modulation and cardiovascular system activity. Sufficient vitamin D concentrations and supplementation of vitamin D may be of benefit in burn-injured pati …
Recently, many studies have demonstrated pleotropic effects of vitamin D, including immune modulation and cardiovascular sy
The Role of Vitamin D in Stroke Prevention and the Effects of Its Supplementation for Post-Stroke Rehabilitation: A Narrative Review.
Marek K, Cichoń N, Saluk-Bijak J, Bijak M, Miller E. Marek K, et al. Nutrients. 2022 Jul 4;14(13):2761. doi: 10.3390/nu14132761. Nutrients. 2022. PMID: 35807941 Free PMC article. Review.
Recently, the potential association between vitamin D levels and stroke has gained increasing attention. Many studies suggest that maintaining normal serum vitamin D levels is associated with improvement of the cardiovascular system and a reduction in …
Recently, the potential association between vitamin D levels and stroke has gained increasing attention. Many studies suggest that ma …
Prevalence of vitamin D insufficiency and evidence for disease prevention in the older population.
Kühn J, Trotz P, Stangl GI. Kühn J, et al. Z Gerontol Geriatr. 2018 Jul;51(5):567-572. doi: 10.1007/s00391-018-1390-z. Epub 2018 Apr 17. Z Gerontol Geriatr. 2018. PMID: 29666919 Review. English.
The role of vitamin D in the prevention of falls and frailty remains unclear. ...To conclude, vitamin D, particularly combined with calcium, has moderately beneficial effects on the skeletal system and is useful for the prevention of respiratory tract infecti …
The role of vitamin D in the prevention of falls and frailty remains unclear. ...To conclude, vitamin D, particularly combined …
The Vitamin D Assessment (ViDA) study - Design and main findings.
Scragg R. Scragg R. J Steroid Biochem Mol Biol. 2020 Apr;198:105562. doi: 10.1016/j.jsbmb.2019.105562. Epub 2019 Dec 3. J Steroid Biochem Mol Biol. 2020. PMID: 31809866 Clinical Trial.
This has initiated the conduct of several large clinical trials to determine if high dose vitamin D supplementation ( 2000 IU/day or monthly equivalent) prevents non-skeletal disease including cardiovascular disease, cancer and mortality. ...Information on study out …
This has initiated the conduct of several large clinical trials to determine if high dose vitamin D supplementation ( 2000 IU/day or …
Vitamin C revisited.
Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Oudemans-van Straaten HM, et al. Crit Care. 2014 Aug 6;18(4):460. doi: 10.1186/s13054-014-0460-x. Crit Care. 2014. PMID: 25185110 Free PMC article. Review.
High-dose vitamin C, however, provides a cheap, strong and multifaceted antioxidant, especially robust for resuscitation of the circulation. Vitamin C given as early as possible after the injurious event, or before if feasible, seems most effective. ...
High-dose vitamin C, however, provides a cheap, strong and multifaceted antioxidant, especially robust for resuscitation of the circu …
The current role and therapeutic targets of vitamin D in gastrointestinal inflammation and cancer.
Cai GH, Li MX, Lu L, Yi Chan RL, Wang JH, Cho CH. Cai GH, et al. Curr Pharm Des. 2015;21(21):2917-23. doi: 10.2174/1381612821666150514103105. Curr Pharm Des. 2015. PMID: 26004419 Review.
Vitamin D, beyond its classical roles in the regulation of calcium and phosphorus homeostasis and bone metabolism, has been implicated in multiple pathological processes, including progression from inflammation to cancer development and also involvement in autoimmune disea
Vitamin D, beyond its classical roles in the regulation of calcium and phosphorus homeostasis and bone metabolism, has been implicate
Association between dietary vitamin C and abdominal aortic calcification among the US adults.
Jia J, Zhang J, He Q, Wang M, Liu Q, Wang T, Chen X, Wang W, Xu H. Jia J, et al. Nutr J. 2023 Nov 15;22(1):58. doi: 10.1186/s12937-023-00889-y. Nutr J. 2023. PMID: 37964312 Free PMC article.
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality, and vascular calcification has been highly correlated with CVD events. ...However, the relationship of vitamin C supplements with AAC was not identified. CONCLUSIONS: The study revealed that …
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality, and vascular calcification has been highly correlated wit …
The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial.
Cheung MM, Dall RD, Shewokis PA, Altasan A, Volpe SL, Amori R, Singh H, Sukumar D. Cheung MM, et al. Nutrition. 2022 Jul-Aug;99-100:111674. doi: 10.1016/j.nut.2022.111674. Epub 2022 Apr 1. Nutrition. 2022. PMID: 35576873 Clinical Trial.
OBJECTIVE: Poor vitamin D and magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associated with a heightened risk of cardiovascular disease. ...METHODS: This 12-week double-blinded randomized controlled trial had three tr …
OBJECTIVE: Poor vitamin D and magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associat …
Modulatory effects of melatonin and vitamin C on oxidative stress-mediated haemolytic anaemia and associated cardiovascular dysfunctions in rats.
Ajibade TO, Oyagbemi AA, Durotoye LA, Omóbòwálé TO, Asenuga ER, Olayemi FO. Ajibade TO, et al. J Complement Integr Med. 2017 Mar 1;14(1):/j/jcim.2017.14.issue-1/jcim-2015-0082/jcim-2015-0082.xml. doi: 10.1515/jcim-2015-0082. J Complement Integr Med. 2017. PMID: 28237973
Pathology of the heart and kidney was also observed in PHE treated group. However, treatment with MLT and vitamin C improved enzymic and non-enzymic antioxidant system together with the restoration of SBP, DBP and MABP to near normal. The architectural anarchy obser …
Pathology of the heart and kidney was also observed in PHE treated group. However, treatment with MLT and vitamin C improved enzymic …
What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review.
Łykowska-Szuber L, Rychter AM, Dudek M, Ratajczak AE, Szymczak-Tomczak A, Zawada A, Eder P, Lesiak M, Dobrowolska A, Krela-Kaźmierczak I. Łykowska-Szuber L, et al. Nutrients. 2021 Jul 30;13(8):2661. doi: 10.3390/nu13082661. Nutrients. 2021. PMID: 34444821 Free PMC article. Review.
Several studies have shown increased rates of cardiovascular disease (CVD) in patients suffering from inflammatory bowel disease (IBD), particularly in cases of early atherosclerosis and myocardial infarction. ...Thus, it is essential to investigate the factors responsible …
Several studies have shown increased rates of cardiovascular disease (CVD) in patients suffering from inflammatory bowel disease (IBD …
Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive services Task Force recommendation statement.
Moyer VA; U.S. Preventive Services Task Force. Moyer VA, et al. Ann Intern Med. 2014 Apr 15;160(8):558-64. doi: 10.7326/M14-0198. Ann Intern Med. 2014. PMID: 24566474 Free article.
DESCRIPTION: Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on vitamin supplementation to prevent cardiovascular disease and cancer. ...(I statement). The USPSTF recommends against beta-carotene or vitamin E supplements for the …
DESCRIPTION: Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on vitamin supplementation to prevent …
Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D.
Grant WB, Boucher BJ, Al Anouti F, Pilz S. Grant WB, et al. Nutrients. 2022 Sep 15;14(18):3811. doi: 10.3390/nu14183811. Nutrients. 2022. PMID: 36145186 Free PMC article. Review.
Thus, RCTs of vitamin D can fail for several reasons: few participants' having low baseline 25(OH)D concentrations, relatively small vitamin D doses, participants' having other sources of vitamin D, and results being analyzed without consideration of achieved …
Thus, RCTs of vitamin D can fail for several reasons: few participants' having low baseline 25(OH)D concentrations, relatively small …
Routine vitamin supplementation to prevent cancer and cardiovascular disease.
U. S. Preventive Services Task Force. U. S. Preventive Services Task Force. Nutr Clin Care. 2003 Oct-Dec;6(3):102-7. Nutr Clin Care. 2003. PMID: 14979452 Review.
Preventive Services Task Force (USPSTF) recommendations on routine vitamin supplementation to prevent cancer and cardiovascular disease and the supporting scientific evidence. The USPSTF concludes that the evidence is insufficient to recommend for or against the use …
Preventive Services Task Force (USPSTF) recommendations on routine vitamin supplementation to prevent cancer and cardiovascular
An update on vitamin E, tocopherol and tocotrienol-perspectives.
Colombo ML. Colombo ML. Molecules. 2010 Mar 24;15(4):2103-13. doi: 10.3390/molecules15042103. Molecules. 2010. PMID: 20428030 Free PMC article. Review.
Vitamin E, like tocotrienols and tocopherols, is constituted of compounds essential for animal cells. ...From a health point of view, at the moment there is a great interest in the natural forms of tocochromanols, because they are considered promising compounds able to mai
Vitamin E, like tocotrienols and tocopherols, is constituted of compounds essential for animal cells. ...From a health point of view,
Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update.
Grzeczka A, Graczyk S, Skowronska A, Skowronski MT, Kordowitzki P. Grzeczka A, et al. Nutrients. 2022 Sep 9;14(18):3712. doi: 10.3390/nu14183712. Nutrients. 2022. PMID: 36145088 Free PMC article.
For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal system, but also for numerous other mammalian organ systems. ...Moreover, VD deficiencies are linked to several pathologies, for instanc …
For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal …
Vitamin D in kidney transplant recipients.
Battaglia Y, Cojocaru E, Fiorini F, Granata A, Esposito P, Russo L, Bortoluzzi A, Storari A, Russo D. Battaglia Y, et al. Clin Nephrol. 2020 Feb;93(2):57-64. doi: 10.5414/CN109735. Clin Nephrol. 2020. PMID: 31319906 Review.
Kidney transplant recipients (KTRs) are susceptible to low levels of vitamin D, which may be responsible for mineral and bone metabolism disorders and play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic, and infectious complication …
Kidney transplant recipients (KTRs) are susceptible to low levels of vitamin D, which may be responsible for mineral and bone metabol …
A brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019.
Cereda E, Bogliolo L, de Stefano L, Caccialanza R. Cereda E, et al. Curr Opin Clin Nutr Metab Care. 2021 Jan;24(1):102-107. doi: 10.1097/MCO.0000000000000701. Curr Opin Clin Nutr Metab Care. 2021. PMID: 33003119 Review.
PURPOSE OF REVIEW: Vitamin D exerts extraskeletal functions, including immunomodulatory activity, protection against respiratory tract infections and pleiotropic effects on the cardiovascular system. ...However, the pandemic progression and the increased know …
PURPOSE OF REVIEW: Vitamin D exerts extraskeletal functions, including immunomodulatory activity, protection against respiratory trac …
Vitamin and mineral supplements.
Hamrick I, Counts SH. Hamrick I, et al. Prim Care. 2008 Dec;35(4):729-47. doi: 10.1016/j.pop.2008.07.012. Prim Care. 2008. PMID: 18928827
Some vitamin and mineral supplements have proved to be clinically useful in preventing various diseases and health problems. ...Primary care physicians should be familiar with the latest research so they can be proactive in advising patients about proper use of vitamins
Some vitamin and mineral supplements have proved to be clinically useful in preventing various diseases and health problems. ...Prima …
Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies.
Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, Khan H, Baena CP, Prabhakaran D, Hoshen MB, Feldman BS, Pan A, Johnson L, Crowe F, Hu FB, Franco OH. Chowdhury R, et al. BMJ. 2014 Apr 1;348:g1903. doi: 10.1136/bmj.g1903. BMJ. 2014. PMID: 24690623 Free PMC article. Review.
OBJECTIVE: To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances. ...Subgroup analyses in the observational studies indicated tha …
OBJECTIVE: To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from c
Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).
Vossen LM, Schurgers LJ, van Varik BJ, Kietselaer BL, Vermeer C, Meeder JG, Rahel BM, van Cauteren YJ, Hoffland GA, Rennenberg RJ, Reesink KD, de Leeuw PW, Kroon AA. Vossen LM, et al. Nutrients. 2015 Oct 28;7(11):8905-15. doi: 10.3390/nu7115443. Nutrients. 2015. PMID: 26516910 Free PMC article. Clinical Trial.
An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have shown that inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and …
An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have s …
A Narrative Review of Recent Studies on the Role of Vitamin D in the Prevention of Cardiac and Renal Risk and Additional Considerations for COVID-19 Vulnerability.
Panteli AE, Theofilis P, Vordoni A, Vlachopanos G, Koukoulaki M, Kalaitzidis RG. Panteli AE, et al. Curr Vasc Pharmacol. 2022;20(2):168-177. doi: 10.2174/1570161119666211119142746. Curr Vasc Pharmacol. 2022. PMID: 34802405 Review.
The role of vitamin D in maintaining a healthy cardiovascular (CV) and the renal system has received increasing attention. ...This narrative review considers recent data on the effects of vitamin D on the CV and renal system, as well as its poss …
The role of vitamin D in maintaining a healthy cardiovascular (CV) and the renal system has received increasing attenti …
Oral vitamin C restores endothelial function during acute inflammation in young and older adults.
Lefferts EC, Hibner BA, Lefferts WK, Lima NS, Baynard T, Haus JM, Lane-Cordova AD, Phillips SA, Fernhall B. Lefferts EC, et al. Physiol Rep. 2021 Nov;9(21):e15104. doi: 10.14814/phy2.15104. Physiol Rep. 2021. PMID: 34762777 Free PMC article.
In conclusion, oral vitamin C restored endothelial function during acute inflammation in young and older adults, with no effect on aortic stiffness. The effect of vitamin C on endothelial function did not appear to be due to reductions in inflammatory markers. ...
In conclusion, oral vitamin C restored endothelial function during acute inflammation in young and older adults, with no effect on ao …
Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium.
Gibson CC, Davis CT, Zhu W, Bowman-Kirigin JA, Walker AE, Tai Z, Thomas KR, Donato AJ, Lesniewski LA, Li DY. Gibson CC, et al. PLoS One. 2015 Oct 15;10(10):e0140370. doi: 10.1371/journal.pone.0140370. eCollection 2015. PLoS One. 2015. PMID: 26469335 Free PMC article.
Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be largely mediated by the metabolite 1,25(OH)2D3. ...In this manuscript we show that the presumed inacti
Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vit
Effects of moderate exercise and a multiple vitamin and mineral complex on the arterial wall.
Potoră CS, Tache S, Albu A, Nagy AL. Potoră CS, et al. Rom J Morphol Embryol. 2018;59(1):249-256. Rom J Morphol Embryol. 2018. PMID: 29940635 Free article.
Its beneficial role may be due to a decrease in oxidative stress. The association of vitamin and mineral supplements to exercise determined contradictory effects on arterial wall and oxidative stress parameters. The aim of this experimental study was to evaluate the effect …
Its beneficial role may be due to a decrease in oxidative stress. The association of vitamin and mineral supplements to exercise dete …
Vitamins for Cardiovascular Diseases: Is the Expense Justified?
Sultan S, Murarka S, Jahangir A, Mookadam F, Tajik AJ, Jahangir A. Sultan S, et al. Cardiol Rev. 2017 Nov/Dec;25(6):298-308. doi: 10.1097/CRD.0000000000000150. Cardiol Rev. 2017. PMID: 28984669 Review.
Despite the knowledge that a well-balanced diet provides most of the nutritional requirements, the use of supplemental vitamins is widespread among adults in the United States. Evidence from large randomized controlled trials over the last 2 decades does not support vit
Despite the knowledge that a well-balanced diet provides most of the nutritional requirements, the use of supplemental vitamins is wi …
Role of vitamin D in pathogenesis and severity of COVID-19 infection.
Honardoost M, Ghavideldarestani M, Khamseh ME. Honardoost M, et al. Arch Physiol Biochem. 2023 Feb;129(1):26-32. doi: 10.1080/13813455.2020.1792505. Epub 2020 Oct 30. Arch Physiol Biochem. 2023. PMID: 33125298
Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, cardiovascular events and associated comorbidities, which are the main causes of severe clinical complications in COVID-19 patients. Con …
Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, …
[Vitamin D and cognition in the elderly].
Constans T, Mondon K, Annweiler C, Hommet C. Constans T, et al. Psychol Neuropsychiatr Vieil. 2010 Dec;8(4):255-62. doi: 10.1684/pnv.2010.0233. Psychol Neuropsychiatr Vieil. 2010. PMID: 21147664 Free article. Review. French.
The understanding of the role of vitamin D in maintaining good health has considerably increased in the recent years. There is a growing evidence that vitamin D has not only a beneficial effect to prevent osteoporosis and the risk of falls in the elderly, but also m …
The understanding of the role of vitamin D in maintaining good health has considerably increased in the recent years. There is a grow …
Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders.
Mohan A, Kumar R, Kumar V, Yadav M. Mohan A, et al. Curr Cardiol Rev. 2023;19(4):e090223213539. doi: 10.2174/1573403X19666230209111854. Curr Cardiol Rev. 2023. PMID: 36757031
However, the long-term effects of sub-medical deficiency have not been thoroughly studied, but they may have a negative impact on the cardiovascular system, pregnancy outcomes, and vascular, renal, cognitive, bone, and eye health. ...Another approach is related to t …
However, the long-term effects of sub-medical deficiency have not been thoroughly studied, but they may have a negative impact on the car
[What is a vitamin?].
Guilland JC. Guilland JC. Rev Prat. 2013 Oct;63(8):1060-9. Rev Prat. 2013. PMID: 24298822 Review. French.
In industrialized countries, the major vitamin deficiency syndromes have virtually disappeared. Today they are superseded by marginal deficits, characterized by insufficient vitamins reserves to maintain normal physiologic state. ...This assumption stems from the an …
In industrialized countries, the major vitamin deficiency syndromes have virtually disappeared. Today they are superseded by marginal …
Routine vitamin supplementation to prevent cancer and cardiovascular disease: recommendations and rationale.
U.S. Preventive Services Task Force. U.S. Preventive Services Task Force. Ann Intern Med. 2003 Jul 1;139(1):51-5. doi: 10.7326/0003-4819-139-1-200307010-00013. Ann Intern Med. 2003. PMID: 12834319 Free article.
Preventive Services Task Force (USPSTF) recommendations on routine vitamin supplementation to prevent cancer and cardiovascular disease and the supporting scientific evidence. Part of the information on which this statement is based, including evidence tables and re …
Preventive Services Task Force (USPSTF) recommendations on routine vitamin supplementation to prevent cancer and cardiovascular
Effect of vitamin E and C supplements on antioxidant defense system in cardiovascular disease patients in Zahedan, southeast Iran.
Karajibani M, Hashemi M, Montazerifar F, Dikshit M. Karajibani M, et al. J Nutr Sci Vitaminol (Tokyo). 2010;56(6):436-40. doi: 10.3177/jnsv.56.436. J Nutr Sci Vitaminol (Tokyo). 2010. PMID: 21422713 Free article. Clinical Trial.
Oxidative stress plays an important role in the pathogenesis of cardiovascular disease (CVD). Growing evidence suggest that antioxidant vitamins might reduce the risk of disease outcomes by their ability to scavenge free radicals. ...The results suggest that supplem …
Oxidative stress plays an important role in the pathogenesis of cardiovascular disease (CVD). Growing evidence suggest that antioxida …
Vitamin-D Deficiency and Supplementation Altered the Network of the Coronary Arteries in a Rodent Model-In Situ Video Microscopic Technique.
Dalloul H, Hainzl T, Monori-Kiss A, Hadjadj L, Nádasy GL, Török M, Várbíró S. Dalloul H, et al. Nutrients. 2022 May 13;14(10):2041. doi: 10.3390/nu14102041. Nutrients. 2022. PMID: 35631182 Free PMC article.
The aim of our study was to identify whether vitamin-D deficiency (VDD) can alter the geometry of the coronary-resistance-artery system. ...In VD- rats, 150-200 and 300 m units were almost missing at higher flow distances from the orifice. Serum vitamin-D alt …
The aim of our study was to identify whether vitamin-D deficiency (VDD) can alter the geometry of the coronary-resistance-artery s
Effect of vitamin D supplementation on measures of arterial stiffness: a systematic review and meta-analysis of randomized controlled trials.
Rodríguez AJ, Scott D, Srikanth V, Ebeling P. Rodríguez AJ, et al. Clin Endocrinol (Oxf). 2016 May;84(5):645-57. doi: 10.1111/cen.13031. Epub 2016 Feb 26. Clin Endocrinol (Oxf). 2016. PMID: 26824510 Review.
Arterial stiffness has prognostic value for cardiovascular disease risk. The aim of this systematic review was to clarify the literature surrounding the use of vitamin D to ameliorate arterial stiffness. ...Therefore, large and well-designed randomized studies are r …
Arterial stiffness has prognostic value for cardiovascular disease risk. The aim of this systematic review was to clarify the literat …
Vitamin E and heart disease: basic science to clinical intervention trials.
Pryor WA. Pryor WA. Free Radic Biol Med. 2000 Jan 1;28(1):141-64. doi: 10.1016/s0891-5849(99)00224-5. Free Radic Biol Med. 2000. PMID: 10656300 Review.
The hypothesis that links vitamin E to the prevention of cardiovascular disease (CVD) postulates that the oxidation of unsaturated lipids in the low-density lipoprotein (LDL) particle initiates a complex sequence of events that leads to the development of atheroscle …
The hypothesis that links vitamin E to the prevention of cardiovascular disease (CVD) postulates that the oxidation of unsatur …
Potential of vitamin D in treating diabetic cardiomyopathy.
Lee TW, Lee TI, Chang CJ, Lien GS, Kao YH, Chao TF, Chen YJ. Lee TW, et al. Nutr Res. 2015 Apr;35(4):269-79. doi: 10.1016/j.nutres.2015.02.005. Epub 2015 Feb 24. Nutr Res. 2015. PMID: 25770692 Review.
Currently, effective treatments for diabetic cardiomyopathy are limited. Vitamin D exerts pleiotropic effects on the cardiovascular system and is associated with DM. ...Herein, we reviewed vitamin D metabolism; evaluated the molecular, cellular, and ne …
Currently, effective treatments for diabetic cardiomyopathy are limited. Vitamin D exerts pleiotropic effects on the cardiovascula
Clinical Significance of Analysis of Vitamin D Status in Various Diseases.
Kowalówka M, Główka AK, Karaźniewicz-Łada M, Kosewski G. Kowalówka M, et al. Nutrients. 2020 Sep 11;12(9):2788. doi: 10.3390/nu12092788. Nutrients. 2020. PMID: 32933052 Free PMC article. Review.
Vitamin D plays a role not only in the proper functioning of the skeletal system and the calcium-phosphate equilibrium, but also in the immune system, the cardiovascular system and the growth and division of cells. ...This article reviews the re
Vitamin D plays a role not only in the proper functioning of the skeletal system and the calcium-phosphate equilibrium, but al
Routine vitamin supplementation to prevent cardiovascular disease: a summary of the evidence for the U.S. Preventive Services Task Force.
Morris CD, Carson S. Morris CD, et al. Ann Intern Med. 2003 Jul 1;139(1):56-70. doi: 10.7326/0003-4819-139-1-200307010-00014. Ann Intern Med. 2003. PMID: 12834320 Free article. Review.
PURPOSE: To assess the evidence of the effectiveness of vitamin supplementation, specifically vitamins A, C, and E; beta-carotene; folic acid; antioxidant combinations; and multivitamin supplements, in preventing cardiovascular disease. ...CONCLUSIONS: Some g …
PURPOSE: To assess the evidence of the effectiveness of vitamin supplementation, specifically vitamins A, C, and E; beta-carot …
Place of vitamin D in the prevention of premature aging and the development of age-associated diseases.
Drapkina OM, Shepel RN, Fomin VV, Svistunov АА. Drapkina OM, et al. Ter Arkh. 2018 Feb 14;90(1):69-75. doi: 10.26442/terarkh201890169-75. Ter Arkh. 2018. PMID: 30701762 Review.
At the same time there is growing evidence geroprotective properties of vitamin D. In this review, described in detail the possible mechanisms by which vitamin D affects differentiation, cell proliferation and apoptosis, and describes the potential benefits of this …
At the same time there is growing evidence geroprotective properties of vitamin D. In this review, described in detail the possible m …
The potential role of antioxidant vitamins in preventing cardiovascular diseases and cancers.
Hercberg S, Galan P, Preziosi P, Alfarez MJ, Vazquez C. Hercberg S, et al. Nutrition. 1998 Jun;14(6):513-20. doi: 10.1016/s0899-9007(98)00040-9. Nutrition. 1998. PMID: 9646292 Review.
Here we present mechanistic data and results of epidemiologic studies on the relationship between antioxidant vitamin intake or biochemical status and the risk of cancer and cardiovascular diseases. ...All these studies indicate that a high dietary intake or high bl …
Here we present mechanistic data and results of epidemiologic studies on the relationship between antioxidant vitamin intake or bioch …
Therapeutic application of vitamin D receptor ligands: an updated patent review.
Takada I, Makishima M. Takada I, et al. Expert Opin Ther Pat. 2015;25(12):1373-83. doi: 10.1517/13543776.2015.1093113. Epub 2015 Sep 24. Expert Opin Ther Pat. 2015. PMID: 26402335 Review.
INTRODUCTION: The vitamin D receptor (VDR) is a promising drug target in the treatment of cancer, autoimmune disease, inflammation, infection and cardiovascular disease, as well as bone and mineral disorders. ...AREAS COVERED: We summarize recent patent activity reg …
INTRODUCTION: The vitamin D receptor (VDR) is a promising drug target in the treatment of cancer, autoimmune disease, inflammation, i …
[Influence of vitamin D on cardiovascular risk].
Cormier C, Courbebaisse M. Cormier C, et al. Presse Med. 2013 Oct;42(10):1364-70. doi: 10.1016/j.lpm.2013.09.002. Epub 2013 Oct 3. Presse Med. 2013. PMID: 24090586 Review. French.
Few interventional studies have reported a positive effect of native vitamin D supplementation on intermediary parameters of insulin resistance, of cardiovascular risk and on major cardiovascular events and mortality....
Few interventional studies have reported a positive effect of native vitamin D supplementation on intermediary parameters of insulin …
Evaluation of the relationship between vitamin D level during pregnancy and the rate of fetal heart problems: a cross-sectional study.
Rastegar M, Fateh M, Rahnama A, Sheybani-Arani M, Salimi Asl A, Rajaei S. Rastegar M, et al. Clin Nutr ESPEN. 2022 Oct;51:262-266. doi: 10.1016/j.clnesp.2022.08.018. Epub 2022 Aug 31. Clin Nutr ESPEN. 2022. PMID: 36184213
Heart problems increased in fetuses of mothers with lower serum vitamin D levels. No abnormality was also observed in the fetal heart of mothers with normal vitamin D levels. ...Vitamin D deficiency in the mother can also be considered an indication of fetal …
Heart problems increased in fetuses of mothers with lower serum vitamin D levels. No abnormality was also observed in the fetal heart …
Vitamin D as therapeutic modulator in cerebrovascular diseases: a mechanistic perspectives.
Rihal V, Khan H, Kaur A, Singh TG. Rihal V, et al. Crit Rev Food Sci Nutr. 2023;63(25):7772-7794. doi: 10.1080/10408398.2022.2050349. Epub 2022 Mar 14. Crit Rev Food Sci Nutr. 2023. PMID: 35285752 Review.
Vitamin D deficiency has been linked to several major chronic diseases, such as cardiovascular and neurodegenerative diseases, diabetes, and cancer, linked to oxidative stress, inflammation, and aging. Vitamin D deficiency appears to be particularly harmful t
Vitamin D deficiency has been linked to several major chronic diseases, such as cardiovascular and neurodegenerative diseases,
Different vitamin D receptor agonists exhibit differential effects on endothelial function and aortic gene expression in 5/6 nephrectomized rats.
Wu-Wong JR, Li X, Chen YW. Wu-Wong JR, et al. J Steroid Biochem Mol Biol. 2015 Apr;148:202-9. doi: 10.1016/j.jsbmb.2014.12.002. Epub 2014 Dec 10. J Steroid Biochem Mol Biol. 2015. PMID: 25500070 Review.
Endothelial dysfunction, common in chronic kidney disease (CKD), significantly increases cardiovascular disease risk in CKD patients. This study investigates whether different vitamin D receptor agonists exhibit different effects on endothelial function and on aorti …
Endothelial dysfunction, common in chronic kidney disease (CKD), significantly increases cardiovascular disease risk in CKD patients. …
[Vitamin D hormone system and diabetes mellitus: lessons from selective activators of vitamin D receptor and diabetes mellitus].
Jódar-Gimeno E, Muñoz-Torres M. Jódar-Gimeno E, et al. Endocrinol Nutr. 2013 Feb;60(2):87-95. doi: 10.1016/j.endonu.2012.04.005. Epub 2012 Jul 2. Endocrinol Nutr. 2013. PMID: 22763025 Review. Spanish.
The vitamin D hormone system has significant skeletal and extra-skeletal effects. ...Specifically, influence of vitamin D on the renin-angiotensin-aldosterone system, inflammatory response, and urinary albumin excretion could explain the relevant impac …
The vitamin D hormone system has significant skeletal and extra-skeletal effects. ...Specifically, influence of vitamin
[Vitamin D: skeletal and extra skeletal effects; recommendations for good practice].
Briot K, Audran M, Cortet B, Fardellone P, Marcelli C, Orcel P, Vellas B, Thomas T, Roux C. Briot K, et al. Presse Med. 2009 Jan;38(1):43-54. doi: 10.1016/j.lpm.2008.08.008. Epub 2008 Nov 11. Presse Med. 2009. PMID: 19004609 Review. French.
During the past decade, major advances have reported the importance of the vitamin D on the bone metabolism, and recent studies have suggested the potential non skeletal effects of the vitamin D. ...A possible role of vitamin D has been implicated in the redu …
During the past decade, major advances have reported the importance of the vitamin D on the bone metabolism, and recent studies have …
Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. SUpplementation en VItamines et Mineraux AntioXydants Study.
Hercberg S, Galan P, Preziosi P, Roussel AM, Arnaud J, Richard MJ, Malvy D, Paul-Dauphin A, Briançon S, Favier A. Hercberg S, et al. Int J Vitam Nutr Res. 1998;68(1):3-20. Int J Vitam Nutr Res. 1998. PMID: 9503043 Review.
The "SUpplementation en VItamines et MinerauxAntioXydants" (SU.VI.MAX) study is a randomized double-blind, placebo-controlled, primary prevention trial designed to test the efficacy of daily supplementation with antioxidant vitamins (vitamin C, 120 mg; vit
The "SUpplementation en VItamines et MinerauxAntioXydants" (SU.VI.MAX) study is a randomized double-blind, placebo-controlled, primar …
Effect of Combined Treatment With Folic Acid, Vitamin B(6), and Vitamin B(12) on Plasma Biomarkers of Inflammation and Endothelial Dysfunction in Women.
Christen WG, Cook NR, Van Denburgh M, Zaharris E, Albert CM, Manson JE. Christen WG, et al. J Am Heart Assoc. 2018 May 18;7(11):e008517. doi: 10.1161/JAHA.117.008517. J Am Heart Assoc. 2018. PMID: 29776960 Free PMC article. Clinical Trial.
BACKGROUND: The aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment with folic acid, vitamin B(6), and vitamin B(12) alters plasma biomarkers of inflammation and endothelial dysfunction in women a …
BACKGROUND: The aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment wi …
Vitamins in dialysis: who, when and how much?
Kosmadakis G, Da Costa Correia E, Carceles O, Somda F, Aguilera D. Kosmadakis G, et al. Ren Fail. 2014 May;36(4):638-50. doi: 10.3109/0886022X.2014.882714. Epub 2014 Feb 6. Ren Fail. 2014. PMID: 24502653 Review.
Vitamins are playing a crucial role in multiple key metabolic pathways. ...Frequent treatment with antibiotics due to infections associated with the acquired uremia-related immunosuppression may derange the vitamin-producing intestinal microflora. Certain agents pre
Vitamins are playing a crucial role in multiple key metabolic pathways. ...Frequent treatment with antibiotics due to infections asso
Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden.
Cruz MAD, Ulfenborg B, Blomstrand P, Faresjö M, Ståhl F, Karlsson S. Cruz MAD, et al. Sci Rep. 2022 Jul 25;12(1):12670. doi: 10.1038/s41598-022-15924-x. Sci Rep. 2022. PMID: 35879377 Free PMC article.
The study participants also answered queries on lifestyle, vitamin intake, heart medication, and estimated health. Vitamin D intake did not in general affect methylation patterns, which is in concert with other studies. ...This confirms a previous finding, where cha …
The study participants also answered queries on lifestyle, vitamin intake, heart medication, and estimated health. Vitamin D i …
The role of the antioxidant vitamin supplementation in the prevention of cardiovascular diseases.
Riccioni G, Bucciarelli T, Mancini B, Di Ilio C, Capra V, D'Orazio N. Riccioni G, et al. Expert Opin Investig Drugs. 2007 Jan;16(1):25-32. doi: 10.1517/13543784.16.1.25. Expert Opin Investig Drugs. 2007. PMID: 17155851 Review.
Industrial and technological revolutions have resulted in dramatic shifts in the diseases that are responsible for illness and death. In particular, cardiovascular disease (CVD) has emerged as the dominant chronic disease in many parts of the world. ...A large number of de …
Industrial and technological revolutions have resulted in dramatic shifts in the diseases that are responsible for illness and death. In par …
The virtues of vitamin D--but how much is too much?
Shroff R, Knott C, Rees L. Shroff R, et al. Pediatr Nephrol. 2010 Sep;25(9):1607-20. doi: 10.1007/s00467-010-1499-9. Pediatr Nephrol. 2010. PMID: 20393752 Review.
Most tissues in the body have a vitamin D receptor and the enzymatic machinery to convert 'nutritional' 25-hydroxyvitamin D to the active form 1,25-dihydroxyvitamin D; it is estimated that 3% of the human genome is regulated by the vitamin D endocrine system. …
Most tissues in the body have a vitamin D receptor and the enzymatic machinery to convert 'nutritional' 25-hydroxyvitamin D to the ac …
Antioxidant vitamins and their use in preventing cardiovascular disease.
Farbstein D, Kozak-Blickstein A, Levy AP. Farbstein D, et al. Molecules. 2010 Nov 9;15(11):8098-110. doi: 10.3390/molecules15118098. Molecules. 2010. PMID: 21063272 Free PMC article. Review.
However, while in vitro and in vivo studies showed promising antiatherogenic effects for vitamins C and E, clinical trials in which patients were given high doses of vitamin E or C showed no benefit and even possible harm. This review will attempt to summarize the k …
However, while in vitro and in vivo studies showed promising antiatherogenic effects for vitamins C and E, clinical trials in which p …
The Role of Vitamins in the Pathogenesis of Asthma.
Zajac D, Wojciechowski P. Zajac D, et al. Int J Mol Sci. 2023 May 10;24(10):8574. doi: 10.3390/ijms24108574. Int J Mol Sci. 2023. PMID: 37239921 Free PMC article. Review.
Vitamins play a crucial role in the proper functioning of organisms. Disturbances of their levels, seen as deficiency or excess, enhance the development of various diseases, including those of the cardiovascular, immune, or respiratory systems. The present paper aim
Vitamins play a crucial role in the proper functioning of organisms. Disturbances of their levels, seen as deficiency or excess, enha
Seaweed vitamins as nutraceuticals.
Škrovánková S. Škrovánková S. Adv Food Nutr Res. 2011;64:357-69. doi: 10.1016/B978-0-12-387669-0.00028-4. Adv Food Nutr Res. 2011. PMID: 22054961 Review.
Seaweeds are a good source of some water- (B(1), B(2), B(12), C) and fat-soluble (beta-carotene with vitamin A activity, vitamin E) vitamins. To ensure that the adequate intake of all vitamins is received in the diet, people (especially people on speci …
Seaweeds are a good source of some water- (B(1), B(2), B(12), C) and fat-soluble (beta-carotene with vitamin A activity, vitamin
Differential effect of basal vitamin D status in monocrotaline induced pulmonary arterial hypertension in normal and vitamin D deficient rats: Possible involvement of eNOS/TGF-beta/alpha-SMA signaling pathways.
Shah S, Vishwakarma VK, Arava SK, Mridha AR, Yadav RK, Seth S, Bhatia J, Hote MP, Arya DS, Yadav HN. Shah S, et al. J Nutr Biochem. 2023 Mar;113:109246. doi: 10.1016/j.jnutbio.2022.109246. Epub 2022 Dec 7. J Nutr Biochem. 2023. PMID: 36496061
Rats were fed a VDD diet and exposed to filtered fluorescent light to deplete vitamin D. Normal rats were pretreated with vitamin D 100 IU/d and treated with vitamin D 100 and 200 IU/d, while VDD rats received vitamin D 100 IU/d. ...Vitamin D 10 …
Rats were fed a VDD diet and exposed to filtered fluorescent light to deplete vitamin D. Normal rats were pretreated with vitamin
A review of select vitamins and minerals used by postmenopausal women.
Dennehy C, Tsourounis C. Dennehy C, et al. Maturitas. 2010 Aug;66(4):370-80. doi: 10.1016/j.maturitas.2010.06.003. Epub 2010 Jun 26. Maturitas. 2010. PMID: 20580500 Review.
METHODS: Review of the relevant literature and results from recent clinical studies, as well as critical analyses of published systematic reviews and meta-analyses were obtained from PubMed and Cochrane Library of Reviews. Vitamin A, the B vitamins, vitamin C …
METHODS: Review of the relevant literature and results from recent clinical studies, as well as critical analyses of published systematic re …
[Vitamins and oxidative stress].
Kodentsova VM, Vrzhesinskaia OA, Mazo VK. Kodentsova VM, et al. Vopr Pitan. 2013;82(3):11-8. Vopr Pitan. 2013. PMID: 24006747 Review. Russian.
Damaging effect on the antioxidant defense system is more pronounced compared to the stress response in animals with an isolated deficiency of vitamins C, A, E, B1 or B6 and the combined vitamins deficiency in the diet. Addition missing vitamin or v
Damaging effect on the antioxidant defense system is more pronounced compared to the stress response in animals with an isolated defi …
Vitamin supplements and cardiovascular diseases.
Shaker R, Al-Ghamdi D, Razzaque M. Shaker R, et al. Saudi Med J. 2010 Jul;31(7):835-6; author reply 835. Saudi Med J. 2010. PMID: 20635024 No abstract available.
Can vitamin D slow down the progression of chronic kidney disease?
Shroff R, Wan M, Rees L. Shroff R, et al. Pediatr Nephrol. 2012 Dec;27(12):2167-73. doi: 10.1007/s00467-011-2071-y. Epub 2011 Dec 10. Pediatr Nephrol. 2012. PMID: 22160397 Review.
RAAS activation can reduce renal Klotho expression, and the Klotho-fibroblast growth factor 23 interaction may further reduce the production of active vitamin D. Results from both clinical and experimental studies suggest that vitamin D therapy is associated with a …
RAAS activation can reduce renal Klotho expression, and the Klotho-fibroblast growth factor 23 interaction may further reduce the production …
Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.
Montero D, Walther G, Stehouwer CD, Houben AJ, Beckman JA, Vinet A. Montero D, et al. Obes Rev. 2014 Feb;15(2):107-16. doi: 10.1111/obr.12114. Epub 2013 Oct 7. Obes Rev. 2014. PMID: 24118784 Review.
The aim of this study was to systematically review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects. ...Ten randomized controlled trials comparing antioxidant vitamin-supplemented and control groups (overall n = …
The aim of this study was to systematically review and quantify the effect of antioxidant vitamin supplementation on endothelial func …
Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness.
Mozos I, Stoian D, Luca CT. Mozos I, et al. Dis Markers. 2017;2017:8784971. doi: 10.1155/2017/8784971. Epub 2017 Jan 12. Dis Markers. 2017. PMID: 28167849 Free PMC article. Review.
The main mechanisms are related to antiatherogenic effects, improvement of endothelial function (vitamins A, C, D, and E) and metabolic profile (vitamins A, B12, C, D, and K), inhibition of the renin-angiotensin-aldosterone system (vitamin D), anti-inf …
The main mechanisms are related to antiatherogenic effects, improvement of endothelial function (vitamins A, C, D, and E) and metabol …
[Update on vitamin D and evaluation of vitamin D status].
Souberbielle JC, Prié D, Courbebaisse M, Friedlander G, Houillier P, Maruani G, Cavalier E, Cormier C. Souberbielle JC, et al. Ann Endocrinol (Paris). 2008 Dec;69(6):501-10. doi: 10.1016/j.ando.2008.07.010. Epub 2008 Sep 18. Ann Endocrinol (Paris). 2008. PMID: 18804195 Free article. Review. French.
Knowledge about vitamin D has greatly improved during the last few years. Vitamin D cannot any more be considered as exclusively necessary to prevent ricket/osteomalacia. ...Vitamin D status can easily be assessed by measuring serum 25 hydroxy vitamin
Knowledge about vitamin D has greatly improved during the last few years. Vitamin D cannot any more be considered as exclusive …
Should hypertensive patients take vitamin D?
Wuerzner G, Burnier M, Waeber B. Wuerzner G, et al. Curr Hypertens Rep. 2012 Aug;14(4):318-23. doi: 10.1007/s11906-012-0271-x. Curr Hypertens Rep. 2012. PMID: 22648128 Review.
The prevalence of both hypertension and vitamin D deficiency is high. The discovery of the vitamin D receptor and its possible effects on components of the cardiovascular system influencing blood pressure, such as the renin angiotensin system, t …
The prevalence of both hypertension and vitamin D deficiency is high. The discovery of the vitamin D receptor and its possible …
High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency.
Zaleski A, Panza G, Swales H, Arora P, Newton-Cheh C, Wang T, Thompson PD, Taylor B. Zaleski A, et al. Dis Markers. 2015;2015:918968. doi: 10.1155/2015/918968. Epub 2015 Sep 16. Dis Markers. 2015. PMID: 26451070 Free PMC article. Clinical Trial.
INTRODUCTION: Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). ...We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial sti …
INTRODUCTION: Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CV …
Impact evidence of the vitamin D status in hypertensive patients in Morocco.
Azmi H, Lamsisi M, Ait Faraji S, El Mzibri M, Ennaji MM. Azmi H, et al. Cell Mol Biol (Noisy-le-grand). 2022 Dec 31;68(12):21-25. doi: 10.14715/cmb/2022.68.12.5. Cell Mol Biol (Noisy-le-grand). 2022. PMID: 37130186
Vitamin D deficiency is a hot topic as it affects about 50% of the world's population. Beyond its extra-osseous effects, notably on the cardiovascular system. In recent years many epidemiological studies have looked at the role of vitamin D status in m
Vitamin D deficiency is a hot topic as it affects about 50% of the world's population. Beyond its extra-osseous effects, notably on t
Effect of Vitamin K Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis.
Verma H, Garg R. Verma H, et al. Endocr Metab Immune Disord Drug Targets. 2019;19(1):13-25. doi: 10.2174/1871530318666180703125007. Endocr Metab Immune Disord Drug Targets. 2019. PMID: 29968548
BACKGROUND: Multiple cross sectional and longitudinal studies reported the benefits of vitamin K intake for management of cardiometabolic risk factors so as to minimize the risk of cardiovascular diseases. ...A total of 13 trials were selected for inclusion into the …
BACKGROUND: Multiple cross sectional and longitudinal studies reported the benefits of vitamin K intake for management of cardiometab …
The molecular biology and pathophysiology of vascular calcification.
McCarty MF, DiNicolantonio JJ. McCarty MF, et al. Postgrad Med. 2014 Mar;126(2):54-64. doi: 10.3810/pgm.2014.03.2740. Postgrad Med. 2014. PMID: 24685968 Review.
Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for cardiovascular events and mortality. Calcification of the arterial media and of heart valves clearly plays a mediating role in this …
Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for …
Improvement in cardiovascular risk markers by the combined effect of natural polyphenols and vitamins in patients after kidney transplantation.
Szentesiova Z, Trebaticky B, Zilinska Z, Breza J, Oravec S, Orszaghova Z, Muchova J. Szentesiova Z, et al. Bratisl Lek Listy. 2022;123(4):254-261. doi: 10.4149/BLL_2022_041. Bratisl Lek Listy. 2022. PMID: 35294211
OBJECTIVES: The aim of this study was to evaluate the potential of supportive therapy by natural polyphenols combined with vitamins C and E on kidney function and risk factors of cardiovascular diseases in renal transplant recipients (RTR). BACKGROUND: Transplant pa …
OBJECTIVES: The aim of this study was to evaluate the potential of supportive therapy by natural polyphenols combined with vitamins C …
Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat.
Papparella I, Ceolotto G, Berto L, Cavalli M, Bova S, Cargnelli G, Ruga E, Milanesi O, Franco L, Mazzoni M, Petrelli L, Nussdorfer GG, Semplicini A. Papparella I, et al. Cardiovasc Res. 2007 Jan 15;73(2):432-8. doi: 10.1016/j.cardiores.2006.10.010. Epub 2006 Oct 20. Cardiovasc Res. 2007. PMID: 17123493
METHODS: Six adult Wistar Kyoto rats received AZT (1 mg/ml) in the drinking water for 8 months, six vitamin C (10 g/kg of food) and AZT, six vitamin C alone, and six served as controls. ...Vitamin C antagonizes these adverse effects of AZT in the cardiovas
METHODS: Six adult Wistar Kyoto rats received AZT (1 mg/ml) in the drinking water for 8 months, six vitamin C (10 g/kg of food) and A …
Free and total vitamin B12 in cerebrospinal fluid.
KIDD HM, GOULD CE, THOMAS JW. KIDD HM, et al. Can Med Assoc J. 1963 Apr 27;88(17):876-81. Can Med Assoc J. 1963. PMID: 14032478 Free PMC article.
Free and total vitamin B(12) levels in serum and cerebrospinal fluid (CSF) were bioassayed, since there were no available data on the relationship between free and total vitamin B(12) in CSF or between free vitamin in serum and CSF vitamin B(12). .../m …
Free and total vitamin B(12) levels in serum and cerebrospinal fluid (CSF) were bioassayed, since there were no available data on the …
Impact of vitamin D3 on cardiovascular responses to glucocorticoid excess.
Ahmed MA. Ahmed MA. J Physiol Biochem. 2013 Jun;69(2):267-76. doi: 10.1007/s13105-012-0209-4. Epub 2012 Sep 19. J Physiol Biochem. 2013. PMID: 22991185
Although the cardiovascular system is not a classical target for 1,25-dihydroxyvitamin D3, both cardiac myocytes and vascular smooth muscle cells respond to this hormone. The present study aimed to elucidate the effect of active vitamin D3 on cardiovascula
Although the cardiovascular system is not a classical target for 1,25-dihydroxyvitamin D3, both cardiac myocytes and vascular …
Atherosclerosis and oxidant stress: the end of the road for antioxidant vitamin treatment?
Thomson MJ, Puntmann V, Kaski JC. Thomson MJ, et al. Cardiovasc Drugs Ther. 2007 Jun;21(3):195-210. doi: 10.1007/s10557-007-6027-1. Cardiovasc Drugs Ther. 2007. PMID: 17484034 Review.
Extensive experimental data have revealed a central role for oxidative stress in atherogenesis and suggested a potential role for 'antioxidant' treatment in cardiovascular disease (CVD) [1-11]. Experimental data, however, have not translated into clinical benefit: most ant …
Extensive experimental data have revealed a central role for oxidative stress in atherogenesis and suggested a potential role for 'antioxida …
Effects of dietary RRR α-tocopherol vs all-racemic α-tocopherol on health outcomes.
Ranard KM, Erdman JW Jr. Ranard KM, et al. Nutr Rev. 2018 Mar 1;76(3):141-153. doi: 10.1093/nutrit/nux067. Nutr Rev. 2018. PMID: 29301023 Review.
Of the 8 vitamin E analogues, RRR alpha-tocopherol likely has the greatest effect on health outcomes. ...To help close this gap, this review evaluates studies that investigated the effects of either RRR alpha-tocopherol or all-racemic alpha-tocopherol on health outcomes, a …
Of the 8 vitamin E analogues, RRR alpha-tocopherol likely has the greatest effect on health outcomes. ...To help close this gap, this …
The Biological Role of Vitamins in Athletes' Muscle, Heart and Microbiota.
Brancaccio M, Mennitti C, Cesaro A, Fimiani F, Vano M, Gargiulo B, Caiazza M, Amodio F, Coto I, D'Alicandro G, Mazzaccara C, Lombardo B, Pero R, Terracciano D, Limongelli G, Calabrò P, D'Argenio V, Frisso G, Scudiero O. Brancaccio M, et al. Int J Environ Res Public Health. 2022 Jan 23;19(3):1249. doi: 10.3390/ijerph19031249. Int J Environ Res Public Health. 2022. PMID: 35162272 Free PMC article. Review.
Vitamins are introduced to the diet because the human body is unable to produce these micronutrients. The aim of this review is to highlight the fundamental role of vitamin supplementation in physical activity. Above all, we focus on the roles of vitamins A,
Vitamins are introduced to the diet because the human body is unable to produce these micronutrients. The aim of this review is to hi
Cardiovascular disease and vitamins. Concurrent correction of 'suboptimal' plasma antioxidant levels may, as important part of 'optimal' nutrition, help to prevent early stages of cardiovascular disease and cancer, respectively.
Gey KF. Gey KF. Bibl Nutr Dieta. 1995;(52):75-91. Bibl Nutr Dieta. 1995. PMID: 8779654 Review.
Material relative risks seem to disappear at 'optimal' antioxidant plasma levels in the order of > or = 50 micromol/l vitamin C, > or = 30 micromol/l lipid-standardized vitamin E (alpha-tocopherol/cholesterol ratio > or = 5.1-5.2), > or = 2.2 micromol/l …
Material relative risks seem to disappear at 'optimal' antioxidant plasma levels in the order of > or = 50 micromol/l vitamin C, & …
Effects of vitamin D supplementation on cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis of randomized controlled trials.
Hauger H, Laursen RP, Ritz C, Mølgaard C, Lind MV, Damsgaard CT. Hauger H, et al. Eur J Nutr. 2020 Apr;59(3):873-884. doi: 10.1007/s00394-019-02150-x. Epub 2020 Feb 14. Eur J Nutr. 2020. PMID: 32060613
METHODS: We systematically searched relevant databases for randomized controlled trials (RCTs) examining effects of vitamin D supplementation compared to placebo or a lower dose of vitamin D on blood glucose, insulin, homeostatic model assessment of insulin resistan …
METHODS: We systematically searched relevant databases for randomized controlled trials (RCTs) examining effects of vitamin D supplem …
Oral vitamin D, still a viable treatment option for psoriasis.
Kamangar F, Koo J, Heller M, Lee E, Bhutani T. Kamangar F, et al. J Dermatolog Treat. 2013 Aug;24(4):261-7. doi: 10.3109/09546634.2011.643219. Epub 2012 Jan 21. J Dermatolog Treat. 2013. PMID: 22103655 Review.
In addition, oral vitamin D improves psoriatic arthropathy. Moreover, vitamin D has been proven to have many health benefits such as prevention of cancer, improved cardiovascular health among many others. Psoriatic patients as a population are at increased ri …
In addition, oral vitamin D improves psoriatic arthropathy. Moreover, vitamin D has been proven to have many health benefits s …
Folate in gastrointestinal health and disease.
Ponziani FR, Cazzato IA, Danese S, Fagiuoli S, Gionchetti P, Annicchiarico BE, D'Aversa F, Gasbarrini A. Ponziani FR, et al. Eur Rev Med Pharmacol Sci. 2012 Mar;16(3):376-85. Eur Rev Med Pharmacol Sci. 2012. PMID: 22530356 Review.
Further studies are needed to assess the role of folates in gastrointestinal tract diseases and in other gynecologic, neurologic, psychiatric, cardiovascular, ophthalmic and neoplastic diseases. Folates supplementation could be considered, in the future, as an effective co …
Further studies are needed to assess the role of folates in gastrointestinal tract diseases and in other gynecologic, neurologic, psychiatri …
The Role of Brain Barriers in Maintaining Brain Vitamin Levels.
Tiani KA, Stover PJ, Field MS. Tiani KA, et al. Annu Rev Nutr. 2019 Aug 21;39:147-173. doi: 10.1146/annurev-nutr-082018-124235. Epub 2019 May 31. Annu Rev Nutr. 2019. PMID: 31150592 Review.
It is increasingly recognized that tissue-specific nutrient deficiencies can exist in the absence of whole-body deficiency and that these deficiencies may result from disease or disease-related physiological processes. Brain and central nervous system tissues require adequ …
It is increasingly recognized that tissue-specific nutrient deficiencies can exist in the absence of whole-body deficiency and that these de …
Vitamin D Supplementation Modulates Platelet-Mediated Inflammation in Subjects With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial.
Johny E, Jala A, Nath B, Alam MJ, Kuladhipati I, Das R, Borkar RM, Adela R. Johny E, et al. Front Immunol. 2022 May 26;13:869591. doi: 10.3389/fimmu.2022.869591. eCollection 2022. Front Immunol. 2022. PMID: 35720377 Free PMC article. Clinical Trial.
BACKGROUND: Recently, our group identified increased platelet-mediated inflammation in type 2 diabetes (T2DM) patients, and it is a well-established risk factor for diabetes complications, particularly for the development of cardiovascular diseases (CVD). Furthermore, v
BACKGROUND: Recently, our group identified increased platelet-mediated inflammation in type 2 diabetes (T2DM) patients, and it is a well-est …
Vitamin K supplementation and progression of coronary artery calcium in older men and women.
Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL. Shea MK, et al. Am J Clin Nutr. 2009 Jun;89(6):1799-807. doi: 10.3945/ajcn.2008.27338. Epub 2009 Apr 22. Am J Clin Nutr. 2009. PMID: 19386744 Free PMC article. Clinical Trial.
BACKGROUND: Coronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent cal …
BACKGROUND: Coronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitam
Vitamin D and osteogenic differentiation in the artery wall.
Hsu JJ, Tintut Y, Demer LL. Hsu JJ, et al. Clin J Am Soc Nephrol. 2008 Sep;3(5):1542-7. doi: 10.2215/CJN.01220308. Epub 2008 Jun 18. Clin J Am Soc Nephrol. 2008. PMID: 18562594 Free PMC article.
Recent epidemiologic evidence suggests that there is a narrow range of vitamin D levels in which vascular function is optimized. Levels above or below this range seem to confer a significant increase in risk for cardiovascular disease. ...These findings raise intere …
Recent epidemiologic evidence suggests that there is a narrow range of vitamin D levels in which vascular function is optimized. Leve …
The cardiovascular safety aspects of calcium supplementations: where does the truth lie? A personal perspective.
Pines A, Langer RD. Pines A, et al. Climacteric. 2015 Feb;18(1):6-10. doi: 10.3109/13697137.2014.947947. Epub 2014 Oct 16. Climacteric. 2015. PMID: 25318377 Review.
During the past years, an ongoing debate defies this paradigm, mainly because of a potential cardiovascular risk on the one hand, and uncertainty in regard to the extent of the beneficial bone effects on the other hand. ...We conclude that the best current evidence support …
During the past years, an ongoing debate defies this paradigm, mainly because of a potential cardiovascular risk on the one hand, and …
Use of vitamin D in chronic kidney disease patients.
Gal-Moscovici A, Sprague SM. Gal-Moscovici A, et al. Kidney Int. 2010 Jul;78(2):146-51. doi: 10.1038/ki.2010.113. Epub 2010 May 26. Kidney Int. 2010. PMID: 20505658 Free article. Review.
Recently, a potentially important role of vitamin D receptor activation (VDRa) in the survival of patients undergoing dialysis has been suggested. Beyond the effect on parathyroid hormone suppression, the pleiotropic effect of vitamin D has been associated with impr …
Recently, a potentially important role of vitamin D receptor activation (VDRa) in the survival of patients undergoing dialysis has be …
Vitamin supplementation: what the gastroenterologist needs to know.
Sharma N, Trope B, Lipman TO. Sharma N, et al. J Clin Gastroenterol. 2004 Nov-Dec;38(10):844-54. doi: 10.1097/00004836-200411000-00003. J Clin Gastroenterol. 2004. PMID: 15492599 Review.
BACKGROUND: The vitamin business is a multimillion dollar industry. Aggressive marketing strategies are used to make claims for the health benefits of these products. Observational studies suggest that people who consume vitamin supplements decrease their risks for …
BACKGROUND: The vitamin business is a multimillion dollar industry. Aggressive marketing strategies are used to make claims for the h …
Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial.
Hasific S, Øvrehus KA, Hosbond S, Lambrechtsen J, Kumarathurai P, Mejldal A, Ravn EJ, Rasmussen LM, Gerke O, Mickley H, Diederichsen A. Hasific S, et al. BMJ Open. 2023 Jul 14;13(7):e073233. doi: 10.1136/bmjopen-2023-073233. BMJ Open. 2023. PMID: 37451735 Free PMC article.
INTRODUCTION: Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction and cardiovascular mortality. Supplementation with vitamin K2 and D3 has been suggested to have a protective role in the progress …
INTRODUCTION: Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction and …
Dietary Supplement Use in Patients with Cardiovascular Disease.
Li S, Petraskova T, Stys N, Blue M, Stys T, Stys A. Li S, et al. S D Med. 2020 Feb;73(2):72-76. S D Med. 2020. PMID: 32135055
DESIGN, SETTING AND PARTICIPANTS: A non-blinded, single medical center clinic open questionnaire was delivered to cardiovascular clinic patients with known cardiovascular diseases. MAIN OUTCOMES AND MEASURES, AND RESULTS: Estimation of naturoceutical usage prevalenc …
DESIGN, SETTING AND PARTICIPANTS: A non-blinded, single medical center clinic open questionnaire was delivered to cardiovascular clin …
NO-dependent proliferation and migration induced by Vitamin D in HUVEC.
Pittarella P, Squarzanti DF, Molinari C, Invernizzi M, Uberti F, Renò F. Pittarella P, et al. J Steroid Biochem Mol Biol. 2015 May;149:35-42. doi: 10.1016/j.jsbmb.2014.12.012. Epub 2015 Jan 20. J Steroid Biochem Mol Biol. 2015. PMID: 25616003
Recently, Vitamin D (Vit. D) has gained importance in cellular functions of a wide range of extraskeletal organs and target tissues, other than bone. In particular, Vit. D has displayed important beneficial effects in the cardiovascular system. Although littl …
Recently, Vitamin D (Vit. D) has gained importance in cellular functions of a wide range of extraskeletal organs and target tissues, …
[Antioxidant vitamin supplementation in the prevention of cardiovascular disease].
Yuen B, Furrer L, Ballmer PE. Yuen B, et al. Ther Umsch. 2005 Sep;62(9):615-8. doi: 10.1024/0040-5930.62.9.615. Ther Umsch. 2005. PMID: 16218497 Review. German.
Various observational epidemiological studies have suggested that antioxidant vitamin intake is associated with reduced cardiovascular morbidity and mortality. Also, experimental studies in animals have demonstrated that antioxidant vitamins slow the progress …
Various observational epidemiological studies have suggested that antioxidant vitamin intake is associated with reduced cardiovasc
The noncalciotropic actions of vitamin D: recent clinical developments.
Maalouf NM. Maalouf NM. Curr Opin Nephrol Hypertens. 2008 Jul;17(4):408-15. doi: 10.1097/MNH.0b013e3283040c99. Curr Opin Nephrol Hypertens. 2008. PMID: 18660678 Free PMC article. Review.
RECENT FINDINGS: 1,25-Dihydroxyvitamin D stimulates the innate immune system, facilitating the clearance of infections such as tuberculosis. ...SUMMARY: The broad tissue distribution of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme and the vitamin D receptor est …
RECENT FINDINGS: 1,25-Dihydroxyvitamin D stimulates the innate immune system, facilitating the clearance of infections such as tuberc …
The Possible Influence of Vitamin D Levels on the Development of Atrial Fibrillation-An Update.
Graczyk S, Grzeczka A, Pasławska U, Kordowitzki P. Graczyk S, et al. Nutrients. 2023 Jun 12;15(12):2725. doi: 10.3390/nu15122725. Nutrients. 2023. PMID: 37375629 Free PMC article. Review.
Atrial fibrillation (AF) is a severe and most common supraventricular arrhythmia in humans, which, if left untreated or treated ineffectively, can lead to ischemic stroke or heart failure. It has been suggested that serum vitamin D (VitD) deficiency may be one of the criti …
Atrial fibrillation (AF) is a severe and most common supraventricular arrhythmia in humans, which, if left untreated or treated ineffectivel …
Hen's egg as a source of valuable biologically active substances.
Zdrojewicz Z, Herman M, Starostecka E. Zdrojewicz Z, et al. Postepy Hig Med Dosw (Online). 2016 Jul 6;70(0):751-9. doi: 10.5604/17322693.1208892. Postepy Hig Med Dosw (Online). 2016. PMID: 27383572 Free article. Review.
The aim of this article is to show current knowledge concerning valuable substances biologically active present in hen eggs and underline important nutritive role of hen eggs. Hen egg is a good source of nutrients such as proteins, vitamins (A, B2, B6, B12, D, E, K), miner …
The aim of this article is to show current knowledge concerning valuable substances biologically active present in hen eggs and underline im …
N-acetylcysteine modulates doxorubicin-induced oxidative stress and antioxidant vitamin concentrations in liver of rats.
Koçkar MC, Nazıroğlu M, Celik O, Tola HT, Bayram D, Koyu A. Koçkar MC, et al. Cell Biochem Funct. 2010 Dec 2;28(8):673-7. doi: 10.1002/cbf.1707. Epub 2010 Nov 8. Cell Biochem Funct. 2010. PMID: 21104935
Doxorubicin (DOX) is a chemotherapeutic agent, and is widely used in cancer treatment. The most common side effect of DOX was indicated on cardiovascular system by experimental studies. There are some studies suggesting oxidative stress-induced toxic changes on live …
Doxorubicin (DOX) is a chemotherapeutic agent, and is widely used in cancer treatment. The most common side effect of DOX was indicated on …
Vitamins as homocysteine-lowering agents.
Brattström L. Brattström L. J Nutr. 1996 Apr;126(4 Suppl):1276S-80S. doi: 10.1093/jn/126.suppl_4.1276S. J Nutr. 1996. PMID: 8642470 Review.
Moderate hyperhomocysteinemia is, today, considered an established risk factor for cardiovascular disease. A graded dose-response relationship between plasma homocysteine concentration over its full range and cardiovascular risk strongly supports causality. ...Suppl …
Moderate hyperhomocysteinemia is, today, considered an established risk factor for cardiovascular disease. A graded dose-response rel …
Additive effect of homocysteine- and cholesterol-lowering therapy on endothelium-dependent vasodilation in patients with cardiovascular disease.
Wustmann K, Klaey M, Burow A, Shaw SG, Hess OM, Allemann Y. Wustmann K, et al. Cardiovasc Ther. 2012 Oct;30(5):277-86. doi: 10.1111/j.1755-5922.2011.00272.x. Epub 2011 Jul 31. Cardiovasc Ther. 2012. PMID: 21884007 Free article. Clinical Trial.
Thus, we evaluated the effect of rosuvastatin, B-group vitamins and their combination on endothelial function in high-risk cardiovascular patients. ...CONCLUSIONS: In conclusion, both treatments, rosuvastatin and B-group vitamin supplementation, improved endo …
Thus, we evaluated the effect of rosuvastatin, B-group vitamins and their combination on endothelial function in high-risk cardiov
Vitamin D and the heart: why we need large-scale clinical trials.
Manson JE. Manson JE. Cleve Clin J Med. 2010 Dec;77(12):903-10. doi: 10.3949/ccjm.77gr.10004. Cleve Clin J Med. 2010. PMID: 21147944 Free article.
Although vitamin D supplementation appears to be a promising intervention for reducing risks of cancer, cardiovascular disease, and other chronic diseases, existing evidence on its benefits and risks is limited and inconclusive. Recruitment is now under way for the …
Although vitamin D supplementation appears to be a promising intervention for reducing risks of cancer, cardiovascular disease …
Safety of Vitamin K in mechanical heart valve patients with supratherapeutic INR: A systematic review and meta-analysis.
Sapapsap B, Srisawat C, Suthumpoung P, Luengrungkiat O, Leelakanok N, Saokaew S, Kanchanasurakit S. Sapapsap B, et al. Medicine (Baltimore). 2022 Sep 9;101(36):e30388. doi: 10.1097/MD.0000000000030388. Medicine (Baltimore). 2022. PMID: 36086772 Free article.
BACKGROUND: Patients who had mechanical heart valves and an international normalized ratio (INR) of >5.0 should be managed by temporary cessation of vitamin K antagonist. This study aimed to investigate the safety of low-dose vitamin K1 in patients with mechanica …
BACKGROUND: Patients who had mechanical heart valves and an international normalized ratio (INR) of >5.0 should be managed by temporary c …
Vitamin D Attenuates Loss of Endothelial Biomarker Expression in Cardio-Endothelial Cells.
Lai CC, Juang WC, Sun GC, Tseng YK, Jhong RC, Tseng CJ, Wong TY, Cheng PW. Lai CC, et al. Int J Mol Sci. 2020 Mar 22;21(6):2196. doi: 10.3390/ijms21062196. Int J Mol Sci. 2020. PMID: 32235811 Free PMC article.
Vitamin D is associated with cardiovascular health through activating the vitamin D receptor that targets genes related to cardiovascular disease (CVD). ...Based on this study, the beneficial effect of vitamin D may be insignificant; however, fu
Vitamin D is associated with cardiovascular health through activating the vitamin D receptor that targets genes related
B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?
Moretti R, Peinkhofer C. Moretti R, et al. Int J Mol Sci. 2019 Nov 18;20(22):5797. doi: 10.3390/ijms20225797. Int J Mol Sci. 2019. PMID: 31752183 Free PMC article. Review.
Many studies have been written on vitamin supplementation, fatty acid, and dementia, but results are still under debate, and no definite conclusion has yet been drawn. ...B-vitamins have anti-inflammatory properties and act in protective roles against neurodegenerat …
Many studies have been written on vitamin supplementation, fatty acid, and dementia, but results are still under debate, and no defin …
New cardiovascular risk factors: homocysteine and vitamins involved in homocysteine metabolism.
De Caterina R, Zampolli A, Madonna R, Fioretti P, Vanuzzo D. De Caterina R, et al. Ital Heart J. 2004 Jun;5 Suppl 6:19S-24S. Ital Heart J. 2004. PMID: 15185912 Review.
There are also, however, suggestions from the literature that group B vitamins, and in particular vitamin B6 (pyridoxine/pyridoxal-phosphate), are modulators of cardiovascular risk independent of homocysteine. The results of a recent study of ours, with a lon …
There are also, however, suggestions from the literature that group B vitamins, and in particular vitamin B6 (pyridoxine/pyrid …
Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis.
Hill A, Clasen KC, Wendt S, Majoros ÁG, Stoppe C, Adhikari NKJ, Heyland DK, Benstoem C. Hill A, et al. Nutrients. 2019 Sep 4;11(9):2103. doi: 10.3390/nu11092103. Nutrients. 2019. PMID: 31487905 Free PMC article.
However, on average, vitamin C had no significant effects on in-hospital mortality (p = 0.76), or on the incidence of stroke (p = 0.82). ...Due to missing reports on organ dysfunction, this meta-analysis cannot answer the question, if vitamin C can improve single- o …
However, on average, vitamin C had no significant effects on in-hospital mortality (p = 0.76), or on the incidence of stroke (p = 0.8 …
Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using (18)F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design.
Peeters FECM, van Mourik MJW, Meex SJR, Bucerius J, Schalla SM, Gerretsen SC, Mihl C, Dweck MR, Schurgers LJ, Wildberger JE, Crijns HJGM, Kietselaer BLJH. Peeters FECM, et al. Nutrients. 2018 Mar 21;10(4):386. doi: 10.3390/nu10040386. Nutrients. 2018. PMID: 29561783 Free PMC article. Clinical Trial.
BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) on imaging measurements of calcification in the bicuspid aortic valve (BAV) and calcific aortic valve stenosis (CAVS). ...Matrix Gla protei …
BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) …
How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?
Brecht P, Dring JC, Yanez F, Styczeń A, Mertowska P, Mertowski S, Grywalska E. Brecht P, et al. Nutrients. 2023 Jul 24;15(14):3264. doi: 10.3390/nu15143264. Nutrients. 2023. PMID: 37513682 Free PMC article. Review.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, far ahead of cancer. ...Particular attention was paid to the effects of deficiency and toxicity of the analyzed compounds in the context of the cardiovascular system and to the role of i
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, far ahead of cancer. ...Particular attention was paid to the
Protective effect of vitamin B5 (dexpanthenol) on cardiovascular damage induced by streptozocin in rats.
Demirci B, Demir O, Dost T, Birincioglu M. Demirci B, et al. Bratisl Lek Listy. 2014;115(4):190-6. doi: 10.4149/bll_2014_040. Bratisl Lek Listy. 2014. PMID: 24797592
OBJECTIVES: This study investigated whether Dexpanthenol (DEX) improves diabetic cardiovascular function and cardiac performance by regulating total oxidant and antioxidant status. ...
OBJECTIVES: This study investigated whether Dexpanthenol (DEX) improves diabetic cardiovascular function and cardiac performance by r …
Trends in use of herbal and nutritional supplements in cardiovascular patients.
Stys T, Stys A, Kelly P, Lawson W. Stys T, et al. Clin Cardiol. 2004 Feb;27(2):87-90. doi: 10.1002/clc.4960270208. Clin Cardiol. 2004. PMID: 14979626 Free PMC article.
Average low-density lipoprotein (106 vs. 108 mg/dl), average blood pressure (132/77 vs. 138/78 mmHg), and average hemoglobin (Hb)A1c (8.7 vs. 7.7%) showed no statistically significant differences between users and nonusers. Patients most commonly took multivitamins, vitamin
Average low-density lipoprotein (106 vs. 108 mg/dl), average blood pressure (132/77 vs. 138/78 mmHg), and average hemoglobin (Hb)A1c (8.7 vs …
Vitamin D insufficiency.
García de Tena J, Abejón L, Horcajo P. García de Tena J, et al. N Engl J Med. 2011 Apr 7;364(14):1378; author reply 1380. doi: 10.1056/NEJMc1101911. N Engl J Med. 2011. PMID: 21470036 No abstract available.
[Vitamins and minerals with antioxidant properties and cardiometabolic risk: controversies and perspectives].
Catania AS, Barros CR, Ferreira SR. Catania AS, et al. Arq Bras Endocrinol Metabol. 2009 Jul;53(5):550-9. doi: 10.1590/s0004-27302009000500008. Arq Bras Endocrinol Metabol. 2009. PMID: 19768246 Review. Portuguese.
Vitamin E is found in the plasma and in the LDL particle, avoiding lipid peroxidation. ...Vitamin C participates in the vitamin E regeneration system, keeping the plasma's antioxidant potential. ...
Vitamin E is found in the plasma and in the LDL particle, avoiding lipid peroxidation. ...Vitamin C participates in the vit
Hypertension and insulin resistance.
Whaley-Connell A, Sowers JR. Whaley-Connell A, et al. Hypertension. 2009 Sep;54(3):462-4. doi: 10.1161/HYPERTENSIONAHA.109.134460. Epub 2009 Jul 27. Hypertension. 2009. PMID: 19635987 Free PMC article. No abstract available.
Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium.
Wilson JX. Wilson JX. Biofactors. 2009 Jan-Feb;35(1):5-13. doi: 10.1002/biof.7. Biofactors. 2009. PMID: 19319840 Free PMC article. Review.
Circulating levels of vitamin C (ascorbate) are low in patients with sepsis. Parenteral administration of ascorbate raises plasma and tissue concentrations of the vitamin and may decrease morbidity. ...
Circulating levels of vitamin C (ascorbate) are low in patients with sepsis. Parenteral administration of ascorbate raises plasma and …
Vitamin D: a pleiotropic hormone.
Verstuyf A, Carmeliet G, Bouillon R, Mathieu C. Verstuyf A, et al. Kidney Int. 2010 Jul;78(2):140-5. doi: 10.1038/ki.2010.17. Epub 2010 Feb 24. Kidney Int. 2010. PMID: 20182414 Free article.
Upon binding of the ligand, the vitamin D receptor heterodimerizes with the retinoid X receptor and binds to vitamin D response elements in the promoter region of target genes to induce/repress their expression. ...Moreover, it has been demonstrated that 1,25(OH)(2) …
Upon binding of the ligand, the vitamin D receptor heterodimerizes with the retinoid X receptor and binds to vitamin D respons …
Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance.
Varela-López A, Navarro-Hortal MD, Giampieri F, Bullón P, Battino M, Quiles JL. Varela-López A, et al. Molecules. 2018 May 20;23(5):1226. doi: 10.3390/molecules23051226. Molecules. 2018. PMID: 29783781 Free PMC article. Review.
For this, a systematic review of English-written literature in PubMed until February 2018, which included both human and animal research on the relationship of each vitamin with periodontal disease, was conducted. Among all the analyzed vitamins those with antioxida …
For this, a systematic review of English-written literature in PubMed until February 2018, which included both human and animal research on …
Effect of calcifediol treatment on cardiovascular outcomes in patients with acute coronary syndrome and percutaneous revascularization.
Navarro-Valverde C, Quesada-Gómez JM, Pérez-Cano R, Fernández-Palacín A, Pastor-Torres LF. Navarro-Valverde C, et al. Med Clin (Barc). 2018 Nov 9;151(9):345-352. doi: 10.1016/j.medcli.2017.11.033. Epub 2018 Jan 3. Med Clin (Barc). 2018. PMID: 29306481 Clinical Trial. English, Spanish.
BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been consistently linked with cardiovascular diseases. ...The aim of this study was to evaluate the effect of treatment with calcifediol (25(OH)D(3)) on the cardiovascular system of patients with non- …
BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been consistently linked with cardiovascular diseases. ...The aim of this …
Vitamins for the management of cardiovascular disease: a simple solution to a complex problem?
Lenhart SE, Nappi JM. Lenhart SE, et al. Pharmacotherapy. 1999 Dec;19(12):1400-14. doi: 10.1592/phco.19.18.1400.30892. Pharmacotherapy. 1999. PMID: 10600089 Review.
Attention is focusing on the relationship between homocysteine and cardiovascular disease and the role of vitamins in the management of this prevalent ailment. ...Vitamin supplements are not warranted in all patients with cardiovascular disease but may …
Attention is focusing on the relationship between homocysteine and cardiovascular disease and the role of vitamins in the mana …
[Atherosclerosis].
Yamada N. Yamada N. Nihon Rinsho. 1999 Oct;57(10):2345-8. Nihon Rinsho. 1999. PMID: 10540884 Review. Japanese.
In the presence of excessive amounts of low-density lipoprotein (LDL), denatured LDL modified by oxidation or other reactions on the vascular wall is taken up by macrophages via scavenger receptors, resulting in the formation of foam cells and accumulation of cholesterol esters. …
In the presence of excessive amounts of low-density lipoprotein (LDL), denatured LDL modified by oxidation or other reactions on the vascula …
Vitamin supplements: current controversies.
Reynolds RD. Reynolds RD. J Am Coll Nutr. 1994 Apr;13(2):118-26. doi: 10.1080/07315724.1994.10718383. J Am Coll Nutr. 1994. PMID: 8006292 Review.
Supplemental use of vitamins to prevent disease constitutes a major commercial enterprise in the United States. ...Recently published data have given strong support to several of the claims for major benefits of disease prevention, including that of cancer, cardiovascul
Supplemental use of vitamins to prevent disease constitutes a major commercial enterprise in the United States. ...Recently published …
[Enteral nutrition in neurological patients: is there enough vitamin D content in commonly used formulas?].
Botella Romero F, Alfaro Martínez JJ, Luna López V, Galicia Martín I; Grupo de Trabajo sobre Calcio y Vitamina D en Nutrición Enteral. Botella Romero F, et al. Nutr Hosp. 2012 Mar-Apr;27(2):341-8. doi: 10.1590/S0212-16112012000200003. Nutr Hosp. 2012. PMID: 22732955 Free article. Review. Spanish.
D and its effects on functional (falls, pain, quality of life) and cardiovascular goals (cardiovascular death, stroke, myocardial infarction, cardiovascular risk factors) have obtained as highlight data a clear reduction of falls and fractures, while the evid …
D and its effects on functional (falls, pain, quality of life) and cardiovascular goals (cardiovascular death, stroke, myocard …
A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
Kumar V, Yadav AK, Lal A, Kumar V, Singhal M, Billot L, Gupta KL, Banerjee D, Jha V. Kumar V, et al. J Am Soc Nephrol. 2017 Oct;28(10):3100-3108. doi: 10.1681/ASN.2017010003. Epub 2017 Jun 30. J Am Soc Nephrol. 2017. PMID: 28667080 Free PMC article. Clinical Trial.
Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. ...Intervention also led to significant favorable changes in pulse wave velocity and circulating IL-6 levels.
Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovas
Vitamin activities in human portal, hepatic and femoral blood after vitamin ingestion.
Baker H, tenHove W, Baker E, Frank O. Baker H, et al. Int J Vitam Nutr Res. 1994;64(1):60-7. Int J Vitam Nutr Res. 1994. PMID: 8200751
All water-soluble vitamins proved elevated after vitamin ingestion principally in portal blood within 10 minutes as compared with hepatic and femoral blood. ...In contrast, ingestion of the fat-soluble vitamins A and E evoked no elevated vitamin activi …
All water-soluble vitamins proved elevated after vitamin ingestion principally in portal blood within 10 minutes as compared w …
Strategies to reduce oxidative stress in cardiovascular disease.
Hamilton CA, Miller WH, Al-Benna S, Brosnan MJ, Drummond RD, McBride MW, Dominiczak AF. Hamilton CA, et al. Clin Sci (Lond). 2004 Mar;106(3):219-34. doi: 10.1042/CS20030379. Clin Sci (Lond). 2004. PMID: 14733610 Review.
A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxygen species) are involved in the development and progression of cardiovascular disease. As ROS appear to have a critical role in athe …
A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxy …
Antioxidant therapy in critical care--is the microcirculation the primary target?
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Parenteral high-dose vitamin C inhibits endotoxin-induced endothelial dysfunction and vasohyporeactivity in humans and reverses sepsis-induced suppression of microcirculatory control in rodents. In severe burn injury, in both animals and patients, parenteral high-dose v
Parenteral high-dose vitamin C inhibits endotoxin-induced endothelial dysfunction and vasohyporeactivity in humans and reverses sepsi …
Human nutrition and blood pressure regulation: an integrated approach.
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This review highlights the complex interactions that constitute the disciplines of nutrition and cardiovascular physiology. Nutritional factors have long been considered as critical in the pathogenesis of human hypertension. ..."Accepted" principles of nutrient interaction …
This review highlights the complex interactions that constitute the disciplines of nutrition and cardiovascular physiology. Nutrition …
Caffeinated energy drinks in the Canadian context: health risk assessment with a focus on cardiovascular effects.
La Vieille S, Gillespie Z, Bonvalot Y, Benkhedda K, Grinberg N, Rotstein J, Barber J, Krahn AD. La Vieille S, et al. Appl Physiol Nutr Metab. 2021 Sep;46(9):1019-1028. doi: 10.1139/apnm-2021-0245. Epub 2021 May 17. Appl Physiol Nutr Metab. 2021. PMID: 34000209 Free article. Review.
HC updated its assessment by reviewing new information with the focus on potential cardiovascular effects associated with the consumption of CEDs available for sale in Canada. Due to limited data on CED consumption among Canadians to derive accurate exposure information, t …
HC updated its assessment by reviewing new information with the focus on potential cardiovascular effects associated with the consump …
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.
Münzel T, Gori T, Keaney JF Jr, Maack C, Daiber A. Münzel T, et al. Eur Heart J. 2015 Oct 7;36(38):2555-64. doi: 10.1093/eurheartj/ehv305. Epub 2015 Jul 4. Eur Heart J. 2015. PMID: 26142467 Free PMC article. Review.
Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin-angiotensin-aldosterone system (RAAS), and with a subsequent inappropriately increased production of reactive oxygen species (ROS). .. …
Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin-a …