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Page 1
Vitamin D supplementation for sickle cell disease.
Soe HHK, Abas AB, Than NN, Ni H, Singh J, Said ARBM, Osunkwo I. Soe HHK, et al. Cochrane Database Syst Rev. 2020 May 28;5(5):CD010858. doi: 10.1002/14651858.CD010858.pub3. Cochrane Database Syst Rev. 2020. PMID: 32462740 Free PMC article.
SELECTION CRITERIA: Randomised controlled trials (RCTs) and quasi-RCTs comparing oral administration of any form of vitamin D supplementation at any dose and for any duration to another type or dose of vitamin D or placebo or no supplementati …
SELECTION CRITERIA: Randomised controlled trials (RCTs) and quasi-RCTs comparing oral administration of any form of vitamin D …
Effects of Vitamin D3 Supplementation on Body Composition in the VITamin D and OmegA-3 TriaL (VITAL).
Chou SH, Murata EM, Yu C, Danik J, Kotler G, Cook NR, Bubes V, Mora S, Chandler PD, Tobias DK, Copeland T, Buring JE, Manson JE, LeBoff MS. Chou SH, et al. J Clin Endocrinol Metab. 2021 Apr 23;106(5):1377-1388. doi: 10.1210/clinem/dgaa981. J Clin Endocrinol Metab. 2021. PMID: 33513226 Free PMC article. Clinical Trial.
CONTEXT: Although observational studies show inverse associations between vitamin D status and body weight/adiposity, there are few large randomized controlled trials (RCTs) investigating this relationship. OBJECTIVE: To determine whether vitamin D3 supplementati …
CONTEXT: Although observational studies show inverse associations between vitamin D status and body weight/adiposity, there ar …
Prevention of Advanced Cancer by Vitamin D(3) Supplementation: Interaction by Body Mass Index Revisited.
Brenner H, Kuznia S, Laetsch C, Niedermaier T, Schöttker B. Brenner H, et al. Nutrients. 2021 Apr 22;13(5):1408. doi: 10.3390/nu13051408. Nutrients. 2021. PMID: 33922032 Free PMC article.
Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D(3) (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men 50 years and women 55 years …
Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D(3) (cholecalciferol) …
VITamin D and OmegA-3 TriaL (VITAL): Effects of Vitamin D Supplements on Risk of Falls in the US Population.
LeBoff MS, Murata EM, Cook NR, Cawthon P, Chou SH, Kotler G, Bubes V, Buring JE, Manson JE. LeBoff MS, et al. J Clin Endocrinol Metab. 2020 Sep 1;105(9):2929-38. doi: 10.1210/clinem/dgaa311. J Clin Endocrinol Metab. 2020. PMID: 32492153 Free PMC article. Clinical Trial.
OBJECTIVE: The objective of this work is to determine whether 2000 IU/day of supplemental vitamin D3 decreases fall risk. DESIGN: VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, placebo-controlled RCT including 25 871 adults, randomly ass …
OBJECTIVE: The objective of this work is to determine whether 2000 IU/day of supplemental vitamin D3 decreases fall risk. DESIGN: …
A Bayesian analysis of the VITAL trial: effects of omega-3 fatty acid supplementation on cardiovascular events.
Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. Hamaya R, et al. Am J Clin Nutr. 2025 May;121(5):1046-1053. doi: 10.1016/j.ajcnut.2025.02.028. Epub 2025 Mar 1. Am J Clin Nutr. 2025. PMID: 40032221 Free PMC article. Clinical Trial.
The VITamin D and OmegA-3 TriaL (VITAL) is the largest trial that tested the effect of omega-3 FA supplementation (840 mg/d of eicosapentaenoic acid and docosahexaenoic acid in 1.2:1) in a primary prevention population in the United States, with nonsig …
The VITamin D and OmegA-3 TriaL (VITAL) is the largest trial that tested the effect of omega-3 FA supplementation …
Identification of individuals who benefit from omega-3 fatty acid supplementation to prevent coronary heart disease: a machine-learning analysis of the VITAL.
Hamaya R, Cook NR, Sesso HD, Mora S, Buring JE, Manson JE. Hamaya R, et al. Eur J Epidemiol. 2025 Jul;40(7):803-813. doi: 10.1007/s10654-025-01259-0. Epub 2025 Jun 26. Eur J Epidemiol. 2025. PMID: 40569483 Free PMC article. Clinical Trial.
We sought to develop an omega-3 effect score to stratify individuals according to their expected benefit from supplementation. Among the 25,871 randomized participants without a history of cardiovascular disease in the VITamin D and OmegA-3 TriaL (VITAL …
We sought to develop an omega-3 effect score to stratify individuals according to their expected benefit from supplementation. Among …
Effects of Supplemental Vitamin D on Bone Health Outcomes in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL).
LeBoff MS, Chou SH, Murata EM, Donlon CM, Cook NR, Mora S, Lee IM, Kotler G, Bubes V, Buring JE, Manson JE. LeBoff MS, et al. J Bone Miner Res. 2020 May;35(5):883-893. doi: 10.1002/jbmr.3958. Epub 2020 Jan 30. J Bone Miner Res. 2020. PMID: 31923341 Free PMC article. Clinical Trial.
We determined whether daily, vitamin D(3) supplementation improves bone mineral density (BMD) and/or structure. VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, placebo-controlled RCT of supplemental vitamin …
We determined whether daily, vitamin D(3) supplementation improves bone mineral density (BMD) and/or structure. VITa …
The role of nutrients in the pathogenesis and treatment of migraine headaches: Review.
Nattagh-Eshtivani E, Sani MA, Dahri M, Ghalichi F, Ghavami A, Arjang P, Tarighat-Esfanjani A. Nattagh-Eshtivani E, et al. Biomed Pharmacother. 2018 Jun;102:317-325. doi: 10.1016/j.biopha.2018.03.059. Epub 2018 Mar 22. Biomed Pharmacother. 2018. PMID: 29571016 Review.
The deficiency of many nutrients including magnesium, niacin, riboflavin, cobalamin, coenzymes Q10, carnitine, alpha-lipoic acid and vitamin D is associated with migraine. Some researchers postulate that mitochondrial dysfunction and impaired antioxidant status can …
The deficiency of many nutrients including magnesium, niacin, riboflavin, cobalamin, coenzymes Q10, carnitine, alpha-lipoic acid and vita …
Effectiveness of Vitamin D and Alpha-Lipoic Acid in COVID-19 Infection: A Literature Review.
Nguyen M, Aulick S, Kennedy C. Nguyen M, et al. Cureus. 2024 Apr 27;16(4):e59153. doi: 10.7759/cureus.59153. eCollection 2024 Apr. Cureus. 2024. PMID: 38803740 Free PMC article. Review.
Vitamin D (VD) deficiency has been associated with respiratory tract infections. Moreover, alpha-lipoic acid (ALA) is a powerful antioxidant and helps reduce inflammatory responses in many pathologic conditions. ...In 2/10 VD supplementation trials, no signif …
Vitamin D (VD) deficiency has been associated with respiratory tract infections. Moreover, alpha-lipoic acid (ALA) is a powerf …