Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
2001 1
2003 1
2004 2
2005 1
2006 2
2007 3
2008 1
2010 3
2011 3
2012 2
2013 5
2014 1
2015 8
2016 6
2017 3
2018 5
2019 5
2020 8
2021 9
2022 7
2023 9
2024 4
2025 5
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

83 results

Results by year

Filters applied: . Clear all
Page 1
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.
Diederichsen ACP, Lindholt JS, Möller S, Øvrehus KA, Auscher S, Lambrechtsen J, Hosbond SE, Alan DH, Urbonaviciene G, Becker SW, Fredgart MH, Hasific S, Folkestad L, Gerke O, Rasmussen LM, Møller JE, Mickley H, Dahl JS. Diederichsen ACP, et al. Circulation. 2022 May 3;145(18):1387-1397. doi: 10.1161/CIRCULATIONAHA.121.057008. Epub 2022 Apr 25. Circulation. 2022. PMID: 35465686 Free PMC article. Clinical Trial.
BACKGROUND: Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in the inhibition of arterial calcification and has been suggested to reduce the progression rate of aortic valve calcification …
BACKGROUND: Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in the in …
Vitamin K - sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity.
Mladěnka P, Macáková K, Kujovská Krčmová L, Javorská L, Mrštná K, Carazo A, Protti M, Remião F, Nováková L; OEMONOM researchers and collaborators. Mladěnka P, et al. Nutr Rev. 2022 Mar 10;80(4):677-698. doi: 10.1093/nutrit/nuab061. Nutr Rev. 2022. PMID: 34472618 Free PMC article. Review.
One possible explanation for this is the diversity of the biological activity of vitamin K, which is not a single compound but a general term covering natural plant and animal forms of vitamin K (K1 and K2) as well as their synthetic congeners (K3 and K4). …
One possible explanation for this is the diversity of the biological activity of vitamin K, which is not a single compound but a gene …
Vitamin K(2)-a neglected player in cardiovascular health: a narrative review.
Hariri E, Kassis N, Iskandar JP, Schurgers LJ, Saad A, Abdelfattah O, Bansal A, Isogai T, Harb SC, Kapadia S. Hariri E, et al. Open Heart. 2021 Nov;8(2):e001715. doi: 10.1136/openhrt-2021-001715. Open Heart. 2021. PMID: 34785587 Free PMC article. Review.
Vitamin K(2) serves an important role in cardiovascular health through regulation of calcium homeostasis. ...Supplementation of vitamin K(2) has been strongly associated with improved cardiovascular outcomes through its modification of sy …
Vitamin K(2) serves an important role in cardiovascular health through regulation of calcium homeostasis. ...Supplement …
Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study.
De Vriese AS, Caluwé R, Pyfferoen L, De Bacquer D, De Boeck K, Delanote J, De Surgeloose D, Van Hoenacker P, Van Vlem B, Verbeke F. De Vriese AS, et al. J Am Soc Nephrol. 2020 Jan;31(1):186-196. doi: 10.1681/ASN.2019060579. Epub 2019 Nov 8. J Am Soc Nephrol. 2020. PMID: 31704740 Free PMC article. Clinical Trial.
METHODS: Patients were randomized to VKAs with target INR 2-3, rivaroxaban 10 mg daily, or rivaroxaban 10 mg daily plus vitamin K2 2000 g thrice weekly during 18 months. Systemic dp-ucMGP levels were quantified to assess vascular vitamin K status. ...CONCLUS …
METHODS: Patients were randomized to VKAs with target INR 2-3, rivaroxaban 10 mg daily, or rivaroxaban 10 mg daily plus vitamin K2 …
Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial.
Hasific S, Øvrehus KA, Hosbond S, Lambrechtsen J, Kumarathurai P, Mejldal A, Ravn EJ, Rasmussen LM, Gerke O, Mickley H, Diederichsen A. Hasific S, et al. BMJ Open. 2023 Jul 14;13(7):e073233. doi: 10.1136/bmjopen-2023-073233. BMJ Open. 2023. PMID: 37451735 Free PMC article.
Supplementation with vitamin K2 and D3 has been suggested to have a protective role in the progression of CAC. ...METHOD AND ANALYSIS: In this multicentre and double-blinded placebo-controlled study, 400 men and women with CAC score 400 are randomised (1:1) to treat …
Supplementation with vitamin K2 and D3 has been suggested to have a protective role in the progression of CAC. ...METHOD AND A …
Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms.
Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, Uchino H. Okuyama H, et al. Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6. Expert Rev Clin Pharmacol. 2015. PMID: 25655639
In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the h …
In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins m …
Should We Recommend Vitamin K2 Supplement to Prevent Coronary Artery Calcification for Patients Receiving Statins and/or Warfarin?
Zhang AJ, Ballantyne CM, Birnbaum Y. Zhang AJ, et al. Cardiovasc Drugs Ther. 2025 Dec;39(6):1585-1588. doi: 10.1007/s10557-024-07661-2. Epub 2024 Dec 13. Cardiovasc Drugs Ther. 2025. PMID: 39671130 Review.
Vitamin K2 travels through systemic circulation, with significant and wide-ranging effects. Several studies using animal models of atherosclerosis have shown that vitamin K2 supplement can attenuate the progression of atherosclerosis, as well as corona …
Vitamin K2 travels through systemic circulation, with significant and wide-ranging effects. Several studies using animal model …
Extent of arterial calcification by conventional vitamin K antagonist treatment.
Hasific S, Øvrehus KA, Gerke O, Hallas J, Busk M, Lambrechtsen J, Urbonaviciene G, Sand NPR, Nielsen JS, Diederichsen L, Pedersen KB, Carter-Storch R, Ilangkovan N, Mickley H, Rasmussen LM, Lindholt JS, Diederichsen A. Hasific S, et al. PLoS One. 2020 Oct 29;15(10):e0241450. doi: 10.1371/journal.pone.0241450. eCollection 2020. PLoS One. 2020. PMID: 33119722 Free PMC article.
VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activation of coagulation factors and activation of matrix-Gla protein, a strong inhibitor of arterial calcifications. This study aimed to clarify whether VKA treatment was asso …
VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activation of coagulation factors and activation of …
Vitamin K in the treatment and prevention of osteoporosis and arterial calcification.
Adams J, Pepping J. Adams J, et al. Am J Health Syst Pharm. 2005 Aug 1;62(15):1574-81. doi: 10.2146/ajhp040357. Am J Health Syst Pharm. 2005. PMID: 16030366 Review.
PURPOSE: The role of vitamin K in the prevention and treatment of osteoporosis and arterial calcification is examined. SUMMARY: Vitamin K is essential for the activation of vitamin K-dependent proteins, which are involved not only in blood coagu …
PURPOSE: The role of vitamin K in the prevention and treatment of osteoporosis and arterial calcification is examined. …
Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial.
Mansour AG, Hariri E, Daaboul Y, Korjian S, El Alam A, Protogerou AD, Kilany H, Karam A, Stephan A, Bahous SA. Mansour AG, et al. J Am Soc Hypertens. 2017 Sep;11(9):589-597. doi: 10.1016/j.jash.2017.07.001. Epub 2017 Jul 13. J Am Soc Hypertens. 2017. PMID: 28756183 Clinical Trial.
The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 …
The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitam …
83 results