Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2000 4
2001 5
2002 5
2003 5
2004 7
2005 7
2006 5
2008 5
2009 8
2010 4
2011 4
2012 4
2013 12
2014 8
2015 3
2016 7
2017 8
2018 3
2019 3
2020 2
2021 6
2022 3
2023 1
2024 2
2025 6
2026 4

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

116 results

Results by year

Filters applied: . Clear all
Page 1
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.
Ma ML, Ma ZJ, He YL, Sun H, Yang B, Ruan BJ, Zhan WD, Li SX, Dong H, Wang YX. Ma ML, et al. Front Public Health. 2022 Aug 11;10:979649. doi: 10.3389/fpubh.2022.979649. eCollection 2022. Front Public Health. 2022. PMID: 36033779 Free PMC article.
INTRODUCTION: Vitamin K (VK) as a nutrient, is a cofactor in the carboxylation of osteocalcin (OC), which can bind with hydroxyapatite to promote bone mineralization and increase bone strength. However, some studies have been inconsistent on whether …
INTRODUCTION: Vitamin K (VK) as a nutrient, is a cofactor in the carboxylation of osteocalcin (OC), which can bind with hydrox …
The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.
Zhang Z, Li Y, Li J, Yuan Y, Liu K, Shi X. Zhang Z, et al. Front Endocrinol (Lausanne). 2025 Nov 5;16:1703116. doi: 10.3389/fendo.2025.1703116. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 41268154 Free PMC article.
Vitamin K2 influences bone metabolism by enhancing osteocalcin gamma-carboxylation. METHODS: This study followed PRISMA guidelines and included randomized controlled trials on the effects of vitamin K2 supplementation on bone turno …
Vitamin K2 influences bone metabolism by enhancing osteocalcin gamma-carboxylation. METHODS: This study followed …
Regulation of bone remodeling by vitamin K2.
Myneni VD, Mezey E. Myneni VD, et al. Oral Dis. 2017 Nov;23(8):1021-1028. doi: 10.1111/odi.12624. Epub 2017 Apr 5. Oral Dis. 2017. PMID: 27976475 Free PMC article. Review.
In recent years, there has been growing interest in promotion of bone health and inhibition of vascular calcification by vitamin K2. This vitamin regulates bone remodeling, an important process necessary to maintain adult bone. ...In this …
In recent years, there has been growing interest in promotion of bone health and inhibition of vascular calcification by vitamin …
Vitamin K2 therapy for postmenopausal osteoporosis.
Iwamoto J. Iwamoto J. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. Nutrients. 2014. PMID: 24841104 Free PMC article. Review.
Vitamin K may play an important role in the prevention of fractures in postmenopausal women with osteoporosis. Menatetrenone is the brand name of a synthetic vitamin K2 that is chemically identical to menaquinone-4. The present review study aime …
Vitamin K may play an important role in the prevention of fractures in postmenopausal women with osteoporosis. Menatetr …
Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
Zhou M, Han S, Zhang W, Wu D. Zhou M, et al. J Bone Miner Metab. 2022 Sep;40(5):763-772. doi: 10.1007/s00774-022-01342-6. Epub 2022 Jun 16. J Bone Miner Metab. 2022. PMID: 35711002
OBJECTIVE: To investigate whether vitamin K2 supplementation plays a role in maintaining bone mineral density (BMD) and reducing the incidence of fractures for postmenopausal women with osteoporosis at a long-term follow-up. ...Vitamin …
OBJECTIVE: To investigate whether vitamin K2 supplementation plays a role in maintaining bone mineral density (BMD) and …
Role of vitamin K2 in the treatment of postmenopausal osteoporosis.
Iwamoto J, Takeda T, Sato Y. Iwamoto J, et al. Curr Drug Saf. 2006 Jan;1(1):87-97. doi: 10.2174/157488606775252629. Curr Drug Saf. 2006. PMID: 18690918 Review.
Vitamin K2, raloxifene, and bisphosphonates, such as etidronate, alendronate, and risedronate, are widely used in the treatment of postmenopausal osteoporosis in Japan. ...On the other hand, the results of a preclinical study do suggest the possible ef …
Vitamin K2, raloxifene, and bisphosphonates, such as etidronate, alendronate, and risedronate, are widely used in the treatmen …
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Knapen MH, et al. Osteoporos Int. 2013 Sep;24(9):2499-507. doi: 10.1007/s00198-013-2325-6. Epub 2013 Mar 23. Osteoporos Int. 2013. PMID: 23525894 Clinical Trial.
We have investigated whether low-dose vitamin K2 supplements (menaquinone-7, MK-7) could beneficially affect bone health. Next to an improved vitamin K status, MK-7 supplementation significantly decreased the age-related decline in bone mineral …
We have investigated whether low-dose vitamin K2 supplements (menaquinone-7, MK-7) could beneficially affect bone healt …
[Vitamin K2].
Shiraki M. Shiraki M. Nihon Rinsho. 1998 Jun;56(6):1525-30. Nihon Rinsho. 1998. PMID: 9648476 Review. Japanese.
Vitamin K2 is a known vitamin to promote post-translational modification of vitamin K-dependent protein such as osteocalcin and blood coagulation factors. The effects of vitamin K2 on cortical bone mineral density in oste …
Vitamin K2 is a known vitamin to promote post-translational modification of vitamin K-dependent protein such as …
Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis.
Iwamoto J, Takeda T, Ichimura S. Iwamoto J, et al. Keio J Med. 2003 Sep;52(3):147-50. doi: 10.2302/kjm.52.147. Keio J Med. 2003. PMID: 14529146 Free article. Review.
It is established in Japan that treatment with 1alpha-hydroxyvitamin D3 (alfacalcidol) slightly reduces bone turnover, sustains lumbar bone mineral density (BMD), and prevents osteoporotic vertebral fractures in postmenopausal women with osteoporosis, …
It is established in Japan that treatment with 1alpha-hydroxyvitamin D3 (alfacalcidol) slightly reduces bone turnover, sustains lumba …
Combined treatment with vitamin k2 and bisphosphonate in postmenopausal women with osteoporosis.
Iwamoto J, Takeda T, Ichimura S. Iwamoto J, et al. Yonsei Med J. 2003 Oct 30;44(5):751-6. doi: 10.3349/ymj.2003.44.5.751. Yonsei Med J. 2003. Retraction in: Yonsei Med J. 2019 Jan;60(1):115. doi: 10.3349/ymj.2019.60.1.115. PMID: 14584089 Free article. Retracted. Review.
Vitamin K2 enhances gamma-carboxylation of bone glutamic acid residues and the secretion of osteocalcin, sustains the lumbar BMD, and prevents osteoporotic fractures in patients with osteoporosis. ...Thus, this combined treatment should be recom …
Vitamin K2 enhances gamma-carboxylation of bone glutamic acid residues and the secretion of osteocalcin, sustain …
116 results