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Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.
Diederichsen ACP, Lindholt JS, Möller S, Øvrehus KA, Auscher S, Lambrechtsen J, Hosbond SE, Alan DH, Urbonaviciene G, Becker SW, Fredgart MH, Hasific S, Folkestad L, Gerke O, Rasmussen LM, Møller JE, Mickley H, Dahl JS. Diederichsen ACP, et al. Circulation. 2022 May 3;145(18):1387-1397. doi: 10.1161/CIRCULATIONAHA.121.057008. Epub 2022 Apr 25. Circulation. 2022. PMID: 35465686 Free PMC article. Clinical Trial.
BACKGROUND: Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in the inhibition of arterial calcification and has been suggested to reduce the progression rate of aortic valve calcification …
BACKGROUND: Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in the in …
Vitamin K in the treatment and prevention of osteoporosis and arterial calcification.
Adams J, Pepping J. Adams J, et al. Am J Health Syst Pharm. 2005 Aug 1;62(15):1574-81. doi: 10.2146/ajhp040357. Am J Health Syst Pharm. 2005. PMID: 16030366 Review.
PURPOSE: The role of vitamin K in the prevention and treatment of osteoporosis and arterial calcification is examined. SUMMARY: Vitamin K is essential for the activation of vitamin K-dependent proteins, which are involved not only in blood coagu …
PURPOSE: The role of vitamin K in the prevention and treatment of osteoporosis and arterial calcification is examined. …
Plausible ergogenic effects of vitamin D on athletic performance and recovery.
Dahlquist DT, Dieter BP, Koehle MS. Dahlquist DT, et al. J Int Soc Sports Nutr. 2015 Aug 19;12:33. doi: 10.1186/s12970-015-0093-8. eCollection 2015. J Int Soc Sports Nutr. 2015. PMID: 26288575 Free PMC article. Review.
Vitamin D receptors (VDR) and vitamin D response elements (VDREs) are located in almost every tissue within the human body including skeletal muscle. ...Currently, the research is inconclusive with regards to the optimal intake of vitamin D …
Vitamin D receptors (VDR) and vitamin D response elements (VDREs) are located in almost every tissue within the …
Inflammation-mediated vitamin K and vitamin D effects on vascular calcifications in people with HIV on active antiretroviral therapy.
Janus SE, Durieux JC, Hajjari J, Carneiro H, McComsey GA. Janus SE, et al. AIDS. 2022 Apr 1;36(5):647-655. doi: 10.1097/QAD.0000000000003149. AIDS. 2022. PMID: 34907958
BACKGROUND: People with HIV (PWH) experience increased systemic inflammation and monocyte activation, leading to increased risk of cardiovascular events (death, stroke, and myocardial infarction) and higher coronary artery calcium scores (CACs). Vitamins D and K2 ha …
BACKGROUND: People with HIV (PWH) experience increased systemic inflammation and monocyte activation, leading to increased risk of cardiovas …
Effect of vitamin K2 on experimental calcinosis induced by vitamin D2 in rat soft tissue.
Seyama Y, Horiuch M, Hayashi M, Kanke Y. Seyama Y, et al. Int J Vitam Nutr Res. 1996;66(1):36-8. Int J Vitam Nutr Res. 1996. PMID: 8698544
It may be suggested that a high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by vitamin D2. Therefore, a pharmacological dose of vitamin K2 might have a usefulness for the prevention and treatment of ar …
It may be suggested that a high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by …
Vitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationship.
Fusaro M, Crepaldi G, Maggi S, Galli F, D'Angelo A, Calò L, Giannini S, Miozzo D, Gallieni M. Fusaro M, et al. J Endocrinol Invest. 2011 Apr;34(4):317-23. doi: 10.1007/BF03347093. Epub 2010 Nov 16. J Endocrinol Invest. 2011. PMID: 21088475 Review.
There are 2 main forms of vitamin K: vitamin K1 (phylloquinone, found in vegetables); vitamin K2 (menaquinone, produced by bacteria in the intestine and in fermented foods). ...Vitamin K2, instead, is also transported to extra-hepatic tis …
There are 2 main forms of vitamin K: vitamin K1 (phylloquinone, found in vegetables); vitamin K2 (menaquinone, p …
Effects of menaquinone-7 supplementation in patients with aortic valve calcification: study protocol for a randomised controlled trial.
Lindholt JS, Frandsen NE, Fredgart MH, Øvrehus KA, Dahl JS, Møller JE, Folkestad L, Urbonaviciene G, Becker SW, Lambrechtsen J, Auscher S, Hosbond S, Alan DH, Rasmussen LM, Gerke O, Mickley H, Diederichsen A. Lindholt JS, et al. BMJ Open. 2018 Aug 23;8(8):e022019. doi: 10.1136/bmjopen-2018-022019. BMJ Open. 2018. PMID: 30139903 Free PMC article.
This study will examine the effect of menaquinone-7 (MK-7) supplementation on progression of aortic valve calcification (AVC). We hypothesise that MK-7 supplementation will slow down the calcification process. METHODS AND ANALYSIS: In this multicenter and double-bli …
This study will examine the effect of menaquinone-7 (MK-7) supplementation on progression of aortic valve calcification (AVC). We hyp …
Effects of Vitamin K2 and D Supplementation on Coronary Artery Disease in Men: A RCT.
Hasific S, Oevrehus KA, Lindholt JS, Mejldal A, Dey D, Dahl JS, Frandsen NE, Auscher S, Lambrechtsen J, Hosbond S, Alan D, Urbonaviciene G, Becker S, Rasmussen LM, Diederichsen AP. Hasific S, et al. JACC Adv. 2023 Nov 24;2(9):100643. doi: 10.1016/j.jacadv.2023.100643. eCollection 2023 Nov. JACC Adv. 2023. PMID: 38938724 Free PMC article.
OBJECTIVES: This study aims to investigate if vitamin K2 and D supplementation can reduce CAC progression. METHODS: A total of 389 participants were randomized to supplementation with vitamin K2 (720 mug/day) and D (25 mug/day) vs placebo in a multicen …
OBJECTIVES: This study aims to investigate if vitamin K2 and D supplementation can reduce CAC progression. METHODS: A total of …
Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[(18)F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design.
Florea A, Kooi ME, Mess W, Schurgers LJ, Bucerius J, Mottaghy FM. Florea A, et al. Nutrients. 2021 Mar 19;13(3):994. doi: 10.3390/nu13030994. Nutrients. 2021. PMID: 33808652 Free PMC article.
INTRICATE is a prospective double-blind placebo-controlled feasibility study, assessing the influence of combined vitamin K2 and vitamin D3 supplementation on micro-calcification in carotid artery disease as imaged by hybrid Sodium [(18)F]Fluori …
INTRICATE is a prospective double-blind placebo-controlled feasibility study, assessing the influence of combined vitamin K2 a …