Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1934 1
1935 1
1936 1
1937 1
1939 3
1940 6
1941 2
1942 6
1943 4
1944 1
1945 21
1946 28
1947 34
1948 42
1949 26
1950 36
1951 62
1952 59
1953 65
1954 77
1955 81
1956 78
1957 80
1958 53
1959 57
1960 56
1961 35
1962 38
1963 96
1964 77
1965 68
1966 68
1967 79
1968 68
1969 76
1970 86
1971 75
1972 71
1973 50
1974 60
1975 44
1976 44
1977 29
1978 33
1979 34
1980 39
1981 43
1982 32
1983 41
1984 43
1985 42
1986 37
1987 47
1988 39
1989 34
1990 35
1991 28
1992 18
1993 24
1994 12
1995 16
1996 25
1997 21
1998 18
1999 39
2000 32
2001 31
2002 30
2003 44
2004 60
2005 46
2006 42
2007 50
2008 30
2009 43
2010 59
2011 69
2012 76
2013 83
2014 84
2015 92
2016 86
2017 85
2018 105
2019 106
2020 118
2021 125
2022 147
2023 168
2024 184
2025 157
2026 25

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

4,571 results

Results by year

Filters applied: . Clear all
Page 1
The vitamin B5/coenzyme A axis: A target for immunomodulation?
Miallot R, Millet V, Galland F, Naquet P. Miallot R, et al. Eur J Immunol. 2023 Oct;53(10):e2350435. doi: 10.1002/eji.202350435. Epub 2023 Jul 28. Eur J Immunol. 2023. PMID: 37482959 Free article. Review.
This review will more specifically focus on the contribution of pathways regulating the availability of the CoA precursor Vitamin B5/pantothenate in vivo and modulating the development of Th17-mediated inflammation, CD8-dependent anti-tumor immunity but also tissue …
This review will more specifically focus on the contribution of pathways regulating the availability of the CoA precursor Vitamin …
Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation.
Chen C, Zhang W, Zhou T, Liu Q, Han C, Huang Z, Chen S, Mei Q, Zhang C, Zhang K, Ma H, Zhou R, Jiang W, Pan W, Zhu S. Chen C, et al. Cell Rep. 2022 Nov 29;41(9):111741. doi: 10.1016/j.celrep.2022.111741. Cell Rep. 2022. PMID: 36450257 Free article.
Here, by screening more than one hundred compounds derived from intestinal microbes or diet, we found that vitamin B5 (VB5) restrains Th17 cell differentiation as well as related autoimmune diseases such as experimental autoimmune encephalomyelitis and colitis. ...
Here, by screening more than one hundred compounds derived from intestinal microbes or diet, we found that vitamin B5 (VB5) re …
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia.
Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D, Morales V, Finch AJ, D'Alessandro A, Bianchi K, Wang J, Gallipoli P, Kordasti S, Kubasch AS, Cross M, Platzbecker U, Wiseman DH, Bonnet D, Bernard DG, Gribben JG, Rouault-Pierre K. Mian SA, et al. Sci Transl Med. 2023 Mar;15(685):eabn5135. doi: 10.1126/scitranslmed.abn5135. Epub 2023 Mar 1. Sci Transl Med. 2023. PMID: 36857430 Free PMC article.
In patients with MDS-RS, loss of protein due to COASY mis-splicing led to depletion of both CoA and succinyl-CoA. Supplementation with COASY substrate (vitamin B5) rescued CoA and succinyl-CoA concentrations in SF3B1(mut) cells and mended erythropoiesis differentiat …
In patients with MDS-RS, loss of protein due to COASY mis-splicing led to depletion of both CoA and succinyl-CoA. Supplementation with COASY …
Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy.
Bourgin M, Kepp O, Kroemer G. Bourgin M, et al. Oncoimmunology. 2022 Jan 25;11(1):2031500. doi: 10.1080/2162402X.2022.2031500. eCollection 2022. Oncoimmunology. 2022. PMID: 35096488 Free PMC article.
Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by the intestinal microbiota. ...These finding suggest that vitamin B5 is yet another B vitamin that stimulates anti-cancer …
Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by th …
Microbial production of vitamin B5: current status and prospects.
Zhao K, Tang H, Zhang B, Zou S, Liu Z, Zheng Y. Zhao K, et al. Crit Rev Biotechnol. 2023 Dec;43(8):1172-1192. doi: 10.1080/07388551.2022.2104690. Epub 2022 Oct 9. Crit Rev Biotechnol. 2023. PMID: 36210178 Review.
Vitamin B5, also called D-pantothenic acid (D-PA), is a necessary micronutrient that plays an essential role in maintaining the physiological function of an organism. ...
Vitamin B5, also called D-pantothenic acid (D-PA), is a necessary micronutrient that plays an essential role in …
Impaired coenzyme A homeostasis in cardiac dysfunction and benefits of boosting coenzyme A production with vitamin B5 and its derivatives in the management of heart failure.
Wedman JJ, Sibon OCM, Mastantuono E, Iuso A. Wedman JJ, et al. J Inherit Metab Dis. 2024 Sep;47(5):885-894. doi: 10.1002/jimd.12737. Epub 2024 Apr 9. J Inherit Metab Dis. 2024. PMID: 38591231 Review.
This cofactor is synthesized de novo in our cells from vitamin B5, also known as pantothenic acid, a water-soluble vitamin abundantly present in vegetables and animal-based foods. ...Hence, we will discuss the potential benefits of CoA restorati …
This cofactor is synthesized de novo in our cells from vitamin B5, also known as pantothenic acid, a water-solub …
Cross-kingdom vitamin B5 biosynthesis and cyst nematode susceptibility.
Li M, Guo B, Liu F, Fu ZQ. Li M, et al. Trends Parasitol. 2023 Jan;39(1):7-9. doi: 10.1016/j.pt.2022.11.004. Epub 2022 Nov 26. Trends Parasitol. 2023. PMID: 36443162
Vitamin deficiencies are known to cause disorders in human beings. Siddique et al. discovered that vitamin B5 biosynthesis in cyst nematodes requires steps in their host plants. Disruption of an Arabidopsis thaliana 'susceptibility gene', which is involved in …
Vitamin deficiencies are known to cause disorders in human beings. Siddique et al. discovered that vitamin B5 biosynthe …
Vitamin B5 Supports Oncogenic Metabolism in MYC-Driven Breast Cancer.
[No authors listed] [No authors listed] Cancer Discov. 2024 Jan 12;14(1):15. doi: 10.1158/2159-8290.CD-RW2023-185. Cancer Discov. 2024. PMID: 37991361
Pantothetic acid is required for metabolic activity that supports MYC-driven breast tumor growth....
Pantothetic acid is required for metabolic activity that supports MYC-driven breast tumor growth....
PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Dibble CC, Barritt SA, Perry GE, Lien EC, Geck RC, DuBois-Coyne SE, Bartee D, Zengeya TT, Cohen EB, Yuan M, Hopkins BD, Meier JL, Clohessy JG, Asara JM, Cantley LC, Toker A. Dibble CC, et al. Nature. 2022 Aug;608(7921):192-198. doi: 10.1038/s41586-022-04984-8. Epub 2022 Jul 27. Nature. 2022. PMID: 35896750 Free PMC article.
CoA is the major carrier of activated acyl groups in cells(4,5) and is synthesized from cysteine, ATP and the essential nutrient vitamin B5 (also known as pantothenate)(6,7). We identify pantothenate kinase 2 (PANK2) and PANK4 as substrates of the PI3K effector kina …
CoA is the major carrier of activated acyl groups in cells(4,5) and is synthesized from cysteine, ATP and the essential nutrient vitamin …
Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJ. Depeint F, et al. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. doi: 10.1016/j.cbi.2006.04.014. Epub 2006 May 1. Chem Biol Interact. 2006. PMID: 16765926 Review.
This review focuses on their essential role in maintaining mitochondrial function and on how mitochondria are compromised by a deficiency of any B vitamin. Thiamin (B1) is essential for the oxidative decarboxylation of the multienzyme branched-chain ketoacid dehydrogenase …
This review focuses on their essential role in maintaining mitochondrial function and on how mitochondria are compromised by a deficiency of …
4,571 results