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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
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1989 3
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1992 2
1993 1
1994 2
1995 1
1996 3
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1998 2
1999 3
2000 3
2001 3
2002 8
2003 8
2004 4
2005 9
2006 7
2007 6
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2009 8
2010 9
2011 11
2012 7
2013 13
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41 results

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Page 1
Vitamin C for sepsis: from mechanisms to individualized therapy.
Xiao Y, Gong F, Zhang L, Gui C. Xiao Y, et al. Front Med (Lausanne). 2025 Dec 18;12:1700351. doi: 10.3389/fmed.2025.1700351. eCollection 2025. Front Med (Lausanne). 2025. PMID: 41488104 Free PMC article. Review.
It is noteworthy that many sepsis patients have insufficient levels of vitamin C, an essential micronutrient. Due to its diverse physiological roles, including antioxidant, anti-inflammatory, immunomodulatory, and antimicrobial-enhancing effects, vitamin …
It is noteworthy that many sepsis patients have insufficient levels of vitamin C, an essential micronutrient. Due to it …
Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial.
Vandervelden S, Cortens B, Fieuws S, Eegdeman W, Malinverni S, Vanhove P, Monsieurs K, Breuls J, Hubloue I, Stifkens F, Creteur J, Wauters L, Desruelles D; C-EASIE investigators. Vandervelden S, et al. Crit Care. 2025 Apr 23;29(1):160. doi: 10.1186/s13054-025-05383-x. Crit Care. 2025. PMID: 40269974 Free PMC article. Clinical Trial.
Vitamin C deficiency is a common, potentially reversible, contributor to morbidity and mortality in sepsis. ...Therefore, this study does not support the use of vitamin C in sepsis patients. TRIAL REGISTRATION: ClinicalTrials.gov Identifi …
Vitamin C deficiency is a common, potentially reversible, contributor to morbidity and mortality in sepsis. ...Therefor …
Unravelling the paradox of vitamin C research in sepsis.
Fujii T, May CN, Lankadeva YR. Fujii T, et al. Crit Care Resusc. 2025 Oct 14;27(3):100134. doi: 10.1016/j.ccrj.2025.100134. eCollection 2025 Sep. Crit Care Resusc. 2025. PMID: 41613893 Free PMC article. Review.
Professor Rinaldo Bellomo's lasting impact on critical care research stems from his commitment to structured, biologically grounded research programs over isolated studies. His work on vitamin C in sepsis exemplifies this approach. While early enthusiasm grew …
Professor Rinaldo Bellomo's lasting impact on critical care research stems from his commitment to structured, biologically grounded research …
Vitamin C Protects Against Myocardial Damage Induced by Sepsis by Regulating the JAK2/STAT3 and NF-kappaB Signaling Pathways.
Han RD, Tian N, Sun ZG, Liu AB, Wang S, Shen Y, Liu J, Feng K, Yang LS, Zhang JF. Han RD, et al. J Surg Res. 2025 Oct;314:209-219. doi: 10.1016/j.jss.2025.07.009. Epub 2025 Aug 6. J Surg Res. 2025. PMID: 40768888 Free article. Review.
INTRODUCTION: Previous studies have shown that vitamin C (VC) has a protective effect on sepsis-induced myocardial injury (SIMI); however, the mechanism of this effect remains unclear. ...
INTRODUCTION: Previous studies have shown that vitamin C (VC) has a protective effect on sepsis-induced myocardial inju …
Beyond Fluid Therapy: The Role of Vitamin C, Steroids, and Thiamine in Sepsis Management.
Idahor CO, Ogunfuwa O, Ogbonna N, Adigwe A, Ogbeide OA. Idahor CO, et al. Cureus. 2025 May 23;17(5):e84666. doi: 10.7759/cureus.84666. eCollection 2025 May. Cureus. 2025. PMID: 40546532 Free PMC article. Review.
This narrative review evaluates current evidence regarding the role of vitamin C, thiamine, and corticosteroids in improving sepsis outcomes. Early studies suggested that vitamin C may reduce organ dysfunction and vasopressor requirements; howev …
This narrative review evaluates current evidence regarding the role of vitamin C, thiamine, and corticosteroids in improving …
Intravenous Vitamin C in Severe Sepsis: A Systematic Review of Evidence From 2020 to 2025.
Ahmed R, Shetty S, Aziz Khan MQ, Kalsoom I, Qasim S, Khan SB, Abdullah S. Ahmed R, et al. Cureus. 2026 Jan 5;18(1):e100867. doi: 10.7759/cureus.100867. eCollection 2026 Jan. Cureus. 2026. PMID: 41658835 Free PMC article. Review.
This systematic review evaluates evidence from 2020 to 2025 on IV vitamin C in adult patients with sepsis or septic shock. Five studies, including randomized controlled trials, cohort studies, and meta-analyses, were included. ...Adverse effects, including ox …
This systematic review evaluates evidence from 2020 to 2025 on IV vitamin C in adult patients with sepsis or septic sho …
Vitamin C improves 28-day survival in patients with sepsis-associated acute kidney injury in the intensive care unit: a retrospective study.
He Y, Liu J. He Y, et al. Front Nutr. 2025 Jun 5;12:1600224. doi: 10.3389/fnut.2025.1600224. eCollection 2025. Front Nutr. 2025. PMID: 40538589 Free PMC article.
This retrospective study aimed to evaluate the potential association between vitamin C supplementation during intensive care unit admission and improved clinical outcomes, specifically in sepsis-associated acute kidney injury (SA-AKI). ...Participants were st …
This retrospective study aimed to evaluate the potential association between vitamin C supplementation during intensive care u …
Vitamin C is associated with improved outcomes in patients with sepsis-induced myocardial injury: insights from the MIMIC-IV database.
Gong R, Huang Z, Zhao J, Tang M, Mu F, Sun K, Cui C, Yan Z, Wang J. Gong R, et al. BMC Infect Dis. 2025 Dec 24;26(1):171. doi: 10.1186/s12879-025-12377-1. BMC Infect Dis. 2025. PMID: 41444946 Free PMC article.
BACKGROUND: Vitamin C (VC) is a water-soluble, essential micronutrient with multiple important physiological functions. ...Due to the extreme oxidative stress and inflammatory response associated with sepsis and its complications, which lead to a rapid deplet …
BACKGROUND: Vitamin C (VC) is a water-soluble, essential micronutrient with multiple important physiological functions. ...Due …
Vitamin C in Sepsis: Exploring Its Role in Modulating Inflammation and Oxidative Stress.
Wazir K, Abubakar M, Anwar A, Rahat Rashid F, Adil A, Sajjad M. Wazir K, et al. Cureus. 2025 Mar 28;17(3):e81386. doi: 10.7759/cureus.81386. eCollection 2025 Mar. Cureus. 2025. PMID: 40296930 Free PMC article.
Objective This study aimed to evaluate the impact of vitamin C supplementation on inflammatory response, oxidative stress, and clinical outcomes in sepsis patients. ...Conclusion Supplementing with vitamin C has been shown to significantly impro …
Objective This study aimed to evaluate the impact of vitamin C supplementation on inflammatory response, oxidative stress, and …
Role of vitamin C infusion in postoperative mechanically ventilated neonates with sepsis: a randomized controlled trial.
Elmesiry AM, Elsheikh MR, Elshimy KM, Abotaleb AM. Elmesiry AM, et al. Eur J Pediatr. 2025 Nov 29;184(12):806. doi: 10.1007/s00431-025-06625-4. Eur J Pediatr. 2025. PMID: 41315087 Free PMC article. Clinical Trial.
This double-blinded randomized controlled trial included 50 full-term neonates who required mechanical ventilation and developed confirmed sepsis after surgery. Neonates were randomly assigned to receive either standard sepsis management with placebo (No Vitamin …
This double-blinded randomized controlled trial included 50 full-term neonates who required mechanical ventilation and developed confirmed …
41 results