Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1963 1
1964 1
1967 1
1971 1
1973 1
1977 1
1979 3
1987 1
1989 3
1990 3
1991 1
1992 2
1993 1
1994 2
1995 1
1996 3
1997 4
1998 2
1999 3
2000 3
2001 3
2002 8
2003 8
2004 4
2005 9
2006 7
2007 6
2008 9
2009 8
2010 9
2011 11
2012 7
2013 13
2014 18
2015 13
2016 12
2017 30
2018 39
2019 51
2020 88
2021 83
2022 87
2023 68
2024 43
2025 42
2026 31

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

282 results

Results by year

Filters applied: in the last 5 years. Clear all
Page 1
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.
Lamontagne F, Masse MH, Menard J, Sprague S, Pinto R, Heyland DK, Cook DJ, Battista MC, Day AG, Guyatt GH, Kanji S, Parke R, McGuinness SP, Tirupakuzhi Vijayaraghavan BK, Annane D, Cohen D, Arabi YM, Bolduc B, Marinoff N, Rochwerg B, Millen T, Meade MO, Hand L, Watpool I, Porteous R, Young PJ, D'Aragon F, Belley-Cote EP, Carbonneau E, Clarke F, Maslove DM, Hunt M, Chassé M, Lebrasseur M, Lauzier F, Mehta S, Quiroz-Martinez H, Rewa OG, Charbonney E, Seely AJE, Kutsogiannis DJ, LeBlanc R, Mekontso-Dessap A, Mele TS, Turgeon AF, Wood G, Kohli SS, Shahin J, Twardowski P, Adhikari NKJ; LOVIT Investigators and the Canadian Critical Care Trials Group. Lamontagne F, et al. N Engl J Med. 2022 Jun 23;386(25):2387-2398. doi: 10.1056/NEJMoa2200644. Epub 2022 Jun 15. N Engl J Med. 2022. PMID: 35704292 Clinical Trial.
BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction. ...CONCLUS …
BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasop …
Vitamin C as a treatment for organ failure in sepsis.
Wang Z, Liu L, Liu L. Wang Z, et al. Eur J Med Res. 2023 Jul 5;28(1):222. doi: 10.1186/s40001-023-01183-7. Eur J Med Res. 2023. PMID: 37408078 Free PMC article. Review.
Exogenous vitamin C supplementation is a potential therapeutic option for the treatment of multi-organ dysfunction in sepsis due to the significantly lower levels of vitamin C in the circulating blood of sepsis patients compared to health …
Exogenous vitamin C supplementation is a potential therapeutic option for the treatment of multi-organ dysfunction in sepsi …
IV Vitamin C in Sepsis: A Latest Systematic Review and Meta-Analysis.
Wen C, Li Y, Hu Q, Liu H, Xu X, Lü M. Wen C, et al. Int J Clin Pract. 2023 Jan 24;2023:6733465. doi: 10.1155/2023/6733465. eCollection 2023. Int J Clin Pract. 2023. PMID: 36743822 Free PMC article.
Studies have shown a lower level of vitamin C in patients with sepsis. Therefore, vitamin C supplementation has become one of the measures to treat sepsis. However, the clinical studies of vitamin C in the treatment of se …
Studies have shown a lower level of vitamin C in patients with sepsis. Therefore, vitamin C supplementati …
Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine.
Li YR, Zhu H. Li YR, et al. Mol Cell Biochem. 2021 Dec;476(12):4449-4460. doi: 10.1007/s11010-021-04240-z. Epub 2021 Sep 3. Mol Cell Biochem. 2021. PMID: 34478032 Free PMC article. Review.
Vitamin C, also known as ascorbic acid or ascorbate, is a water-soluble vitamin synthesized in plants as well as in animals except humans and several other animal species. ...To set a stage for discussing the effects and mechanisms of vitamin …
Vitamin C, also known as ascorbic acid or ascorbate, is a water-soluble vitamin synthesized in plants as well as …
Vitamin C for sepsis: Questions remain.
Fujii T, Udy AA, Lankadeva YR. Fujii T, et al. Anaesth Crit Care Pain Med. 2022 Dec;41(6):101151. doi: 10.1016/j.accpm.2022.101151. Epub 2022 Sep 6. Anaesth Crit Care Pain Med. 2022. PMID: 36075562 No abstract available.
Vitamin C for sepsis: from mechanisms to individualized therapy.
Xiao Y, Gong F, Zhang L, Gui C. Xiao Y, et al. Front Med (Lausanne). 2025 Dec 18;12:1700351. doi: 10.3389/fmed.2025.1700351. eCollection 2025. Front Med (Lausanne). 2025. PMID: 41488104 Free PMC article. Review.
It is noteworthy that many sepsis patients have insufficient levels of vitamin C, an essential micronutrient. Due to its diverse physiological roles, including antioxidant, anti-inflammatory, immunomodulatory, and antimicrobial-enhancing effects, vitamin …
It is noteworthy that many sepsis patients have insufficient levels of vitamin C, an essential micronutrient. Due to it …
Intravenous high-dose vitamin C monotherapy for sepsis and septic shock: A meta-analysis of randomized controlled trials.
Zeng Y, Liu Z, Xu F, Tang Z. Zeng Y, et al. Medicine (Baltimore). 2023 Oct 20;102(42):e35648. doi: 10.1097/MD.0000000000035648. Medicine (Baltimore). 2023. PMID: 37861551 Free PMC article.
BACKGROUND: Vitamin C has been used as an adjuvant in the treatment of sepsis and septic shock; however, its role remains controversial. ...Further RCTs and other studies should be conducted to determine whether vitamin C should be recommended a …
BACKGROUND: Vitamin C has been used as an adjuvant in the treatment of sepsis and septic shock; however, its role remai …
Reevaluating vitamin C in sepsis and septic shock: a potential benefit in severe cases?
Alissa A, Alrashed MA, Alshaya AI, Al Sulaiman K, Alharbi S. Alissa A, et al. Front Med (Lausanne). 2024 Oct 29;11:1476242. doi: 10.3389/fmed.2024.1476242. eCollection 2024. Front Med (Lausanne). 2024. PMID: 39540046 Free PMC article. Review.
Vitamin C (Ascorbic acid) has evolved as an emergent co-intervention for sepsis and septic shock patients. ...Nevertheless, most randomized clinical trials failed to show the clinical impact of adding vitamin C to sepsis and …
Vitamin C (Ascorbic acid) has evolved as an emergent co-intervention for sepsis and septic shock patients …
Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials.
Martimbianco ALC, Pacheco RL, Bagattini ÂM, de Fátima Carreira Moreira Padovez R, Azevedo LCP, Riera R. Martimbianco ALC, et al. J Crit Care. 2022 Oct;71:154099. doi: 10.1016/j.jcrc.2022.154099. Epub 2022 Jun 25. J Crit Care. 2022. PMID: 35763993
PURPOSE: to critically appraise and synthesize the evidence on the effects of vitamin C-based regimens for patients with sepsis or septic shock. METHODS: a broad search was performed on May 2021 to identify randomized clinical trials (RCTs) assessing vitam …
PURPOSE: to critically appraise and synthesize the evidence on the effects of vitamin C-based regimens for patients with se …
Intravenous vitamin C therapy in adult patients with sepsis: A rapid practice guideline.
Reintam Blaser A, Alhazzani W, Belley-Cote E, Møller MH, Adhikari NKJ, Burry L, Coopersmith CM, Al Duhailib Z, Fujii T, Granholm A, Gunst J, Hammond N, Ke L, Lamontagne F, Loudet C, Morgan M, Ostermann M, Reinikainen M, Rosenfeld R, Spies C, Oczkowski S. Reintam Blaser A, et al. Acta Anaesthesiol Scand. 2023 Nov;67(10):1423-1431. doi: 10.1111/aas.14311. Epub 2023 Jul 27. Acta Anaesthesiol Scand. 2023. PMID: 37500083
The panel judged the undesirable consequences of using IV vitamin C to probably outweigh the desirable consequences, and therefore issued a conditional recommendation against using IV vitamin C therapy in sepsis. CONCLUSIONS: The panel suggests …
The panel judged the undesirable consequences of using IV vitamin C to probably outweigh the desirable consequences, and there …
282 results