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ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux.
Margier M, Collet X, le May C, Desmarchelier C, André F, Lebrun C, Defoort C, Bluteau A, Borel P, Lespine A, Reboul E. Margier M, et al. FASEB J. 2019 Feb;33(2):2084-2094. doi: 10.1096/fj.201800956R. Epub 2018 Sep 17. FASEB J. 2019. PMID: 30222077
Thus, we showed here for the first time that ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.-Margier, M., Colle …
Thus, we showed here for the first time that ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it …
P-glycoprotein (ABCB1) is involved in vitamin K efflux.
Margier M, Le May C, Antoine T, Halimi C, Nowicki M, Lespine A, Reboul E. Margier M, et al. Food Chem. 2021 May 1;343:128510. doi: 10.1016/j.foodchem.2020.128510. Epub 2020 Nov 1. Food Chem. 2021. PMID: 33172753
ABCB1 (P-glycoprotein/MDR1) is a multidrug efflux transporter that has previously been involved in cholesterol and vitamin D metabolism. ...
ABCB1 (P-glycoprotein/MDR1) is a multidrug efflux transporter that has previously been involved in cholesterol and vitamin …
Brain Endothelial P-Glycoprotein Level Is Reduced in Parkinson's Disease via a Vitamin D Receptor-Dependent Pathway.
Kim H, Shin JY, Lee YS, Yun SP, Maeng HJ, Lee Y. Kim H, et al. Int J Mol Sci. 2020 Nov 12;21(22):8538. doi: 10.3390/ijms21228538. Int J Mol Sci. 2020. PMID: 33198348 Free PMC article.
The progressive neurodegeneration in Parkinson's disease (PD) is accompanied by neuroinflammation and endothelial vascular impairment. Although the vitamin D receptor (VDR) is expressed in both dopamine neurons and brain endothelial cells, its role in the regulation …
The progressive neurodegeneration in Parkinson's disease (PD) is accompanied by neuroinflammation and endothelial vascular impairment. Altho …
Vitamin D(3) increases the Caspase-3 p12, MTHFR, and P-glycoprotein reducing amyloid-beta(42) in the kidney of a mouse model for Down syndrome.
Gomes FC, de Melo-Neto JS, Ferrari MFR, Carlos CP, Goloni-Bertollo EM, Pavarino ÉC. Gomes FC, et al. Life Sci. 2019 Aug 15;231:116537. doi: 10.1016/j.lfs.2019.06.012. Epub 2019 Jun 6. Life Sci. 2019. PMID: 31176774
Here, we present a proposal for how the triplication of the amyloid beta precursor protein (APP) and, mainly the amyloid beta peptide 1-42 (Abeta(42)) can favor the development of renal abnormalities in DS. We evaluated the effects of vitamin D(3) (VD(3)) supplement …
Here, we present a proposal for how the triplication of the amyloid beta precursor protein (APP) and, mainly the amyloid beta peptide 1-42 ( …
Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.
Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA. Durk MR, et al. Pharm Res. 2015 Mar;32(3):1128-40. doi: 10.1007/s11095-014-1524-y. Epub 2014 Oct 16. Pharm Res. 2015. PMID: 25319098
PURPOSE: Since the vitamin D receptor (VDR) was found to up-regulate cerebral P-glycoprotein expression in vitro and in mice, we extend our findings to rats by assessing the effect of rat Vdr activation on brain efflux of quinidine, a P-gp substrate th …
PURPOSE: Since the vitamin D receptor (VDR) was found to up-regulate cerebral P-glycoprotein expression in vitro …
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow EC, Durk MR, Cummins CL, Pang KS. Chow EC, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):846-59. doi: 10.1124/jpet.111.179101. Epub 2011 Mar 18. J Pharmacol Exp Ther. 2011. PMID: 21421739
Secondary farnesoid X receptor (FXR) effects, in addition to vitamin D receptor (VDR) effects, were observed in the rat liver after treatment with 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], the natural ligand of VDR, caused by increased bile acid absorption …
Secondary farnesoid X receptor (FXR) effects, in addition to vitamin D receptor (VDR) effects, were observed in the rat liver …
1alpha,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.
Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, Cannon RE, Bendayan R, Miller DS, Pang KS. Durk MR, et al. J Neurochem. 2012 Dec;123(6):944-53. doi: 10.1111/jnc.12041. Epub 2012 Nov 1. J Neurochem. 2012. PMID: 23035695 Free PMC article.
Induction of the multidrug resistance protein 1 (MDR1)/P-glycoprotein (P-gp) by the vitamin D receptor (VDR) was investigated in isolated rat brain capillaries and rat (RBE4) and human (hCMEC/D3) brain microvessel endothelial cell lines. ...
Induction of the multidrug resistance protein 1 (MDR1)/P-glycoprotein (P-gp) by the vitamin D receptor (VDR) was …
Vitamin D Receptor-Mediated Upregulation of CYP3A4 and MDR1 by Quercetin in Caco-2 cells.
Chae YJ, Cho KH, Yoon IS, Noh CK, Lee HJ, Park Y, Ji E, Seo MD, Maeng HJ. Chae YJ, et al. Planta Med. 2016 Jan;82(1-2):121-30. doi: 10.1055/s-0035-1557898. Epub 2015 Sep 14. Planta Med. 2016. PMID: 26366751
The vitamin D receptor siRNA was used to assess the involvement of the vitamin D receptor. Vitamin D receptor activation using a vitamin D responsive element-mediated cytochrome P450 3A4 reporter gene assay was investigated …
The vitamin D receptor siRNA was used to assess the involvement of the vitamin D receptor. Vitamin D …
Influence of 25-hydroxyvitamin D(3) and 1,25-dihydroxyvitamin D(3) on expression of P-glycoprotein and cytochrome P450 3A in sheep.
Wilkens MR, Maté LM, Schnepel N, Klinger S, Muscher-Banse AS, Ballent M, Virkel G, Lifschitz AL. Wilkens MR, et al. J Steroid Biochem Mol Biol. 2016 Nov;164:271-276. doi: 10.1016/j.jsbmb.2015.08.019. Epub 2015 Aug 28. J Steroid Biochem Mol Biol. 2016. PMID: 26319202
In order to improve calcium and phosphorus balance, beef cattle and dairy cows can be supplemented with vitamin D. However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and c …
In order to improve calcium and phosphorus balance, beef cattle and dairy cows can be supplemented with vitamin D. However, di …
Intranasal administration of vitamin D attenuates blood-brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats.
Enkhjargal B, McBride DW, Manaenko A, Reis C, Sakai Y, Tang J, Zhang JH. Enkhjargal B, et al. J Cereb Blood Flow Metab. 2017 Jul;37(7):2555-2566. doi: 10.1177/0271678X16671147. Epub 2016 Jan 1. J Cereb Blood Flow Metab. 2017. PMID: 27671249 Free PMC article.
These protective effects of vitamin D3 were completely attenuated by intracerebroventricular injection of transcription inhibitor Actinomycin D and significantly inhibited by small interfering ribonucleic acid (siRNA) for vitamin D receptor and OPN in Pre-SAH + VitD …
These protective effects of vitamin D3 were completely attenuated by intracerebroventricular injection of transcription inhibitor Actinomyci …
59 results