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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 2
1966 1
1967 1
1968 2
1969 6
1970 1
1971 2
1972 2
1973 3
1974 3
1975 2
1976 4
1978 3
1979 5
1980 2
1981 2
1982 5
1983 3
1984 2
1985 6
1986 1
1987 4
1988 1
1989 7
1990 7
1991 11
1992 13
1993 19
1994 26
1995 34
1996 40
1997 37
1998 56
1999 71
2000 90
2001 85
2002 80
2003 105
2004 110
2005 110
2006 108
2007 109
2008 100
2009 108
2010 113
2011 119
2012 158
2013 171
2014 156
2015 180
2016 131
2017 159
2018 151
2019 149
2020 116
2021 94
2022 108
2023 69
2024 64
2025 34

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2,969 results

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Filters applied: Clinical Trial. Clear all
Page 1
Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease.
Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D'Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WC, Buring JE; VITAL Research Group. Manson JE, et al. N Engl J Med. 2019 Jan 3;380(1):33-44. doi: 10.1056/NEJMoa1809944. Epub 2018 Nov 10. N Engl J Med. 2019. PMID: 30415629 Free PMC article. Clinical Trial.
BACKGROUND: It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. ...A major cardiovascular event occurred in 805 participants (396 in the vitamin D group …
BACKGROUND: It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and dat …
Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial.
Thompson B, Waterhouse M, English DR, McLeod DS, Armstrong BK, Baxter C, Duarte Romero B, Ebeling PR, Hartel G, Kimlin MG, Rahman ST, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Neale RE. Thompson B, et al. BMJ. 2023 Jun 28;381:e075230. doi: 10.1136/bmj-2023-075230. BMJ. 2023. PMID: 37380191 Free PMC article. Clinical Trial.
OBJECTIVE: To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence of major cardiovascular events. DESIGN: Randomised, double blind, placebo controlled trial of monthly vitamin D (the D-Health Trial). ...The medi …
OBJECTIVE: To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence of major cardiov …
Cardiovascular and Cerebrovascular Response to RedBull Energy Drink Intake in Young Adults.
Costa R, Rocha C, Santos H. Costa R, et al. Anatol J Cardiol. 2023 Jan;27(1):19-25. doi: 10.14744/AnatolJCardiol.2022.2315. Anatol J Cardiol. 2023. PMID: 36680443 Free PMC article. Clinical Trial.
BACKGROUND: Energy drinks contain caffeine, taurine, sucrose, vitamins, and other amino acids. The dosage of these varies depending on the drink chosen. ...This study analyzed the cardio- and cerebrovascular responses after consumption of an energy drink - RedBull - under …
BACKGROUND: Energy drinks contain caffeine, taurine, sucrose, vitamins, and other amino acids. The dosage of these varies depending o …
Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial: a randomized controlled trial.
Virtanen JK, Nurmi T, Aro A, Bertone-Johnson ER, Hyppönen E, Kröger H, Lamberg-Allardt C, Manson JE, Mursu J, Mäntyselkä P, Suominen S, Uusitupa M, Voutilainen A, Tuomainen TP, Hantunen S. Virtanen JK, et al. Am J Clin Nutr. 2022 May 1;115(5):1300-1310. doi: 10.1093/ajcn/nqab419. Am J Clin Nutr. 2022. PMID: 34982819 Free PMC article. Clinical Trial.
BACKGROUND: Vitamin D insufficiency is associated with risks of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits with vitamin D supplementation is limited. ...After 12 months, the concentrations were 73 nmol/L (SD, …
BACKGROUND: Vitamin D insufficiency is associated with risks of cardiovascular diseases (CVD) and cancer in observational stud …
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.
Sesso HD, Manson JE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Carrick WR, Anderson GL; COSMOS Research Group. Sesso HD, et al. Am J Clin Nutr. 2022 Jun 7;115(6):1490-1500. doi: 10.1093/ajcn/nqac055. Am J Clin Nutr. 2022. PMID: 35294962 Free PMC article. Clinical Trial.
The primary outcome was a composite of confirmed incident total cardiovascular events, including myocardial infarction (MI), stroke, coronary revascularization, cardiovascular death, carotid artery disease, peripheral artery surgery, and unstable angina. ...Potentia …
The primary outcome was a composite of confirmed incident total cardiovascular events, including myocardial infarction (MI), stroke, …
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.
Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O. Gaede P, et al. N Engl J Med. 2003 Jan 30;348(5):383-93. doi: 10.1056/NEJMoa021778. N Engl J Med. 2003. PMID: 12556541 Free article. Clinical Trial.
BACKGROUND: Cardiovascular morbidity is a major burden in patients with type 2 diabetes. In the Steno-2 Study, we compared the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment on modifiable risk factors for cardiovascula …
BACKGROUND: Cardiovascular morbidity is a major burden in patients with type 2 diabetes. In the Steno-2 Study, we compared the effect …
The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease.
Manson JE, Bassuk SS, Lee IM, Cook NR, Albert MA, Gordon D, Zaharris E, Macfadyen JG, Danielson E, Lin J, Zhang SM, Buring JE. Manson JE, et al. Contemp Clin Trials. 2012 Jan;33(1):159-71. doi: 10.1016/j.cct.2011.09.009. Epub 2011 Oct 2. Contemp Clin Trials. 2012. PMID: 21986389 Free PMC article. Clinical Trial.
Data from laboratory studies, observational research, and/or secondary prevention trials suggest that vitamin D and marine omega-3 fatty acids may reduce risk for cancer or cardiovascular disease (CVD), but primary prevention trials with adequate dosing in general p …
Data from laboratory studies, observational research, and/or secondary prevention trials suggest that vitamin D and marine omega-3 fa …
Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial.
Bischoff-Ferrari HA, Vellas B, Rizzoli R, Kressig RW, da Silva JAP, Blauth M, Felson DT, McCloskey EV, Watzl B, Hofbauer LC, Felsenberg D, Willett WC, Dawson-Hughes B, Manson JE, Siebert U, Theiler R, Staehelin HB, de Godoi Rezende Costa Molino C, Chocano-Bedoya PO, Abderhalden LA, Egli A, Kanis JA, Orav EJ; DO-HEALTH Research Group. Bischoff-Ferrari HA, et al. JAMA. 2020 Nov 10;324(18):1855-1868. doi: 10.1001/jama.2020.16909. JAMA. 2020. PMID: 33170239 Free PMC article. Clinical Trial.
IMPORTANCE: The benefits of vitamin D, omega-3 fatty acids, and exercise in disease prevention remain unclear. OBJECTIVE: To test whether vitamin D, omega-3s, and a strength-training exercise program, alone or in combination, improved 6 health outcomes among older a …
IMPORTANCE: The benefits of vitamin D, omega-3 fatty acids, and exercise in disease prevention remain unclear. OBJECTIVE: To test whe …
Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials.
Manson JE, Bassuk SS, Buring JE; VITAL Research Group. Manson JE, et al. J Steroid Biochem Mol Biol. 2020 Apr;198:105522. doi: 10.1016/j.jsbmb.2019.105522. Epub 2019 Nov 13. J Steroid Biochem Mol Biol. 2020. PMID: 31733345 Free PMC article. Clinical Trial.
Whether supplemental vitamin D reduces risk of cancer or cardiovascular disease (CVD) is relatively unexplored in randomized trial settings. ...Vitamin D did not significantly reduce the co-primary endpoint of major CVD events (HR = 0.97 [0.85-1.12]), other …
Whether supplemental vitamin D reduces risk of cancer or cardiovascular disease (CVD) is relatively unexplored in randomized t …
Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial.
Okereke OI, Reynolds CF 3rd, Mischoulon D, Chang G, Vyas CM, Cook NR, Weinberg A, Bubes V, Copeland T, Friedenberg G, Lee IM, Buring JE, Manson JE. Okereke OI, et al. JAMA. 2020 Aug 4;324(5):471-480. doi: 10.1001/jama.2020.10224. JAMA. 2020. PMID: 32749491 Free PMC article. Clinical Trial.
IMPORTANCE: Low levels of 25-hydroxyvitamin D have been associated with higher risk for depression later in life, but there have been few long-term, high-dose large-scale trials. OBJECTIVE: To test the effects of vitamin D3 supplementation on late-life depression risk and …
IMPORTANCE: Low levels of 25-hydroxyvitamin D have been associated with higher risk for depression later in life, but there have been few lo …
2,969 results