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118 results

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Page 1
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8(+) T cell responses in vitiligo.
Yang X, Ding W, Lou F, Xu H, Sheng A, Sun Y, Cai X, Zhou M, Lin F, Jin R, Zheng X, Wang Z, Deng S, Xu Z, Zhang T, Cheng J, Zheng X, Xu A, Wang H. Yang X, et al. Immunity. 2025 Aug 12;58(8):2086-2103.e9. doi: 10.1016/j.immuni.2025.05.018. Epub 2025 Jun 16. Immunity. 2025. PMID: 40527324
Vitiligo is an autoimmune disease characterized by depigmented patches of skin. Autoreactive CD8(+) T cells kill melanocytes in vitiligo, but the immunopathogenesis remains elusive and ideal drug targets are lacking. ...Taken together, our results reve …
Vitiligo is an autoimmune disease characterized by depigmented patches of skin. Autoreactive CD8(+) T cells kill melanocyte …
Mechanisms of melanocyte death in vitiligo.
Chen J, Li S, Li C. Chen J, et al. Med Res Rev. 2021 Mar;41(2):1138-1166. doi: 10.1002/med.21754. Epub 2020 Nov 17. Med Res Rev. 2021. PMID: 33200838 Free PMC article. Review.
Vitiligo is an autoimmune depigment disease results from extensive melanocytes destruction. ...Of note, the self-responsive immune function directly contributes to the bulk of melanocyte deaths in vitiligo. The aberrantly heightened innate immun …
Vitiligo is an autoimmune depigment disease results from extensive melanocytes destruction. ...Of note, the self-respon …
Vitiligo.
Böhm M, Tanew A. Böhm M, et al. J Dtsch Dermatol Ges. 2025 Aug;23(8):968-987. doi: 10.1111/ddg.15706. J Dtsch Dermatol Ges. 2025. PMID: 40788636 Free PMC article. Review.
Vitiligo is a common pigment disorder of the skin resulting in destruction of melanocytes. ...Genetic predisposition and increased vulnerability of melanocytes towards stressors lead to a melanocyte-specific CD8(+) T cell-driven im …
Vitiligo is a common pigment disorder of the skin resulting in destruction of melanocytes. ...Genetic predisposition and incre …
The immunology of vitiligo.
Turk MJ, Huang YH. Turk MJ, et al. Nat Rev Immunol. 2026 Apr;26(4):284-297. doi: 10.1038/s41577-025-01249-z. Epub 2026 Jan 2. Nat Rev Immunol. 2026. PMID: 41482575 Review.
Vitiligo has emerged as a prototypical CD8(+) T cell-mediated autoimmune disease, with cooperation between innate immune cells, dendritic cells, T cells, keratinocytes and fibroblasts driving autoimmune pathology against the uniquely susc …
Vitiligo has emerged as a prototypical CD8(+) T cell-mediated autoimmune disease, with cooperation betwee …
Anatomically distinct fibroblast subsets determine skin autoimmune patterns.
Xu Z, Chen D, Hu Y, Jiang K, Huang H, Du Y, Wu W, Wang J, Sui J, Wang W, Zhang L, Li S, Li C, Yang Y, Chang J, Chen T. Xu Z, et al. Nature. 2022 Jan;601(7891):118-124. doi: 10.1038/s41586-021-04221-8. Epub 2021 Dec 15. Nature. 2022. PMID: 34912121
Aberrant activation of immune cells can induce common skin autoimmune diseases such as vitiligo, which are often characterized by bilateral symmetric lesions in certain anatomic regions of the body(4-6). Understanding what orchestrates the activities of cutaneous im …
Aberrant activation of immune cells can induce common skin autoimmune diseases such as vitiligo, which are often characterized …
The IFN-gamma-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment.
Liu H, Wang Y, Le Q, Tong J, Wang H. Liu H, et al. Eur J Immunol. 2024 Apr;54(4):e2250281. doi: 10.1002/eji.202250281. Epub 2024 Mar 5. Eur J Immunol. 2024. PMID: 37937817 Free article. Review.
Vitiligo is a disease featuring distinct white patches that result from melanocyte destruction. ...Specifically, the interferon-gamma (IFN-gamma), C-X-C motif chemokine ligands (CXCL9/10), and C-X-C motif chemokine receptor (CXCR3) signaling axis, collectively refer …
Vitiligo is a disease featuring distinct white patches that result from melanocyte destruction. ...Specifically, the interfero …
Networks of CD8(+) T Cell Response Activation in Melanoma and Vitiligo.
Fukuda K. Fukuda K. Front Immunol. 2022 Apr 1;13:866703. doi: 10.3389/fimmu.2022.866703. eCollection 2022. Front Immunol. 2022. PMID: 35432377 Free PMC article. Review.
Vitiligo is an autoimmune skin disease resulting from the destruction of melanocytes by autoreactive CD8(+) T cells. Vitiligo induced by cancer immunotherapy is a favorable prognostic factor in patients with melanoma, and growing evidence supports the …
Vitiligo is an autoimmune skin disease resulting from the destruction of melanocytes by autoreactive CD8(+) T cells. …
Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo.
Richmond JM, Strassner JP, Zapata L Jr, Garg M, Riding RL, Refat MA, Fan X, Azzolino V, Tovar-Garza A, Tsurushita N, Pandya AG, Tso JY, Harris JE. Richmond JM, et al. Sci Transl Med. 2018 Jul 18;10(450):eaam7710. doi: 10.1126/scitranslmed.aam7710. Sci Transl Med. 2018. PMID: 30021889 Free PMC article.
Vitiligo is an autoimmune disease of the skin mediated by CD8(+) T cells that kill melanocytes and create white spots. Skin lesions in vitiligo frequently return after discontinuing conventional treatments, supporting the hypothesis that autoimmune …
Vitiligo is an autoimmune disease of the skin mediated by CD8(+) T cells that kill melanocytes and create white spots. …
Dimethyl itaconate suppresses dendritic cell and CD8(+) T cell responses to halt vitiligo.
Wang Y, Chen Y, Ma J, Wu L, Kang P, Chen J, Du P, Wu W, Wang X, He K, Yang Y, Guo S, Guo W, Liu L, Jian Z, Gao T, Li S, Li C. Wang Y, et al. BMC Med. 2025 Dec 29;23(1):698. doi: 10.1186/s12916-025-04512-1. BMC Med. 2025. PMID: 41466279 Free PMC article.
BACKGROUND: Although dendritic cell (DC)- and CD8(+) T cell-mediated autoimmunity is critical for destroying melanocytes in vitiligo, treatment options remain limited by the absence of therapies that cotarget both cell types. ...The admin …
BACKGROUND: Although dendritic cell (DC)- and CD8(+) T cell-mediated autoimmunity is critical for destroying …
scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T(reg) function.
Gellatly KJ, Strassner JP, Essien K, Refat MA, Murphy RL, Coffin-Schmitt A, Pandya AG, Tovar-Garza A, Frisoli ML, Fan X, Ding X, Kim EE, Abbas Z, McDonel P, Garber M, Harris JE. Gellatly KJ, et al. Sci Transl Med. 2021 Sep 8;13(610):eabd8995. doi: 10.1126/scitranslmed.abd8995. Epub 2021 Sep 8. Sci Transl Med. 2021. PMID: 34516831 Free PMC article.
Vitiligo is an autoimmune skin disease characterized by the targeted destruction of melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in CD8(+) T cell infiltration of vitiligo lesions, but the ful …
Vitiligo is an autoimmune skin disease characterized by the targeted destruction of melanocytes by T cells. Cytokine si …
118 results