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2002 1
2003 2
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2006 1
2012 1
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Page 1
Evaluation of Therapeutics for Severely Debilitating or Life-Threatening Diseases or Conditions: Defining Scope to Enable Global Guidance Development.
Liu M, Fields FO, Prescott JS, Bello A, Bower N, Darakjy S, Hartke J, Kadambi V, Lapadula D, Stoch A, Derzi M. Liu M, et al. Among authors: kadambi v. Clin Pharmacol Ther. 2020 Mar;107(3):514-520. doi: 10.1002/cpt.1673. Epub 2019 Nov 22. Clin Pharmacol Ther. 2020. PMID: 31608984 Review.
In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices.
Valentin JP, Guillon JM, Jenkinson S, Kadambi V, Ravikumar P, Roberts S, Rosenbrier-Ribeiro L, Schmidt F, Armstrong D. Valentin JP, et al. Among authors: kadambi v. J Pharmacol Toxicol Methods. 2018 Sep-Oct;93:7-14. doi: 10.1016/j.vascn.2018.07.001. Epub 2018 Jul 17. J Pharmacol Toxicol Methods. 2018. PMID: 30030184
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.
Sells TB, Chau R, Ecsedy JA, Gershman RE, Hoar K, Huck J, Janowick DA, Kadambi VJ, LeRoy PJ, Stirling M, Stroud SG, Vos TJ, Weatherhead GS, Wysong DR, Zhang M, Balani SK, Bolen JB, Manfredi MG, Claiborne CF. Sells TB, et al. Among authors: kadambi vj. ACS Med Chem Lett. 2015 Apr 22;6(6):630-4. doi: 10.1021/ml500409n. eCollection 2015 Jun 11. ACS Med Chem Lett. 2015. PMID: 26101564 Free PMC article.
Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database.
Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ. Monticello TM, et al. Among authors: kadambi vj. Toxicol Appl Pharmacol. 2017 Nov 1;334:100-109. doi: 10.1016/j.taap.2017.09.006. Epub 2017 Sep 8. Toxicol Appl Pharmacol. 2017. PMID: 28893587
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Csizmadia V, Hales P, Tsu C, Ma J, Chen J, Shah P, Fleming P, Senn JJ, Kadambi VJ, Dick L, Wolenski FS. Csizmadia V, et al. Among authors: kadambi vj. Toxicol Res (Camb). 2016 Aug 25;5(6):1619-1628. doi: 10.1039/c6tx00220j. eCollection 2016 Nov 1. Toxicol Res (Camb). 2016. PMID: 30090462 Free PMC article.
Use of animals for toxicology testing is necessary to ensure patient safety in pharmaceutical development.
Mangipudy R, Burkhardt J, Kadambi VJ. Mangipudy R, et al. Among authors: kadambi vj. Regul Toxicol Pharmacol. 2014 Nov;70(2):439-41. doi: 10.1016/j.yrtph.2014.07.014. Epub 2014 Jul 21. Regul Toxicol Pharmacol. 2014. PMID: 25058855
Exclusive antagonism of the α4 β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates.
Fedyk ER, Wyant T, Yang LL, Csizmadia V, Burke K, Yang H, Kadambi VJ. Fedyk ER, et al. Among authors: kadambi vj. Inflamm Bowel Dis. 2012 Nov;18(11):2107-19. doi: 10.1002/ibd.22940. Epub 2012 Mar 14. Inflamm Bowel Dis. 2012. PMID: 22419649
Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists.
Blackburn C, LaMarche MJ, Brown J, Che JL, Cullis CA, Lai S, Maguire M, Marsilje T, Geddes B, Govek E, Kadambi V, Doherty C, Dayton B, Brodjian S, Marsh KC, Collins CA, Kym PR. Blackburn C, et al. Among authors: kadambi v. Bioorg Med Chem Lett. 2006 May 15;16(10):2621-7. doi: 10.1016/j.bmcl.2006.02.044. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16524729
Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins.
Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. Donoghue M, et al. Among authors: kadambi v. J Mol Cell Cardiol. 2003 Sep;35(9):1043-53. doi: 10.1016/s0022-2828(03)00177-9. J Mol Cell Cardiol. 2003. PMID: 12967627
Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy.
Dash R, Schmidt AG, Pathak A, Gerst MJ, Biniakiewicz D, Kadambi VJ, Hoit BD, Abraham WT, Kranias EG. Dash R, et al. Among authors: kadambi vj. Cardiovasc Res. 2003 Mar;57(3):704-14. doi: 10.1016/s0008-6363(02)00772-1. Cardiovasc Res. 2003. PMID: 12618232
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